Low Volume Research Articles

Safety, feasibility, and incremental value of ultralow and zero contrast PCI in an all-comers registry.

Patients with chronic kidney disease and CAD have been denied revascularization because of fear of precipitating acute renal failure from contrast exposure. Skepticism on whether Ultra-Low contrast percutaneous coronary intervention (PCI) or Zero contrast PCI (ULC/ZC PCI) can be safely performed has limited its adoption. This observational registry enrolled 200 consecutive patients referred for elective PCI at a single center from June 2021 to December 2022. The study investigated whether the clinical outcomes of PCI performed with UL/ZC-PCI (n-48) were comparable to outcomes following standard PCI (n-152). Both groups were well matched in baseline and procedural characteristics. The groups had a highly statistical difference in the use of CV. Mean CV was 19.17 ± 7.29 cc in the ULC/ZC-group and 147.14 ± 73.55 cc in the control arm. The principal findings of the study were that the incidence of ontrast-induced acute kidney injury (AKI) was eightfold lower in patients receiving UL/ZC compared to the control group that received standard PCI. The incidence of all-cause mortality, myocardial infarction and major bleeding were similar in both groups. At 6 months, the decrement in renal function was lower in the group that received lower volumes of contrast. This single center observational registry demonstrated that UL-C/ZC-PCI is safe and effective in a broad spectrum of complex lesions. The skillsets needed to perform this are teachable, widely applicable and do not require a large upgrade of capital equipment. AKI rates and decrement in renal function at 6 months were both significantly lower in the UL-ZC group.

Hippocampal, thalamic, and amygdala subfield morphology in major depressive disorder: an ultra-high resolution MRI study at 7-Tesla.

Morphological changes in the hippocampal, thalamic, and amygdala subfields have been suggested to form part of the pathophysiology of major depressive disorder (MDD). However, the use of conventional MRI scanners and acquisition techniques has prevented in-depth examinations at the subfield level, precluding a fine-grained understanding of these subfields and their involvement in MDD pathophysiology. We uniquely employed ultra-high field MRI at 7.0 Tesla to map hippocampal, thalamic, and amygdala subfields in MDD. Fifty-six MDD patients and 14 healthy controls (HCs) were enrolled in the final analysis. FreeSurfer protocols were used to segment hippocampal, thalamic, and amygdala subfields. Bayesian analysis was then implemented to assess differences between groups and relations with clinical features. While no effect was found for MDD diagnosis (i.e., case-control comparison), clinical characteristics of MDD patients were associated with subfield volumes of the hippocampus, thalamus, and amygdala. Specifically, the severity of depressive symptoms, insomnia, and childhood trauma in MDD patients related to lower thalamic subfield volumes. In addition, MDD patients with typical MDD versus those with atypical MDD showed lower hippocampal, thalamic, and amygdala subfield volumes. MDD patients with recurrent MDD versus those with first-episode MDD also showed lower thalamic subfield volumes. These findings allow uniquely fine-grained insights into hippocampal, thalamic, and amygdala subfield morphology in MDD, linking some of them to the clinical manifestation of MDD.

VOLUME REPLENISHMENT BY BOLUS LIQUID INFUSION: WHATROLE IN THE ACUTE MANAGEMENT OF INTRADIALYTIC HYPOTENSION (IDH)?

Introduction: Intradialytic hypotension (IDH) is a common complication associatedwith high morbidity and mortality in hemodialysis patients. Its management isprimarilypreventive, but if itoccurs, itrequires urgent measuresincluding volume infusion of solute to restore volemia. The objective of ourworkis to evaluate the role of bolus liquid infusion for the acute management of IDH. Materials and Methods: This is a retrospectivestudyconductedfromJanuary 2017 to December 2021 at the hemodialysis center of the militaryhospital in Agadir involving 90 chronichemodialysis patients. Volume replenishment to treat IDH wascarried out by infusing an online bolus liquid. Results and Discussion: Weanalyzed 30,689 sessions. IDH with or withoutsymptomswasfoundin 19.6% of cases. 14% of sessions with IDH required bolus infusion (27% of total sessions) with an average volume injected of 26315 ± 1622 ml. Factorsassociatedwith bolus administration includedadvancedage (643 ± 127 vs. 61.6 ± 12.7 years, P<0.001), femalesex (H/F ratio of 0.5 vs. 1.1, P<0.001), diabetes (47.4% vs. 44%, P<0.001), lowpre-dialyticnatremia (134 ± 14 vs. 136 ± 10 mmol/l, P<0.001), and underestimated dry weight (70.6 ± 12.5 vs. 73 ± 14.2 kg, P<0.001). Sessions with bolus infusion werecharacterized by a low total effective UF volume (2000 ± 870 ml vs. 2285.8 ± 854.8, P<0.001), shorter duration withpremature session disconnection (209 ± 25 min vs. 235 ± 7 min, P=0.02), and loweraveragedialysatetemperature (P<0.001). The final relative blood volume washigher (87 ± 9 vs. 82 ± 9, P<0.001) favoring the risk of overloadassociatedwith bolus infusion. Conclusion: Despiteadvances in hemodialysis, IDH remains a common per-dialytic incident. Our study highlights the importance of close monitoring of hemodynamicparametersduringhemodialysis sessions to prevent IDH, actearly, and avoidliquid bolus administration associatedwith the risk of overload.

Higher proceduralist stroke thrombectomy volume is associated with reduced inpatient mortality

BackgroundThe aim of this study was to determine the impact of endovascular thrombectomy (EVT) proceduralist volume on in-hospital mortality in acute ischemic stroke (AIS) patients.MethodsWe performed a retrospective cohort study...

Digital Microfluidics for Sample Preparation in Low-Input Proteomics.

Low-input proteomics, also referred to as micro- or nanoproteomics, has become increasingly popular as it allows one to elucidate molecular processes in rare biological materials. A major prerequisite for the analytics of minute protein amounts, e.g., derived from low cell numbers, down to single cells, is the availability of efficient sample preparation methods. Digital microfluidics (DMF), a technology allowing the handling and manipulation of low liquid volumes, has recently been shown to be a powerful and versatile tool to address the challenges in low-input proteomics. Here, an overview is provided on recent advances in proteomics sample preparation using DMF. In particular, the capability of DMF to isolate proteomes from cells and small model organisms, and to perform all necessary chemical sample preparation steps, such as protein denaturation and proteolytic digestion on-chip, are highlighted. Additionally, major prerequisites to making these steps compatible with follow-up analytical methods such as liquid chromatography-mass spectrometry will be discussed.

Effect of platelet indices on mortality and comorbidity in peritoneal dialysis: a cohort study.

There were limited data investigating platelet indices in predicting peritoneal dialysis (PD) outcomes on comorbidities. The aim of this study was to evaluate the association between platelet indices and new-onset comorbidity and all-cause mortality in PD patients. A single-center, retrospective observational cohort study was conducted in incident PD patients from 28 December 2011 to 24 January 2018, and followed up until 31 December 2022. Time to the first new-onset cardiovascular disease (CVD) and time to the first new-onset infection event after PD were identified as the primary outcomes. All-cause mortality was identified as the secondary endpoint. The correlation between platelet indices and comorbidities and all-cause mortality were assessed by Cox model. Data of liver disease status was not collected and analyzed. Survival curves were performed by Kaplan-Meier method with log-rank tests. A total of 250 incident PD patients with a median follow-up of 6.79 (inter-quarter range 4.05, 8.89) years was included. A total of 81 and 139 patients experienced the first new-onset CVD and infection event respectively during the follow-up period. High mean platelet volume (MPV) was independently associated with high risk of time to the first new-onset CVD (HR 1.895, 95% CI 1.174-3.058, p = 0.009) and all-cause mortality (HR 1.710, 95% CI 1.155-2.531, p = 0.007). Patients with low mean platelet volume to platelet count ratio (MPV/PC) were prone to occur the new-onset infection events (log rank 5.693, p = 0.017). Low MPV/PC (HR 0.652, 95% CI 0.459-0.924, p = 0.016) was significantly associated with the time to the first new-onset infection event on PD. Platelet indices were associated with the new-onset CVD, infectious comorbidities and all-cause mortality on PD. Low MPV/PC was associated with time to the first new-onset infection event in PD patients. Moreover, high MPV was associated with new-onset CVD and all-cause mortality in the incident PD patients.

Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons.

To investigate associations between health-related behaviors as measured using the Brain Care Score (BCS) and neuroimaging markers of white matter injury. This prospective cohort study in the UK Biobank assessed the BCS, a novel tool designed to empower patients to address 12 dementia and stroke risk factors. The BCS ranges from 0 to 21, with higher scores suggesting better brain care. Outcomes included white matter hyperintensities (WMH) volume, fractional anisotropy (FA), and mean diffusivity (MD) obtained during 2 imaging assessments, as well as their progression between assessments, using multivariable linear regression adjusted for age and sex. We included 34,509 participants (average age 55 years, 53% female) with no stroke or dementia history. At first and repeat imaging assessments, every 5-point increase in baseline BCS was linked to significantly lower WMH volumes (25% 95% CI [23%-27%] first, 33% [27%-39%] repeat) and higher FA (18% [16%-20%] first, 22% [15%-28%] repeat), with a decrease in MD (9% [7%-11%] first, 10% [4%-16%] repeat). In addition, a higher baseline BCS was associated with a 10% [3%-17%] reduction in WMH progression and FA decline over time. This study extends the impact of the BCS to neuroimaging markers of clinically silent cerebrovascular disease. Our results suggest that improving one's BCS could be a valuable intervention to prevent early brain health decline.

The effect of cooling rate on the precipitation behavior and fracture toughness of the η phase in LDED CoCrFeNiTi high-entropy alloy

Precipitation strengthening is recognized as an effective method for strengthening high-entropy alloys (HEAs) or medium-entropy alloys (MEAs), especially the recently developed CoCrFeNiTi HEA. The η phase plays a crucial role in strengthening CoCrFeNiTix HEAs, though it remains relatively understudied. In this study, CoCrFeNiTi HEA was fabricated by laser directed energy deposition (LDED). The research investigated the effect of cooling rate on the precipitation behavior and fracture toughness of the η phase in non-equilibrium solidified CoCrFeNiTi HEA. The findings revealed that the precipitation of the η phase in the as-deposited LDED sample was restrained, resulting in a very low volume fraction. However, a high-volume-fraction η phase was achieved through annealing at 900 °C for 6 h, followed by air cooling. This approach not only maintained the desired ∼6.2 % volume fraction of the η phase but also prevented its growth and coarsening (∼403 nm), resulting in an optimal combination of microstructure and mechanical properties. The η phase exhibited the Blackburn type orientation relationship with the FCC phase: <11 2‾ 0>η//<1 1‾ 0>FCC and {0001}η//{111}FCC. The L interface of the η phase demonstrated a coherent relationship with the FCC phase ({0001}η//{111}FCC), while the W interface was incoherent with the FCC phase ({11 2‾ 0}η//{1 1‾ 0}FCC). The unique interface characteristics promoted a higher growth rate at the W interface compared to the L interface, leading to the preferred growth of the η phase. The chemical compositions of both the FCC phase and η phase were accurately predicted by experiments and simulations, elucidating the precipitation kinetics of the η phase. When v ≥ vWC, the nucleation and precipitation of the η phase were inhibited. Conversely, when v ≤ vFC, significant coarsening of the η phase occurred. However, when v ≈ vAC, the AC sample exhibited superior mechanical properties, with a microhardness of ∼860 HV and excellent fracture toughness. These findings provide valuable insights and guidance for further enhancement and optimization of HEAs/MEAs strengthened by the η phase.

An Analysis of the Standardized Infection Ratio in California from 2015 to 2019: A Publicly Reported, Validated Measure of Hospital Case-mix Complexity and Quality for Surgical Site Infections in Hip Arthroplasty

The Standardized Infection Ratio (SIR), developed by the National Healthcare Safety Network (NHSN), is a validated healthcare quality outcome measure utilized by the California Department of Public Health (CDPH). Our primary goal was to use information from the SIR as measures of risk-adjusted surgical case-mix complexity and Healthcare Associated Infection (HAI) quality for surgical site infections (SSIs) in hip prosthesis (HPRO) surgery. We acquired NHSN SSI data files for HPRO surgery from 330 acute care hospitals. We categorized hospitals into 5 types (teaching, rural, community low volume, community medium volume, and community high volume) and sorted hospitals by procedure count, generating volume terciles. We multiplied each SIR and 95% confidence limits by a scale factor to allow for a comparison to the average SIR in California for the study period. The highest and lowest expected infection rates (case-mix complexity) were found in teaching hospital (0.86%) and community, high- volume hospitals (0.56%). When all non-teaching hospitals were combined, teaching hospitals treated a higher case complexity (95% Confidence Limit (CL): 0.7713 to 0.9727) than non-teaching hospitals (95% CL 0.5774, 0.6518). The lowest and highest SIR values were seen in community high volume (0.78) and rural hospitals, (1.38). The lowest- volume hospitals performed significantly worse (SIR 1.15: 95%CL 1.058-1.256) than the highest- volume hospitals (SIR 0.83: 95% CL 0.747-0.920). The SIR model developed by NHSN provides important public information about risk-adjusted surgical case-mix complexity and hospital quality for SSIs that incorporates parameters that may more accurately account for technical challenges in HPRO surgery.

UV-ozone treated glass fiber based lateral flow DNA extraction platform integrated with LAMP for rapid detection of pathogen bacteria in whole blood

The need for a fast and reliable platform for the detection of pathogens in point-of-care (POC) applications is increasing day by day. Molecular detection of pathogens is made possible by a good DNA isolation method, which allows for efficient and pure extraction from the cell. To address this need, our work presents a new lateral flow platform based on UV ozone-treated glass fiber pads for high-throughput DNA isolation from very low volumes of bacterial samples. The platform we developed mainly consists of UV ozone-treated glass fiber, which serves as the essential component binding DNA, and a cellulose-based absorbent pad acting as a reservoir for washing buffers and undesired substances from bacterial cells. UV ozone treatment increased the DNA recovery efficiency of glass fiber by 2.5 times compared to untreated glass fiber. qPCR results confirmed the isolation of pure DNA from both gram-negative and gram-positive bacteria samples performed on the developed platform. For five different bacteria concentrations (10–109 cfu/mL), a good linearity between Cq values and bacteria concentrations was obtained. A minimum concentration of 10 cfu/mL could be detected for both bacterial samples of 10 µL. The developed DNA extraction platform was also integrated with a portable heater for the LAMP-based detection application. We successfully demonstrated that the proposed extraction platform, combined with the colorimetric LAMP-based system, can detect Staphylococcus aureus bacteria spiked in whole blood samples in under one hour, including both extraction and detection processes. Our simplified paper-based platform will be a good alternative for the DNA extraction and molecular detection of pathogens without the need for complex laboratory equipment in POC applications.

Single-pass ultra-high-power laser welding of thick nickel-based GH3535 superalloy: Microstructure evolution and microhardness

In comparison to narrow-gap laser welding, the ultra-high-power laser welding (UHPLW) represents an efficient method for single-pass welding of 22 mm thick GH3535 superalloy. This paper explored the microstructure evolution and microhardness distribution along the direction of weld penetration. The results showed that the direction of grain growth changed from horizontal to an inclined downward direction towards the bottom of the joint along the penetration direction. Precipitates distributed in the interdendritic region were identified as M2C and M6C carbides. The rapid cooling rate in the lower zone (LZ) of the joint resulted in slight elemental microsegregation and a lower volume fraction of precipitates than in other zones. The smaller grain size and the higher volume fraction of the precipitates resulted in a higher microhardness in the middle zone (MZ) of the entire joint. The study results will facilitate the application of UHPLW for the efficient welding of GH3535 thick plates.

Research on compound amidohydroxysulfobetaine foamer for high-temperature and high-salinity clastic reservoirs

A high-quality foaming agent should exhibit excellent solubility in formation water and strong foaming ability, while also meeting the requirements of stability under high-temperature and high-salinity conditions, as well as low adsorption capacity. This study explores the potential of amidohydroxysulfobetaine surfactant as a foaming agent in sandstone reservoirs under specific reservoir conditions of 110 ℃ and 25.0×104 mg/L salinity. The findings indicate that compounding EHSB with a small amount of LHSB to form LA13 significantly reduces the Krafft point of EHSB. Furthermore, LA13 demonstrates outstanding solubility in 25.0×104 mg/L brine and exhibits an overall adsorption capacity on quartz sand surfaces lower than 0.6 mg/g when its concentration is below 1.0 wt%. Performance evaluation of bulk foam for LA31 at concentrations ranging from 0.05 wt% to 0.4 wt% suggests that using a foaming agent concentration of 0.05 wt% results in relatively low foaming volume and foam decay half-life; however, consistent foaming performance is observed across other concentrations, leading to highly stable foam due to the compound system's higher surface dilational modulus being the primary factor contributing to foam stability. Flow experiments reveal that the foam generated in cores with permeabilities of 46.5 mD, 185.5 mD, 632.0 mD, and 2005.3 mD exhibits a high resistance factor when the concentration of LA13 exceeds 0.1 wt%, while also demonstrating commendable gas-channeling regulation capability. Therefore, it is recommended to use LA13 as a foaming agent for field applications when its concentration surpasses 0.1 wt%. Additionally, comparing the mobility of foam formed by concentrations of 0.1 wt% and 0.2 wt% LA13 in cores with varying permeabilities shows that LA13 exhibits selective mobility regulation specifically in cores with permeabilities lower than 632.0 mD.

COVID-19 and speeding: Results of population-based survey of ontario drivers

Introduction: During COVID-19, increased speeding was observed in many jurisdictions. Yet, evidence is limited on what factors predicted increased speeding during the pandemic. This study’s purpose was to examine speeding, and person and situation factors associated with increased speeding since the start of the pandemic. Methods: An online panel survey sampled 1,595 drivers using sex, age, and region quota sampling and weighting to approximate the Ontario, Canada adult population. Measures included: (1) person factors: socio-demographics (age, sex, region); psychological trait of risk propensity (Competitive Attitudes Toward Driving Scale (CATDS)); psychological states (distress - general and COVID-19-related); and behaviors (kilometers driven, alcohol use, police stops and collisions); and (2) COVID-19-related situation factors: perceived changes in (traffic volume, police enforcement). Results: 67.2% of respondents reported speeding; 7.2% reported increased speeding since the start of the pandemic. Bivariate analyses indicated that person factors of younger age, male sex, higher CATDS, higher distress, more alcohol use, more kilometers traveled, police stops, and collisions since the start of the pandemic were associated with increased speeding. Situation factor of perceived less traffic volume since the start of the pandemic was associated with increased speeding. Logistic regression analysis identified odds of reported increased speeding during the pandemic was significantly higher for drivers with higher scores on the CATDS, higher kilometers traveled, and more alcohol use during the pandemic. Conclusions: These findings suggest that higher risk propensity as well as the more kilometers driven and increased alcohol consumption were risk factors for increased speeding. Practical Applications: COVID-19-related factors of lower traffic volume and enforcement are less predictive of increased speeding than driver personality and pandemic-related behaviors of more driving and drinking. Interventions to reduce speeding still need to focus on these person factors through education, enforcement, and strong sanctions for speeding.

Associations between brain structure and dual decline in gait and cognition

Dual decline in gait and cognition is associated with an increased risk of dementia, with combined gait and memory decline exhibiting the strongest association. To better understand the underlying pathology, we investigated the associations of baseline brain structure with dual decliners using three serial gait speed and cognitive assessments in memory, processing speed-attention, and verbal fluency. Participants (n=267) were categorized based on annual decline in gait speed and cognitive measures. Lower gray and white matter volume and higher white matter hyperintensity volume increased the risk of being a dual decliner in gait and both the memory and processing speed-attention groups (all p < 0.05). Lower hippocampal volume (p = 0.047) was only associated with dual decline in gait and memory group. No brain structures were correlated with dual decline in gait and verbal fluency. These results suggest that neurodegenerative pathology and white matter hyperintensities are involved in dual decline in gait and both memory and processing speed-attention. Smaller hippocampal volume may only contribute to dual decline in gait and memory.

Identifying sarcoidosis trends using web search and real-world data in Sweden: a retrospective longitudinal study.

Web search data are associated with disease incidence, population interest, and seasonal variations.This study aimed to investigate seasonal and geographical variations of web search data for sarcoidosis and to explore its association with external factors and sarcoidosis incidence in Sweden. Therefore, sarcoidosis-related data from Google Ads Keyword Planer (2017-2020) were generated for Sweden according to its 21 counties. The relationship between search volume and season, region, population demographics, environmental factors, and the sarcoidosis incidence listed in the National Patient Register was assessed. Analyses revealed seasonal variations for Sweden with an overall peak in the spring and autumn. Geographical differences were observed, with a higher search volume for north-western counties and the lowest search volume for Stockholm County. At the country level, the search volume was positively associated with the sarcoidosis incidence. Higher male proportion and older mean age were associated with a higher search volume, while a higher proportion of foreign-born residents, humidity, and mean temperature were associated with a lower search volume. Our analyses detected correlations between web search data, sarcoidosis incidence, and external factors. Analyses of sarcoidosis web search data therefore appear to be a valuable approach to disease surveillance to address medical needs and public interest.

Theoretical study of the MWCNT particle layer and size impact on sodium alginate heat transfer

This paper theoretically studies the effects of the size of multiwalled carbon nanotube (MWCNT) nanoparticles and layers on the flow of sodium alginate (SA) base fluid in a vertical channel. The nanoparticles are used to improve the thermal characteristics of the base fluid. The nanolayer shows the relationship between the particles and the base fluid, justifying the rise in thermal conductivity, even at a low volume of the nanoparticle in the base fluid. The mechanics of the fluid through the channels are developed using nonlinear models of coupled higher order differentials analyzed using the adomian decomposition method, an analytical scheme. The nanolayer effect of MWCNT particles on pure sodium alginate enhances heat transfer by 31.83% upon a step increase of 0.4 from 0.2 nm. Additionally, the combined effects of the rheological parameters of particle size, radiation and shear stress lead to a high heat transfer rate. The results obtained from the analysis were verified with results obtained from the literature for simple conditions, which validated the analysis. The results of this study may provide meaningful insight into the physical application of the sodium alginate.

Environmental impacts from traffic on highway construction work zones: Framework and simulations

Emissions from internal combustion engine vehicles on highways are the major contributors to global warming in the United States. Transportation sector pavement-related emissions come from gasolines and diesel use in vehicles from pavement-vehicle interaction, which is affected by pavement conditions, and by the trucking of new pavement materials and demolition. The objective of this study was to develop a framework for determining the fuel use resulting in environmental impacts caused by construction work zones (CWZs) on a range of vehicles and to produce initial calculations of these impacts by modeling traffic closure conditions for highway maintenance and rehabilitation activities. The study included two common highway categories—freeways/multi-lane highways and two-lane highways. The framework was demonstrated using three CWZ operations under different traffic congestion levels. In the simulation results for a freeway with a CWZ and heavy congestion, fuel consumption increased by 85% and the carbon-dioxide equivalent emissions increased by 86%. Changing CWZ traffic congestion from heavy (average speed 5 mph) to medium (average speed 25 mph for a freeway section) reduced fuel consumption by 40% on a freeway. This study also included use of a pilot car in a CWZ on a two-lane road typical of lower traffic volume state highways and county roads to compare with the drive cycles in MOVES used for the scenarios. The pilot-car operation scenario results indicate that a one-lane closure with pilot-car operation on a two-lane road might consume 13% excess fuel because of idling time and the slow movement of vehicles following the pilot car.

Hydrothermal synthesis of SnO2/MoO3-x/rGO ternary nanocomposites as a high-performance anode for lithium ion batteries

The theoretical specific capacity of tin dioxide (SnO2) as a lithium-ion batteries (LIBs) anode material is up to 1494 mAh·g−1, far exceeding that of graphite. However, the low conductivity, volume expansion, crushing failure and particles agglomeration during charge/discharge cycles limit its application in LIBs. In this work, the SnO2/MoO3-x/rGO composite material was synthesized by one-step hydrothermal method, with SnO2 and amorphous MoO3-x tightly and uniformly anchored at the surface of reduced graphene oxide (rGO). The results of structural characterization and electrochemical performance evaluation show that amorphous MoO3-x can increase the reactive active sites, inhibit Sn particles aggregation, and promote the reversible reaction of SnO2. rGO effectively improves the electrical conductivity of the composite and buffers the volume change of Li-Sn alloying/dealloying during cycles. In addition, due to introduction of MoO3-x and rGO a stable SEI film can be formed at the material's surface to improve the cycle stability. SnO2/MoO3-x/rGO exhibits excellent rate performance and cycle performance. When the rGO content is 10.9 wt%, the reversible capacity of the composite reach 813 mAh·g−1 after 800 cycles at current density of 1.0 A·g−1, and 450.6 mAh·g−1 after 1000 cycles at current density of 5.0 A·g−1, with the capacity retention rate of 96.9%.

Competence of allogenic demineralized tooth matrix in socket seal surgery for alveolar ridge preservation: a randomized control clinical trial.

To assess and compare the clinical, radiological, and histological outcomes of socket seal surgery between two protocols: deproteinized demineralized tooth matrix (dpDTM) and freeze-dried bone allograft (FDBA) each covered with a free gingival graft. Twenty extraction sockets in the anterior or premolar region were randomly allocated to either the dpDTM or FDBA protocol (n = 10 per group). Measurements of the alveolar ridge changes were obtained using an intraoral scanner and cone-beam computed tomography at 3 months post-operation. Three-month post surgery, the dental implant was installed (n = 5 per group), bone biopsies were obtained for histomorphometrical and micro-computed tomography analyses. Implant stability quotients (ISQs) were determined and compared at 3 months post-implant. Lower significant reductions in buccal alveolar ridge height and hard tissue volume were observed in dpDTM group compared to FDBA group at 3 months (0.25 ± 0.35mm vs. 1.60 ± 0.66mm [p = .000] and 9.64 ± 15.39% mm3 vs. 31.45 ± 18.11% mm3 [p = .010], respectively). At the same time, lower soft tissue volume reduction was detected in the dpDTM group compared to FDBA group (4.21 ± 5.25% mm3 vs. 5.25 ± 5.79% mm3). No statistically significant difference in the percentage of mineralized tissue formation was found between dpDTM group (53.39 ± 11.16%) and FDBA group (49.90 ± 3.27%). Even though the ISQ in the dpDTM group showed a higher value than the FDBA group at 3 months post-implant, the results were without statistical significance. Alveolar ridge preservation using dpDTM is an efficacious procedure for providing the conditions for the development of functional and esthetic implants.

A Dietary Supplement in the Management of Patients with Lumbar Osteochondrosis: A Randomized, Double-Blinded, Placebo-Controlled Study.

Various nutritional supplements are available over the counter, yet few have been investigated in randomized controlled trials. The rationale for using the specific mix of nutritional substances including collagen type II, hyaluronic acid, n-acetyl-glucosamine, bamboo extract, L-lysine, and vitamin C is the assumption that combining naturally occurring ingredients of the intervertebral disc would maintain spine function. This double-blinded, placebo-controlled randomized trial aimed to evaluate the efficacy of a nutraceutical supplement mix in the management of lumbar osteochondrosis. Fifty patients were randomly assigned to either the supplement or placebo group in a 1:1 ratio. Patient-Reported Outcome Measures (PROMs) included the Oswestry Disability Index (ODI), the visual analogue scale for pain (pVAS), short form-12 (SF-12) physical and mental component summary subscale scores (PCS and MCS, respectively), and global physical activity questionnaire (GPAQ). Magnetic resonance imaging (MRI) was used to evaluate degenerative changes of intervertebral discs (IVD) including Pfirrmann grades as well as three-dimensional (3D) volume measurements. Data were collected at baseline and after the 3-month intervention. None of the PROMs were significantly different between the supplement and placebo groups. Disc degeneration according to Pfirrmann classifications remained stable during the 3-month intervention in both groups. Despite no significance regarding the distribution of Pfirrmann grade changes (improvement, no change, worsening; p = 0.259), in the supplement group, one patient achieved a three-grade improvement, and worsening of Pfirrmann grades were only detected in the placebo group (9.1%). Furthermore, in-depth evaluations of MRIs showed significantly higher 3D-measured volume changes (increase) in the supplement (+740.3 ± 796.1 mm3) compared to lower 3D-measured volume changes (decrease) in the placebo group (-417.2 ± 875.0 mm3; p < 0.001). In conclusion, this multi-nutrient supplement might not only stabilize the progression of lumbar osteochondrosis, but it might also potentially even increase IVD volumes as detected on MRIs.