Low Syndrome Research Articles

Síndrome de Lowe: Um estudo de caso

This study highlights the complexity of Lowe's syndrome, also known as oculocerebrorenal syndrome (OCR), first described by Lowe in 1952, is a rare genetic condition that primarily affects the eyes, brain, and kidneys. Genetic diagnosis, although possible, is often limited by the costs and slowness of the public health system. Thus, diagnosis is often based on clinical criteria and laboratory tests. The prevalence is estimated at 1 in 500,000 in the general population. The case report presents LG, a child with Lowe's Syndrome with neuropsychomotor delay, congenital cataract and glaucoma. The transdisciplinary team, composed of diverse healthcare professionals, has taken a holistic approach to addressing the complex clinical and therapeutic challenges of the syndrome. The therapeutic interventions focused on improving the quality of life, highlighting the importance of speech therapy and the need for early intervention integrated with a transdisciplinary approach, in addition to the active inclusion of the family in the therapeutic process. The study emphasizes the crucial role of third sector institutions in supporting populations in vulnerable situations and highlights the need for articulation between institutions and the public health system.

The correlations on psychopathology in children self-rating, psychopathology in children as related by their parents and psychopathology in parents self-rating in a Kenyan school setting: towards an inclusive family-centered approach

Several studies have reported on the association between parental and childhood psychopathologies. Despite this, little is known about the psychopathologies between parents and children in a non-clinical population. We present such a study, the first in a Kenyan setting in an attempt to fill this gap. The objective of this study was to determine the association between self-rating psychopathology in children, parent-rating psychopathology in their children and self-rating psychopathology in parents in a non-clinical population of children attending schools in Kenya. We identified 113 participants, comprising children and their parents in 10 randomly sampled primary schools in South East Kenya. The children completed the Youth Self-Report (YSR) scale and parents completed the Child Behavior Check List (CBCL) on their children and the Adult Self-Reports (ASR) on themselves. These instruments are part of the Achenbach System of Empirically Based Assessment (ASEBA), developed in the USA for a comprehensive approach to assessing adaptation and maladaptive behavior in children and adolescents. There was back and forth translation of the instruments from English to Swahili and the local dialect, Kamba. Every revision of the English translation was sent to the instrument author who sent back comments until the revised version was in sync with the version developed by the author. We used the ASEBA in-built algorithm for scoring to determine cut-off points for problematic and non-problematic behavior. Correlations, linear regression and independent sample t-test were used to explore these associations. The mean age of the children was 12.7. While there was no significant association between child problems as measured by YSR (self-reported) and parent problems as measured by ASR and CBCL in the overall correlations, there was a significant association when examining specific groups (clinical range vs. non-clinical). Moreover, significant association existed between total problems on YSR and ASR internalizing problems (t=-2.3,p = 0.023), with clinical range having a higher mean than the normal range. In addition, a significant relationship (p < 0.05) was found between psychopathology in children as reported by both parents (CBCL) and psychopathology in parents as self-reported (ASR).Mothers were more likely to report lower syndrome scores of their children as compared to fathers. Our findings indicate discrepancies between children self-rating and parent ratings, suggesting that one cannot manage psychopathology in children without reference to psychopathology in their parents. We suggest broad-based psycho-education to include children and parents to enhance shared awareness of psychopathology and uptake of treatment.

OCRL1 Deficiency Affects the Intracellular Traffic of ApoER2 and Impairs Reelin-Induced Responses.

Lowe Syndrome (LS) is a rare X-linked disorder characterized by renal dysfunction, cataracts, and several central nervous system (CNS) anomalies. The mechanisms underlying the neurological dysfunction in LS remain unclear, albeit they share some phenotypic characteristics similar to the deficiency or dysfunction of the Reelin signaling, a relevant pathway with roles in CNS development and neuronal functions. In this study, we investigated the role of OCRL1, an inositol polyphosphate 5-phosphatase encoded by the OCRL gene, mutated in LS, focusing on its impact on endosomal trafficking and receptor recycling in human neuronal cells. Specifically, we tested the effects of OCRL1 deficiency in the trafficking and signaling of ApoER2/LRP8, a receptor for the ligand Reelin. We found that loss of OCRL1 impairs ApoER2 intracellular trafficking, leading to reduced receptor expression and decreased levels at the plasma membrane. Additionally, human neurons deficient in OCRL1 showed impairments in ApoER2/Reelin-induced responses. Our findings highlight the critical role of OCRL1 in regulating ApoER2 endosomal recycling and its impact on the ApoER2/Reelin signaling pathway, providing insights into potential mechanisms underlying the neurological manifestations of LS.

Syndromic congenital glaucoma clinical features and therapeutic results

Aims/Purpose: The objective is to study the clinical particularities and the results therapies.Methods: This is a retrospective study of 15 children (25 eyes) since 2012 until 2021 at the paediatric ophthalmology department of the August 20 hospital from Casablanca‐Morocco.Results: In our study, there were 15 cases including 9 cases (13 eyes) of syndrome of Sturge weber Krabb, 2 cases (4 eyes) of Axenfield Reiger syndrome, 2 case (4 eyes) of Peters syndrome 1 case (2 eyes) of lower syndrome, 1 case (2 eyes) of polymalformative syndrome (cardiopathy, pulmonary stenosis, bilateral femoral epiphyseal dysplasia). The average age is 8 years with a sex ratio of 1.7, the notion of inbreeding exists in 43%. The warning sign was buphthalmos in 72% of cases, on clinical examination the cornea was edematous in 60% of cases with an average diameter 13.2 mm corneal, with anterior iris synechiae in 32% of cases, bilateral cataract in 4% of cases, persistence of primary vascularization in 4% of cases and an average of excavation of 7/10, an average TO at 34 mmHg. The most common systemic abnormalities were facial angioma (56%), epilepsy (41%) and mental retardation (30%).Treatment was trabeculectomy in 96% of cases associated with medical treatment in 100% of cases.Conclusions: It is a rare, blinding pathology, the clinical forms of which are numerous with complex ocular and general malformations, which can pose etiological and therapeutic problems that are difficult.

Lowe Oculocerebrorenal Syndrome Comparison of Anterior Segment Anatomy in Eyes with and without Glaucoma

Ultrasound biomicroscopy comparison of two infants with Lowe oculocerebrorenal syndrome, one with glaucoma and one without, found differences in corneal curvature, iris thickness, trabecular-iris angle, and lens morphology are potential glaucoma-associated features.

Oculocerebrorenal syndrome of Lowe (OCRL) controls leukemic T-cell survival by preventing excessive PI(4,5)P2 hydrolysis in the plasma membrane

T-cell acute lymphoblastic leukemia (T-ALL) is one of the deadliest and most aggressive hematological malignancies, but its pathological mechanism in controlling cell survival is not fully understood. Oculocerebrorenal syndrome of Lowe is a rare X-linked recessive disorder characterized by cataracts, intellectual disability, and proteinuria. This disease has been shown to be caused by mutation of oculocerebrorenal syndrome of Lowe 1 (OCRL1; OCRL), encoding a phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] 5-phosphatase involved in regulating membrane trafficking; however, its function in cancer cells is unclear. Here, we uncovered that OCRL1 is overexpressed in T-ALL cells, and knockdown of OCRL1 results in cell death, indicating the essential role of OCRL in controlling T-ALL cell survival. We show OCRL is primarily localized in the Golgi and can translocate to plasma membrane (PM) upon ligand stimulation. We found OCRL interacts with oxysterol-binding protein-related protein 4L, which facilitates OCRL translocation from the Golgi to the PM upon cluster of differentiation 3 stimulation. Thus, OCRL represses the activity of oxysterol-binding protein-related protein 4L to prevent excessive PI(4,5)P2 hydrolysis by phosphoinositide phospholipase C β3 and uncontrolled Ca2+ release from the endoplasmic reticulum. We propose OCRL1 deletion leads to accumulation of PI(4,5)P2 in the PM, disrupting the normal Ca2+ oscillation pattern in the cytosol and leading to mitochondrial Ca2+ overloading, ultimately causing T-ALL cell mitochondrial dysfunction and cell death. These results highlight a critical role for OCRL in maintaining moderate PI(4,5)P2 availability in T-ALL cells. Our findings also raise the possibility of targeting OCRL1 to treat T-ALL disease.

Heterogeneity in Lowe Syndrome: Mutations Affecting the Phosphatase Domain of OCRL1 Differ in Impact on Enzymatic Activity and Severity of Cellular Phenotypes.

Lowe Syndrome (LS) is a condition due to mutations in the OCRL1 gene, characterized by congenital cataracts, intellectual disability, and kidney malfunction. Unfortunately, patients succumb to renal failure after adolescence. This study is centered in investigating the biochemical and phenotypic impact of patient's OCRL1 variants (OCRL1VAR). Specifically, we tested the hypothesis that some OCRL1VAR are stabilized in a non-functional conformation by focusing on missense mutations affecting the phosphatase domain, but not changing residues involved in binding/catalysis. The pathogenic and conformational characteristics of the selected variants were evaluated in silico and our results revealed some OCRL1VAR to be benign, while others are pathogenic. Then we proceeded to monitor the enzymatic activity and function in kidney cells of the different OCRL1VAR. Based on their enzymatic activity and presence/absence of phenotypes, the variants segregated into two categories that also correlated with the severity of the condition they induce. Overall, these two groups mapped to opposite sides of the phosphatase domain. In summary, our findings highlight that not every mutation affecting the catalytic domain impairs OCRL1's enzymatic activity. Importantly, data support the inactive-conformation hypothesis. Finally, our results contribute to establishing the molecular and structural basis for the observed heterogeneity in severity/symptomatology displayed by patients.

Asociaciones de hallazgos diagnósticos con actividad de la enfermedad en el síndrome de Sjögren primario: un análisis de conglomerados

ObjectiveThe diagnosis of primary Sjögren's syndrome still relies upon a constellation of clinical, laboratory, imaging, and pathological findings. We aimed to evaluate the relation of the disease activity with the results of diagnostic tests for primary Sjögren's syndrome. MethodsA principal component with cluster analysis was performed to classify 69 patients with primary Sjögren's syndrome based on the results of diagnostic evaluations. ResultsAnti-SSA autoantibody was the most represented feature on the principal components. The anti-SSA and ultrasound score were positively correlated (p=0.001). We identified two distinct clusters of low or high disease activity (p<0.001). Except for disease duration and serum beta2-microglobulin, the clusters were significantly different in salivary flow (p=0.004), ultrasound findings (p<0.001), IgG (p=0.001), and salivary beta2-microglobulin (p=0.048). Also, positive findings were significantly different between the clusters in rheumatoid factor, antinuclear antibody, anti-SSA, and anti-SSB (all p≤0.013). ConclusionPatients with higher syndrome activity were best recognized with serological and ultrasound assessments. However, patients with lower syndrome activity had a longer disease duration, higher stimulated salivary flow rate, and a positive biopsy of minor salivary glands (56%).

Associations of diagnostic findings with disease activity in primary Sjӧgren's syndrome: a cluster analysis

ObjectiveThe diagnosis of primary Sjӧgren's syndrome still relies upon a constellation of clinical, laboratory, imaging, and pathological findings. We aimed to evaluate the relation of the disease activity with the results of diagnostic tests for primary Sjӧgren's syndrome. MethodsA principal component with cluster analysis was performed to classify 69 patients with primary Sjӧgren's syndrome based on the results of diagnostic evaluations. ResultsAnti-SSA autoantibody was the most represented feature on the principal components. The anti-SSA and ultrasound score were positively correlated (p=0.001). We identified two distinct clusters of low or high disease activity (p<0.001). Except for disease duration and serum beta2-microglobulin, the clusters were significantly different in salivary flow (p= 0.004), ultrasound findings (p<0.001), IgG (p= 0.001), and salivary beta2-microglobulin (p= 0.048). Also, positive findings were significantly different between the clusters in rheumatoid factor, antinuclear antibody, anti-SSA, and anti-SSB (all p≤0.013). ConclusionPatients with higher syndrome activity were best recognized with serological and ultrasound assessments. However, patients with lower syndrome activity had a longer disease duration, higher stimulated salivary flow rate, and a positive biopsy of minor salivary glands (56%).

Inherited Fanconi syndrome.

Fanconi-Debré-de Toni syndrome (also known as Fanconi renotubular syndrome, or FRST) profoundly increased the understanding of the functions of the proximal convoluted tubule (PCT) and provided important insights into the pathophysiology of several kidney diseases and drug toxicities. We searched Pubmed and Scopus databases to find relevant articles about FRST. This review article focuses on the physiology of the PCT, as well as on the physiopathology of FRST in children, its diagnosis, and treatment. FRST encompasses a wide variety of inherited and acquired PCT alterations that lead to impairment of PCT reabsorption. In children, FRST often presents as a secondary feature of systemic disorders that impair energy supply, such as Lowe's syndrome, Dent's disease, cystinosis, hereditary fructose intolerance, galactosemia, tyrosinemia, Alport syndrome, and Wilson's disease. Although rare, congenital causes of FRST greatly impact the morbidity and mortality of patients and impose diagnostic challenges. Furthermore, its treatment is diverse and considers the ability of the clinician to identify the correct etiology of the disease. The early diagnosis and treatment of pediatric patients with FRST improve the prognosis and the quality of life.

Participation of OCRL1, and APPL1, in the expression, proteolysis, phosphorylation and endosomal trafficking of megalin: Implications for Lowe Syndrome.

Megalin/LRP2 is the primary multiligand receptor for the re-absorption of low molecular weight proteins in the proximal renal tubule. Its function is significantly dependent on its endosomal trafficking. Megalin recycling from endosomal compartments is altered in an X-linked disease called Lowe Syndrome (LS), caused by mutations in the gene encoding for the phosphatidylinositol 5-phosphatase OCRL1. LS patients show increased low-molecular-weight proteins with reduced levels of megalin ectodomain in the urine and accumulation of the receptor in endosomal compartments of the proximal tubule cells. To gain insight into the deregulation of megalin in the LS condition, we silenced OCRL1 in different cell lines to evaluate megalin expression finding that it is post-transcriptionally regulated. As an indication of megalin proteolysis, we detect the ectodomain of the receptor in the culture media. Remarkably, in OCRL1 silenced cells, megalin ectodomain secretion appeared significantly reduced, according to the observation in the urine of LS patients. Besides, the silencing of APPL1, a Rab5 effector associated with OCRL1 in endocytic vesicles, also reduced the presence of megalin's ectodomain in the culture media. In both silencing conditions, megalin cell surface levels were significantly decreased. Considering that GSK3ß-mediated megalin phosphorylation reduces receptor recycling, we determined that the endosomal distribution of megalin depends on its phosphorylation status and OCRL1 function. As a physiologic regulator of GSK3ß, we focused on insulin signaling that reduces kinase activity. Accordingly, megalin phosphorylation was significantly reduced by insulin in wild-type cells. Moreover, even though in cells with low activity of OCRL1 the insulin response was reduced, the phosphorylation of megalin was significantly decreased and the receptor at the cell surface increased, suggesting a protective role of insulin in a LS cellular model.

Oculocerebrorenal syndrome of Lowe protein controls cytoskeletal reorganisation during human platelet spreading.

Lowe syndrome (LS) is a rare, X-linked disorder characterised by numerous symptoms affecting the brain, the eyes, and the kidneys. It is caused by mutations in the oculocerebrorenal syndrome of Lowe (OCRL) protein, a 5-phosphatase localised in different cellular compartments that dephosphorylates phosphatidylinositol-4,5-bisphosphate into phosphatidylinositol-4-monophosphate. Some patients with LS also have bleeding disorders, with normal to low platelet (PLT) count and impaired PLT function. However, the mechanism of PLT dysfunction in patients with LS is not completely understood. The main function of PLTs is to activate upon vessel wall injury and stop the bleeding by clot formation. PLT activation is accompanied by a shape change that is a result of massive cytoskeletal rearrangements. Here, we show that OCRL-inhibited human PLTs do not fully spread, form mostly filopodia, and accumulate actin nodules. These nodules co-localise with ARP2/3 subunit p34, vinculin, and sorting nexin 9. Furthermore, OCRL-inhibited PLTs have a retained microtubular coil with high levels of acetylated tubulin. Also, myosin light chain phosphorylation is decreased upon OCRL inhibition, without impaired degranulation or integrin activation. Taken together, these results suggest that OCRL contributes to cytoskeletal rearrangements during PLT activation that could explain mild bleeding problems in patients with LS.

Long-term results of pathogenetically-grounded methods of treatment of patients with postthrombotic syndrome of the lower extremities according to three-year follow-up

The aim of this study was to evaluate the effectiveness of surgical treatment using a modified method of correction of venous hemodynamic disorders of the lower extremities by the state of function of the leg muscle pump during long-term follow-up in the postoperative period of patients with postthrombotic syndrome of the lower extremities. 148 patients with lower limb postthrombotic syndrome (С5, 6, S, Es, As, d, p, Pr, LI by CEAP classification) were divided in two groups. The first group included 71 patients, which were treated by traditional methods of surgical intervention (crossectomy and venecseresis). The second group consisted of 77 patients who underwent closed separation of the perforating veins and paratibial fasciotomy in the complex of surgical treatment. The function of the leg muscle pump was studied using three methods: a 6-minute marching test measuring the circumference of the limbs, the amplitude indices of movements in the ankle joint with a protractor, and electromyography using a multichannel electromyography with skin electrode application. The quality of life was studied using the CIVIQ questionnaire, the severity of venous pathology by the VCSS scale and disability rates by the VDS disability scale. The examination was performed before the surgery, after 1 year and after 3 years of observation. In both groups of patients, there was a decrease in the basal levels of a 6-minute marching test, the movement amplitude in the ankle joint, the electromyography indicators, the presence of a strong correlation between these parameters, indicating venous dysfunction in the lower extremities. In the postsurgical period (in 1 and 3 years), there was a reduced circumference of the legs during the marching test, an increased amplitude of movements in the ankle joint and electromyography indicators – the mean and maximum amplitude of oscillations. In patients of group II, the results were better than in patients of group I. In the pre-surgical period, a significant deterioration of the life quality was observed in terms of the CIVIQ questionnaire, the severity of venous pathology – by the VCSS scale and a decrease in working capacity – by the VDS disability scale in both groups. In the long-term postsurgical period, there was an improvement of these indicators, more pronounced in patients of group II. Clinical study of long-term results of the closed separation of perforating veins and paratibial fasciotomy operation confirmed the high efficiency of this method and allowed us to consider it as a pathogenetically-grounded method of surgical treatment of patients with postthrombotic syndrome of the lower extremities.

An Update on the Oculocerebrorenal Syndrome of Lowe: A Review Article

Context: Lowe syndrome (LS) is a very uncommon syndrome that causes the death of young patients due to kidney diseases. This narrative review aimed to assess the clinical manifestations of LS, mainly the novel investigations of LS, to provide an update on the clinical manifestations improving the misdiagnosis of LS. Methods: For this narrative review, the articles from several sources, including Scopus, Google Scholar, Embase, Web of Science, PubMed, and the Directory of Open Access Journals, were used. Results: This syndrome is heredity and a multiple system disorder with the three main symptoms of renal tubular dysfunction, mental retardation, and cataracts. Other features include growth retardation, behavioral problems, stereotypical behavior, areflexia, severe muscular hypotonia, intellectual disability, nontender joint swelling, subcutaneous nodules, potassium loss, sodium loss, renal dysfunction, aminoaciduria, bicarbonaturia, and low-molecular-weight proteinuria. An X-linked recessive pattern inherits this syndrome. The hereditary transmission of this syndrome is X-linked recessive. Conclusions: It is essential to investigate the diverse clinical manifestations of LS. The prognosis and severity of the disease have not yet been determined. It is recommended to perform extensive general studies on the prevalence, diagnosis, and management of this syndrome.

44. A Wireless Intramuscular Near-infrared Spectroscopy Device Detects Muscle Oxygenation Changes in Porcine Model of Lower Extremity Compartment Syndrome

44. A Wireless Intramuscular Near-infrared Spectroscopy Device Detects Muscle Oxygenation Changes in Porcine Model of Lower Extremity Compartment Syndrome

Efficacy and Safety of Rupatadine Fumarate Combined with Acupoint Application in Allergic Rhinitis Complicated with Diabetes.

The prevalence of allergic rhinitis has exhibited an upward trend, and diabetes is a common endocrine metabolic disorder. Treatment of allergic rhinitis complicated with diabetes has been marginally explored. This study aimed to observe the effect of rupatadine fumarate combined with acupoint application in the treatment of allergic rhinitis complicated with diabetes and its effect on serum IgE levels. Totally 80 patients with allergic rhinitis complicated with diabetes admitted to our hospital from December 2019 to December 2020 were recruited and assigned to receive either rupatadine fumarate (control group) or rupatadine fumarate plus acupoint application (research group). The clinical observation indexes of the two groups of patients before and after treatment were analyzed, and the clinical efficacy of the two groups was evaluated. Rupatadine fumarate plus acupoint application was associated with a significantly higher efficacy (23 cases of markedly effective, 14 cases of effective, and 3 cases of ineffective) versus rupatadine fumarate alone (14 cases of markedly effective, 16 cases of effective, and 10 cases of ineffective) (χ2 = 4.501, p = 0.034). The immunoglobulin E (IgE) and nasal mucosal eosinophils (EOS) levels of the two groups of patients after treatment decreased significantly, and the research group had lower results (p < 0.05). Patients in the research group showed significantly lower syndrome scores than those in the control group (p < 0.05). Rupatadine fumarate plus acupoint application resulted in significantly lower physical sign scores and interleukin-4 (IL-4) levels and higher levels of interferon-gamma (INF-γ) versus rupatadine fumarate alone (p < 0.05). The two groups showed a similar incidence of adverse events (p > 0.05). Rupatadine fumarate plus acupoint application may offer a viable alternative for the treatment of allergic rhinitis as it alleviates the clinical symptoms, improves the treatment efficiency, and enhances the anti-allergic effect of the drug, with a high safety profile.

Perineural Adductor Canal Catheter Placement for Prevention of Complex Regional Pain Syndrome-I Exacerbation After Knee Arthroscopy: A Case Report

Arthroscopic knee surgery is a common trigger for lower extremity complex regional pain syndrome (CRPS). Few studies assess nerve block catheters for CRPS treatment; they do not appear to be studies of regional anesthesia to treat CRPS that occurs after knee surgery. We present a case of CRPS-I triggered by knee surgery on multiple prior occasions but finally prevented by perineural adductor canal catheter placement. The literature presents only moderate evidence supporting interventions such as intravenous regional anesthesia and sympathetic blockade; continuous nerve blockade may be an effective treatment of CRPS-I and in particular postoperative CRPS-I.

Case of concurrent factor VII and factor XI deficiencies manifesting as spontaneous lower extremity compartment syndrome

Factor VII and XI deficiencies are rare bleeding disorders typically associated with mild or provoked bleeding. This case report describes a patient with factor VII and XI deficiencies with an unprovoked episode of lower extremity hematoma causing compartment syndrome requiring multiple surgeries, extensive transfusion of blood products, and ultimately amputation.

EP447: Family history helps solve the case: Prenatal case report of Lowe syndrome

Oculocerebrorenal syndrome (Lowe Syndrome), is a rare X-linked disorder affecting 1/500,000 males, that most frequently affects the eyes, central nervous system, and kidneys. Phenotypic presentation includes congenital cataracts, developmental delay, intellectual disability, and Fanconi-type renal dysfunction. Lowe Syndrome is caused by a variant in the OCRL gene. OCRL loss of function variants result in decreased enzyme levels and an accumulation of the enzyme’s substrate, phosphatidylinositol (4,5) biphosphate (PiP2), and cytoskeletal defects.

Результати лікування хворих із нижньопоперековим больовим синдромом, де домінували прояви спондилоартрозу, із використанням радіочастотної денервації фасеточних суглобів у поєднанні з періартикулярним введенням місцевих анестетиків та стероїдних препараті

Актуальність. Висока поширеність дегенеративно-дистрофічного ураження хребта при малій ефективності терапії спондилоартрозу робить актуальним дослідження щодо лікування нижньопоперекового болю, зумовленого переважно спондилоартрозом, інноваційним міні-інвазивним методом високочастотної денервації фасеточних суглобів у поєднанні з періартикулярним введенням місцевих анестетиків і стероїдних препаратів. Мета дослідження: визначити ефективність впливу радіочастотної денервації фасеточних суглобів у поєднанні з періартикулярним введенням місцевих анестетиків і стероїдних препаратів з урахуванням ранніх та віддалених результатів лікування на ліквідацію больового синдрому у хворих із нижньопоперековим больовим синдромом, в яких переважали прояви спондилоартрозу. Матеріали та методи. Проведений аналіз ранніх та віддалених результатів лікування 78 пацієнтів (37 чоловіків та 41 жінка віком від 51 до 79 років) із нижньопоперековим больовим синдромом, в яких провідним клінічним проявом був артроз дуговідросткових суглобів, які становили основну групу, та проведена радіочастотна денервація фасеточних суглобів (за допомогою апарата RFG-1A/RFG-1B фірми Radionics) у поєднанні з періартикулярним введенням місцевого анестетика та стероїдного препарату. Оцінка больового синдрому проводилася чотири рази — у доопераційному, післяопераційному періодах (протягом тижня), через три місяці та через один рік після лікування. Використовувалася візуальна аналогова шкала болю та опитувальник індексу непрацездатності Освестрі. Контрольну групу становили 136 пацієнтів (73 чоловіки та 63 жінки віком від 44 до 81 року) із нижньопоперековим болем із домінуванням проявів спондилоартрозу, які лікувались виключно за допомогою методу радіочастотної денервації фасеточних суглобів. Результати. Як відразу ж після проведеного лікування, так і через три місяці після його здійснення отриманий вірогідний результат лікування хронічного нижньопоперекового больового синдрому, зумовленого переважно ураженням дуговідросткових суглобів, як в основній, так і контрольній групах, що свідчить про ефективність обох методів лікування. Разом із тим відмічається чітка вірогідна різниця між основною та контрольною групами як відразу після проведеного лікування, так і через три місяці після його здійснення, що свідчить про вірогідну вищу ефективність методу радіочастотної денервації фасеточних суглобів у поєднанні з періартикулярним введенням місцевого анестетика та стероїдного препарату в ранньому післяопераційному періоді. У віддаленому періоді (через 1 рік після лікування) отриманий вірогідний результат лікування як в основній так і в контрольній групах, але відмінність у результатах лікування між цими групами відсутня. Висновки. Отримані результати в ранньому та віддаленому періодах після лікування свідчать про ефективність та безпечність як радіочастотної денервації фасеточних суглобів, так і радіочастотної денервації фасеточних суглобів у поєднанні з періартикулярним введенням місцевого анестетика та стероїдного препарату у хворих із нижньопоперековим больовим синдромом, де домінують прояви спондилоартрозу. Вірогідно кращі результати в ранньому періоді отримані в групі пацієнтів, яким проводилось поєднання радіочастотної денервації фасеточних суглобів із періартикулярним введенням місцевого анестетика та стероїдного препарату. Тоді як у віддаленому періоді (через 1 рік після лікування) така відмінність між основною та контрольною групами відсутня. Періартикулярне введення місцевих анестетиків та стероїдів ефективне в короткотерміновій перспективі, а радіочастотна денервація фасеточних суглобів ефективна як у короткотерміновій, так і в довготерміновій перспективі. Обидві методики можуть бути рекомендовані до включення в алгоритм лікування фасеточного синдрому при неефективності консервативного лікування.