Magnetic Mesoporous Silica Research Articles

Thrombin Immobilized on Magnetic Core-Shell Mesoporous Silica Nanoparticles for Screening of the Enzyme Inhibitors From Notopterygium Incisum.

Thrombin was immobilized on magnetic core-shell mesoporous silica nanoparticles (Fe3O4@nSiO2@mSiO2) for the first time and used to screen enzyme inhibitors from extracts of Notopterygium incisum. The immobilized thrombin was characterized by Fourier-transform infrared spectroscopy, transmission electronic microscopy, thermal gravimetric analysis, and vibrating sample magnetometry. The results demonstrated that the immobilized thrombin possessed good thermal stability and high-temperature resistance for feasible storage and reuse. Two ligands, notopterol (1) and isoimperatorin (2) were fished out from the extract of N. incisum using the immobilized thrombin. They inhibited thrombin with IC50 values of 59.35±1.420 and 107.8±1.660µM, respectively. This is the first report of thrombin-inhibitory activity associated with notopterol and isoimperatorin. Meanwhile, the inhibition mechanism of both compounds was investigated by enzyme kinetic analysis and molecular docking. The method used enables rapid screening for thrombin inhibitors from medicinal plants, providing an efficient tool for the discovery of anti-thrombotic active compounds.

Green Synthesis of Some 2‐Amino‐4 h‐Benzo[H]Chromene Derivatives in the Presence of Bimetallic Nanocomposite Based on Magnetic Mesoporous Silica Nanoparticles at Ambient Conditions

AbstractIn this research, some of 2‐amino‐4H‐benzo[h]chromene derivatives were synthesized by multicomponent reaction of 1‐naphthol, benzaldehyde derivatives and malononitrile. The reaction was performed under green conditions using water as the solvent in the presence of heterogeneous nano catalyst containing Co(II) and Cu(II) stabilized on magnetic mesoporous silica nanoparticles/tannic acid (M–MSN/TA/Co(II),Cu(II)) at room temperature. The prepared catalyst showed excellent efficiency and its magnetic properties allow easy separation. The structure and morphology of prepared catalyst was identified using Fourier transform infrared (FT‐IR), X‐ray diffraction (XRD), field emission scanning electron microscopy (FE‐SEM), energy dispersive X‐ray spectroscopy (EDX), elemental mapping, thermogravimetric analysis (TGA) and vibrating‐sample magnetometry (VSM) analysis. All of products were obtained in high to excellent yields (78–94 %) after short reaction times (20–45 min) in optimal conditions and their structures were confirmed using FT‐IR and Proton nuclear magnetic resonance (1H NMR) spectroscopic techniques. This study shows that the M–MSN/TA/Cu(II), Co(II) presents a good catalytic activity, reusability and stability compared to other catalysts.

GSH-responsive magnetic mesoporous silica nanoparticles for efficient controlled drug delivery in tumor cells

In this study, glutathione (GSH)-responsive magnetic mesoporous silica nanoparticles grafted by disulfide organosilicon (SMNPs) were synthesized, characterized, and evaluated as controlled drug carriers. The nanoparticles exhibited consistent dispersion, considerable drug-loading capacity, and high saturation magnetization. Importantly, they demonstrated the ability to release doxorubicin (DOX) by up to 43% in a reducing tumor microenvironment, highlighting their potential for targeted therapy. In addition, the SMNPs displayed favorable biocompatibility, making them suitable for biomedical applications. Most notably, the SMNPs loaded with DOX effectively killed both HepG2 and HeLa cancer cells, while also showing efficient cellular uptake in HeLa cells. These findings suggest that SMNPs are a promising platform for magnetic-targeted and GSH-responsive delivery of therapeutic agents.

Magnetic mesoporous silica nanoparticles loaded with peptides for the targeted repair of cavernous nerve injury underlying erectile dysfunction

Erectile dysfunction (ED) is a common male sexual disorder characterized by repeated or persistent difficulty in achieving or maintaining an erection. It can arise from various factors, with cavernous nerve injury (CNI) from radical prostatectomy being a predominant cause of iatrogenic ED, posing significant clinical concerns. The complexity of cavernous tissue damage in CNI-induced ED (CNIED) often results in poor efficacy and resistance to conventional vascular ED treatments. To address CNI-induced ED, this study developed a system of magnetic mesoporous silica nanoparticles (MSNs) loaded with peptides for targeted treatment. Core-shell Fe3O4-coated MSNs were used as drug carriers and loaded with RADA16-I/RAD-RGI peptides (PD) to create a neurotrophic microenvironment to treat peripheral nerve defects. Furthermore, the neuro-targeting peptide HLNILSTLWKYR (PT) was grafted onto MSNs. The in vivo therapeutic effect was evaluated using a rat bilateral cavernous nerve injury (BCNI) model. The results showed that the neuro-targeted Fe3O4@SiO2-PT-PD nanoparticles significantly promoted regeneration of the cavernous nerve and restored erectile function. This promising strategy offers significant clinical potential for treating CNI-induced ED. Nanomedicine technology has the potential to not only improve treatment outcomes but also reduce side effects in healthy cells, paving the way for more accurate targeted repair of cavernous nerve damage.

Magnetically actuated cisplatin-loaded nanoparticle collectives enhance drug penetration for potentiated ovarian cancer chemotherapy

Chemotherapy is the main clinical treatment for ovarian cancer, but still faces challenges of low drug targeting efficiency and insufficient drug permeability. Drug-loaded nanoparticle collectives, which are actuated by magnetic field, could be targeted to a designated location and achieve targeted drug delivery. In this work, we report a strategy that utilizes magnetic mesoporous silica nanoparticles loaded with cis-diaminodichloroplatinum (Fe3O4@SiO2-CDDP) for targeted delivery of chemotherapeutic drugs and enhances penetration into deep tumors. The Fe3O4@SiO2-CDDP collectives actively moved to the target tumor site, and this movement was regulated by a magnetic actuation system. Under the action of a torque-force hybrid magnetic field (TFMF), Fe3O4@SiO2-CDDP could further penetrate into the interior of tumors and achieve pH-responsive drug release in the tumor environment. The feasibility of this strategy was verified in three-dimensional cell spheres in vitro and in a tumor-bearing mouse model in vivo. This magnetically actuated nanoparticle collectives enhanced drug penetration strategy provides a new paradigm for targeted drug delivery and potentiated tumor therapy.

Construction of quaternary ammonium nitroxy-hybrid magnetic mesoporous silica adsorbent system and its selective adsorption research of Re(Ⅶ)/Cu(Ⅱ)

This study focussed on the development of a quaternary ammonium nitroxy-hybrid magnetic mesoporous silica adsorption system (Fe3O4@MS-SiO2@3-CPTES@Tetra-N-ACE, Fe3O4@MS-SiO2@3-CPTES@Tetra-2N@ACE and Fe3O4@MS-SiO2@3-CPTES@Tetra-DE) was established with adsorption structures consisting of 1,4,7,10,13-pentaoxa-16-azacyclooctadecane (N-ACE), 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (2N-ACE) and a similar linear structure, 3,6-dioxy-1,8-octylenediamine (DE) for the selective separation of Re/Cu. The composites were characterized by Fourier transform Infrared spectroscopy(FT-IR), Energy dispersive spectrometer(EDS), X-ray Diffraction(XRD), Transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) measurements. The characterization of composites exhibits mesoporous and rich functional groups. The experimental results demonstrated that the Fe3O4@MS-SiO2@3-CPTES@Tetra-2N@ACE and Fe3O4@MS-SiO2@3-CPTES@Tetra-DE possessed superior adsorption capacities of Re(VII) in a wide acidic environment (pH=3–6). The maximum adsorption capacity of Fe3O4@MS-SiO2@3-CPTES@Tetra-2N@ACE and Fe3O4@MS-SiO2@3-CPTES@Tetra-DE were respectively up to 331.77 mg·g−1, 395.54 mg·g−1 at pH 5.0. Furthermore, the adsorption rate of these adsorbents was fast for only 2 h to absorb more than 80 % of Re(VII). Notably, when Fe3O4@MS-SiO2@3-CPTES@Tetra-2N@ACE and Fe3O4@MS-SiO2@3-CPTES@Tetra-DE were added into the rhenium copper binary solution with the concentration ratio from 1:1 and 1:50, the Re (Ⅶ) / Cu (Ⅱ) selectivity was constantly excellent (SelRe/Cu value > 1.46, SelRe/Cu max = 4.96). After 5 desorption processes for Re (Ⅶ) with 3 mol·L−1 NaCl and 1 mol·L−1 NaCl, respectively, the adsorption efficiency decreased by less than 10 % at Fe3O4@MS-SiO2@3-CPTES@Tetra-2N@ACE and Fe3O4@MS-SiO2@3-CPTES@Tetra-DE. The adsorption mechanism between the adsorbents and Re(VII) was mainly electrostatic interaction and ion exchange through TEM-EDS, FT-IR, and XPS. This novel adsorption system had a promising application in the selective separation of Re(VII)/Cu(Ⅱ).

Magnetic Mesoporous Silica Functionalized with Amine Groups for Efficient Removal of Heavy Metals and Bacterial Inhibition

Magnetic Mesoporous Silica Functionalized with Amine Groups for Efficient Removal of Heavy Metals and Bacterial Inhibition

Stepwise synthesis of magnetic mesoporous silica nanoparticles decorated with SnO2 quantum dots as an efficient, recyclable, and green nanocatalyst for the synthesis of benzo[a]pyrano[3,2‐c]phenazine derivatives

In this research, magnetic mesoporous silica nanoparticles decorated with SnO2 quantum dots (M‐MSNs/SnO2[QDs]) were successfully synthesized and characterized using several advanced techniques including FT‐IR, XRD, FE‐SEM, EDS, elemental mapping, VSM, and BET. This study demonstrates the synthesis of benzo[a]pyrano[3,2‐c]phenazine derivatives via a four‐component reaction between 2‐hydroxy‐1,4‐naphthoquinone, ortho‐phenylenediamine, malononitrile, and benzaldehyde derivatives in the presence of M‐MSNs/SnO2(QDs) in ethanol as a green solvent. The proposed catalyst efficiently catalyzed the synthesis of these compounds with yields of 87–96% in 70–100 minutes. The presented method offers a cost‐effective and environmentally friendly approach with numerous advantages, including high product yields, simple operation, short reaction times, low‐cost purification, and facile catalyst recovery.

PH and temperature dual-responsive magnetic yolk-shell mesoporous silica nanoparticles for controlled drug delivery

New magnetic yolk-shell mesoporous silica nanoparticles (Fe3O4@V-mSiO2-PNVCL) were prepared by grafting temperature-sensitive amino-terminated poly (N-vinylcaprolactam) (PNVCL-NH2) on the surface of aldehyde-functionalized magnetic mesoporous silica nanoparticles (Fe3O4@V-mSiO2-CHO) through a Schiff base reaction. Various characterizations were used to confirm the structures, and the drug loading and release behaviors were studied. The drug loading was achieved as PNVCL stretched at room temperature and the drug loading content was up to 54.7% due to the large cavities. The encapsulation of drug from leakage in the blood environment was realized as PNVCL collapsed at physiological temperature. The fracture of pH-liable imine bonds in a slightly acidic tumor environment triggered the burst release of cargo. The Fe3O4@V-mSiO2-PNVCL showed super paramagnetic behavior (21.01 emu∙g−1) which could achieve magnetic targeting. The MTT assay confirmed that the nanoparticles exhibited low cytotoxicity. Furthermore, the cellular uptake experiments indicated that DOX-loaded nanoparticles were successfully internalized into cancer cells. Therefore, the composite nanoparticles are ideal choices for drug carriers.

Magnetic Mesoporous Silica Nanocomposite Supported Ionic Liquid/Cu as a Powerful and Highly Stable Catalyst for Chan-Lam Coupling Reaction

Magnetic Mesoporous Silica Nanocomposite Supported Ionic Liquid/Cu as a Powerful and Highly Stable Catalyst for Chan-Lam Coupling Reaction

Supported Bis-(NHC)-Pd(II) complex: A phosphine-free catalyst supported on magnetic mesoporous silica for the CO-free carbonylation of aryl halides

In this work, our previously reported bis(NHC)-Pd(II) catalyst grafted on Fe3O4@SBA-15 has been successfully used as a phosphine-free heterogeneous magnetic catalyst in the CO-free carbonylation of aryl halides. It is shown that the immobilized Pd(II)-complex efficiently catalyzes the carbonylation of different aryl halides with HCOOH and DCC in the presence of Et3N as the base. Optimal reaction conditions were determined by screening various parameters such as solvent, HCOOH/DCC molar ratio, base, temperature, and catalyst dosage. The catalyst was magnetically retrievable and separated by an external magnet, washed, and re-used in the subsequent runs over seven catalytic cycles. The hot filtration experiment was conducted to determine the heterogeneous nature of the catalyst.

Mitoxantrone-Derivative Drug Structure-Directing Agent for the Synthesis of Magnetic Mesoporous Silica Nanoparticles for Breast Cancer Treatment

Mitoxantrone-Derivative Drug Structure-Directing Agent for the Synthesis of Magnetic Mesoporous Silica Nanoparticles for Breast Cancer Treatment

Aspergillus oryzae β-D-galactosidase immobilization on glutaraldehyde pre-activated amino-functionalized magnetic mesoporous silica: Performance, characteristics, and application in the preparation of sesaminol

Aspergillus oryzae β-D-galactosidase (β-Gal) efficiently hydrolyzes sesaminol triglucoside into sesaminol, which has higher biological activity. However, β-Gal is difficult to be separate from the reaction mixture and limited by stability. To resolve these problems, β-Gal was immobilized on amino-functionalized magnetic nanoparticles mesoporous silica pre-activated with glutaraldehyde (Fe3O4@mSiO2-β-Gal), which was used for the first time to prepare sesaminol. Under the optimal conditions, the immobilization yield and recovered activity of β-Gal were 57.9 ± 0.3 % and 46.5 ± 0.9 %, and the enzymatic loading was 843 ± 21 Uenzyme/gsupport. The construction of Fe3O4@mSiO2-β-Gal was confirmed by various characterization methods, and the results indicated it was suitable for heterogeneous enzyme-catalyzed reactions. Fe3O4@mSiO2-β-Gal was readily separable under magnetic action and displayed improved activity in extreme pH and temperature conditions. After 45 days of storage at 4 °C, the activity of Fe3O4@mSiO2-β-Gal remained at 92.3 ± 2.8 %, which was 1.29 times than that of free enzyme, and its activity remained above 85 % after 10 cycles. Fe3O4@mSiO2-β-Gal displayed higher affinity and catalytic efficiency. The half-life was 1.41 longer than free enzymes at 55.0 °C. Fe3O4@mSiO2-β-Gal was employed as a catalyst to prepare sesaminol, achieving a 96.7 % conversion yield of sesaminol. The excellent stability and catalytic efficiency provide broad benefits and potential for biocatalytic industry applications.

Copper(II)-polymer chelate grafted from magnetic mesoporous silica for the O-arylation of phenols via the Ullmann reaction

The present work describes the grafting of polymer-metal chelates (PMC) from Fe3O4@SBA-15 via the Surface Initiated-Atom Transfer Radical Polymerization (SI-ATRP) method. Fe3O4@SBA-15 were silylated by 2-bromo-2-methyl-N-(3-(trimethoxysilyl)propanamide (BTPAm) to give the surface-anchored ATRP initiator. Acrylamide (AAm) was polymerized from the Fe3O4@SBA-15 surface via the ATRP approach and trans-amidated with ethylenediamine to give poly(N-2-aminoethylacrylamide) grafted magnetic mesoporous silica, Fe3O4@SBA-g-PAE-AAm. The grafted chelating polymer ligand (CPL) was treated with an acetonitrile solution of Cu(OAc)2 to afford the Fe3O4@SBA-g-PAE-AAm-Cu(II). The grafted PMC was characterized by FT-IR, CP/MAS 13C NMR, thermo-gravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) analysis. The oxidation state of copper (+2) was confirmed using X-ray photoelectron spectroscopy (XPS). The catalytic activity of the grafted PMC was examined in the CO bond formation via the Ullmann-type O-arylation reaction between haloarenes and phenols after establishing the optimal reaction conditions. The excellent recyclability of the catalyst was shown by small deactivation over seven runs.

MRI-traceable multifunctional magnetic mesoporous silica nanoparticles (MMSN) capped with graphene quantum dots (GQD) as a theragnostic system in colorectal cancer treatment

In the study, a multifunctional nanosystem composed of magnetic core-mesoporous silica nanoparticles (MMSN) capped with graphene quantum dots (GQD) was proposed as a theragnostic platform against colorectal cancer cells. The theragnostic carrier was well characterized and had an average particle size of 140 nm, with a specific surface of 475.82 m2 g−1. The superparamagnetic nanoparticles showed a hysteresis loop, with a maximum magnetization of 14.93 emu.g−1 and a remanence of 2.64 emu.g−1. The functionalization of MMSN was confirmed using the ninhydrin test. Regorafenib (REGO), an anticancer drug, was used with a loading capacity of 77.5 μg mg−1. The drug release profiles from the carrier and the sensitivity of the interaction between MMSN and GQD to pH were examined, revealing that more drug release was observed in acidic pH. The cytotoxicity of the MMSN-REGO/GQD system was evaluated on colorectal cancer cell line SW-480 using MTT assay, and the results indicated that no cytotoxicity was observed for the MMSN/GQD carrier. Furthermore, the IC50 of REGO was significantly reduced from 85 μg ml−1 to 6 μg ml−1 in the loaded form. The response of MMSN/GQD nanoparticles to the external magnetic field exhibited the capability of the theragnostic system as an MRI contrast agent. Generally, biocompatible, theragnostic, pH-responsive, multifunctional MMSN/GQD can be considered promising candidates for treatment, MRI imaging, and hyperthermia in colorectal cancer treatment.

Immobilization of ionic liquids (ILs) on magnetic mesoporous silica nanotubes: A high throughput and reusable nanocatalyst for the green synthesis of indeno[1,2-b]indolone derivatives

The acidic ionic liquid supported on the magnetic mesoporous silica nanotubes (M-MSNTs/IL) was prepared as a new magnetic catalyst and fully characterized with FE-SEM, HR-TEM, EDS, TGA, BET, VSM, FT-IR, EDX, elemental mapping and XPS. The template of catalyst was magnetic aminated MWCNTs (M-MWCNTs/CONHBu), which removed through calcination process and magnetic mesoporous silica nanotubes (M-MSNTs) were obtained and functionalized using adenine based ionic liquid. The prepared catalyst was successfully applied as a new reusable heterogeneous catalyst for the one-pot three-component indeno[1,2-b]indole-9,10-dione derivatives in water at 75 °C. All of desired products were obtained in good to excellent yields (79–96 %) after relatively short reaction times. M-MSNTs/IL also exhibited a remarkable performance with TOF of 61.2 h-1 and TON of 86.7. The use of M-MSNTs/IL catalyst in the synthesis of indeno[1,2-b]indole-9,10-dione derivatives revealed several advantages including mild reaction conditions, high yield of pure products, clean reaction conditions, avoiding the production of toxic waste, chemical stability of the catalyst, low amount and reusability of catalyst. In addition, the applied nanocatalyst was recovered with an external magnet and reused 6 times without considerable reduction in its catalytic activity.

Interfacial Si–O–Zr bonds induced well dispersed zirconia on magnetic mesoporous silicas for enhanced tetracycline removal

Constructing recoverable materials with both high adsorption capacity and excellent photocatalytic performance towards antibiotics elimination is very meaningful and challenging in wastewater remediation. In this work, we demonstrate a simple interface engineering strategy to design well dispersed zirconia on core–shell structured magnetic mesoporous silica microspheres (MMS) for efficient removal of tetracycline hydrochloride (TC). With ultrahigh specific surface area (682.0 m2/g) and interfacial Si-O-Zr serving as active sites, the optimal sample (MMS-Zr10) exhibits enhanced TC adsorption capacity of 266.5 mg/ZrO2 g, which is 19.2-fold than that of pure ZrO2. Simultaneously, the photocatalytic degradation rate constant of TC over MMS-Zr10 in the presence of peroxydisulfate (PDS) is 12.5 times that of ZrO2 under visible light irradiation, which may be attributed to the enhanced light harvest capability and high charge separation efficiency facilitated by interfacial Zr–O–Si charge transfer channels. Furthermore, in consecutive adsorption cycles in both deionized (DI) water solution and actual wastewater, no obvious decline in TC removal % is observed. The TC adsorption is mainly governed by pore filling, hydrogen bonding and electrostatic interactions; whilst O2•−, h+, SO4•−, •OH and 1O2 species are responsible for enhanced photocatalytic degradation of TC.

Magnetic Mesoporous Silica for Targeted Drug Delivery of Chloroquine: Synthesis, Characterization, and In Vitro Evaluation.

Malaria is a dangerous tropical disease, with high morbidity in developing countries. The responsible parasite has developed resistance to the existing drugs; therefore, new drug delivery systems are being studied to increase efficacy by targeting hemozoin, a parasite paramagnetic metabolite. Herein, magnetic mesoporous silica (magMCM) was synthesized using iron oxide particles dispersed in the silica structure for magnetically driven behavior. The X-ray diffractogram (XRD) and Mössbauer spectra show patterns corresponding to magnetite and maghemite. Furthermore, Mössbauer spectroscopy revealed superparamagnetic behavior, attributed to single magnetic domains in particles smaller than 10 nm. Even in the presence of iron oxide particles, the hexagonal structure of MCM is clearly identified in XRD (low-angle region) and the channels are visible in TEM images. The drug chloroquine (CQ) was encapsulated by incipient wetness impregnation (magMCM-CQ). The N2 adsorption-desorption isotherms show that CQ molecules were encapsulated in the pores, without completely filling the mesopores. BET surface area values were 630 m2 g-1 (magMCM) and 467 m2 g-1 (magMCM-CQ). Encapsulated CQ exhibited rapid delivery (99% in 3 h) in buffer medium and improved solubility compared to the non-encapsulated drug, attributed to CQ encapsulation in amorphous form. The biocompatibility assessment of magMCM, magMCM-CQ, and CQ against MRC5 non-tumoral lung fibroblasts using the MTT assay after 24 h revealed no toxicity associated with magMCM. On the other hand, the non-encapsulated CQ and magMCM-CQ exhibited comparable dose-response activity, indicating a similar cytotoxic effect.

Modification of magnetic mesoporous silica nanoparticles with antimicrobial peptide as recyclable and durable antibacterial agents

Antimicrobial peptides (AMPs) play a significant role in combating antimicrobial resistance. However, the applications of AMPs are constricted by insufficient stability under physiological conditions. Therefore, developing novel and effective antibacterial materials with AMPs is an urgent demand. In this study, magnetic mesoporous silica nanoparticles were fabricated through a facile method and stable modifications of AMPs through the bond formation of Fe-S in the mesopores. The resultant nanoparticles (denoted as Fe3O4@mSiO2@CysHHC10) consisted of Fe3O4 core, SiO2 out layer with cylindrical mesoporous channels, and abundant CysHHC10 immobilized in the mesopores. Fe3O4@mSiO2@CysHHC10 exhibited powerful antibacterial performance against both Gram-negative and Gram-positive bacteria. Also, owing to the CysHHC10 being sheltered with mesoporous channels, Fe3O4@mSiO2@CysHHC10 retained almost more than 99.9% antibacterial efficiency for bacteria throughout nine cycles. Furthermore, the resultant nanoparticles exhibit favorable biocompatibility in vitro. This work provides a novel way for the fabrication of antibacterial magnetic materials with recyclable and durable antibacterial activity.

Synthesis and characterization of surface-modified magnetic mesoporous silicate materials for phosphate adsorption.

The magnetic mesoporous silica material, Mag-MCM-41, was synthesized by coating magnetite (Fe3O4) nanoparticles with a mesoporous material called MCM-41. Mag-MCM-41 and modified nanomaterials Mag-MCM-41-NN and Mag-MCM-41-NN-Fe+3 which were modified with aminopropyl functional groups. In water and wastewater, phosphate anions are considered significant contaminants due to their detrimental impact on the environment. They promote the growth of algae, leading to eutrophication. The purpose of this study is to investigate the removal of phosphate anions from aqueous solutions using modified magnetic silica particles. The Mag-MCM-41 material exhibits hexagonal properties and belongs to the class of "mesoporous" materials. It has a surface area of 923 m2.g-1, which was determined through N2 adsorption-desorption isotherms, FTIR, TEM, BET, and SAXS analysis. Kinetic and adsorption isotherm studies were conducted using Mag-MCM-41, Mag-MCM-41-NN, and Mag-MCM-41-NN-Fe+3 adsorbents to examine the behavior of phosphate anions. The kinetic and adsorption isotherm studies of phosphate anions revealed that the adsorption process on Mag-MCM-41, Mag-MCM-41-NN, and Mag-MCM-41-NN-Fe+3 adsorbents followed the chemical adsorption mechanism. Phosphate adsorption on all adsorbents occurred in a monolayer, and the MCM-41-NN-Fe+3 adsorbent exhibited the highest maximum adsorption capacity (qm) value of 112.87 mg.g-1 compared to the other adsorbents.