Luminescent Metal-organic Framework Research Articles

A Novel Mn‐MOF Sensitive Detection of Antibiotic Difloxacin Hydrochloride in Water

ABSTRACTAntibiotic pollution in hydrophytic ecosystems has aroused widespread notice due to its adverse impact on both the ecological environment and human physical well‐being. Thus, the development of effective antibiotic detection materials is not only urgently needed but is also challenging. Herein, the luminescent metal–organic framework [Mn3/2(HBCTC)·5H2O] (1) was successfully synthesized based on [9,9′‐bicarbazole]‐3,3′,6,6′‐tetracarboxylic acid (H4BCTC) under solvothermal conditions. Compound 1 can be employed as a fluorescent probe to detect antibiotic difloxacin hydrochloride (DIF) in water, demonstrating a remarkable linear relationship between fluorescence intensity ratio I0/I and the concentration of DIF (0–40 μM), with Ksv of 79,405 M−1 and LOD of 114 nM. More importantly, 1 represents the first fluorescent sensing material based on MOF for the detection of DIF, exhibiting exceptional selectivity, sensitivity, and anti‐interference capability. Furthermore, the mechanism of fluorescence quenching was studied comprehensively.

Emission Library and Applications of 2,1,3‐Benzothiadiazole and Its Derivative‐Based Luminescent Metal–Organic Frameworks

AbstractOrganic linker‐based luminescent metal–organic frameworks (LMOFs) have received extensive attention due to their promising applications in chemical sensing, energy transfer, solid‐state‐lighting and heterogeneous catalysis. Benefiting from the virtually unlimited emissive organic linkers and the intrinsic advantages of MOFs, significant progress has been made in constructing LMOFs with specific emission behaviors and outstanding performances. Among these reported organic linkers, 2,1,3‐benzothiadiazole and its derivatives, as unique building units with tunable electron‐withdrawing abilities, can be used to synthesize numerous emissive linkers with a donor‐bridge‐acceptor‐bridge‐donor type structure. These linkers were utilized to coordinate with different metal nodes, forming LMOFs with diverse underlying nets and optical properties. In this Minireview, 2,1,3‐benzothiadiazole and its derivative‐based organic linkers and their corresponding LMOFs are summarized with which an emission library is built between the linker structures and the emission behaviors of constructed LMOFs. In particular, the preparation of LMOFs with customized emission properties ranging from deep‐blue to near‐infrared and sizes from dozens to hundreds of nanometers is discussed in detail. The applications of these LMOFs, including chemical sensing, energy harvesting and transfer, and catalysis, are then highlighted. Key perspectives and challenges for the future development of LMOFs are also addressed.

Emission Library and Applications of 2,1,3-Benzothiadiazole and Its Derivative-Based Luminescent Metal-Organic Frameworks.

Organic linker-based luminescent metal-organic frameworks (LMOFs) have received extensive attention due to their promising applications in chemical sensing, energy transfer, solid-state-lighting and heterogeneous catalysis. Benefiting from the virtually unlimited emissive organic linkers and the intrinsic advantages of MOFs, significant progress has been made in constructing LMOFs with specific emission behaviors and outstanding performances. Among these reported organic linkers, 2,1,3-benzothiadiazole and its derivatives, as unique building units with tunable electron-withdrawing abilities, can be used to synthesize numerous emissive linkers with a donor-bridge-acceptor-bridge-donor type structure. These linkers were utilized to coordinate with different metal nodes, forming LMOFs with diverse underlying nets and optical properties. In this Minireview, 2,1,3-benzothiadiazole and its derivative-based organic linkers and their corresponding LMOFs are summarized with which an emission library is built between the linker structures and the emission behaviors of constructed LMOFs. In particular, the preparation of LMOFs with customized emission properties ranging from deep-blue to near-infrared and sizes from dozens to hundreds of nanometers is discussed in detail. The applications of these LMOFs, including chemical sensing, energy harvesting and transfer, and catalysis, are then highlighted. Key perspectives and challenges for the future development of LMOFs are also addressed.

Size-controlled synthesis and sensing properties of anthracene-based metal-organic frameworks for detection of singlet oxygen in photodynamic therapy

Developing fluorescent probes to detect singlet oxygen (1O2) is essential to understanding the critical role of 1O2 in immunological and pathological processes in various organs. In this study, size-controlled DPA-MOF (X) with good biocompatibility and excellent optical stability was used as a nanoprobe for real-time imaging and monitoring of 1O2 in photodynamic therapy (PDT). The experimentally synthesized DPA-MOF (X), which can be adjusted in particle size by dilution, exhibits blue fluorescence signals. The results show that smaller-sized DPA-MOF (60) has a faster response to 1O2 and higher cell uptake ability. The ratio of fluorescence intensity (F0/Fi) of DPA-MOF (60) showed a linear correlation with the concentration of 1O2 in the range of 0–7 mM, with a detection limit of 88 μM. DPA-MOF has a distinct advantage over most carrier loading sensors in that it effectively avoids the issue of fluorophore leakage from the nanomaterial matrix, thereby improving its stability. Additionally, the controlled synthesis of DPA-MOF can potentially improve probe accumulation in tumors and lower the uptake by the body system. This study presents a luminescent metal-organic framework (LMOF) sensor that utilizes a 1O2 capture unit as a measuring ligand. This sensor has been shown to have exceptional biocompatibility and can be utilized for highly specific and efficient detection of 1O2 in vivo or living cells.

Dynamic Rare-Earth Metal-Organic Frameworks Based on Molecular Rotor Linkers with Efficient Emissions and Ultrasensitive Optical Sensing Performance.

4,4',4″-Triphenylamine tricarboxylate (TPA-COOH) with a distinct molecular rotor structure was reacted with rare-earth (RE) metal ions to obtain seven dynamic RE-based luminescent MOFs (RE-LMOFs) (i.e., emission colors in the blue, yellow-green, red, and near-infrared regions and emission peak wavelengths between 400 and 1600 nm) via the effective transfer of absorbed energy from TPA-COOH to the RE metal ions through the antenna effect. Due to the large energy level difference between RE ions, it was rare in the early days to use the same ligand to construct energy-level matching RE-LMOF homologues with multiple RE metal centers. The uncoordinated oxygen atoms on the molecular rotor linkers in RE-LMOFs provide active sites that can specifically capture highly toxic metal ions and strong oxidative pollutants. The limit of detection (LOD) of RE-LMOF for Al(III) ions is far below the maximum concentration of Al(III) ions in drinking water stipulated by the U.S. Environmental Protection Agency (USEPA) and that for H2O2 is much lower than the H2O2 content in cancer cells, showing excellent application potential for diagnosing early cell cancelation.

Nanosized Zirconium-Organic Frameworks with Redox Behaviors for the Switchable Detection of Hypochlorous Acid and Ascorbic Acid.

Luminescent metal-organic frameworks (LMOFs) exhibit promising applications as chemical sensors, especially for organic-linker-based LMOFs due to their unlimited structures and pre- and postfunctionality. However, it is still a challenge to introduce specific functional groups into LMOFs as reaction sites for sensing. Herein, a new luminescent zirconium-based metal-organic framework (Zr-MOF), HIAM-4009L, is reported with csq underlying net. By integrating the hydroquinone moiety into the skeleton of the organic linker via the reaction between o-diamine and aldehydes, nanosized HIAM-4009L exhibits reversible emission responses toward hypochlorous acid (HClO) and l-ascorbic acid (vitamin C, Vc) due to the switchable hydroquinone/quinone reaction. This nano-MOF can be used as a reaction-based chemical sensor for HClO and Vc detection with high selectivity and sensitivity. The present work not only provides nanosized MOFs for the reversible detection of HClO and Vc but also sheds light on the rational design of LMOFs with specific functional groups using an o-diamine- and aldehyde-based reaction.

Luminescent Metal–Organic Frameworks as Multimodal Platforms for Advanced Anticounterfeiting and Security Applications

Luminescent Metal–Organic Frameworks as Multimodal Platforms for Advanced Anticounterfeiting and Security Applications

AIE pyrene-based luminescent zinc MOF for selective and sensitive ATP and ADP sensing in water by analyte-induced structure decomposition

Adenosine triphosphate (ATP) is a natural and universal energy carrier that produces adenosine diphosphate (ADP) by releasing chemical energy through hydrolysis, which plays a key role in various biological processes. Hence, the design of probes for the selective ATP and ADP sensing among various nucleosides is significant. In this work, 4,4′-(pyrene-1,6-diyl)dibenzoic acid (H2PDBA) has been synthesized and shows an aggregation-induced emission (AIE) effect in a THF-H2O mixture at 10 % water fraction. Based on H2PDBA, a new zinc metal–organic framework (MOF), namely {[Zn(PDBA)]·2(CH3)2NH}n (Zn-MOF, PDBA = deprotonation of H2PDBA), has been constructed under hydrothermal conditions with a coordination-induced emission (CIE) effect. Significantly, Zn-MOF has been utilized to detect ATP and ADP in water with high selectivity and quick response time (within 1 min) by fluorescence quenching. The Ksv values and detection limits have been measured to be 7.83/8.78 × 103 M−1 and 0.82/1.71 μM for ATP and ADP, respectively. The sensing mechanism investigation indicates that the interactions between the ATP or ADP and Zn2+ nodes of the framework lead to the partial collapse of the framework, followed by the release of the ligand H2PDBA with weak luminescence in pure water. Moreover, Zn-MOF has successfully been applied for the determination of ATP and ADP with the recovery method by using fetal bovine serum samples.

Fine-Scale Aerosol-Jet Printing of Luminescent Metal-Organic Framework Nanosheets.

Fabrication of metal-organic framework (MOF) thin films is an ongoing challenge to achieve effective device integration. Inkjet printing has been employed to print various luminescent metal-organic framework (MOF) films. Luminescent metal-organic nanosheets (LMONs), nanometer-thin particles of MOF materials with comparatively large micrometer lateral dimensions, provide an ideal morphology that offers enhancements over analogous MOFs in luminescent properties such as intensity and photoluminescent quantum yield. The morphology is also better suited to the formation of thin films. This work harnesses the preferential features of LMONs to access the advanced technique of aerosol-jet printing (AJP) to print luminescent films with precise geometries and patterns across the micrometer and centimeter length scales. AJP of LMONs exhibiting red (R), green (G), and blue (B) emission were studied systematically to reveal the increase of luminescence upon additive layering printing until a threshold was reached limited by self-quenching. By combining different LMON emitters, emission chromaticity and intensity were shown to be tunable, including the combination of RGB emitters to fabricate white-light-emitting films. A white-light LMON film was printed onto a UV light emitting diode (LED), producing a working white-light-emitting diode. Printing with multiple distinct photoluminescent inks produced intricate multicolor patterns that dynamically responded to excitation wavelength, acting either as micrometer-scale LED-type cells or larger visual tags. Collectively, the work offers an advancement for MOF thin films by printing MON materials using AJP, offering a precise method for manufacturing a wide range of critical functional devices, from luminescent sensors to optoelectronics, and more broadly even the opportunity for printed circuitry with conductive MONs.

Luminescent Cd-MOF and its mixed matrix membrane as a chemical sensor for selective and reversible detection of folic acid and Fe3+, and visible fingerprint identifying

A new luminescent metal-organic framework (MOF), {Cd2(L)2(HCO2)(OH)(H2O)}n (1) (HL = 4-(4-(pyridin-4-yl)benzamido) benzoic acid) was synthesized under solvothermal conditions, which was then incorporated into poly(methyl methacrylate) (PMMA) to produce a flexible Cd-MOF-based MMM, 1@PMMA. 1@PMMA could serve as a selective and sensitive fluorescent sensor with remarkable recyclability for detecting folic acid (FA) and Fe3+. More fascinatingly, 1@PMMA displayed a visual and convenient detection for FA and Fe3+ by naked eyes. Furthermore, 1@PMMA was successfully applied for the determination of FA and Fe3+ in the bovine calf serum samples, which demonstrates that the luminescent MOF-based MMMs could serve as promising applicants for detecting biomolecules and metal ions in biological samples. In addition, 1 could be applied for the visible identification of fingerprints.

AIEgens-based luminescent metal-organic frameworks as novel electrochemiluminescence emitters Integrated with co-reaction amplification strategy for CA15-3 detection

A current research focus in the field of electrochemiluminescence (ECL) is the development of novel high-performance emitters. Herein, we reported the synthesis of a zirconium-based metal–organic framework (Zr-TBAPy-MOF) using the aggregation-induced emission luminogens (AIEgens) 1,3,6,8-tetra(4-carboxyphenyl)pyrene (H4TBAPy) as ligands and Zr6-clusters as nodes. The resulting AIE-active luminescent MOF (AIE-LMOF) exhibited superior ECL properties and was used as an ECL emitter to construct a high-sensitivity ECL immunosensor. Conceptual experiments demonstrated that Zr-TBAPy-MOF showed significantly stronger ECL emission compared to both the monomers and aggregates of H4TBAPy, attributed to the effective restriction of intramolecular motion (RIM). On the sensor substrate, we designed an Au@ZnO/Cu2O nanocomposite as a co-reactant accelerator. This significantly promoted the generation of sulfate radicals (SO4•−) from persulfate (S2O82−) through the sustainable switching of Cu+/Cu2+ oxidation states in copper oxide (Cu2O). Additionally, zinc oxide (ZnO), which had excellent electrochemical properties, further enhanced the catalytic activity of the materials. Leveraging these advantages, we developed a sandwich-type ECL immunosensor for the ultrasensitive detection of carbohydrate antigen 15–3 (CA15-3), demonstrating a wide sensitive range (0.001 − 100 U/mL) and a low detection limit (0.0007 U/mL). Overall, this work paves the way for the development of efficient ECL luminophores with significant potential in the field of immunoassays for the early diagnosis of disease.

Smartphone-assisted ratiometric fluorescent sensor to quantitatively detect curcumin in traditional Chinese medicine based on Förster resonance energy transfer.

A ratiometric fluorescence sensor (Fe-MIL-88-NH2/curcumin) based on luminescent metal-organic frameworks (LMOFs) for the determination of curcumin was constructed. Upon the addition of curcumin, the 535-nm emission of curcumin was enhanced, while the fluorescence emission at 438nm was quenched, under 367-nm excitation. This sensor demonstrated a broad linear range from 1.5 to 40μM, a low detection limit of 35nM, and a fast response time of at most 30s. We verified the Förster resonance energy transfer (FRET) mechanism between donor (Fe-MIL-88-NH2) and acceptor (curcumin), which further proved the selectivity of theapproach. The sensing system enabled the detection of curcumin in the traditional Chinese medicine (TCM)Turmeric. A smartphone-assisted sensing platform was prepared to visually detect curcumin in a portable manner. This study represents the first attempt to fabricate LMOFs for ratiometric fluorescence detection of curcumin, which has promising potential for application in TCM.

Two Stable Pillar-Layered Zn-LMOFs for Highly Fluorescence Sensing of Inorganic Pollutants and Nitro Aromatic Compounds in Water.

Luminescent metal-organic frameworks (LMOFs) are a potential class of functional materials for the photoluminescent detection of a wide range of analytes as well as for the detection of pollutants in wastewater. Herein, by using the pillar-layered strategy, two new luminescence Zn-LMOFs (JLU-MOF222 and JLU-MOF223) were successfully solvothermal synthesized. The 2D layers are both consisting of Zn2+ and TPHC [TPHC = (1,1':2',1″-terphenyl)-3,3″,4,4',4″,5'-hexacarboxylic acid] ligands and then pillared by the different N-donor ligands to form the 3D Zn-LMOFs with fsh topology. Benefiting from the uncoordinated carboxylate sites, uncoordinated N atom, or -NH2 group in the pillaring ligands and excellent stability in pH = 2-13 aqueous phase, JLU-MOF222 and JLU-MOF223 not only can sensitively detect trace amounts of inorganic pollutants (Fe3+, Cr2O72-) and nitro aromatic compounds TNP and 2,4-DNP (TNP = 2,4,6- trinitrophenol, 2,4-DNP = 2,4-dinitrophenol) through luminescence quenching but also exhibit high selectivity of other anti-interference competing analytes. The two new Zn-LMOFs can be used as potential luminescent sensors for pollutant detection in water due to their high KSV and low limit of detection (LOD).

Luminescent Metal-Organic Framework-Based Fluorescent Sensor Array for Screening and Discrimination of Bisphenols.

Extensive applications of bisphenols in industrial products have led to their release into aquatic environments, causing a great threat to human health due to their endocrine-disrupting effects, whereas existing methods are difficult to implement the rapid and high-throughput detection of multiple bisphenols. To circumvent this issue, we constructed a sensor array using two luminescent metal-organic frameworks (LMOFs) (Zr-BUT-12 and Ga-MIL-61) for the rapid discrimination of six bisphenol contaminants (BPA, BPS, BPB, BPF, BPAF, and TBBPA). Wherein, Zr-BUT-12 and Ga-MIL-61 exhibited different fluorescence-emission properties and good luminescent stability. Interestingly, bisphenols with different structures had diverse quenching effects on the fluorescence intensity of Zr-BUT-12 and Ga-MIL-61 via the adsorptive interaction, resulting in unique fluorescent fingerprints. Based on pattern recognition methods, different bisphenols were successfully identified, with the limit of detection in the range of 1.59-16.7 ng/mL for six bisphenols. More importantly, the developed sensor array could be effectively utilized for distinguishing different ratios of mixed bisphenols, which was further applied for bisphenol discrimination in real water samples. Consequently, our finding provides a promising strategy for the simultaneous recognition of multiple bisphenols, which encourages the development of a sensor array for the detection of multiple contaminants in environmental monitoring and food safety.

Full-Color Emissive Zirconium-Organic Frameworks Constructed via in situ "One-Pot" Single-Site Modification for Tryptophan Detection and Energy Transfer.

Organic linker-based luminescent metal-organic frameworks (LMOFs) have received extensive studies due to the unlimited species of emissive organic linkers and tunable structure of MOFs. However, the multiple-step organic synthesis is always a great challenge for the development of LMOFs. As an alternative strategy, in situ "one-pot" strategy, in which the generation of emissive organic linkers and sequential construction of LMOFs happen in one reaction condition, can avoid time-consuming pre-synthesis of organic linkers. In the present work, we demonstrate the successful utilization of in situ "one-pot" strategy to construct a series of LMOFs via the single-site modification between the reaction of aldehydes and o-phenylenediamine-based tetratopic carboxylic acid. The resultant MOFs possess csq topology with emission covering blue to near-infrared. The nanosized LMOFs exhibit excellent sensitivity and selectivity for tryptophan detection. In addition, two component-based LMOFs can also be prepared via the in situ "one-pot" strategy and used to study energy transfer. This work not only reports the construction of LMOFs with full-color emissions, which can be utilized for various applications, but also indicates that in situ "one-pot" strategy indeed is a useful and powerful method to complement the traditional MOFs construction method for preparing porous materials with tunable functionalities and properties.

Identification of S-phenylmercapturic acid using heterometallic Zn–Eu MOF as a fluorescence sensor

S-phenylmercapturic acid (S-PMA) can be served as an important biomarker for detecting benzene metabolites in clinical diagnosis. In this work, a 3D luminescent heterometal-organic framework (HMOF) with two kinds of pores was designed and synthesized by choosing d/f heterometals salts and two ligands with abundant coordination sites, {[EuZn2(imdc)2(bpe)(H2O)3(OH)]·bpe}n (H3imdc = 1H-imidazole-4,5-dicarboxylic acid; bpe = 1,2-bis (4-pyridyl)-ethylene), namely, MOF 1, which could be utilized to selectively recognize S-PMA by the fluorescence quench. It demonstrated that an efficient recoverable luminescent probe MOF 1 had determined S-PMA with excellent sensitivity (the limit of detection = 3.0 × 10–8 M), rapid response time (less than 20 s), and a wide linear concentration range (3.70 ∼ 180 µM). More interestingly, this is the first instance of utilizing a luminescent MOF for the detection of S-PMA. A low-cost portable composite film for the convenient detection of S-PMA had been designed to recognize S-PMA by visual changes in luminescent color. In addition, the fluorescence sensing mechanism of S-PMA by MOF 1 was elaborated.

A new three-dimensional luminescent MOF for the detection of Fe3+, CrO42−, and Cr2O72− in aqueous solution

A new luminescent MOF were synthesized by solvothermal method based on 1,1,2,2-tetrakis(4-(pyridin-4-yl)phenyl)ethene (TPPE), with the molecular structure of [Zn2(TPPE)0.5(ndc)2]n (ndc = 1,4-Naphthalenedicarboxylic acid) (LMOF-1). The single crystal structure indicates that LMOF-1 stacks in a three-dimensional structure. The fluorescence test results indicate that LMOF-1 emits blue light with quantum yield at 37.93 %, due to ligand–ligand charge transfer. PXRD and TG analysis confirmed that LMOF-1 has good stability, and PXRD analysis after different solvent exchanges confirmed that LMOF-1 has good stability in water. The results of ion titration experiments show that Fe3+, CrO42−, and Cr2O72− have significant quenching effects on LMOF-1, and the detection limits are 3.83 × 10−6 M, 2.57 × 10−5 M, and 4.33 × 10−6 M, respectively. Indicating that LMOF-1 can serve as a multifunctional ion detector.

Confining Thiolysis of Dinitrophenyl Ether to a Luminescent Metal-Organic Framework with a Large Stokes Shift for Highly Efficient Detection of Hydrogen Sulfide in Rat Brain.

Hydrogen sulfide (H2S) is a gaseous signaling molecule that regulates various physiological and pathological processes in the central nervous system. It is vital to develop an effective method to detect H2S in vivo to elucidate its critical role. However, current fluorescent probes for accurate quantification of H2S still face big challenges due to complicated fabrication, small Stokes shift, unsatisfactory selectivity, and especially delayed response time. Herein, based on simple postsynthetic modification, we present an innovative strategy by confining H2S-triggered thiolysis of dinitrophenyl (DNP) ether within a luminescent metal-organic framework (MOF) to address those issues. Due to the cleavage of the DNP moiety by H2S, the nanoprobe gives rise to a remarkable fluorescence turn-on signal with a large Stokes shift of 190 nm and also provides high selectivity to H2S against various interferents including competing biothiols. In particular, by virtue of the unique structural property of the MOF, it exhibits an ultrafast sensing ability for H2S (only 5 s). Moreover, the fluorescence enhancement efficiency displays a good linear correlation with H2S concentration in the range of 0-160 μM with a detection limit of 0.29 μM. Importantly, these superior sensing performances enable the nanoprobe to measure the basal value and monitor the change of H2S level in the rat brain.

Exploring the Photophysical and Mechanical Behavior of Fluorescent Metal-Organic Framework Monoliths.

Luminescent metal-organic frameworks exhibit great potential as materials for nanophotonic applications because of their programmable properties and tunable structures. In particular, luminescent guests (LG) can be hosted by metal-organic frameworks due to their porosity and guest confinement capacity, forming LG@MOF composite systems. However, such guest-host systems are mainly produced as loose powders, preventing their widespread use in practical devices and technological applications that require implementation of a stable continuum solid. In this regard, using monolithic MOF hosts might be a workable option to solve this challenge. Herein, we reported the facile synthesis and fabrication of novel prototypical sol-gel monolithic systems, designated as LG@monoMOF. Red (rhodamine B), blue (7-methoxycoumarin), and yellow (fluorescein) emitting dyes were encapsulated in a robust UiO-66 monolithic host, resulting in the red, blue, and yellow light-emitting luminescent monoliths. The mechanical and photophysical characterization of the three LG@monoMOF systems was systematically carried out in order to unravel the role of guest-host interactions in the mechanical and optical response of the bespoke LG@monoMOF composites.

Terbium-benzoyl acetate complex encored indium-MOFs through post-synthetic modification for luminescent sensitive detection of organophosphorus insecticides

Metal-organic frameworks (MOFs) are represented ideal candidate materials for chemical sensing of different kinds of species because they contain optically active sites may be in organic linker or ions node, moreover, MOFs have high porosity that capture different types of guests. Lanthanide MOFs (Ln-MOFs) was very common in sensing chemical species due to identical light emission characteristics. The problem of Ln-MOFs was the difficulty of its preparation; therefore, post-synthetic modification (PSM) technique was excellent for incorporation of lanthanide site in the network. Unlike other MOFs, In-MOF can be post-synthesized because of its free amino group in the network, therefore, it was chosen in the current work. Here, Tb-In-MOF-EBA was generated by PSM of In-MOF in two steps: (1) formation of the amide by the reaction of In-MOF with ethyl benzoyl acetate; (2) chelation of Tb3+ cations by the diketone fragment. The main challenge of present work is not to give another luminescent MOF based sensor rather than using decorative technique based PSM route to tune optically active sensors for organophosphorus (OP) insecticides (dimethoate, chlorpyrifos, and pirimiphos-methyl) identification quantitatively and qualitatively. The emission intensity of Tb-In-MOF-EBA were reduced with 8 %, 50 %, and 81 %, after adding dimethoate, chlorpyrifos, and pirimiphos-methyl for the parent compounds, respectively. Tb-In-MOF-EBA showed interesting selectivity toward dimethoate, chlorpyrifos, pirimiphos-methyl, therefore, it can be used in measuring the concentration of OP insecticide with high accuracy.