Event Abstract Back to Event Developmental plasticity of brain circuits for navigational behavior Ying Shing Chan1*, F P. Botelho1, C W. Ma1, W Shi1 and Daisy K. Shum1 1 University of Hong Kong, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, China With the use of graviceptive behavior as the readout, we have revealed the postnatal period critical for switching on the vestibular nucleus (VN) circuitry for display of such innate behavior in rats. Neonatal perturbation of the VN with agonist, antagonist, or neuromodulators of GABA-mediated transmission effected shifts in the time frame for postnatal emergence of the graviceptive behaviors. The perturbation exerted lasting impacts on spatial map formation in relay stations of the vestibular system as well as navigational behavior into adulthood. Zooming into the mechanism with use of brainstem slices of postnatal rats, we found modulations of pre-/post-synaptic efficacy of GABA-A receptor-mediated transmission among VN interneurons following treatment with endocannabinoid or BDNF. Altogether, tuning the vestibular network for spatial coding during a postnatal period of plasticity is critical for the expression of innate sensori-motor behaviors in young rats and the learning of navigational behavior in adults. Acknowledgements HKRGC-GRF 761812, 762313, N_HKU735/14 Keywords: BDNF, plasticity, vestibular nucleus, GABA-A, graviceptive behavior Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016. Presentation Type: Symposium 1: Motor Control and Sensorimotor Integration: Circuitry and Plasticity Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry Citation: Chan Y, Botelho FP, Ma CW, Shi W and Shum DK (2016). Developmental plasticity of brain circuits for navigational behavior. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00008 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 Jul 2016; Published Online: 11 Aug 2016. * Correspondence: Prof. Ying Shing Chan, University of Hong Kong, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, Hong Kong, Hong Kong SAR, China, yschan@hku.hk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Ying Shing Chan F P Botelho C W Ma W Shi Daisy K Shum Google Ying Shing Chan F P Botelho C W Ma W Shi Daisy K Shum Google Scholar Ying Shing Chan F P Botelho C W Ma W Shi Daisy K Shum PubMed Ying Shing Chan F P Botelho C W Ma W Shi Daisy K Shum Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
Read full abstract