Burnout is a familiar term for today's health care professionals with emotional, psychological, physical, and social consequences for those who experience it. It leads to job dissatisfaction, low organizational commitment, absenteeism, as well as inter personal conflict in teams and patient care. The commitment of nurses is a worldwide concern which is necessary to describe their commitment and what keep them committed in nursing and hospitals. it is an undeniable fact that organizations need workers with high commitment and low burnout levels more than ever before. Aim : The aim of the study was to explore the relationship between nurses burnout on organizational commitment among nurses in selected department (emergency and intensive care units of medical and surgical, , cardiovascular intensive care units,) and general medical surgical departments) at Tanta University Hospitals. Material and method: Correlation design was used. the study was conducted at Tanta University Hospitals, The sample consisted of (123) staff nurses from emergency and intensive care units N=75) and medical-surgical departments( N=48) at Tanta University Hospitals. Two tools were used for data collection, first; Maslach Burnout Inventory which included 22 questions cover areas of: 1- emotional exhaustion (8question), personal accomplishment ( 8 questions) and depersonalization (6questions), second organizational commitment questionnaire It included 39questions divided into eight categories namely: feeling experienced at work(2 questions) 1-2,perceived strategy(1questions) 3, perceived identification with hospital (9questions) 4-12 ,Equity(1questions)13 investment(9questions)14 -22,, trust(3questions) 23-25, resistance(4 questions) 26-30, grievance(1questions)31, compliance(2questions) 32-33and participation(7 questions)34-39. Results: two third of staff nurses (66.6% ) in general medical surgical departments experienced high level of total burnout compared to 60%of staff nurses in emergency or intensive care units have the same level of total burnout. Three fourth of staff nurses (75.6%) have moderate level of total organizational commitment. in emergency or intensive units and general medical surgical units. There were negative correlations between organizational commitment and Emotional Exhaustion (r = -0.36 ). Also, there is statistical significant negative correlations between organizational commitment and Accomplishment(r = -0.42). However, non-significant correlation was observed between organizational commitment and Depersonalization. Conclusion: High percent of staff nurses. in emergency or intensive units and general medical surgical units experienced high level of burnout and moderate level of organizational commitment. It recommended that work redesign plans as well as early assessment and intervention may be helpful in the reduction of job burnout in staff nurse working in hospitals. Key wards: Burnout , Nurses, Organizational commitment,