Main Site Of Origin Research Articles

Evaluation of the Histopathologic Reports of Oral Lesions in Razi Laboratory in Rasht in 2014-2018

Background: Oral lesions can affect people’s quality of life by interfering with chewing, swallowing, and speech. These lesions may originate from epithelial or mesenchymal tissues. Malignant oral lesions can be life-threatening. Epidemiological data of oral lesions in Iran is limited. Objective: This study aims to investigate the frequency of oral lesions in Rasht, Iran. Methods: In this cross-sectional study, histopathologic data of oral lesions reported by Razi laboratory in Rasht from 2015 to 2019 were evaluated. The data collected: Patients’ age and sex, histopathologic findings, and location, type and origin of lesions. Non-specific diagnoses and dental and bone lesions were excluded. Results: A total of 259 pathologic reports were included. The mean age patients was 52.09±19 years, and 40.2% were male. Oral lesions in patients aged <40 years were mainly benign (64.2%), whereas half of lesions in patients ≥70 years were mostly malignant. Tongue was the most common location of the lesions (34.7%) and the main location for malignant lesions (46.7%). Benign lesions were significantly higher in females whereas malignant lesions were significantly higher in males (P=0.011). Epithelial tissues were the most common site of origin (49%) and salivary glands were the least common site of origin (11.6%) for oral lesions. Conclusion: Malignant oral lesions are more common in Iranian men aged >70 years, where the tongue is the most common site of involvement and epithelial tissue is the main site of origin.

Decompression as an Initial Procedure in Unicystic Ameloblastoma

Unicystic ameloblastoma (UCA) is a variant of ameloblastoma that presents as a single cystic cavity. Usually, slightly more than 50% of the cases occur in the second decade of life. They are characterized by slow growth and relatively local aggressiveness, with the posterior portion of the mandible as the main site of origin. This case report describes a UCA occurring in the left mandible of an 18-year-old boy. He presented with progressive asymptomatic swelling with expansion of the buccal cortical plates of the left mandible. Panoramic imaging showed a well-defined unilocular asymmetric radiolucency with root resorption of some teeth in the affected area. An incisional biopsy revealed a single cavity lesion; thus, a plastic device was placed for decompression. The histopathological diagnosis was UCA. A follow-up after 3 months showed significant bone formation and decrease of the lesion. The patient is under follow-up.

Ophthalmic Metastasis of Breast Cancer and Ocular Side Effects from Breast Cancer Treatment and Management: Mini Review.

Breast cancer is one of the most common malignant diseases occurring in women, and its incidence increases over the years. It is the main site of origin in ocular metastatic disease in women, and, due to its hematogenous nature of metastatic spread, it affects mainly the uveal tissue. The purpose of this paper is to summarize the clinical manifestations of the breast cancer ocular metastatic disease, alongside the side effects of the available treatment options for the management and regression of the systematic and ophthalmic disease.

Unicystic ameloblastoma

Unicystic ameloblastomas are a rare variant of ameloblastomas, which usually occur in younger populations. They are characterized by slow growth and being relatively locally aggressive, with the main site of origin being the posterior portion of the mandible. Late recurrence following surgical management is relatively common and is related to the histological type, the site of origin, and the initial treatment modality. This case report describes a unicystic ameloblastoma occurring in the right posterior mandible of an 8-year-old girl. She presented with progressive swelling of the right lower deciduous molar region for 3 months. Panorex imaging showed a well-defined unilocular radiolucency surrounding the impacted permanent first molar, root resorption of the deciduous second molar, and mesial displacement of the partially formed second bicuspid. Computed tomography revealed expansion of both buccal and lingual cortical plates of the right posterior mandible by the cystic lesion with inclusion of the permanent lower first molar. It was initially diagnosed as a dentigerous cyst and was treated by enucleation and removal of the permanent first molar and the deciduous second molar. The partially formed second premolar and the permanent second molar were left undisturbed. A histopathological examination of the specimen showed a mural variant of a unicystic ameloblastoma. After surgery, healing of the right mandibular bone defect was uneventful, as shown by follow-up panoramic radiography. No recurrence was detected at an 18-month follow-up. We suggest that the long-term follow-up is mandatory because late recurrence of unicystic ameloblastomas has been reported.

The main site of origin for malignancies detected during risk-reducing surgery for ovarian cancer

The main site of origin for malignancies detected during risk-reducing surgery for ovarian cancer

Primary Non-Hodgkins Lymphoma of Muscle

A retrospective analysis was made of all patients with primary muscle non-Hodgkin's lymphomas registered with the Scotland and Newcastle Lymphoma Group over a 15-year period. Only eight patients were identified. The median age was 69 years (range 27–93). Five patients were male and six lymphomas were of high grade histology. The glutei and upper arm muscles were the main sites of origin, with the additional involvement of adjacent bone in four patients; only three had lymph node involvement at presentation. Most patients (6/8) received both chemotherapy and radiotherapy. The median survival was 33 months. The conclusion is that this is a small group of patients whose outlook is not as poor as has been suggested in previous reports.

Quantitative studies on the supraoptic nucleus in the rat. II. Afferent fiber connections.

A quantitative electron microscopic study of synaptic terminal degeneration was performed in the supraoptic nucleus (NSO) after a variety of major transections or ablations, destroying or interrupting in different combinations the afferent pathways known from earlier and own light microscopic degeneration studies. Solutions of a set of equations, expressing the percentage degenerations in synaptic profiles after different combinations in which the several pathways are interrupted by the various interferences, enabled the authors to give the following percentage numbers for afferent synapses from different sources. 32.7% of supraoptic afferents originate from the brain stem probably representing the monoaminergic innervation of this nucleus. The medial basal hypothalamus (21.0%), amygdala (13.5%), septum (13.5%), hippocampus (8.5%) and olfactory tubercle and further rostral cortical region (17.0%) are the other main sites of origin of supraoptic nucleus afferents. There are no supraoptic afferents from the optic nerve, superior cervical ganglion or fimbria hippocampi.