Luminance is the fundamental photometric quantity representing the technical meaning of brightness. It is usually measured from a distance using a matrix sensor, which is the basis of the professional instrument. However, specific technical requirements must be fulfilled to achieve accurate results. This paper considers whether modern high-resolution smartphone cameras are suitable for luminance measurements. Three cameras from high-end smartphones were evaluated on a dedicated laboratory stand. The sensors’ output characteristics showed relatively good linearity of the individual R, G, and B channels. Unfortunately, the spectral sensitivities were unfavorable, as the minimum error achieved was about 17%. This device is classified outside the generally accepted quality scale for photometric instruments. The presented investigation confirmed that none of the high-resolution smartphone cameras tested was suitable for use as a universal luminance camera. However, one of the test devices can be developmental if restrictively calibrated and used only in a specialistic laboratory stand. Using a smartphone (or only its camera) for luminance measurements requires proper advanced calibration. It is possible, but it limits us to only dedicated applications. The pilot study presented in this paper will help create a suitable test stand for spectacle vision systems, e.g., virtual reality equipment.