Low Resistance Research Articles

Emerging trends in antimicrobial resistance in bloodstream infections: multicentric longitudinal study in India (2017–2022)

BackgroundAntimicrobial resistance (AMR) has escalated to pandemic levels, posing a significant global health threat. This study examines the patterns and trends of AMR in Bloodstream Infections (BSIs) across India, aiming to inform better surveillance and intervention strategies. MethodsSix-year data from 21 tertiary care centers in the Indian Council of Medical Research's AMR Surveillance Network (IAMRSN) were retrospectively analyzed to estimate cluster-robust trends in resistance. Time-series analysis was used to discern lead/lag relationships between antibiotic pairs and the directional influence of resistance in community and hospital-acquired BSIs(CA/HA BSIs). A data-driven Bayesian network ensemble averaged over 301 bootstrap samples was modelled to uncover systemic associations between AMR and Sustainable Development Goals (SDGs). FindingsOur findings indicate significant (p<0.001) monthly increases in Imipenem and Meropenem resistance for Klebsiella, E. coli, and Acinetobacter BSIs. Importantly, Carbapenem resistance in HA-BSIs preceded that in CA-BSIs for Klebsiella and Acinetobacter (p<0.05). At a national level, Cefotaxime resistance emerged as a potential early indicator for emerging Carbapenem resistance, proposing a novel surveillance marker. In Klebsiella BSIs, states with higher achievement of SDG3 goals showed lower Imipenem resistance. A model-based AMR scorecard is introduced for focused interventions and continuous monitoring. InterpretationThe identified spatiotemporal trends and drug resistance associations offer critical insights for AMR surveillance aligning with WHO GLASS standards.The escalation of carbapenem resistance in BSIs demands vigilant monitoring and may be crucial for achieving SDGs by 2030. Implementing the proposed framework for data-driven evidence can help nations achieve proactive AMR surveillance. FundingNo specific funding was received for this analysis.

THE EFFECT OF CRUMB RUBBER ON THE PROPERTIES OF MODIFIED PORTLAND CEMENT SYSTEMS

The use of rubber crumb from used tires in concrete as a partial replacement of natural aggregates is an ecologically oriented direction of their utilization. When rubber crumb was added to Portland cement, a decrease in strength was observed. Modification of rubber-containing Portland cement systems with a complex organic and mineral additive makes it possible to compensate for the loss of compressive strength and provide increased impact strength. Samples without rubber show high strength but are characterized by fragility and sudden destruction of the material. Samples containing rubber show relatively low mechanical resistance but also exhibit elastic behavior where slow fragmentation and slow failure of the material after crack initiation are observed. They also are characterized by additional load resistance after reaching the failure stress, which is associated with the bridging effect of rubber particles.

Evaluation of injection current frequency on molten NaCl solidification images reconstructed by high-temperature electrical resistance tomography

Abstract The injection current frequency has been evaluated on molten NaCl solidification images reconstructed by high-temperature electrical resistance tomography (htERT). The evaluation is performed by an electrical equivalent circuit consisting of an electrical double layer (EDL), bulk solution and current-voltage path (CV path). The EDL and bulk solution are the elements to indicate electrochemical noise and bulk noise due to random thermally excited vibrations of Na+ and Cl-. The CV path compensates the measurement device errors due to low resistivity of molten NaCl. The molten NaCl solidification images were reconstructed by htERT in an alumina crucible with platinum-wire electrodes under the initial temperature air T 0= 820 ˚C and temperature drop rate γ= 6.67 ˚C/min. As a result, the solid volume fraction of molten NaCl φ was properly obtained in the appropriate injection current frequency of L f &lt; f &lt; H f, which is determined by the electrical equivalent circuit with EDL, bulk solution and CV path. The electrical equivalent circuit was validated by comparing the SNR and Nyquist plot obtained experimentally with an error of resistance. The best frequency range implemented into htERT for molten NaCl solidification images was determined as L f= 1.4 kHz and H f= 41 kHz.

Structural Optimization of PA12/MVQ@POE-g-MAH Ternary Composite for Superior Toughness and Low Temperature Resistance.

To enhance the low-temperature toughness and resistance of the engineering plastic polyamide PA12, this study introduces novel PA12/MVQ@POE-g-MAH ternary composites using a two-step process and dynamic curing. Analytical results indicate that incorporating MVQ@POE-g-MAH into the PA12 matrix markedly enhances its toughness and heat resistance. As the MVQ@POE-g-MAH content increases, the elongation at break of PA12 composites significantly expands from 52.83% to 204.69%, and the notch impact strength escalates from 8.69 to 74.34kJ/m2. Additionally, the brittleness temperature of PA12 decreases from -59.5 to -67.0°C. Experimental findings confirm that POE-g-MAH is dispersed at the interface between MVQ and PA12, creating an encapsulated structure of MVQ@POE-g-MAH. This enhancement significantly broadens the potential applications of PA12 by improving its toughness, and resistance to both low and high temperatures, as well as impact endurance. This article is protected by copyright. All rights reserved.

Enhanced low-temperature resistance of lithium-ion batteries based on methyl propionate-fluorinated ethylene carbonate electrolyte

Low temperature has been a major challenge for lithium-ion batteries to maintain satisfied electrochemical performance, as it leads to poor rechargeability and low capacity retention. Traditional carbonate solvents, vinyl carbonate and dimethyl carbonate are indispensable components of commercial electrolytes. However, the higher melting point of these carbonate solvents causes their electrical conductivity to be easily reduced when temperatures drop below zero, limiting their ability to facilitate lithium ion transport. In this work, we demonstrate that the use of methyl propionate (MP) carboxylate and fluorocarbonate vinyl (FEC) electrolytes can overcome the limitations of low temperature cycling. Compared with carbonate electrolyte, MP has the characteristics of low melting point, low viscosity and low binding energy with Li+, which is crucial to improve the low temperature performance of the battery, while FEC is an effective component to inhibit the side reaction between MP and lithium metal. The carefully formulated MP-based electrolyte can generate a solid electrolyte interface with low resistance and rich in inorganic substances, which is conducive to the smooth diffusion of Li+, allowing the battery to successfully cycle at a high rate of 0.5 C at −20 °C, and giving it a reversible capacity retention rate of 65.3% at −40 oC. This work designs a promising advanced electrolyte and holds the potential to overcome limitations of lithium-ion batteries in harsh conditions.

Fluorine-Doped Li7La3Zr2O12 Fiber-Based Composite Electrolyte for Solid-State Lithium Batteries with Enhanced Electrochemical Performance.

Garnet-based electrolytes with high ionic conductivity and excellent stability against lithium metal anodes are promising for commercial applications in solid-state lithium batteries (SSLBs). However, the further development of SSLBs is inhibited by issues such as low ionic conductivity and uncontrolled lithium dendrite growth. Herein, we report the synthesis of fluorine-doped Li7La3Zr2O12 (LLZO-F0.2) fibers by electrospinning and the subsequent calcination at high temperatures. The solid composite electrolyte with LLZO-F0.2 exhibits an ionic conductivity of 5.37 × 10-4 S cm-1 and a high lithium-ion transference number of 0.61 at room temperature. Meanwhile, it exhibits lower resistance and more uniform lithium metal stripping and deposition in symmetric cells. The full cell with LiFePO4 cathode exhibits excellent rate capability and cycling stability for 800 cycles at 0.5 C with a discharge specific capacity retention of 97.7%. This fluorine-doped fibrous garnet-type electrolyte provides a viable option for preparing high-performance SSLBs.

Highly Stable Silver Nanowire Plasmonic Electrodes for Flexible Polymer Light-Emitting Devices.

Silver nanowire (AgNW) transparent electrodes are considered as a promising candidate for applications in flexible optoelectronic devices. However, it remains a great challenge to obtain flexible AgNW electrodes with excellent optoelectrical properties and mechanical flexibility. Here, highly stable Ag nanoparticle (AgNP)-enhanced plasmonic AgNW electrodes are demonstrated via the controllable in situ growth of AgNPs at the AgNW junctions and introduction of an l-histidine (l-His) wrapping layer. The flexible transparent electrodes of AgNW-AgNP/l-His possess a low sheet resistance (Rsh) of ∼17.5 Ω sq-1, a high transmittance of ∼92.5% (550 nm), and a robust mechanical stability (100,000 bending cycles). Benefiting from plasmon-coupling effects, flexible polymer light-emitting devices (FPLEDs) with AgNW-AgNP/l-His electrodes present a current efficiency (CE) of ∼14.8 cd A-1 and an external quantum efficiency (EQE) of ∼5.6%, constituting ∼80% and ∼75% increases compared to those of the reference devices with AgNW electrodes, respectively. Additionally, the laminated flexible transparent PLEDs (FT-PLEDs) are demonstrated by integrating polydimethylsiloxane/AgNW-AgNP anodes by a soft lamination process. The FT-PLEDs present a CE of ∼7.1 cd A-1 (cathode side: ∼3.9 cd A-1; anode side: ∼3.2 cd A-1) and an EQE of ∼2.7% (cathode side: ∼1.5%; anode side: ∼1.2%). Furthermore, the FPLEDs and FT-PLEDs exhibit robust mechanical durability, maintaining ∼89% and ∼86% of their initial luminance after 1000 bending cycles at a bending radius of 2 mm, respectively. This work opens up a new avenue for the development of high performance and stable flexible optoelectronic devices.

(1-x)Ni0.9Mn2.1O4-xLaCr0.6Mn0.4O3 composite ceramic with controllable electrical properties for low resistance NTC thermistors

A series of NTC composite ceramics based on (1-x)Ni0.9Mn2.1O4-xLaCr0.6Mn0.4O3 (x = 0.2, 0.25, 0.3, 0.4, and 0.5) were prepared by the solid-state method. The composite ceramics are mainly composed of the orthogonal perovskite phase and the cubic spinel phase. The Ni ions are diffused into the perovskite phase, La and Cr ions are diffused into the spinel phase. The interdiffusion of ions in two phases leads to the structural change of the two phases in the composite ceramics. The conduction mechanism of composite ceramics is the coexistence of electron jumping and double exchange conduction. The resistivity ρ25 and B values vary in the range of 17.4–1056 Ω cm and 2140–3600 K, respectively. Indicating that the electrical properties can be adjusted arbitrarily. In addition, increasing the content of perovskite can improve the stability of the material. The prepared NTC composite ceramic has good electrical properties and stability, so it has good application potential in the field of low resistance.

Material screening for future diffusion barriers in Cu interconnects: Modeling of binary and ternary metal alloys and detailed analysis of their barrier performance

One of the challenges in the semiconductor industry is to find new barrier materials and copper (Cu) alternative solutions in interconnects. In this work, we focused to find alternative diffusion barrier materials. Different binary (CoMo, CoRu, CoTa, CoW, MoRu, RuTa, RuW) and ternary (CoMoTa, CoRuTa, MoRuTa) metal alloys were evaluated theoretically with the Miedema model to find the amorphous phase composition range. Afterward, thin films of the alloys with various compositions were deposited by magnetron sputtering and theoretical values were compared to the experimental results. From the experimental measurements, which included grazing incidence x-ray diffraction analysis and resistivity measurements, suitable binary and ternary alloys were chosen for diffusion analysis. By annealing thin film stacks at temperatures ranging from 500 to 675°C, diffusion was induced and detected by x-ray photoelectron spectroscopy depth profiles. Seventeen alloys were evaluated by their diffusion barrier effectiveness, and five of those, which include Ru60Ta40, Ru45W55, Mo47Ru53, Mo36Ru50Ta14, and Co40Mo35Ta25, showed excellent barrier properties against copper diffusion. Furthermore, all of the stated materials have a lower resistivity than TaN. Last, the adhesion of the best performing alloys to SiCOH and Cu was evaluated by the modified edge lift-off test. Only Ru45W55 had reasonable adhesion at both interfaces. The other materials showed low adhesion strength to Cu, which would make an adhesion promoter (liner), such as cobalt, necessary for the integration.

Steady-state rolling resistance prediction model of non-pneumatic tyres considering tread temperature: theory and experiment

Non-pneumatic tires have potential advantages over pneumatic tires, including lower rolling resistance. First, a non-pneumatic mechanical elastic wheel (ME-Wheel) was designed. Based on its structural characteristics, a tread temperature prediction model under steady-state rolling conditions was established, and the accuracy of the established model was verified through temperature measurement experiments. Combined with the tread temperature prediction model, a steady-state rolling resistance prediction model of ME-Wheel was established, and the basic parameters (ground length CL , ground width CW , radial stiffness SR ) required for the model were identified through experiments. Finally, the experimental data were compared with the predicted values under different speed and load conditions. The results showed that the average simulation value of the rolling resistance coefficient of ME-Wheel was 0.01853, which was positively correlated with speed and load. The test results and predicted values showed a similar trend under the same operating conditions, with a maximum error of less than 3.5%. This proved that the novel non-pneumatic tyre steady-state rolling resistance prediction model based on tread temperature could accurately predict the steady-state rolling resistance of tyres. This research addresses a significant topic in tyre technology and has the potential to influence future designs and optimizations of non-pneumatic tyres.

A review of etching methods and applications of two-dimensional MXenes.

MXenes have been attracting much attention since their introduction due to their amazing properties such as unique structure, good hydrophilicity, metal-grade electrical conductivity, rich surface chemistry, low ionic diffusion resistance, and excellent mechanical strength. It is noteworthy that different synthesis methods have a great influence on the structure and properties of MXenes. In recent years, some modification strategies of MXenes with unique insights have been developed with the increasing research. In summary, this paper reviews and summarizes the recent research progress of MXenes from the perspective of preparation processes (including hydrofluoric acid direct etching, fluoride/concentrated acid hybrid etching, fluoride melt etching, electrochemical etching, alkali-assisted etching and Lewis acid etching strategies), which can provide valuable guidance for the preparation and application of high-performance MXenes-based materials.&#xD.

Nacreous Glass Composites with Superior Performance Engineered through Mechanical Vibration and Silanization

AbstractBioinspiration offers alternative solutions to overcome the inherent drawbacks of glass, such as low fracture toughness, strength, and impact resistance. Synthetic composites inspired by natural materials, such as nacre, have been recently introduced as an alternative to glasses. However, these have all suffered from trade‐offs between rigidity, optical clarity, fabrication scalability, and complexity. Here, two wave‐based fabrication techniques are presented to create a nacreous structure from glass flakes and polymethyl methacrylate. The glass's surface energy is controlled by adjusting the silane coverage on the glass surface, enabling high levels of structural compactness, mechanical properties, and optical clarity. The scalable glass composite, with a ≈60% glass volume fraction, possesses strength, fracture toughness, and impact resistance values, outperforming annealed glass by 4300%, 350%, and 400%, respectively. It also has a haze level of ≈18%, almost 60% less than that of the similar centrifuged‐based glass composite. This composite is proposed as a potential glass alternative in diverse applications.

Activity and mechanism of action of antimicrobial peptide ACPs against Candida albicans

AimsCandida albicans is the most prevalent pathogenic fungus, exhibiting escalating multidrug resistance (MDR). Antimicrobial peptides (AMPs) represent promising candidates for addressing this issue. In this research, five antimicrobial peptides, ACP1 to ACP5 which named ACPs were studied as alternative fungicidal molecules. Main methodsCD assay was used to analyze the 2D structures, Absorbance method was used to test the antimicrobial activity, haemolytic activity, time-kill kinetics, biofilm inhibition and reduction activity, resistance induction activity and assessment against fluconazole-resistant C. albicans. SEM, TEM, CLSM, flow cytometer and FM were carried out to provide insight into the mechanisms of anti-Candida action. Key findingsACPs possessed an α-helical structure and strong anti-Candida activities, with minimum inhibitory concentrations (MICs) from 3.9 to 15.6 μg/mL. In addition, ACPs did not produce hemolysis at concentrations lower than 10 or 62 × MIC, indicating their low cytotoxicity. Fungicidal kinetics showed that they completely killed C. albicans within 8 h at 2 to 4 × MIC. Notably, ACPs were highly fungicidal against fluconazole-resistant C. albicans and showed low resistance. In addition, they were effective in inhibiting mycelium and biofilm formation. Fluorescence microscopy revealed that while fluconazole had minimal to no inhibitory effect on biofilm-forming cells, ACPs induced apoptosis in all of them. The research on mechanism of action revealed that ACPs disrupted the cell membranes, with ROS increasing and cellular mitochondrial membrane potential decreasing. SignificanceACPs could be promising candidates for combating fluconazole-resistant C. albicans infections.

Ultralow-freezing-point (−70 °C), organic solvent-free aqueous electrolyte with superior ionic conductivity and thermodynamics stability

Water-in-salt and organic solvent-additive strategies have significantly improved the electrochemical stability window of aqueous electrolyte, while it still faces poor low-temperature thermodynamics stability and unsatisfied transport kinetics, as well as flammability risks caused by organic solvent. Herein we report a novel “cation-water-urea ternary interaction strategy” via environmental-friendly and non-flammable urea (CO(NH2)2) to solve the above dilemma. The cation-water-urea ternary interaction strategy preferentially develops CO(NH2)2-cation solvation structures for weakened cation-anion associations, improved anti-salt-precipitation capability, and thus enhanced ionic conductivity, meanwhile it improves the low-temperature thermodynamics stability via the stronger CO(NH2)2-water hydrogen-bond interactions to suppress the freezing and electrolysis of water. The optimum ternary aqueous electrolyte exhibits an ultralow freezing point (−70 °C), wide electrochemical stability window (2.9 V) and outstanding ionic conductivity (135 mS cm−1@25 °C and 5.3 mS cm−1@−50 °C), demonstrating superior performance compared to traditional organic solvent-additive and water-in-salt electrolytes. Finally, to demonstrate its potential for practical applications, ternary aqueous electrolyte-based supercapacitors are fabricated using commercial activated carbon electrodes, which exhibit outstanding capacitance retention (71.4 %) and much lower ion transport resistance even at ultralow temperature of −40 °C. This work proposes a novel ternary aqueous electrolyte with improved thermodynamics stability and kinetics for safe, low-temperature energy storage applications.

Reversion to sensitivity explains limited transmission of resistance in a hospital pathogen.

Bacterial pathogens that are successful in hospital environments must survive times of intense antibiotic exposure and times of no antibiotic exposure. When these organisms are closely associated with human hosts, they must also transmit from one patient to another for the resistance to spread. The resulting evolutionary dynamics have, in some settings, led to rising levels of resistance in hospitals. Here, we focus on an important but understudied aspect of this dynamic: the loss of resistance when the resistant organisms evolve in environments where the antibiotic pressure is removed. Based on prior data, we hypothesize that resistance arising in the context of strong selection may carry a high cost and revert to sensitivity quickly once the selective pressure is removed. Conversely, resistant isolates that persist through times of no antibiotic pressure should carry a lower cost and revert less quickly. To test this hypothesis, we utilize a genetically diverse set of patient-derived, daptomycin-resistant Enterococcus faecium isolates that include cases of both de novo emergence of resistance within patients and putatively transmitted resistance. Both of these sets of strains have survived periods of antibiotic exposure, but only putatively transmitted resistant strains have survived extended periods without antibiotic exposure. These strains were then allowed to evolve in antibiotic free laboratory conditions. We find that putatively transmitted resistant strains tended to have lower level resistance but that evolution in antibiotic-free conditions resulted in minimal loss of resistance. In contrast, resistance that arose de novo within patients was higher level but exhibited greater declines in resistance in vitro. Sequencing of the experimentally evolved isolates revealed that reversal of high level resistance resulted from evolutionary pathways that were frequently genetically associated with the unique resistance mutations of that strain. Thus, the rapid reversal of high-level resistance was associated with accessible evolutionary pathways where an increase in fitness is associated with decreased resistance. We describe how this rapid loss of resistance may limit the spread of resistance within the hospital and shape the diversity of resistance phenotypes across patients.

Development of an Apple Snack Enriched with Probiotic Lacticaseibacillus rhamnosus: Evaluation of the Refractance Window Drying Process on Cell Viability.

The objective of this study was to develop a dried apple snack enriched with probiotics, evaluate its viability using Refractance Window (RWTM) drying, and compare it with conventional hot air drying (CD) and freeze-drying (FD). Apple slices were impregnated with Lacticaseibacillus rhamnosus and dried at 45 °C using RWTM and CD and FD. Total polyphenol content (TPC), color (∆E*), texture, and viable cell count were measured, and samples were stored for 28 days at 4 °C. Vacuum impregnation allowed for a probiotic inoculation of 8.53 log CFU/gdb. Retention values of 6.30, 6.67, and 7.20 log CFU/gdb were observed for CD, RWTM, and FD, respectively; the population in CD, RWTM remained while FD showed a decrease of one order of magnitude during storage. Comparing RWTM with FD, ∆E* was not significantly different (p < 0.05) and RWTM presented lower hardness values and higher crispness than FD, but the RWTM-dried apple slices had the highest TPC retention (41.3%). Microstructural analysis showed that RWTM produced a smoother surface, facilitating uniform moisture diffusion and lower mass transfer resistance. The effective moisture diffusion coefficient was higher in RWTM than in CD, resulting in shorter drying times. As a consequence, RWTM produced dried apple snacks enriched with probiotics, with color and TPC retention comparable to FD.

Ultra-sensitive strain sensor with film-nanowire double layers for health monitoring and smart clothing

Flexible wearable strain sensors are becoming increasingly popular due to their ability to monitor physiological signals and to detect motion in a wide range of applications. However, the development of strain sensors with high sensitivity and wide sensing range remains a challenge. Herein, a film-nanowire double sensoring layer structure (FNDLS) crack strain sensor with high sensitivity, wide strain range and fast response is proposed. The FNDLS with hierarchical synergistic are integrated onto fabrics using a heat pressing process. The FNDLS has a very low initial resistance and a high density of channel cracks to have the high sensitivity of the strain sensor and to extend the strain range of the strain sensor through the synergistic bridging effect of the AgNWs. Due to this structure, the sensitivity of the sensor can reach 70945, the strain range can reach about 40 %, and response time is less than 129 ms. Furthermore, the sensor demonstrates exceptional cycling stability and favourable frequency characteristics. Its superior performance makes it suitable for monitoring pulse waves and detecting motion through smart clothing.

Effect of open vs. closed kinetic chain exercises in ACL rehabilitation on knee joint pain, laxity, extensor muscles strength, and function: a systematic review with meta-analysis.

PROSPERO [CRD42023475230].

Facile synthesis of SiOx/C as high-performance anodes for lithium-ion batteries

Despite its high capacity (∼2615 mAh·g−1), silicon oxide (SiOx) suffers from low electrical conductivity and volume expansion during cycling, leading to capacity fading. In this work, a SiOx/C composite was synthesized by magnesium thermal reduction using co-assembled mesoporous SiO2 and graphitic carbon nitride (g-C3N4) as precursors. The SiOx/C composite displays a sheet-like nanostructure with highly dispersed SiOx. The presence of carbon enhances the conductivity and structural stability of the composite, leading to a low charge resistance (94.0 Ω), fast lithium diffusion (DLi+ = 5.15 × 10−14 cm2·s−1), and excellent cycling capability (863 mAh·g−1 after 160 cycles).

High-Performance Supercapacitors Based on Graphene/Activated Carbon Hybrid Electrodes Prepared via Dry Processing

Graphene has a high specific surface area and high electrical conductivity, and its addition to activated carbon electrodes should theoretically significantly improve the energy storage performance of supercapacitors. Unfortunately, such an ideal outcome is seldom verified in practical commercial supercapacitor design and production. In this paper, the oxygen-containing functional groups in graphene/activated carbon hybrids, which are prone to induce side reactions, are removed in the material synthesis stage by a special process design, and electrodes with high densities and low internal resistances are prepared by a dry process. On this basis, a carbon-coated aluminum foil collector with a full tab structure is designed and assembled with graphene/activated carbon hybrid electrodes to form a commercial supercapacitor in cylindrical configuration. The experimental tests confirmed that such supercapacitors have high capacity density, power density, low internal resistance (about 0.06 mΩ), good high-current charging/discharging characteristics, and a long lifetime, with more than 80% capacity retention after 10 W cycles.