Aims and objectives: To examine the recent literature on the barriers to adherence in adolescents with cystic fibrosis (CF) and to propose recommendations for providers to improve adherence and overcome these obstacles. Background: Non-adherence in chronically ill adolescents has become a public health concern as it contributes to a significant increase in morbidity and mortality. CF is a progressive, genetic disease with a particularly complex and time-consuming treatment regimen. Adolescent patients with CF fail to achieve optimal adherence goals. Design: Systematic review using the guidelines of the Cochrane Collaboration described in the 2009 PRISMA statement. Methods: PubMed, Web of Science and Google Scholar were searched from 1/2009 to 10/2014. A systematic review of the literature was done to identify the primary barriers to treatment adherence in adolescents with CF. Results: Ten studies involving 512 participants with an average age range of 12.0 to 19.3 years across 4 countries were included. We classified the data into three main categories of barriers to adherence: psychological barriers (body image, internalizing disorders, perception of disease), physical barriers (schedule, time management, pain) and social barriers (family dynamics, friendship quality). Conclusions: There are numerous potential obstacles to adherence for adolescents with CF. Whether the barriers are physical, psychological or social, the aim of the provider is to identify areas of strength and weakness in the treatment regimen, customize the interventions in the context of their lifestyle, and then set realistic goals for improvement. Relevance to clinical practice: Screening adolescents with CF for potential psychological, physical or social obstacles to treatment compliance will allow the provider identify problematic areas and prioritize their clinic visits accordingly.Aims and objectives: To examine the recent literature on the barriers to adherence in adolescents with cystic fibrosis (CF) and to propose recommendations for providers to improve adherence and overcome these obstacles. Background: Non-adherence in chronically ill adolescents has become a public health concern as it contributes to a significant increase in morbidity and mortality. CF is a progressive, genetic disease with a particularly complex and time-consuming treatment regimen. Adolescent patients with CF fail to achieve optimal adherence goals. Design: Systematic review using the guidelines of the Cochrane Collaboration described in the 2009 PRISMA statement. Methods: PubMed, Web of Science and Google Scholar were searched from 1/2009 to 10/2014. A systematic review of the literature was done to identify the primary barriers to treatment adherence in adolescents with CF. Results: Ten studies involving 512 participants with an average age range of 12.0 to 19.3 years across 4 countries were included. We classified the data into three main categories of barriers to adherence: psychological barriers (body image, internalizing disorders, perception of disease), physical barriers (schedule, time management, pain) and social barriers (family dynamics, friendship quality). Conclusions: There are numerous potential obstacles to adherence for adolescents with CF. Whether the barriers are physical, psychological or social, the aim of the provider is to identify areas of strength and weakness in the treatment regimen, customize the interventions in the context of their lifestyle, and then set realistic goals for improvement. Relevance to clinical practice: Screening adolescents with CF for potential psychological, physical or social obstacles to treatment compliance will allow the provider identify problematic areas and prioritize their clinic visits accordingly.
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