Abstract Meteorological satellite imagery is a critical asset for observing and forecasting weather phenomena. The Joint Polar Satellite System (JPSS) Visible Infrared Imaging Radiometer Suite (VIIRS) Day–Night Band (DNB) sensor collects measurements from moonlight, airglow, and artificial lights. DNB radiances are then manipulated and scaled with a focus on digital display. DNB imagery performance is tied to the lunar cycle, with the best performance during the full moon and the worst with the new moon. We propose using feed-forward neural network models to transform brightness temperatures and wavelength differences in the infrared spectrum to a pseudo-lunar reflectance value based on lunar reflectance values derived from observed DNB radiances. JPSS NOAA-20 and Suomi National Polar-Orbiting Partnership (SNPP) satellite data over the North Pacific Ocean at night for full moon periods from December 2018 to November 2020 were used to design the models. The pseudo-lunar reflectance values are quantitatively compared to DNB lunar reflectance, providing the first-ever lunar reflectance baseline metrics. The resulting imagery product, Machine Learning Nighttime Visible Imagery (ML-NVI), is qualitatively compared to DNB lunar reflectance and infrared imagery across the lunar cycle. The imagery goal is not only to improve upon the consistent performance of DNB imagery products across the lunar cycle, but ultimately to lay the foundation for transitioning the algorithm to geostationary sensors, making global continuous nighttime imagery possible. ML-NVI demonstrates its ability to provide DNB-derived imagery with consistent contrast and representation of clouds across the full lunar cycle for nighttime cloud detection. Significance Statement This study explores the creation and evaluation of a feed-forward neural network to generate synthetic lunar reflectance values and imagery from VIIRS infrared channels. The model creates lunar reflectance values typical of full moon scenes, enabling quantifiable comparisons for nighttime imagery evaluations. Additionally, it creates imagery that highlights low clouds better than its infrared counterparts. Results indicate the ability to create visually consistent nighttime visible imagery across the full lunar cycle for the improved nighttime detection of low clouds. Wavelengths chosen are available on both polar and geostationary satellite sensors to support the utilization of the algorithm on multiple sensor platforms for improved temporal resolution and greater simultaneous geographic coverage over polar orbiters alone.