Low Tendency Research Articles

Elimination of torasemide from aqueous medium: influence of sorption and photocatalytic processes parameters supported by DFT analysis.

The sorption and photocatalytic activity of pharmaceutical torasemide using an immobilized TiO2 photocatalyst were investigate. The experimental design included optimization of reaction conditions such as pH and initial pharmaceutical concentration in aqueous solution using the response surface modeling approach, scavenger tests to gain insight into the photocatalysis mechanism, and application of the process to more complex water matrices. TiO2 in the role of sorbent showed a low capacity for torasemide (12.23-29.83μg/g within 24h of contact), making this type of removal inefficient on its own. Investigating the sorption process influenced by different process parameters such as pH, temperature, ionic strength, and dosage of TiO2 applied, the low tendency to this kind of material was affirmed by low Kd values (0.70 to 6.78mL/g) obtained by linear isotherms. Photocatalysis proved to be the better choice for the removal of torasemide from water, with the best kinetics at pH 4 and concentration of 5mg/L with half-time for degradation of 34.83min. Computational DFT analysis identified the zwitterionic torasemide structure as predominant under neutral and acidic conditions. It also showed that negatively charged areas around nitrogen-containing fragments probably have the highest potential to promote the TiO2 sorption at low pH conditions, where it is highest, through electrostatic attractions and N-H∙∙∙∙∙OTiO2 hydrogen-bonding contacts.

Penggunaan Internet dan Peluang Berwirausaha di Indonesia

Currently, the internet has become a necessity in social and economic life that provides convenience in communication and social interaction. In addition, the presence of the internet supported by advances in digital technology is expected to provide business opportunities. Internet access has become easier with the increasing use of mobile phones/handphones. This study aims to see the effect of internet use on entrepreneurial opportunities in Indonesia through descriptive analysis methods and binary logistic regression. This research uses data from the 2019 National Socio-Economic Survey. Entrepreneurs in this study are limited to individuals who try to be assisted by permanent workers or paid workers in the age range of 25 to 44 years. Of the 348,735 samples that were the analysis units, 7,108 were entrepreneurs or around 2.04 percent. This study found that individuals who use the internet have a higher chance of becoming entrepreneurs than individuals who do not use the internet and this finding is statistically significant. In addition, the level of education significantly influences individuals to become entrepreneurs, but individuals with higher education have a lower tendency to become entrepreneurs than those with high school education or below. Keywords: Internet, Binary Logistic Regression, Entrepreneurship

Like Shooting Phish in a Barrel: Cue Utilization and Cognitive Reflection Aid Performance in Controlled, but Not Naturalistic Phishing Tasks

The study tested the role of cue utilization and cognitive reflection tendencies in email users’ phishing decision capabilities in both controlled and naturalistic settings. 94 university students completed measures of their phishing cue utilization and cognitive reflection, a phishing decision task, and a naturalistic simulated phishing campaign, in which they were sent simulated phishing emails to their personal inboxes. For the phishing decision task, results revealed that participants with lower cognitive reflection tendencies were more likely to misclassify genuine emails as phishing, compared to participants with higher cognitive reflection. Further, participants with higher cognitive reflection and lower cue utilization took the most time to diagnose emails, but participants low in both cue utilization and cognitive reflection demonstrated the shortest response latencies. These findings suggest that greater cognitive reflection can offset lower levels of cue utilization. For the naturalistic simulation, neither cue utilization nor cognitive reflection predicted an increased propensity to interact with a suspicious email. This result highlights a potential gap between phishing investigations conducted in controlled and naturalistic settings. The implications extend to future research, emphasizing the need for studies that employ naturalistic methodologies to better understand and address phishing threats in real-world environments.

Influence of parental mediation and social skills on adolescents' use of online video games for escapism: A cross-sectional study.

The widespread use of video games among adolescents has raised concerns about their impact on psychological and social development. This study aimed to assess the effects of different types of parental mediation on adolescents' tendency to use video games to avoid negative emotions and determine the relationship between adolescents' interpersonal skills and their reliance on online video games for escapism. Participants were 452 adolescents from 15 middle and high schools. Data on sociodemographic information, gaming habits, parental control of online gaming, interpersonal skills, and reasons for playing online games were also collected. Hierarchical multiple regression was used to analyze the data, with online video game escapism as the dependent variable. Results supported the study's hypothesis that both parental mediation and adolescent interpersonal skills significantly predict the use of online video games for escapism. Higher levels of parental monitoring were associated with a lower tendency of adolescents to use video games to escape negative emotions, while parental mediation supporting autonomy showed a similar but weaker protective effect. At the same time, parental monitoring was also found to be associated with lower interpersonal skills, notably higher impulsivity, narcissism, and stress in social situations. In addition, adolescents with higher levels of impulsivity were more likely to use video games for escapism. These findings highlight the importance of balanced parental involvement and the development of adolescents' social skills to mitigate the risks of problematic online gaming. Interventions should promote effective parental mediation strategies and enhance adolescents' interpersonal skills to reduce their tendency to use video games as a coping mechanism for real-life challenges. Effective parental mediation and improved interpersonal skills are critical for promoting healthier gaming habits and reducing adolescent escapism.

Inside the gamer's mind: How violent video games and emotional dysregulation affect EEG interbrain synchronization

BackgroundExposure to violent video games influences players’ cortical activations. In addition, intra-individual variables like emotional regulation play an important role in the consequences of such exposures. However, most research has studied these relationships at the intra-individual level. Therefore, the present study investigated the effects of violent video games on the interbrain synchronization (IBS) of dyads in which one member played video games, and evaluated IBS differences between high and low-emotionally dysregulated groups. MethodsEighteen participants (M = 24.1 ± 2.1) were enrolled in this study. Participants gazed into another person's eyes before playing (“First Direct Gaze”), after playing a violent video game (“Post-VV”), and after playing a nonviolent video game (“Post-NVV”) during an electroencephalographic hyperscanning acquisition. Afterward, each participant completed a socio-demographic questionnaire and the Difficulties in Emotion Regulation Scale. ResultsA cluster-based analysis revealed an increased theta IBS Post-VV compared to Post-NVV. A median split was used to define the high emotionally dysregulated (“HED”) and low emotionally dysregulated (“LED”) groups. Results showed a decreased alpha IBS in the First Direct Gaze, Post-VV, and Post-NVV in the HED group compared to the LED group. ConclusionsExposure to violent video games was associated with higher theta IBS, suggesting a greater social attunement, potentially due to a higher perceived dominance and control or due to an effort of managing the emotional activations elicited. In addition, difficulties in emotional regulation could elicit specific alpha activities regardless of exposure to a video game, leading to a lower tendency to attune with another person on this band.Results from this study should not be generalized to infer that playing any type of video game causes harm to people's brains.

Justification of the effective sequence of group fitness classes with second mature women (45-55 years old)

This article deals with issues that are aimed at the organization of strength training. First of all, it is necessary to note significant differences between women and men in terms of strength. In women, they are 15-20% lower than in men. Women have a lower tendency to gain muscle mass. This is primarily related to the hormonal background, since the male hormone testosterone is responsible for the growth of muscle mass, and its amount in the body of women is many times smaller than that of men. At the same time, women's ability to display strength indicators of leg muscles is close to men's. Experts in age-related physiology note that at the age of 40-45, reverse processes begin in a woman's body. The main metabolism slows down, the productivity of various organs and systems decreases, the possibility of various pathological processes, chronic diseases, etc. increases. In connection with the decrease in the hormonal background, negative changes are observed in all organs and systems of the body. Blood pressure often rises, a tendency to osteoporosis appears, fat metabolism is disturbed, which often leads to an increase in body fat. There are significant changes in the respiratory system, the vital capacity of the lungs decreases, the mobility of the chest decreases. After 40 years, there is a significant decrease in muscle strength in women. The elasticity of muscles, tendons, and joint performance is lost. At the same time, muscle tone decreases, which leads to negative changes in posture.

Cloning, Expression, and Purification of Phage Display-Selected Fab for Biophysical and Biological Studies.

The antigen-binding fragment (Fab) is the ∼50-kDa monovalent arm of an antibody molecule. In the laboratory, the Fab can be produced via either enzymatic digestion or recombinant expression, and its use facilitates the accurate assessment of affinity and specificity of monoclonal antibodies. The high melting temperature of the Fab, together with its low tendency to aggregate and ready conversion to natural and nonnatural immunoglobulin (Ig) formats (without affecting antigen binding properties), have made it a preferred format for phage display, as well as a tool for accurate assessment of affinity, specificity, and developability of monoclonal antibodies. Here, we outline a strategy to clone, express, and purify human or chimeric nonhuman/human Fabs that have previously been selected by phage display. Fabs purified using this approach, which results in milligram amounts, enable a variety of downstream biophysical and biological assays that ultimately inform the success of phage display library generation and selection.

Generation and Selection of Phage Display Antibody Libraries in Fab Format.

Monoclonal antibodies (mAbs) have exceptional utility as research reagents and pharmaceuticals. As a complement to both traditional and contemporary single-B-cell cloning technologies, the mining of antibody libraries via display technologies-which mimic and simplify B cells by physically linking phenotype (protein) to genotype (protein-encoding DNA or RNA)-has become an important method for mAb discovery. Among these display technologies, phage display has been particularly successful for the generation of mAbs that bind to a wide variety of antigens with exceptional specificities and affinities. Rather than multivalent whole antibodies, phage display typically uses monovalent antibody fragments, such as "fragment antigen binding" (Fab), as the format of choice. The ∼50-kDa Fab format consists of four immunoglobulin (Ig) domains on two polypeptide chains (light chain and shortened heavy chain), and exhibits its antigen binding site in a natural configuration found in bivalent IgG and other multivalent Ig molecules. The Fab fragment has a high melting temperature and a low tendency to aggregate, and can be readily converted to natural and nonnatural Ig formats without affecting antigen binding properties, which has made it a favored format for phage display for more than three decades. Here, I briefly summarize some of the approaches used for the generation and selection of phage display antibody libraries in Fab format, from human and nonhuman antibody repertoires.

The Impact of Online Pandemic-Related Information on Prosocial Behavior among Healthcare Students: The Role of Emotional Contagion and Epistemic Motivation.

Prosocial behavior is fundamental for healthcare students, shaped by their traits and the external environment. Online information seeking is the most commonly used way for healthcare students to access pandemics; however, it is unclear whether the willingness of healthcare students to help others will be affected by pandemic information via the Internet environment. The current study takes the COVID-19 pandemic as an example, investigating how 81 healthcare students with varying prosocial tendencies behaved helpfully after being exposed to pandemic-related pictures online. Study 1 measured the influence of emotional contagion (positive emotion/negative emotion) from online information on students' prosocial behavior; Study 2 examined online information's influence on prosocial behavior by controlling individuals' epistemic motivation (goal-directed task/no-goal-directed task) to gain pandemic information. The results indicated that negative pandemic information was more likely to influence students with low prosocial tendencies, which would then lead to a decrease in prosocial actions (F = 7.842, p = 0.005). Further, students with low prosocial tendencies were more likely to engage in prosocial behavior when they did not aim goal-directed attention to the pandemic-related information, compared to those with goal-directed attention (F = 9.159, p = 0.003). Participants with high prosocial tendencies did not differ much in helping others (p > 0.05). The results indicated that only healthcare students with limited prosocial tendencies were less inclined to assist others after receiving negative information about the pandemic. Thus, reducing their deliberate approach to online information related to the pandemic will increase their chances of taking prosocial behavior.

Changes in work status after cancer diagnosis and their associations with depressive symptoms among cancer survivors: findings from the Korean longitudinal study of ageing1

PurposeCancer survivors encounter significant psychological suffering and are prone to develop depressive symptoms. Work contributes to personal fulfillment and social connections, and by doing so, enhances a cancer survivor’s resilience against adversities. However, maintaining employment can be challenging for some cancer survivors. This research aimed to identify the association between changes in work status and depressive symptoms among cancer survivors in South Korea.MethodsThis study used the panel data from the Korean Longitudinal Study of Ageing (KLoSA) and included 199 cancer survivors–799 observations–aged 65 or younger, between 2005 and 2018. Changes in work status consisted of continuous unemployment or employment, quitting a job, and getting a job. We defined depressive symptoms as a CES-D-10 score of 10 or higher and a cut-off of 4 was utilized for sensitivity analysis. Multivariable generalized estimating equation was employed to estimate the odds ratio (OR), adjusting for the number of household members, education level, sex, age, marital status, occupations, cancer treatment, cancer type, catastrophic healthcare expenditure (CHE), and survivorship. Subgroup analysis and interaction between changes in work and cancer types were further explored.ResultsFor depressive symptoms, the OR of the continuous unemployment group was 2.27 (95% CI = 1.10–4.69), and the OR of the group that quit a job was 2.20 (95% CI = 1.03–4.72), compared to the continuous employment group. As survivorship increased, the odds of depressive symptoms decreased (OR = 0.94, 95% CI = 0.89–1.00). CHE was associated with depressive symptoms (OR = 2.23, 95% CI = 1.18–4.20). In cancer types with a low tendency to depression, continuous unemployment was associated with depressive symptoms (OR = 3.19, 95% CI = 1.12–9.06). In sensitivity analysis, changes in work, survivorship, and CHE were consistently associated with depressive symptoms.ConclusionsCancer survivors who quit a job or continued unemployment were more likely to experience depressive symptoms. The findings of this study imply that assistance for cancer survivors to continue a job or return to employment, including adjustment of workload and hours, may be helpful. Psychological care may be crucial, particularly in the early stage of cancer survivorship. Furthermore, support may be needed to alleviate the burden of healthcare expenditure.

Performance of normal-weight and lightweight 3D printed cementitious composites with recycled glass: Sorption and microstructural perspective

The development of sustainable mixtures has been a widely researched topic in the last decade, as the cement and concrete industries are among the most polluting sectors. Recycled materials can eliminate the need for extraction of natural materials through re-utilization of waste, reducing the environmental impact. To date, few studies have analyzed the effects of incorporating recycled glass aggregates on the water transport properties and microstructure of 3D printable mixtures.This study assesses the feasibility of incorporating recycled glass as a replacement for natural aggregate in 3D printable mixtures. For this purpose, three normal-weight and three lightweight mixtures containing 0, 50, and 100 vol.% of recycled glass aggregate as basalt aggregate replacement were evaluated in cast and printed samples. Expanded thermoplastic microspheres (ETM) were included to create the lightweight mixture composition. This experimental work evaluated the effects of incorporating recycled glass, ETM, and the impact of the printing process on the microstructure, sorption, and capillary water porosity (CWP).The printing process has proven to be an influential factor affecting the shape, size, and quantity of porosity. In addition, the printing process was demonstrated to be more influential on porosity formation than the inclusion of recycled glass or ETM. Incorporating recycled glass results in a slight decrease in the PHg porosity, more spherical pores, and lower anisotropic tendency. Furthermore, adding ETM has a filling effect, leading to a more compact microstructure.

Personal Resources for Psychological Well-Being in University Students: The Roles of Psychological Capital and Coping Strategies.

In recent years, research has noted the increasing prevalence of mental health problems among university students. The current mental health needs of the university population, along with the multitude of stressors they face, have increased the importance of examining their psychological well-being and determining the personal resources that effectively promote it. In this context, the present research aims to analyze the roles of psychological capital (PsyCap) and coping strategies as personal resources that are significantly related to the psychological well-being (PWB) of university students. Specifically, the mediating roles of various coping strategies (both adaptive and maladaptive) in the relationship between PsyCap and PWB are explored. The study involves 391 university students from Spain. The results show partial mediation effects of adaptive coping strategies (cognitive restructuring and social support) on the relationship between PsyCap and PWB. Likewise, PsyCap is shown to be a direct positive predictor of adaptive coping strategies and PWB, as well as a direct negative predictor of maladaptive coping strategies (self-criticism). Therefore, it is concluded that PsyCap and some adaptive coping strategies serve as valuable personal resources that predict PWB in university students. PsyCap is also associated with a lower tendency to engage in maladaptive coping strategies, such as self-criticism. Similarly, the use of cognitive restructuring and/or social support is related to high levels of PWB among university students.

Differences in drivers’ risk behaviour behind the wheel in relation to road risk perception: Insights from a study on a group of Polish car drivers

Numerous risky driving behaviours are considered the main causes of road accidents. Meanwhile, a number of studies conducted so far indicate that perceiving a higher risk in a certain behaviour is associated with a lower tendency to engage in that behaviour. Accordingly, the aim of this study was to examine whether there are differences in specific types of risky behaviours behind the wheel in relation to drivers’ perceptions of road risk. The Road Traffic Behaviour Questionnaires KZD and KZD-P were used to evaluate, respectively, different risky behaviours and risk perceptions in road traffic. Two groups of Polish car drivers with similar average KZD scores but significantly different KZD-P scores, i.e., higher vs. lower, were compared. The profiles of the answers were statistically analysed. It was found that drivers with a lower risk perception were far more likely to engage in those behaviours that are the most commonly reported and directly endanger road safety, e.g., speeding and running a red light. Simultaneously, there were several unsafe driving behaviours, e.g., driving without a seatbelt or speaking on a mobile phone while driving, which were taken regardless of risk perception, i.e., even by the drivers who were aware of their riskiness. The results suggest that risk perception is a significant factor in preventing not all types but only selected hazardous behaviours in road traffic. The significance of the findings for traffic safety as well as ideas for further research in this area are discussed.

Impact of comorbid sleep-disordered breathing on escitalopram treatment in patients newly diagnosed with generalized anxiety disorder: A 12-week prospective observational study

We aimed to evaluate the presence of sleep-disordered breathing (SDB) in generalized anxiety disorder (GAD) patients and its impacts after 12-week of escitalopram treatment. In this prospective observational study, GAD patients were followed up to determine whether comorbid SDB affects their treatment response. They underwent a home sleep apnea test (HSAT), and oxygen desaturation index ≥5 was considered indicative of SDB. All participants were treated with escitalopram 5 mg in the first 2 weeks and 10 mg in the remaining 10 weeks. They underwent assessments of heart rate variability and completed questionnaires for sleep, mood, attention, and daytime sleepiness on the day of enrollment, and 2 weeks, 4 weeks, and 12 weeks later. A total of 45 GAD participants (mean age, 56.2 years) were included in the study. Of these, 53.3% had comorbid SDB. Participants with GAD and SDB had higher baseline Beck Anxiety Inventory (BAI) and STOP-BANG scores. Both groups of participants with GAD showed overall improvement in anxiety, depression, and insomnia symptoms after 12 weeks of escitalopram treatment. Additionally, there were no statistically significant differences in the changes in BAI, Beck Depression Inventory, and Epworth Sleepiness Scale scores between the two groups at the Week 2, Week 4, and Week 12 assessments compared to baseline. However, the GAD group with comorbid SDB seemed to have a lower tendency for improvement in depressive symptoms than the group with non-comorbid SDB. Compared with the GAD group without comorbid SDB, the GAD group with comorbid SDB exhibited more severe anxiety symptoms at baseline and tended to show less improvement in depressive symptoms after 12 weeks of escitalopram treatment.

Exploring the Versatility of Ferrocene and its Derivatives: A Comprehensive Review

Ferrocene is a remarkable organometallic compound with an iron ion sandwiched between two cyclopentadienyl rings. This unique molecular structure and diverse characteristics such as improved solubility, altered reactivity, and enhanced biological activity make them potential candidates for drug development and diverse applications including cancer therapy. Additionally, ferrocene-based compounds exhibit a lower tendency to induce severe side effects, making them a safer option for cancer treatment. They also have shown potential in overcoming resistance encountered by platinum compounds in treating certain types of cancer. The three primary metabolic pathways for ferrocene include oxidation, cyclization catalyzed by acid, and hydroxylation, forming quinone methide, cyclic indene, and allylic alcohol, respectively. Building on this foundation, researchers have delved deeper into synthesizing and assessing novel ferrocene derivatives to enhance their effectiveness in addressing cancer and other illnesses. This review comprehensively examines potential derivative reactions, highlighting the possibilities for tailoring these compounds to achieve specific therapeutic objectives.

Impact of patient's sex on groin hernia repair: A systematic review and meta-analysis.

Groin hernia repair (GHR) is a performed procedure worldwide, with approximately 20million surgeries carried out each year. Despite being less common in females, there is a lack of research on how sex influences the outcomes of GHR. This systematic review and meta-analysis aim to assess how patient sex impacts results in GHR. We performed a systematic review and meta-analysis according to Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. We searched for studies up to October 2023 in MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials. The studies included focused on sex outcomes for both robotic and open GHR procedures. Data extraction and quality assessment were conducted using the Risk of Bias in Non-Randomized Studies - Of Interventionstool. Our statistical analysis was performed using the metafor package in RStudio. After screening a total of 3917 articles, we identified 29 studies that met our criteria, comprising a total of 1,236,694 patients. Among them, 98,641 (7.98%) patients were females. Our findings showed that females had higher rates of hernia recurrence (RR 1.28), chronic pain (RR 1.52), and surgical site infections (SSIs) (RR 1.46) compared to males. Females showed a lower tendency to undergo minimally invasive surgery (MIS) with a relative risk of 0.82 (95% CI 0.69-0.97; p=0.02). Females tend to face higher rates of complications after GHR such as an elevated risk of chronic pain, recurrence, and surgical site infections (SSI). Moreover, they undergo fewer MIS options compared to males. These results underscore the importance of research to enhance outcomes for women undergoing GHR.

The Relationship Between Addiction and Emotional Intelligence in the Ukrainian Socio-Cultural Context: Challenges of Emigration

Introduction: The development of emotional intelligence has a positive impact on the process of adaptation of migrants from Ukraine in the European Union and prevents the spread of addictions. Aim: The aim of this research was to study the relationship between migrants' emotional intelligence and the development of addictions in the context of adaptation to new conditions due to the hostilities. Methods: the study used such methods as testing and questionnaires, respectively, ASI and Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT). Results: It was found that individuals with a higher level of emotional intelligence have a lower tendency to form various types of addictions, while those with a lower level of EI are more vulnerable to these problems. This suggests that a high level of emotional intelligence contributes to better emotion management, the ability to adapt to stressful situations, and a better understanding of one's own needs and motivations. Conclusion: a high level of emotional intelligence makes it possible to prevent the formation of dependencies in the process of cross-cultural adaptation of migrants from Ukraine to new conditions against the background of a hostilities in Ukraine.

Potential of near-infrared spectroscopy (NIRS) for prediction of acrylamide formation in French fries in the potato breeding process

Breeding goals of potatoes for deep-frying purposes include high starch contents, good suitability for long-term storage, and low tendency to form reducing sugars as acrylamide precursors. Due to the extensive number of samples, an accurate analysis of acrylamide in French fries and its precursors in tubers is difficult to implement in the breeding process. Therefore, this study aimed to evaluate the suitability of NIRS measurements after minimal sample processing for the prediction of reducing sugar contents in the tubers or acrylamide contents in French fries. An external validation with more than 650 samples consisting of 194 potato genotypes resulted in a prediction accuracy of 51 % for acrylamide and 76 % for reducing sugar content. RPD values of less than 1.5 for acrylamide and between 1.64 and 2.23 for reducing sugar prediction rendered low medium to medium model quality. Nevertheless, acrylamide prediction models based on NIRS measurement of mashed tubers categorised over 80 % of unknown samples correctly as being below or above the European threshold value, indicating suitability as rapid test procedure in the breeding process.

Antifungal Activity and Multi-Target Mechanism of Action of Methylaervine on Candida albicans.

The discovery of a lead compound against Candida albicans is urgently needed because of the lack of clinically available antifungal drugs and the increase in drug resistance. Herein, a β-carboline alkaloid methylaervine (MET) exhibited potential activity against C. albicans (MIC = 16-128 μg/mL), no hemolytic toxicity, and a low tendency to induce drug resistance. An antifungal mechanism study indicated that MET effectively inhibited the biofilm formation and disrupted the mature biofilm. Moreover, filamentation formation and spore germination were also weakened. The electron microscopy analysis revealed that MET could damage the cell structure, including the cell wall, membrane, and cytoplasm. In particular, the permeability and integrity of the cell membrane were destroyed. When it entered the fungi cell, it interfered with the redox homeostasis and DNA function. Overall, MET can inhibit the growth of C. albicans from multiple channels, such as biofilm, filamentation, cell structure, and intracellular targets, which are difficult to mutate at the same time to generate drug resistance. This work provides a promising lead compound for the creation of new antifungal agents against C. albicans.

Thermodynamic and kinetic study of palladium(II) complexation with 1-methyl-2-mercaptoimidazole (methimazole) and their importance for structural design of metallodrugs

The acidobasic and complexing properties of 1-methyl-2-mercaptoimidazole (Methimazole, an anti-thyroid drug) were investigated. The pKa 11.49 ± 0.03 was estimated by molecular absorption spectroscopy (I = 0.10 M NaCl, t = 25.0 ± 0.1 °C). This value is in good agreement with the value 11.58 ± 0.05, obtained using the solvent-extraction technique. Theoretical (LFER and quantum chemical calculations) and experimental (1H/13C NMR spectroscopy) methods confirmed that the ligand prefers to be in the thion form, and the proton dissociation takes place on the nitrogen atom. Using glass electrode potentiometry, the complexation of the Pd(II) ion by the methimazole ligand occurs without the participation of protons. The best chemical model considers the [Pd(HL)]2+, [Pd(HL)2]2+ and [Pd(HL)3]2+ complex species, whose stability constants were also determined using spectroscopy and capillary zone electrophoretic (CZE) measurements. The metal complexes dissociate at –log [H+] > 7, where an uncharged palladium(II) hydroxide is formed. The formation kinetics of the palladium(II) complex with methimazole were studied in perchloric and hydrochloric acids (I = 1.00 M, t = 15–40 °C) and the determined rate constants and activation parameters are consistent with literature values determined for the reactions of the Pd(II) ion with thiourea derivatives. The rate constants decrease by two orders of magnitude in both media, which can be assigned to a lower tendency of the chloride ion to dissociate from the [PdCl4]2− complex species than the water molecule from the [Pd(H2O)4]2+ ion. The presented results can be utilized for the design of new Pd and Pt metallodrugs.