Magnesium Aluminium Silicate Research Articles

Magnesium sulphate resistance of fly ash one-part geopolymers: Influence of solid alkali activators on physical, mechanical and chemical performance

The commitment to promoting circular economy and durable construction materials has led to the advocacy for one-part geopolymer (OPG), as an eco-friendly substitute for traditional ordinary Portland cement (OPC). Solid alkali activator is the fundamental component of OPG and significantly influences the sulphate resistance. To identify the types of solid alkali activators best suited for the development of sulphate-resistant OPGs, OPGs activated with Na2SiO3 (M-OPG), Na2SiO3+Na2CO3 (MC-OPG), Na2SiO3+NaOH (MH-OPG) and Na2SiO3+NaAlO2 (MA-OPG) were exposed to 5 % and 10 % of MgSO4 solutions for 28 days. The fine pore structures of MH-OPG and MC-OPG mitigated deterioration from the more concentrated MgSO4 solution, resulting in higher residual compressive strengths after exposure to the 10 % MgSO4 compared to the 5 %. Exposure to the 5 % MgSO4 solution resulted in strength deterioration for M-OPG, MH-OPG and MC-OPG due to the discontinuity of the aluminosilicate structure, as evidenced by the diminished Q4(3Al) sites. Conversely, the MA-OPG exhibited a 24.1 % increase in compressive strength, accompanied by the emergence of sodium magnesium aluminium silicate hydrate ((N,M)-A-S-H) gel. Hence, Na2SiO3+NaAlO2 should be acknowledged as the primary candidate for solid alkali activators in the development of sulphate-resistant OPGs.

In vivo assessment, formulation, characterization and enhancing pharmacotherapy of encapsulated mini tablets for immediate release Sildenafil citrate and sustained release Bosentan

The purpose of this study was to prepare and evaluate multiple unit mini tablets (MTs) of prolonged released (PR) bosentan (BSN) and fast release (FR) sildenafil citrate (SDC) on the basis of encapsulation method for the effective management of pulmonary artery hypertension. The system consists of MTs are in the form of uncoated tablets containing the superdisintegrating agents where as the PRMTs contains the polymer with film coating. All the units are prepared by direct compression method and encapsulated using size 1 hard gelatin capsule shells. The formulations were evaluated for differential scanning calorimetry, dissolution test and post compression studies for their quality attributes and it was found that all the parameters were in the acceptable limits. The optimized formulation for BSN PRMTs i.e BS3 which contains 5 % HPMC K15M shows a promising sustained release profile of 82.31 % in 24 h similarly FRMTs of SDC of formulation SD6 that having 3 % of magnesium aluminium silicate shows about 90 % of drug release within 15 min. The in-vivo pharmacokinetic characterization of the system was carried out using wister rats where the AUC value for SDC FRMTs and BSN PRMTs was found to be 94256.88625 ± 123.65 ng h/mL and 142438.084 ± 324.11 ng h/mL respectively. The other pharmacokinetics are also determined and found to be satisfactory. The six months stability samples showed no significant change in the drug content, hardness and uniformity of the content of the optimized formulations.

THE ROLE OF DANTADHAVANA (TOOTH BRUSHING) TO PROMOTE ORAL HEALTH

Ayurveda is the science of life. The knowledge of Ayurveda originated in India more than 5000 years ago. Ayurveda is considered to be a part of Atharva Veda. The goal of Ayurveda is to maintain health and cure diseases. To maintain positive health in healthy individual. Ayurveda has mentioned Dinacharya, it is one of the most important things in our daily life. It means ``The Daily Routine’ one should follow the Dinacharya properly to lead a healthy and disease-free life. Acharya Charaka, Sushruta and Vagbhatta have a separate chapter for Dantadhavana, it is the most important part of our daily routine in every morning and after food. In the modern era due to sedentary lifestyle, unhealthy eating habits, addiction of tobacco and alcohol, improper oral hygiene and other factors oral diseases are increasing progressively. People don’t have time to clean their teeth’s properly and do not maintain oral hygiene properly. Because of that various dental problems arise. In Ayurveda has mentioned Dantadhavan kashta (twigs for brushing like Arka, karanja, khadira, Arjuna etc) to prevent dental caries and plaque formation and other peri odontal diseases. Some herbs are promoting oral health as their antimicrobial, anti-viral, anti-fungal, anti-inflammatory properties. Oral hygiene protects us from many Mukha rogas, which leads to proper health management and a healthy immune system. Chemicals toothpastes like chlorhexidine, calcium carbonate, hydrated silica, magnesium aluminium silicate, silica, fluoride, potassium nitrate, sodium silicate, cellulose etc. are used in toothpaste. It prevents various dental diseases now a days.

Magnesium Aluminium Silicate-Metformin Hydrochloride Complexes - The Use of Isothermal Calorimetry for Probing Clay and Drug Nanocomplexations.

Studying complexation between a wide variety of drugs and clay is of high importance in expanding the knowledge about controlled drug delivery and its exploitation. This study reports the use of isothermal calorimetry (ITC) in understanding the complexation process occurring between magnesium aluminium silicate (MAS) and metformin hydrochloride (MET), as a potentially controlled release drug delivery system. To fully characterise and understand the complexes formed between MAS and MET and how that might impact on controlled release systems. MAS and MET complex dispersions and particles were formulated and analysed using ITC, DSC, XRPD, ATR-FTIR, SEM/EDX, digital microscopy and 2D-SAXS. The calorimetric results confirmed the binding between MET and MAS at various pHs (5, 7 and 9) and temperatures (25 ºC and 37 ºC). The overall change in enthalpy was found to be exothermic with a comparatively small entropic contribution to the total change in Gibbs free energy, implying that the binding was an enthalpically driven process. These findings suggest that the binding process was dominated by hydrogen bonding and electrostatic interactions. pH and temperature variation did not have a great impact on the binding, as observed from the similarity in enthalpy (ΔH), entropy (ΔS) or Gibbs free energy (ΔG), with the reaction being only slightly more exothermic at pH 5 and at 37 ºC. 2D-SAXS was able to differentiate between MAS particulates and MAS-MET complexes when analysed in their liquid form suggesting the importance of appropriate methodology and instrumentation used in characterisation. ITC was successfully used in understanding the complexation process occurring between MAS and MET. Care and consideration however should thus be taken in the accurate determination and characterisation techniques for the formation of complexes for controlled release using MAS.

Microwave Heating of Cordierite Ceramic Substrate for After Treatment Systems

Selective catalyst reduction is one of the most affordable and successful technologies aimed at reducing NOx emissions from diesel engines. However, the reduction process can be achieved if a certain temperature is reached for the ceramic substrate of the catalytic core. The required temperatures for catalytic reaction vary from 2500 C to 4500 C depending on the technology applied in the catalytic processes. This paper aims at presenting preliminary research in microwave cordierite heating, which is a type of magnesium aluminium silicate used as ceramic honeycomb substrate (catalyst monolith) in the after treatment system in the automotive industry. The research focused on testing the Mg2Al4Si5O18 composite material (cordierite) for different microwave heating regimes in order to establish the level of microwave power required for fast heating. This application will be subject for the further development of new MW-SCR after treatment systems in order to reduce the NOx emissions at cold start engine or low operating regimes of non-road mobile machinery engines. The ceramic composite material was heated for 5 levels of microwave power, from 600 W to 1400 W, using a 6 kW microwave generator coupled with a matching load impedance tuner, and the temperatures were recorded using an IR pyrometer.

Use of thermodynamics in understanding drug release from xanthan gum matrices: The influence of clay-drug complexes

The aim of this study was to outline a novel way of understanding the controlled drug release from drug-clay-polymer matrices using isothermal calorimetry (ITC) as a complementary technique to dissolution studies. ITC results showed that the binding phenomenon between the model drug propranolol hydrochloride (PPN) and magnesium aluminium silicate (MAS) in the presence of xanthan gum (XG was spontaneous and enthalpically driven (negative enthalpy (ΔH) and small entropy (-T∆S)). This may be due to the competition for PPN due to the anionic nature of XG. Dissolution results showed that when using the MAS-PPN complexes, 10% w/w XG polymer level was enough to significantly reduce the burst release. When used together, ITC and dissolution studies may help a formulator understand and identify interactions which occur during dissolution studies and may be beneficial to the controlled drug delivery system.

Structural characterisation of magnesium (sodium) aluminium silicate hydrate (M-(N)-A-S-H) phases by X-ray absorption near-edge spectroscopy

Magnesium silicate hydrate phases (M-S-H) have been observed forming in low pH cements, which came in contact with Mg-rich ground waters or argillaceous rock formations, such as Opalinus Clay. Their crystallographic structure has been suggested to be a purely ordered sheet-like phyllosilicate with a tetrahedral octahedral (TOT O) layering, i.e. similarly to a talc plus brucite structure. In nature, Mg phyllosilicates with this type of layering contain several type of cations, in particular Al, as well as alkaline earth metals. This study shows that the X-ray near-edge spectra of synthesised Mg-Al- silicate hydrates and Mg-Al-Na silicate hydrates (M-A-S-H and M-N-A-S-H) show distinct differences to M-S-H, indicating the possible accommodation of Al in their structure. This is further supported by the great similarity of the spectra to natural Mg–Al containing phyllosilicates, i.e. clinochlore, having a TOT O layering. The results, furthermore, suggest that Na is not taken up in the structure due to the strong similarities of the M-N-A-S-H with the M-A-S-H phases. The comparison of the latter spectra with natural references show high resemblance not only with clinochlore, but also with sepiolite, a Mg containing phyllosilicate with water molecules bridging between broken octahedral chains. It is, therefore, suggested that the Mg in the M-(N)-A-S-H phases is bound similarly to clinochlore with a TOT O layering and that water molecules or OH groups are present between broken octahedral layers. Aluminium is possibly accommodated in the tetrahedral and/or octahedral layers.

A molecular understanding of magnesium aluminium silicate – drug, drug – polymer, magnesium aluminium silicate – polymer nanocomposite complex interactions in modulating drug release: Towards zero order release

This study reports the use of ITC in understanding the thermodynamics occurring for a controlled release system in which complexation has been exploited. In this study, a model drug, propranolol hydrochloride (PPN) was complexed with magnesium aluminium silicate (MAS) and these complexes were used in combination with polyethylene oxide (PEO) as a hydrophilic carrier at various concentrations to sustain the release of PPN. DSC, XRPD, ATR-FTIR and SEM/EDX were successfully used in characterising the produced complexes. 2D- SAXS data patterns for MAS and the produced complexes were shown to be symmetric and circular with the particles showing no preferred orientation at the nanometre scale. ITC studies showed differences between PPN adsorption onto MAS compared with PPN adsorption onto a MAS-PEO mixture. At both temperatures studied the binding affinity Ka was greater for the titration of PPN into the MAS-PEO mixture (5.37E + 04 ± 7.54E + 03 M at 25 °C and 8.63E + 04 ± 6.11E + 03 M at 37 °C), compared to the affinity obtained upon binding between PPN and MAS as previously reported suggesting a stronger binding with implications for the dissolution process. MAS-PPN complexes with the PEO polymer compacts displayed desired manufacturing and formulation properties for a formulator including, reduced plastic recovery therefore potentially reducing the risk of cracking/splitting and on tooling wear, controlled release of PPN at a significantly low (5%) polymer level as well as a zero-order release profile (case II transport) using up to 50% polymer level.

The use of visible and UV dissolution imaging for the assessment of propranolol hydrochloride in liquisolid compacts of Sesamum radiatum gum

This work explores the first use of UV imaging in liquisolid systems. The aim of this study was to simultaneously measure a model drug propranolol hydrochloride (PPN) release and compact swelling behaviour from liquisolid systems using sesamum radiatum gum by exploiting the visible and UV imaging capabilities of the novel surface dissolution instrument (SDI2). Liquisolid compacts were successfully prepared using polysorbate 80 as the liquid solvent. The influence of either colloidal silica or veegum (magnesium aluminium silicate) was also evaluated in the liquisolid sesamum gum compacts. Solid-state characterization using differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD) showed a decrease in the crystallinity of the model cationic drug. Visible and UV imaging was successfully used to detect differences between the conventional or physical mixture formulations containing veegum or colloidal silica and the liquisolid preparations as well as differences between their swelling behaviour. The use of this imaging technique provides added insights into the drug release behaviour of formulations.

Solubility and Dissolution Enhancement of Atorvastatin Calcium using Solid Dispersion Adsorbate Technique

Atorvastatin (ATR) is poorly soluble anti-hyperlipidemic drug; it belongs to the class II group according to the biopharmaceutical classification system (BCS) with low bioavailability due to its low solubility. Solid dispersions adsorbate is an effective technique for enhancing the solubility and dissolution of poorly soluble drugs.
 The present study aims to enhance the solubility and dissolution rate of ATR using solid dispersion adsorption technique in comparison with ordinary solid dispersion. polyethylene glycol 4000 (PEG 4000), polyethylene glycol 6000 (PEG 6000), Poloxamer188 and Poloxamer 407were used as hydrophilic carriers and Aerosil 200, Aerosil 300 and magnesium aluminium silicate (MAS) as adsorbents.
 All solid dispersion adsorbate (SDA) formulas were prepared in ratios of 1:1:1 (drug: carrier: adsorbent) and evaluated for their water solubility, percentage yield, drug content, , dissolution, crystal structure using X-ray powder diffraction (XRD) and Differential Scanning Calorimetry (DSC) studies and Fourier Transform Infrared Spectroscopy (FTIR) for determination the drug-carrier- adsorbate interaction.
 The prepared (SDA) showed significant improvement of drug solubility in all prepared formula. Best result was obtained with formula SDA12(ATR :Poloxamer407 : MAS 1:1:1) that showed 8.07 and 5.38 
 fold increase in solubility compared to solubility of pure ATR and solid dispersion(SD4) (Atorvastatin: Poloxamer 407 1:1) respectively due to increased wettability and reduced crystallinity of the drug which leads to improve drug solubility and dissolution .

Thermodynamics of clay–drug complex dispersions: Isothermal titration calorimetry and high-performance liquid chromatography

An understanding of the thermodynamics of the complexation process utilized in sustaining drug release in clay matrices is of great importance. Several characterisation techniques as well as isothermal calorimetry were utilized in investigating the adsorption process of a model cationic drug (diltiazem hydrochloride, DIL) onto a pharmaceutical clay system (magnesium aluminium silicate, MAS). X-ray powder diffraction (XRPD), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and optical microscopy confirmed the successful formation of the DIL-MAS complexes. Drug quantification from the complexes demonstrated variable behaviour in the differing media used with DIL degrading to desacetyl diltiazem hydrochloride (DC-DIL) in the 2 M HCl media. Here also, the authors report for the first time two binding processes that occurred for DIL and MAS. A competitor binding model was thus proposed and the thermodynamics obtained suggested their binding processes to be enthalpy driven and entropically unfavourable. This information is of great importance for a formulator as care and consideration should be given with appropriate media selection as well as the nature of binding in complexes.

Evaluation of Clay-Functionalized Wafers and Films for Nicotine Replacement Therapy via Buccal Mucosa.

The functional physicochemical properties of nicotine (NIC)-loaded composite freeze-dried wafers and solvent-evaporated films comprising hydroxypropylmethylcellulose (HPMC) and sodium alginate (SA), stabilized with magnesium aluminium silicate (MAS), have been reported. The formulations were characterized for swelling capacity, mucoadhesion, in vitro drug dissolution properties in simulated saliva (SS) and PBS at pH 6.8, and ex vivo and in vitro permeation using pig buccal mucosa membrane and EpiOralTM buccal tissue culture, respectively; finally, the cell viability of the EpiOralTM tissues after contact with the NIC-loaded formulations was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and the functional characteristics compared with those of commercially available NIC strips. Swelling and NIC release from the HPMC–SA wafers were more prolonged (30 min) compared to the commercially available NIC strips which disintegrated rapidly and released the drug within 5 min. Generally, swelling, mucoadhesion, and drug release was faster in PBS than in SS, and the presence of MAS was essential for maintaining a high dose recovery compared to non-MAS formulations and commercial NIC strips, which showed lower percentage of NIC content, possibly due to evaporation during analysis. Permeation studies showed that the NIC released was able to cross both porcine buccal membrane and the EpiOralTM buccal tissue, with the latter showing higher permeation flux for all the formulations tested. All the NIC-loaded, MAS-stabilized formulations showed high tissue viability, with values above 80%, showing their great potential for use as buccal delivery platforms for NIC replacement therapy to aid smoking cessation.

Real time calorimetric characterisation of clay – drug complex dispersions and particles

Isothermal titration calorimetry (ITC) along with attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM/EDX) and high-performance liquid chromatography (HPLC) were employed to investigate the process of adsorption of propranolol hydrochloride (PPN) onto magnesium aluminium silicate (MAS) and to characterise the MAS-PPN particles formed upon complexation. The composition of MAS was confirmed by infrared (IR) spectroscopy and a calcimeter. The calorimetric results confirmed the binding between PPN and MAS at various pHs and temperatures. The overall change in enthalpy was found to be exothermic with a comparatively small entropic contribution to the total change in Gibbs free energy. These findings suggest that the binding process was enthalpically driven and entropically unfavourable (lower affinity) suggesting hydrogen bonding and electrostatic interactions dominating the interaction. The variation of pH and temperature did not have a great impact on the thermodynamics of the binding process, as observed from the similarity in enthalpy (ΔH), entropy (ΔS) or Gibbs free energy (ΔG). A slight reduction in the binding affinity (Ka) with varing pH and temperature was however observed. SEM/EDX studies showed the occurrence of changes in the microstructural properties of MAS following complexation which may explain the potential of MAS-PPN complexes for controlled drug release promoting pharmaceutical innovation.

Magnesium aluminium silicate–gentamicin complex for drug delivery systems

This paper presents the characteristics of magnesium aluminium silicate–gentamicin complexes for drug delivery systems. The work describes the results of studies on the successful introduction of gentamicin (an aminoglycoside antibiotic) into the interlayers of smectite clay and examines the possible use of intercalated smectite as a carrier for sustained drug release. Characterisation of magnesium aluminium silicate–gentamicin complexes was carried out by means of X-ray diffraction, Fourier transform infrared spectroscopy, thermal analysis and scanning electron microscopy with EDX analysis. The possibility of using the gentamicin intercalated smectite as a carrier for sustained release of the drug was investigated during in vitro study, in which the release rate of gentamicin from the smectite clay matrix was monitored based on absorption at 330 nm using a UV–Vis spectrometer and the kinetic of drug release was evaluated based on the zero-order, first-order, Higuchi and Korsmeyer–Peppas models. The results confirmed the efficiency of intercalation and indicate the potential for introducing gentamicin into the interlayer space of montmorillonite. Accordingly, the obtained material may thus be used as a drug carrier in modulated drug delivery systems.

Nicotine stabilization in composite sodium alginate based wafers and films for nicotine replacement therapy

Composite wafers and films comprising HPMC and sodium alginate (SA) were formulated for nicotine (NIC) replacement therapy via the buccal route. Magnesium aluminium silicate (MAS) was added in different concentration ratios (0.25, 0.5, 0.75) to stabilize NIC and its effect on mechanical properties, internal and surface morphology, physical form, thermal properties, swelling, mucoadhesion, drug content and release behaviour of the formulations was investigated. MAS changed the physico-mechanical properties of the composite formulations causing a decrease in mechanical hardness, collapsed wafer pores, increased roughness of film surface, increase in crystallinity and decreased mucoadhesion of the wafers. However, MAS increased swelling in both films and wafers as well as interaction between NIC and SA, which increased drug-loading capacity. Further, MAS resulted in rapid and slow release of NIC from wafers and films respectively. The results suggest that the ideal formulation for the stabilization of NIC in the composite formulations was MAS 0.25.

Effects of oregano essential oil and attapulgite on growth performance, intestinal microbiota and morphometry in broilers

Two experiments were conducted to study the effects of a blend of oregano essential oil (OEO) (as a source of natural antibacterial growth-promoting substances) and attapulgite (as a source of toxin-binder and as an antidiarrhoeal agent) on growth performance, intestinal microbiota, and intestinal morphometry in broiler chickens (Ross-308). In the first trial, the control group was fed a basal diet without antibiotic growth promoters, and the experimental group was fed the basal diet supplemented with 5% OEO (OEO) (Ecodiar ® powder at 150 g/tn) and 80% attapulgite 80% (Ultrafed ® at 6 kg/tn) blend. In the second trial, the experimental group was given the basal diet supplemented with 5% OEO (Ecodiar ® powder at 300 g/tn) and 80% attapulgite (Ultrafed ® at 3 kg/tn) blend. Intestinal microbiota was enumerated by conventional techniques with selective agar media at the end of the trial at both ileum and caecum, and intestinal morphology was assessed in the duodenum, jejunum and ileum. Results showed that in the first trial, despite the positive impact on daily gain and feed-to-gain ratio, growth performance was not affected by the blend with OEO and attapulgite. Furthermore, no effect was found on intestinal morphometry. However, the counts of lactic acid bacteria were increased significantly, and coliforms were decreased in caecal contents. In the second trial, a positive impact was noticed on daily gain and feed-to-gain ratio by the high OEO and low attapulgite blend. Dietary supplementation of OEO and attapulgite increased ileal villus height and lactic acid bacteria significantly and reduced coliforms in ileal and caecal contents compared with the control group. In conclusion, the combination of OEO at 15 mg/kg and attapulgite at 2.4 g/kg exerted a positive effect on growth performance, ileal villus height and intestinal microbiota of broilers. Keywords: Gut microflora, intestinal architecture, magnesium aluminium silicate, oregano

DESIGN AND EVALUATION OF ROSUVASTATIN SMEDDS FOR ENHANCING SOLUBILITY AND DISSOLUTION RATE

The objective of present study was to improve solubility and dissolution rate of rosuvastatin by formulating it as a self micro emulsifying drug delivery system (SMEDDS). The SMEDDS were prepared by using capmul McM and capryol 90 as oils Polaxomer 407 as surfactant and Transcutol hP and Soluphor P as co-surfactants. The liquid SMEDDS were then converted into free flowing powder by adsorbing onto solid carriers like magnesium aluminium silicate. The prepared SMEDDs were further evaluated for particle size, phase separation, droplet size, drug content and for in vitro drug release. From the results, it was observed that the SMEDDs were found to be stable. Among the prepared SMEDDS the formulations prepared with oil to co-surfactant ratios of 1:3 showed highest rates of dissolution. The FTIR and DSc analysis on optimised formulations revealed that there were no major interactions between drug and excipients.

Design and Characterization of Buccoadhesive Liquisolid System of an Antihypertensive Drug.

Nifedipine is an antihypertensive BCS class II drug which has poor bioavailability when given orally. The objective of the present study was to increase the bioavailability of nifedipine, by formulation and evaluation of a buccoadhesive liquisolid system using magnesium aluminium silicate (Neusilin) as both carrier and coating material and dissolution media were selected based on the solubility studies. A mixture of carboxymethylcellulose sodium and carbomer was used as mucoadhesive polymers. Buccoadhesive tablets were prepared by direct compression. FTIR studies confirmed no interaction between drug and excipients. XRD studies indicated change/reduction in crystallinity of drug. The powder characteristics were evaluated by different flow parameters to comply with pharmacopoeial specifications. The dissolution studies for liquisolid compacts and tablet formulations were carried out and it was found that nifedipine liquisolid tablets formulated from bioadhesive polymers containing 49% liquisolid system, 17.5% carbomer, and 7.5% carboxymethylcellulose sodium showed the best results in terms of dissolution properties. Prepared formulation batches were evaluated for swelling, bioadhesion strength, ex vivo residence time, and permeability studies. The optimized batch was showing promising features of the system. Formulating nifedipine as a buccoadhesive tablet allows reduction in dose and offers better control over the plasma levels.

Investigation of the mechanical properties and fracture morphology of glass ceramic fibers

The mechanical properties of magnesium aluminium silicate (MAS) and lithium aluminium silicate (LAS) single fibers were investigated. The fibers were prepared using different methods namely melt drawing (MAS) and continuous drawing (LAS) respectively. The glass ceramic fibers were subjected to the optimized thermal treatments and tested using the single fiber test method (SFT) in order to obtain and evaluate their mechanical properties before and after crystallization. The tested fibers were further characterized by scanning electron microscopy (SEM) and the results showed that the average tensile strength values were a function of the gage length and the fiber diameters.

FORMULASI SUSPENSI KERING KOMBINASI EKSTRAK ETANOL KUNYIT (Curcuma longa L.) DAN SERBUK DAGING BUAH PISANG KEPOK (Musa balbisiana Colla.) DENGAN VARIASI BAHAN PENSUSPENSI

Background : For long time ago various research has been done on both curcuma and banana fruit. Result showed that curcumin which contained in curcuma and cytoindosin, tannin, amylum on banana function as antipeptic ulcer. PUD (peptic ulcer disease) is remain the most common disease of gastrointestinal tract, so which influence life quality, disorder in works, and higher of medical treatment cost. Most of patient of which expect prompt effect of preparations. Based on this, suspension was made to give the prompt effect, due to fine particles of the suspensoid which is not degradated or aggregated in time. The Aim : to obtain dry suspension from which is pharmaceutically stable from combination of curcuma (Curcuma longa L.) aethanolic extracts and the powder of banana (Musa balbisiana Colla.) flesh using a various of suspending agent. Method : it was experimental method which was a research method in laboratory conducted by preparing some formulation designs of dry suspension fromcombination of curcuma (Curcuma longa L.) aethanolic extracts and the powder of banana (Musa balbisiana Colla.) flesh. Conclusion : the suspending agent producing the pharmaceutically stable dry suspension is magnesium aluminium silicate with 4% concentration Keyword : Curcuma, Banana Fruit, Dry Suspension, Peptic Ulcer.