Machining of titanium alloys using hybrid cutting techniques is acquiring importance now-a-days due to the benefits of integrating two or more processes. This study explores such a novel in-house developed hybrid cutting technique, which is a combination of ultrasonic assistance and vortex tube based spot cooling with CO2 gas as coolant for machining Ti6Al4V alloy. CFD aided finite element model was developed and experimentally validated for this novel technique termed spot cooled vibration assisted turning (SCVAT). Parametric study of cooling (nozzle inclination, nozzle tool distance, nozzle diameter, coolant pressure and cold fraction), vibration (amplitude) and machining parameters was carried out in order to identify the role of each parameter on cutting force and cutting temperature. The parametric study showed that flow variables (cold fraction and coolant pressure) are more significant than nozzle variables in influencing cutting force and cutting temperature. SCVAT reduced cutting temperature by 21.66% and 3.45%, respectively, than VAT and spot cooling alone. However, cutting force reduced by 7.65% compared to spot cooling and increased by 11.78% compared to VAT. Overall observations from the CFD aided Finite element model revealed superior performance of SCVAT than its individual counterparts.