For the existing tracking control schemes of flexible-joint robots, precise sensor measurement is an implicit premise. However, idealized sensors are difficult to achieve due to manufacturing technology or other external factors. To this end, this paper further investigates the tracking control problem for flexible-joint robots with unknown measurement sensitivity. Specifically, for such multi-input multi-output Euler-Lagrange systems with completely unknown system dynamics, a novel measurement values-based adaptive control method is proposed by fusing sensitivity information and system variables into Lyapunov function candidates, where the restriction on system states in other the approximation lemma-based results is removed, since unknown nonlinearities are scaled by the structural characteristics of system variables. Above all, even if there are measurement errors, satisfactory tracking performance can be obtained by adjusting the design parameters, which is proved by rigorous theoretical analysis. Finally, hardware experiments further verify the effectiveness of the proposed method. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Note to Practitioners</i> —This work is motivated by the trajectory tracking control problem for flexible-joint robots under imprecise sensor measurements. Due to manufacturing technology limitations and component aging, there is inevitably a deviation between the measured values of sensors and real values, and this problem may become more prominent as the working environment of flexible-joint robots tends to become more complex. To our knowledge, most of the existing solutions for flexible-joint robots are developed based on precise sensor measurements, and they may fail to achieve satisfactory performance when real state information is not available. Moreover, the prior knowledge about model parameters and measurement sensitivity is difficult or impossible to exactly obtain in practice, which seriously hinders the further application of control methods that are dependent on system dynamics. To this end, this paper proposes a novel tracking control scheme based on measurement information for flexible-joint robots with unknown measurement sensitivity, where the dependence on model information is eliminated with the elaborately constructed Lyapunov function candidates, and the real tracking error is still adjusted to an acceptable range even if there are measurement errors. Preliminary experiments on a flexible-joint robot developed by Quanser company demonstrate the feasibility and effectiveness of the proposed method. In future studies, designing an effective scheme to achieve direct preset tracking control is the focus of the work.