Low Iron Values Research Articles

Vitamin D-A New Therapeutic Target in the Management of Type 2 Diabetes Patients.

Background: Vitamin D is a fat-soluble vitamin that prevents cardiovascular diseases and diabetes mellitus (DM). The present research aimed to study the impact of 25-hydroxyvitamin D (25(OH)D) level on the health status of patients with type 2 DM (T2DM) hospitalized in the "Pius Brînzeu" Emergency Clinical County University Hospital in Timisoara, Romania. Methods: The study retrospectively included 160 patients with T2DM who were clinically and biologically evaluated during hospitalization. Results: 13.1% of patients had optimal, 23.1% insufficient, and 63.8% deficient 25(OH)D values. Patients with 25(OH)D deficiency presented poorer glycemic control and were older, with higher weight, but had altered renal function, anemia, and lower iron values. Also, patients with associated neoplasia, diabetic neuropathy, cardiovascular disease (CVD), dementia, and grade 3 arterial hypertension (HTN) had lower values of 25(OH)D. An age > 55 years (sensitivity 69.9, specificity 82.5, AUROC 0.786, p < 0.001) and an HbA1c > 7.7% (sensitivity 89.3, specificity 92.9, AUROC 0.938, p < 0.001) predict 25(OH)D deficiency in T2DM patients. Conclusions: Vitamin D influences almost every system and organ in the body, so it should be a routine test for all patients with DM to correct the deficiency and prevent other diseases and complications.

Yaşlılarda Anemi, Demir ve D Vitamini Eksikliği: Retrospektif Bir İnceleme

Aim: Anaemia, iron, and vitamin D deficiency are prevalent health problems in society. Nevertheless, the number of studies on the prevalence of vitamin D in the elderly is minimal. This study aimed to determine the prevalence of vitamin D, anaemia, and iron deficiency in the elderly in Amasya Province. Materials and Methods: This study was conducted retrospectively on the patient records of individuals aged 65 and over who applied to Amasya University Training and Research Hospital Internal Medicine Polyclinics between 01.01.2015 and 31.12.2020. Information including age, gender, hemogram, vitamin D, and serum iron levels of the individuals, the status of any chronic disease, the date of application of the individual to the health institution, and the reason for the application was recorded in the data collection form to be used in the study. Results: 66.6% of the elderly individuals are female, and 33.4% are male. Anaemia was detected in 38.4% of the elderly, iron deficiency in 48.1%, and vitamin D severe deficiency in 40.7%. In elderly individuals, haemoglobin values were moderately positively correlated with gender and low iron values. In contrast, haemoglobin values were found to be negatively correlated with age and vitamin D values at a low level. The regression analysis results show that being underage, having low iron levels, and being of the female gender are associated with lower haemoglobin values in elderly individuals. Conclusion: This study reveals that anaemia, iron deficiency, and vitamin D deficiency/insufficiency are common in the elderly.

Assessment of Iron Status and the Effect of Red Blood Cell Transfusion in Premature Infants.

Objective The objective of this study was to evaluate iron deficiency in preterm infants and determine impact of blood transfusions on serum iron (SI) and ferritin (FTN). Study Design A prospective evaluation of baseline and weekly hemoglobin (Hgb), hematocrit (Hct), SI, FTN levels in premature infants with birth weights (BWs) &lt; 2,500 g or gestational age (GA) &lt; 34 weeks was performed to determine the impact of GA, BW, and blood transfusion on iron status. Comparisons of the baseline and 1 month values of these measures were performed as well as pre- and posttransfusion. Results In 125 preterm infants, the mean Hgb, Hct, and SI levels at birth were lower for infants &lt; 28 weeks GA. Post hoc analysis revealed statistically significant lower iron values in infants ≤ 28 weeks GA compared with infants at 28 to 34 weeks GA (p = 0.013) and infants ≥ 34 weeks GA (p = 0.007). FTN and SI values at 1 month were not significantly impacted by blood transfusions. Conclusion Infants &lt; 28 weeks have lower SI levels at birth. The SI and FTN at 1 month of age were not significantly influenced by blood transfusions.

The Relationship between Soil Chemistry and the Occurrence ofEchinacea laevigatain Northeast Georgia

ABSTRACT Echinacea laevigata, or smooth coneflower, is a federally listed endangered species found in open woods and human maintained clearings, including roadsides and utility rights of way. The species is disjunctly distributed in the eastern United States, with populations in Virginia, North Carolina, South Carolina, and Georgia, where they are associated with calcium and magnesium rich soils. This research was designed to determine if there is a nonrandom relationship between soil chemistry and the occurrence of E. laevigata along roadsides in northeast Georgia. Soil samples were collected from sites along roadsides with known populations and from arbitrarily selected sites without E. laevigata along the same roadsides. Multiple response permutation procedure (MRPP) found a nonrandom relationship between soil chemistry and occurrence. Sites with E. laevigata had a wider range of pH values but had lower iron values than the set of arbitrarily selected sites, suggesting that the species may be excluded ...

Deficiências e desequilíbrios minerais em bovinos e ovinos &lt;FONT FACE=Symbol&gt;¾&lt;/FONT&gt; revisão dos estudos realizados no Brasil de 1987 a 1998

É apresentada uma revisão dos estudos realizados no Brasil sobre distúrbios no metabolismo mineral em bovinos, sobretudo deficiências minerais, no período de 1987-1998. Esta revisão foi feita em continuação de duas revisões prévias sobre o assunto, que abrangeram os períodos de 1943-1976 e 1976-1987. Nessas revisões são omitidos os estudos realizados apenas através de dosagens químicas de amostras de pastagem e de solo, sendo referidos aqueles baseados em análises de amostras de fígado ou outros tecidos ou fluidos dos animais e/ou experimentação, complementados ou não por análises químicas de pastagem e de solo. Em relação aos macroelementos, destacam-se os estudos sobre a deficiência de fósforo, já estabelecida anteriormente como a deficiência mineral mais importante no Brasil. Valores baixos de ferro em amostras de fígado foram constatados em bovinos afetados pela hematúria enzoótica, o que é compreensível, já que os animais apresentam marcada anemia devido a perda contínua de sangue. Destacaram-se, por outro lado, os valores elevados de ferro em diversas regiões; em algumas delas foi demonstrado que os níveis desse elemento estavam associados a valores baixos de cobre. As deficiências de cobre e cobalto foram as mais frequentes entre as de microelementos. Diversas ocorrências de intoxicação por cobre em ovinos foram comunicadas. A deficiência subclínica de zinco tem sido verificada com bastante frequência. A deficiência subclínica de manganês foi raramente constatada; ao contrário, houve verificações de valores elevados deste elemento. Em relação ao selênio, os dados continuam escassos, insuficientes para se saber qual a importância da deficiência desse elemento em bovinos e ovinos no Brasil; a miopatia nutricional em bezerros foi diagnosticada uma única vez. Entre os estudos realizados neste último período devem ser mencionados, especialmente, aqueles que abordam duas doenças cuja etiologia ainda não foi estabelecida, vulgarmente conhecidas como "ronca" e "doença do peito inchado", ambas de evolução crônica, afetando bovinos adultos. Na enfermidade conhecida como "ronca", os valores hepáticos de cobre são muito baixos e os de ferrro extremamente altos; deve-se considerar a hipótese de que os níveis hepáticos de ferro estão muito elevados em decorrência da sua não-utilização em função da deficiência de cobre. Na "doença do peito inchado", os valores hepáticos de manganês e de cobalto são baixos e os de ferro são muito elevados; é possível que as alterações nos níveis hepáticos de ferro sejam apenas o reflexo do acúmulo de sangue no fígado, uma vez que essa enfermidade é caracterizada por insuficiência cardíaca crônica que cursa com acentuada congestão hepática. Ainda deve ser destacada, no Rio Grande do Sul, a ocorrência de "morte súbita" em bovinos, cujos valores hepáticos para cobre foram muito baixos; nenhuma planta tóxica pode ser responsabilizada por essas ocorrências. Nesta mesma área, a hipomielinogênese congênita em bovinos foi diagnosticada. A ocorrência das deficiências minerais diagnosticadas durante o período correspondente a esta revisão foram lançadas em um mapa, com as respectivas referências bibliográficas.

Deficiências e desequilíbrios de microelementos em bovinos e ovinos em algumas regiões do Brasil

O presente trabalho constitui uma continuação da publicação dos resultados dos estudos sobre deficiências minerais em bovinos e ovinos obtidos nos últimos 25 anos e que vem sendo realizados pelos autores desde a década de 50. Esses estudos consistiram na obtenção de históricos de doenças possivelmente causadas por deficiências minerais, observações de campo e exames clínicos de bovinos e ovinos afetados por essas doenças, realização de necropsias com coleta de material para exames histopatológicos e dosagens químicas de cobre, cobalto, zinco, manganês, selênio e ferro em amostras de fígado. Para alcançar também as deficiências minerais mais leves, que não provocam quadros clínico-patológicos característicos, foram coletadas amostras de fígado para análises de microelementos também no decurso do estudo de doenças de outra natureza, sobretudo das causadas por plantas tóxicas. Na interpretação, os dados analíticos foram avaliados sempre em contexto com o histórico e o quadro clínico-patológico dos animais. Deficiência de cobre foi revelada nos municípios de Barra do Bugres (Mato Grosso), Parintins (Amazonas) e Carolina (Maranhão), no nordeste de Minas Gerais, na parte sul do Estado do Rio de Janeiro, e nos municípios de Itaquí e Uruguaiana (Rio Grande do Sul). Valores baixos de cobre foram encontrados também em bovinos afetados pela doença conhecida por "ronca", de etiologia ainda não esclarecida, no município de Aquidauana (Mato Grosso do Sul). Deficiência de cobalto foi diagnosticada nos municípios de Barra dos Bugres e Diamantina (Mato Grosso), Boa Vista (Roraima), Manaus e Itacoatiara (Amazonas), no nordeste de Minas Gerais e nos municípios de Luiz Antonio (São Paulo) e Seropédica (Rio de Janeiro). Valores baixos de cobalto também foram encontrados em bovinos afetados pela "doença do peito inchado", de etiologia ainda não esclarecida, que ocorre no leste de Santa Catarina. Valores de zinco indicando deficiência foram verificados no município de Seropédica (Rio de Janeiro). Valores baixos de manganês foram encontrados no nordeste de Minas Gerais e em bovinos afetados pela "doença do peito inchado". Valores altos de manganês foram obtidos nos municípios de Cacequí, Itaquí e Uruguaiana (Rio Grande do Sul). Valores baixos de selênio foram verificados em amostras coletadas em Mato Grosso do Sul nos municípios de Corumbá e Aquidauana. Valores elevados de selênio foram obtidos no município de Boa Vista (Roraima). Os valores de ferro obtidos em grande parte das amostras de todos os Estados são elevados, sobretudo naquelas com baixos valores de cobre; nos animais afetados pelo "ronca" e pela "doença do peito inchado", os valores de ferro são particularmente altos. Valores baixos de ferro foram constatados em bovinos afetados pela hematúria enzoótica.

ANTHROPOMETRY, HEMOGLOBIN AND METAL INTER-RELATIONSHIP IN SÃO PAULO SCHOOL CHILDREN.

To evaluate the nutritional status of low socio economic school children and its relation with hemoglobin (HB), iron, copper and zinc plasma levels, 294 children (2-14 years)divided into two groups ≤ 84 months (group A) and > 84 months (Group B), were studied. Nutritional status was analysed by weight for height (W/H)index and metal was evaluated by atomic absorption spectrophotometry. Mean ±SD levels of HB were 12.1±1.1g/dl, with 13% of anemia. Iron levels were 79.0±31.3 mg/dl with 15% of low iron values. Zinc values were 104.6±32.3ug/dl with 11% hypozinkemia;copper values were 117.6+36.8 with 19% of hypocupremia. The majority of the dificiencies appeared in group A, except for copper(p<0.001). HB values were directly proportional to zinc and iron, and inversely proportional to copper values (p<0.005).W/H < 90% was found in 8,4% of A and 12% of B, predominantly stunted. In groupB, HB, zinc and iron values were lower and copper ones were higher than in B, presenting no relation to nutritional status, thus reflecting competitive absorption sites.

Sequential changes in erythrocyte volume distribution and microcytosis associated with iron deficiency in kittens.

Hemograms, erythrocyte volume distribution curves, serum iron and percent transferrin saturation determinations were done on samples from 50 kittens to characterize feline erythrocytic responses between one and ten weeks of age. At one week of age, all kittens had marked macrocytosis and anisocytosis. Most of the macrocytic cells no longer were present by five weeks. Macrocytes were replaced by erythrocytes of normal volume in 30% of the kittens. At five weeks of age, 70% of the kittens had produced microcytic cells which correlated with significantly lower packed cell volume values (p less than 0.02) and mean corpuscular volume values (p less than 0.001). By seven weeks of age, kittens with microcytosis were producing normocytic erythrocytes. Between two and four weeks of age, kittens with microcytosis had significantly lower serum iron and percent transferrin saturation values (p less than 0.01) compared to kittens without microcytosis. Between five and seven weeks of age, all kittens had very high iron values which were significantly greater than those of healthy adult cats (p less than 0.01). Six kittens with low iron values received an iron dextran injection at two to three weeks of age. At five weeks, these kittens had significantly greater mean corpuscular volumes, packed cell volumes (p less than 0.01) and lower percentage of microcytic cells (p less than 0.001) than littermate controls. These data demonstrate that transient microcytosis and anemia observed in kittens is attributable to iron deficiency. It also was demonstrated that erythrocyte volume distribution curves were more sensitive than the mean corpuscular volume in detecting microcytosis in kittens.

Modified aca method for determination of iron chelated by deferoxamine and other chelators.

Iron in serum and urine specimens containing deferoxamine (a chelator used in treating acute iron intoxication) can be measured by the DuPont aca discrete-analyzer method for iron if 0.5 mL of a 100 mL/L solution of thioglycolic acid (mercaptoacetic acid) is added to the IRN-1 and IRN-2 test packs before their use. This reagent releases the unreactive chelated iron, allowing reliable colorimetry. Because about 50% of hemoglobin iron is measured by the modified method, hemolysed samples should not be used (or results should be corrected for hemoglobin iron). The modification allows emergency determination to total serum iron and assessment of urinary iron during chelation therapy, as well as measurement of plasma iron in samples treated with sodium citrate or oxalate plus fluoride (the unmodified aca iron method gives falsely low iron values in the presence of these chelators). About 60% of iron present as the dextran complex (Imferon) is measured by the modified aca method, as compared with <5% by the unmodified aca technique.

Preoperative Correction of Anemia of Chronic Diseases and Application of Bloodless Technology in Mitral and Aortic Valve Replacement

The article is dedicated to the optimization of the treatment of postoperative anemia in patients with mitral and aortic valve replacement through blood saving technology (BST).&#x0D; The aim. To investigate the preoperative combined effect of iron (III) hydroxide and erythropoietin on the level of postoperative anemia after mitral and aortic valve replacement (MAVR) through BST in the conditions of artificial circulation.&#x0D; Material and methods. Preoperative levels of Hb, Ht, iron, and enzymes were studied in 53 patients with com-bined mitral and aortic heart defects. All the patients are divided into groups A, B, C. Patients with normal levels of Hb, Ht, RBC, iron were divided into groups A and B. Patients of group A were operated with the use of donor blood components, and in group B - no donor blood components were used. In group C where the patients had low iron values, preoperative iron correction and erythropoietin stimulation were performed. Operations in group C were performed using BST.&#x0D; Results. According to the study results, the patients of group A needed sufficient volume components of donor blood (621.0 ± 103.0 ml of red cell mass and 713.0 ± 89.0 ml of fresh-frozen plasma) in the operative period. MAVR with BST in group B was possible without transfusion of donor blood preparations, however, Hb decrease by 17.1% dictated the need for preoperative preparation of donor blood components.&#x0D; Correction of low levels of preoperative serum iron in group C resulted in its 8.9-fold rise compared to the pre-operative level, as well as Hb increase by 5.8%. The use of BST during MAVR reduces postoperative anemia by 7.7% and helps to avoid transfusion of donor blood components.&#x0D; Conclusions. Correction of low preoperative levels of iron and erythropoietin in patients with mitral and aortic heart defects reduces the level of postoperative anemia after operations with mitral and aortic valve replacement through BST.

Hematologic and serologic studies in cystic fibrosis

The hematologic and serologic data of 87 cystic fibrosis patients, between the ages of 5 and 16 years, showed the following characteristics as compared with a group of age-matched normal control children: The cystic fibrosis patients were shorter, weighed less, and had lower pO 2 values than the control group. Although moderately polycythemic, they had lower MCHC's lowe serum-bound iron values, and higher iron-binding capacities. However, both BI and TIBC values were low in the group with the klowest pO 2 values. The blood vlumes, based upon height, were normal. Iron absorption, particularly in thosse with low iron values, was increased. Whereas the level of serum-bound iron was the major factor in regulation iron absorptioin, the red cell mass was, directly related to the degree of hypoxia. Pancreatic extract impeded absorption of iron, but to a lesser extent than it did in the control group.

V. THE IRON CONTENT OF BLOOD FREE TISSUES AND VISCERA

When hemoglobin is set free in the circulation the kidney plays an important part in the conservation of iron. When the renal threshold is not exceeded by the hemoglobin in the blood there is little or no excess iron deposited in the kidney but when superthreshold doses of blood hemoglobin are given the epithelium of the convoluted tubules accumulates much iron and the iron analyses may show 5 times normal values. The normal dog (140 to 150 per cent hemoglobin) has a large reserve store of iron in the liver, spleen and marrow. Diets may modify this storage of iron in these tissues. To bring conclusive proof relating to the individual diet factors, the reserve store of iron should be depleted by an anemia period of 2 to 3 months. Complete removal of red cells from tissue capillaries is essential for accurate iron assays of fresh tissue. The method described accomplishes this without causing gross tissue edema. The lowest iron content is observed in the pancreas, stomach, jejunum, colon and urinary bladder. These figures average from 1 to 2 mg. iron per 100 gm. fresh tissue. This shows that smooth muscle and mucous membranes contain little iron. Striated muscle (heart, psoas) shows a relatively low iron content but uniform values close to 4 mg. per 100 gm. tissue. Lungs show a considerable fluctuation with low iron values in anemia (3.7 mg.) and higher values in health (6 to 7 mg.). The spleen shows maximal fluctuations and the highest reserve storage of iron per 100 gm. fresh tissue. The spleen iron analyses show low values in anemia (7 to 15 mg.) and wide differences in controls (25 to 50 mg.). With hemoglobin injections the iron storage is conspicuous and iron analyses may run as high as l50 to 175 mg. iron per 100 gm. fresh tissue. Bone marrow of the rib runs in parallel with the spleen as regards iron storage following hemoglobin injections and depletion following anemia periods. The liver because of its weight always contains the main bulk of the iron stored in the blood free tissues of the body. Its store is depleted by anemia even to levels of 4 to 5 mg. iron per 100 gm. fresh tissue. In the normal dog the iron store in the liver averages 25 mg. per 100 gm. tissue. Frequent hemoglobin injections may increase this level to 31 mg. iron per 100 gm. The liver is considered the most active clearing house for iron storage and utilization.