Lower Activity Energy Expenditure Research Articles

Sedentarism and Chronic Health Problems.

Increased mechanization and technological advances have simplified our lives on the one hand and increased sedentary behaviors on the other hand, paving the way for emerging global health concerns, i.e., sedentarism, which could be the leading cause of all major chronic health problems worldwide. Sedentarism is a habitual behavior of choosing and indulging in low-energy expenditure activities (≤1.5 metabolic equivalents), such as chairtype (sitting, studying, traveling) or screen-type activities (TV, computers, mobile). With technological advancements, there is a significant transition in the lifestyles of people from being active (walking) to being more deskbound (sitting). Prolonged sitting can have unintended consequences for health with sitting time >7 h/d, leading to a 5% increase in all-cause mortality with each additional hour spent sitting (i.e., +7 h/d), while considering physical activity levels. This review will highlight how sedentarism is emerging as a major risk factor for the rising incidence of non-communicable diseases, especially among young adults and adults. Chronic diseases, such as obesity, diabetes, coronary heart disease, and cancer, are the leading causes of death worldwide. Hence, there is an urgent need for collective action to mitigate the burgeoning public health crisis posed by sedentarism in the 21st century. This paper intends to set in motion a call for all policymakers and public health professionals placed nationally or internationally to reach a consensus on ending sedentarism and provide viable resolutions for effective management of excessive sedentary behaviors and healthy adoption and maintenance of active lifestyles among individuals of all age groups.

Reduced Liver-Specific PGC1a Increases Susceptibility for Short-Term Diet-Induced Weight Gain in Male Mice.

The central integration of peripheral neural signals is one mechanism by which systemic energy homeostasis is regulated. Previously, increased acute food intake following the chemical reduction of hepatic fatty acid oxidation and ATP levels was prevented by common hepatic branch vagotomy (HBV). However, possible offsite actions of the chemical compounds confound the precise role of liver energy metabolism. Herein, we used a hepatocyte PGC1a heterozygous (LPGC1a) mouse model, with associated reductions in mitochondrial fatty acid oxidation and respiratory capacity, to assess the role of liver energy metabolism in systemic energy homeostasis. LPGC1a male, but not female, mice had a 70% greater high-fat/high-sucrose (HFHS) diet-induced weight gain compared to wildtype (WT) mice (p < 0.05). The greater weight gain was associated with altered feeding behavior and lower activity energy expenditure during the HFHS diet in LPGC1a males. WT and LPGC1a mice underwent sham surgery or HBV to assess whether vagal signaling was involved in the HFHS-induced weight gain of male LPGC1a mice. HBV increased HFHS-induced weight gain (85%, p < 0.05) in male WT mice, but not LPGC1a mice. These data demonstrate a sex-specific role of reduced liver energy metabolism in acute diet-induced weight gain, and the need for a more nuanced assessment of the role of vagal signaling in short-term diet-induced weight gain.

Effects of aerobic training on physical activity in people with stroke: A randomized controlled trial.

Individuals with stroke have low physical activity levels and spend high amount of time in low-energy expenditure activities. To investigate the effects of aerobic treadmill training on physical activity levels and time spent in low-energy expenditure activities (primary outcomes), as well as on cardiorespiratory fitness, endurance, depression, mobility, quality of life and participation (secondary outcomes) after stroke. A randomized controlled trial, with 22 adults with chronic stroke was performed. Experimental group: aerobic treadmill training at 60-80% of heart rate reserve. outdoor-overground walking below 40% of heart rate reserve. Both groups: three 40 min sessions/week over 12 weeks. Outcomes were measured at baseline, post-training, and 16-week follow-up. No changes in the primary outcomes were found for any of the groups. The experimental group showed greater improvements in quality of life at 16-week follow-up (13 points;95% CI:3.5-23). Both groups improved depression (2.2 points;95% CI:0.01-4.3), endurance (Six-minute walk test:31 m;95% CI:5.6-57, Incremental shuttle-walk test:55 m;95% CI:3.8-107), and mobility (0.12 m/s;95% CI:0.02-0.2). Aerobic treadmill training improved quality of life. Aerobic treadmill training or outdoor-overground walking improved depression, endurance and mobility. Further studies are needed to clarify the effects of aerobic training on physical activity levels and time spent in low-energy expenditure activities after stroke.

Tempo sedentário e ambiente percebido sobre o bairro em adolescentes de 12 a 17 anos

O ambiente no entrono da residência pode contribuir para atenuar ou acentuar o tempo em atividades sedentárias em adolescentes. Objetivou-se avaliar a associação entre o tempo sedentário e a percepção do ambiente sobre o bairro em adolescentes de 12 a 17 anos residentes no sul do Brasil. Este foi um estudo transversal realizado entre os meses Agosto, 2013 e Maio, 2014, em uma amostra de adolescentes, recrutados em 32 setores censitários da cidade de Curitiba-PR, Brasil. Os setores foram selecionados de acordo com as características de walkability e renda. O ambiente percebido foi avaliado com o questionário NEWS-Y. O tempo sedentário foi avaliado de maneira objetiva por meio de acelerômetros (GT1M, GT3x e GT3x+) durante sete dias consecutivos. Modelos de regressão linear foram empregados para testar as associações, sendo consideradas como variáveis de confundimento a idade, o estado nutricional, o nível socioeconômico e a escolaridade. As análises foram realizadas considerando o valor de p&lt;0,05 através do software SPSS 20,0. A amostra analítica contou com 364 adolescentes com dados válidos de acelerômetros (meninas=50,5%; idade média=14,7 anos, DP=1,7 anos), tendo apresentando 489,6 minutos/dia (DP=99,5 minutos/dia) de tempo em atividades sedentárias. Após ajuste para as variáveis de confundimento apenas a percepção de lugares para caminhar e para pedalar manteve-se associada com tempo sedentário tanto para meninos (B=-23,402; p=0,016) quanto para meninas (B=-15,572; p=0,079). A percepção de locais para caminhar e pedalar tem relação inversa com tempo sedentário entre adolescentes residentes em locais com extremos de walkability nível socioeconômico.

Effects of aerobic training on physical activity in people with stroke: protocol for a randomized controlled trial

BackgroundPost-stroke physical inactivity is explained by several factors related to the stroke, which have been suggested as the causes and consequences of functional declines and health problems. Therefore, it is important to increase physical activity levels and reduce the time spent in low-energy expenditure activities after a stroke. Since the maintenance of cardiorespiratory fitness is a significant predictor of physical activity levels post-stroke, it may be important to investigate whether aerobic training is effective in increasing physical activity levels and reducing the time spent in low-energy expenditure activities in this population. The efficacy of aerobic training on these variables is not well known. The primary objective of this trial will be to investigate the effects of aerobic treadmill training on physical activity levels and on time spent in low-energy expenditure activities in people with stroke. The secondary aim will be to evaluate the effects of the training on cardiorespiratory fitness, endurance, depression, mobility, quality of life, and participation.Methods/designA randomized controlled trial, with blinded assessments, will be performed in a community-based setting. Altogether, 22 adults with a diagnosis of stroke (>6 months) who are sedentary or insufficiently active will be included. Participants will be randomly assigned to either: (1) aerobic treadmill training (experimental group, at 60–80% of their heart rate reserve) or (2) walking outside (control group, below 40% of heart rate reserve). Both groups will attend 40-min training sessions, three times per week over 12 weeks, in groups of two to four participants, with a trained physiotherapist. Primary outcomes are physical activity levels and time spent in low-energy expenditure activities (Multi-sensor SenseWear Mini® and Human Activity Profile). Secondary outcomes are cardiorespiratory fitness (peak oxygen uptake VO2peak and ventilatory threshold), endurance, depression, mobility, quality of life, and participation. The effects of the training will be analyzed from the collected data using intention to treat. Between-group differences will be measured by two-way repeated measures ANOVA, considering the baseline, post-training, and 4-week follow-up.DiscussionThe results of this trial will likely provide valuable new information on the effects of aerobic treadmill training on physical activity levels and on time spent in low-energy expenditure activities of individuals with stroke, through changes in cardiorespiratory fitness.Trial registrationClinicalTrials.gov, NCT02798237. Registered on 13 June 2016.

Sedentary Behavior Research Priorities--NHLBI/NIA Sedentary Behavior Workshop Summary.

Over the course of 2013, the National Heart, Lung and Blood Institute (NHLBI) and the National Institute on Aging (NIA) collaborated with a multi-national group of expert scientists to convene, host and facilitate a four-part virtual webinar workshop on sedentary behavior. Participants met to evaluate and discuss the current epidemiological, clinical and other relevant literature on sedentary behavior and to identify research priorities relative to preventing cardiovascular disease and mitigating aging-related disability and functional outcomes. The workshop was predicated on findings of insufficient levels of population adherence to current physical activity recommendations (1,12) and the need to address the NHLBI and NIA research portfolio gaps in the area of sedentary behavior.

Self-reported sitting time is not associated with incidence of cardiovascular disease in a population-based cohort of mid-aged women

BackgroundIn Westernised societies adults are increasingly spending many hours each day in sedentary, low energy expenditure activities such as sitting. Although there is growing evidence on the relationship between television/screen time and increased cardiovascular disease mortality, very little is known about the association between total sitting time (in different domains) and cardiovascular disease incidence. We investigated this in a population-based cohort of mid-aged women in Australia.FindingsData were from 6154 participants in the 1946–51 birth cohort of the Australian Longitudinal Study on Women’s Health who were free of cardiovascular disease at baseline. Survival analysis was used to determine the association between self-reported sitting time and cardiovascular disease incidence, determined through hospital diagnoses and cause of death data. During a mean (± SD) follow-up time of 9.9 ± 1.2 years, 177 cases of cardiovascular disease occurred. Mean sitting time (± SD) was 5.4 ± 2.6 hours a day. Sitting time was not associated with incident cardiovascular disease (adjusted hazard ratio 0.97, 95% CI 0.92 to 1.03). We found no interaction between physical activity and sitting time and cardiovascular disease.ConclusionsIn mid-aged women sitting time does not appear to be associated with cardiovascular disease incidence. These findings are contrary to expectations, given the growing evidence of a relationship between sitting time and cardiovascular disease mortality. Research in this area is scarce and additional studies are needed to confirm or refute these findings.

High energy expenditure masks low physical activity in obesity

To investigate energy expenditure in lean and obese individuals, focusing particularly on physical activity and severely obese individuals. Total daily energy expenditure (TDEE) was assessed using doubly labeled water, resting metabolic rate (RMR) by indirect calorimetry, activity energy expenditure (AEE) by difference and time spent in physical activity by multisensor activity monitors. In all, 177 lean, Class I and severely obese individuals (age 31-56 years, body mass index 20-64 kg m(-2)) were analyzed. All components of energy expenditure were elevated in obese individuals. For example, TDEE was 2404±95 kcal per day in lean and 3244±48 kcal per day in Class III obese individuals. After appropriate adjustment, RMR was similar in all groups. Analysis of AEE by body weight and obesity class indicated a lower AEE in obese individuals. Confirming lower physical activity, obese individuals spent less time engaged in moderate-to-vigorous physical activity (2.7±1.3, 1.8±0.6, 2.0±1.4 and 1.2±1.0 h per day in lean, Class I, Class II and Class III individuals) and more time in sedentary behaviors. There was no indication of metabolic efficiency in even the severely obese, as adjusted RMR was similar across all groups. The higher AEE observed in the obese is consistent with a higher cost of activities due to higher body weight. However, the magnitude of the higher AEE (20-25% higher in obese individuals) is lower than expected (weight approximately 100% higher in Class III individuals). Confirming a lower volume of physical activity in the obese, the total time spent in moderate-to-vigorous physical activity and average daily metabolic equivalent of task level were lower with increasing obesity. These findings demonstrate that high body weight in obese individuals leads to a high TDEE and AEE, which masks the fact that they are less physically active, which can be influenced by duration or intensity of activity, than in lean individuals.

Differences in psychomotor activity in patients suffering from unipolar and bipolar affective disorder in the remitted or mild/moderate depressive state

Abnormalities in psychomotor activity are a central and essential feature of affective disorder. Studies measuring differences in psychomotor activity between unipolar and bipolar disorder show divergent results and none have used a combined heart rate and movement monitor for measuring activity during free-living conditions. To compare objectively measured psychomotor activity in patients with unipolar and bipolar disorder in a remitted or mild/moderate depressive state. Further, both groups were compared to a healthy control group. A cross-sectional study of outpatients suffering from unipolar (n=20) and bipolar (n=18) disorder and healthy controls (n=31), aged 18-60 years. For three consecutive days a combined acceleration (m/s(2)) and heart rate (beats per minute) monitoring was used in conjunction with a step test to estimate activity energy expenditure (J/min/kg) as measures of psychomotor activity and physical fitness. Overall score on Hamilton-17 items ranged between 0 and 22. Patients had higher sleeping heart rate (p<0.001), lower fitness (p=0.02), lower acceleration (p=0.004), and lower activity energy expenditure (p=0.004) compared to controls. Comparing unipolar and bipolar patients and adjusting for differences in Hamilton-17 revealed lower acceleration (p=0.01) and activity energy expenditure in bipolar patients (p=0.02); the difference was most prominent in the morning. Electronic monitoring of psychomotor activity may be a promising additional tool in the distinction between unipolar and bipolar affective disorder when patients present in a remitted or depressive state.

Energy intake and expenditure profile in chronic peritoneal dialysis patients complicated with circulatory congestion

BackgroundCirculatory congestion is an adverse predictor of mortality in peritoneal dialysis (PD) patients. ObjectiveThis study evaluated the nutritional status, energy intake, and expenditure profile of PD patients with and without previous circulatory congestion. DesignWe conducted a cross-sectional study in 244 PD patients, of whom 92 had previous circulatory congestion. We estimated dietary energy intake by using a locally validated 7-d food-frequency questionnaire and by assessing resting energy expenditure (REE) and total energy expenditure (TEE) with indirect calorimetry and a locally validated physical activity questionnaire, respectively. ResultsIn comparison with those without circulatory congestion, patients with previous circulatory congestion were more malnourished by subjective global assessment (59% compared with 36%; P < 0.001), had lower handgrip strength, had lower midarm muscle circumference, had lower dietary protein (0.98 ± 0.45 compared with 1.19 ± 0.44 g · kg−1 · d−1; P < 0.001), and had lower energy intake (92.5 ± 37.0 compared with 110.9 ± 35.7 kJ · kg−1 · d−1; P < 0.001) but had higher C-reactive protein (P = 0.025) and higher REE (P < 0.001). However, no difference in TEE was noted between the 2 groups, which indicated lower activity energy expenditure among patients with previous circulatory congestion. The resulting energy balance was significantly more negative for patients with previous circulatory congestion than for those without previous circulatory congestion (P = 0.050). Furthermore, the prevalence of malnutrition increased with increasing episodes of circulatory congestion (P = 0.017). ConclusionsPatients with previous circulatory congestion had significantly more inflammation, more muscle wasting, and higher REE but lower activity energy expenditure and energy and protein intakes in keeping with an anorexia-cachexia syndrome. The mechanisms of increased REE and reduced energy intake among patients with previous circulatory congestion warrant further investigation.

Physical activity leisure‐time participation of boys with developmental coordination disorder

Physical activity leisure‐time participation of boys with developmental coordination disorder

The influence of physical activity-induced energy expenditure on the variance in body weight change among individuals during a diet intervention

We investigated the relationship between the variability in body weight change among individuals and diet restriction or physical activity during a 14-week intervention. A prospective clinical trial with a 14-week weight reduction intervention design. In total, 90 middle aged, Japanese, obese women enrolled as subjects. The outcome variable was the change in body weight during the intervention period. Other primary variables were total energy intake, carbohydrate intake, fat intake, protein intake, total energy expenditure (TEE), and activity energy expenditure (AEE). Diet intake was assessed by 3 days, weighed dietary records and dietary recall interviews. Physical activity was assessed by a uniaxial accelerometry sensor and a diary of exercise. Significant reductions were observed in body weight (-8.5 kg) as a result of intervention. When the subjects were assigned to three categories depending on AEE during intervention, the loss of body weight was significantly greater for subjects within the upper (-9.6 kg) AEE category than for those in the middle (-8.5 kg) or lower AEE (-7.5 kg) categories. In addition, a significant correlation (r = 0.57, p < 0.0001) was observed between a subject's AEE before and during the intervention. On the other hand, no significant correlation was observed between body weight reduction and energy intake, indicating that strict diet restriction does not always result in a large weight loss. Activity energy expenditure, not only through voluntary exercise but also through spontaneous, daily, physical activities can have a positive effect on reducing body weight.

Patterns of Activity Energy Expenditure Among Australian Adolescents

This study examined the pattern of activity energy expenditure (AEE) among New South Wales (NSW) high school students in relation to age, sex, socioeconomic status (SES), place of residence, cultural background, season, participation in moderate- and vigorous-intensity and in organized and non-organized physical activity.Methods:Cross-sectional survey of a randomly-selected sample (N = 2026). Respondents self-reported their physical activity participation during a usual week in summer and winter.Results:Boys reported greater AEE than girls and, whereas AEE was greater among grade 10 than grade 8 boys, the reverse was true for girls. Boys reported the same AEE for summer and winter, but girls reported less AEE during winter. Both boys and girls reported spending the same proportion of their AEE in vigorous-intensity (72%) compared with moderate-intensity activity (28%) and in non-organized (60%) compared with organized activity. There was no clear association between urban/rural place of residence and AEE. Although AEE tended to be positively associated with SES among girls, there was no association among boys. Girls from Asian cultural backgrounds reported much lower AEE than girls from other cultural backgrounds.Conclusion:Patterns of energy expenditure among adolescent boys and girls should be considered in developing interventions to ensure needs are adequately met.

Free-living activity energy expenditure in women successful and unsuccessful at maintaining a normal body weight

Although physical inactivity is believed to contribute to the rising prevalence of obesity, the role and magnitude of its contribution to weight gain are unknown. We compared total free-living activity energy expenditure (AEE) and physical activity level in women successful and unsuccessful at maintaining a normal body weight. Premenopausal, generally sedentary women were studied at their normal weight and 1 y later after no intervention. Two groups were identified on the basis of extreme weight changes: maintainers (n = 27) had a weight gain of less-than-or-equal 3% of their initial body weight ( less-than-or-equal 2 kg/y) and gainers (n = 20) had a weight gain of >10% (>6 kg/y). At baseline and follow-up, evaluations were conducted during 4 wk of diet-controlled, energy-balance conditions. Free-living AEE and physical activity were assessed with the use of doubly labeled water, exercise energy economy and muscle strength with the use of standardized exercise tests, and sleeping EE and substrate utilization with the use of chamber calorimetry. Maintainers lost a mean (plus minusSD) of 0.5 plus minus 2.2 kg/y and gainers gained 9.5 plus minus 2.1 kg/y. Gainers had a lower AEE (P < 0.02), a lower physical activity level (P < 0.01), and less muscle strength (P < 0.001); these differences between groups remained significant from baseline to follow-up. Sleeping EE, exercise economy, and sleeping or 24-h substrate utilization were not significantly different between the 2 groups. A lower AEE in the gainers explained approximately 77% of their greater weight gain after 1 y. The general US population should increase their daily physical activity levels to decrease the rising prevalence of obesity.