The symptoms of this illness include mood swings, protracted melancholy, disinterest, and diminished cognitive performance. These symptoms give the patient discomfort and have a substantial negative impact on their capacity to function and lead fulfilling personal, social, and professional lives. Depression treatment has to be comprehensive and involve medicine. For several centuries, herbal chemicals have been the subject of scientific inquiry, and ongoing studies are being conducted to explore their possible medical benefits. Herbs used in traditional medicine have been shown to be highly beneficial in lowering depression and its symptoms as well as enhancing patient function. Plants are used in biology and medicine in a variety of ways. They are an excellent resource for the creation of innovative drugs due to their high levels of safety, accessibility, availability, tolerance, and low levels of toxicity. Depression is caused by a multitude of variables, such as inflammation, brain-derived neurotropic factor (BDNF), hypothalamic-pituitary-adrenal (HPA) axis, and monoamine neurotransmitters (dopamine, serotonin (5-HT), noradrenaline, and 5-HT). Herbal medicines have gained a lot of attention lately since they are less costly and have less adverse effects than traditional depression treatments. Recent years have seen a significant amount of study on the possible application of sedative and antidepressant plants. The primary emphasis of this review has been herbal medications with antidepressant properties. Keywords: Depression, herbal medications. Herb, antidepressant plants