INTRODUCTION: Motor neurone disease (MND) is a disabling and ultimately fatal disease of the motor system, with few effective treatments. Considerable heterogeneity is observed in the clinical motor features of MND, with extra-motor manifestations now also recognized as part of the condition. Progressive motor weakness and bulbar dysfunction lead to premature death, usually from respiratory failure. Diagnosis remains clinical. There are no specific laboratory markers which make the diagnosis independent of the clinical pattern but there are a few appropriate investigations to exclude mimics. The clinical syndrome once observed is recognized easily because of a distinctive appearance and course. OBJECTIVES: To demonstrate and compare the etiology, demography & clinical profile of various forms of Motor Neuron Diseases DESIGN: Cross sectional (Observational) study SETTING: Sapthagiri Institute of Medical Sciences & Research Centre METHODS: 30 MND cases diagnosed clinically (as per Awaji Shima modification of the El Escorial Criteria) with few supportive investigations that presented to our centre over the past 3 years were compiled and compared CONCLUSIONS: Mortality rates in MND depends on type of MND and subtypes like Madras Motor Neuron disease, SMA, PLS has the slowest progression and best prognosis of all the subtypes. Secondary MND due to exposure to heavy metals has faster progression and worst prognosis