Low Recovery Research Articles

Effect of Copper and Lead Cations on Flotation Behavior of Pyrite in Alkaline Seawater

ABSTRACT In this study, pyrite flotation in seawater in the presence of Cu2+and Pb2+ and the underlying mechanisms were investigated systematically. Flotation results indicated that Cu2+ and Pb2+ increased pyrite recovery from 52.51% to 79.45% and 72.57% in weak alkaline seawater (pH 8) due to the increased surface hydrophobicity. Solution species distribution and electrochemical studies cross-confirmed that the Cu2S and Pb(OH)2 layer formed on the pyrite surface at pH 8, subsequently increasing the adsorption sites of xanthate on the pyrite surface. Differently, the pyrite flotation remained at a lower recovery of around 20% than that with the addition of 10−7–10−5 M Cu2+ and Pb2+ in strong alkaline seawater (pH 10). No activation species were adsorbed on the pyrite surface at pH 10 due to the coverage of hydrophilic precipitation on the pyrite surface, resulting in a poor floatability. This study therefore provides scientific guidelines for pyrite separation in seawater in the presence of Cu2+ and Pb2+.

Research on Roof Cutting and Pressure Relief Technology of Gob-side Entry Retaining with Hard Roof

Traditional coal pillar roadway protection is easy to cause roadway stress concentration, roadway deformation instability, and low recovery rate of coal resources. In order to solve the stability of roadway mining process and coal mine efficiency. Aiming at the problem of gob-side entry protection by deep hole pre-splitting blasting with hard roof, taking 1207 working face of Jiegou Coal Mine as the engineering background, through theoretical analysis, numerical simulation, field industrial test and other methods, the technology of roof cutting and pressure relief and constant resistance anchor cable reinforcement and roadway protection is put forward, and the key parameters such as appropriate roof cutting height and roof cutting angle are analyzed to achieve the effect of roof cutting and pressure relief, and the roadway reinforcement support scheme is designed. The field research shows that the roof cutting and roadway protection technology has a good control effect on 1207 working face roadway, realizes the safe production of working face, and provides certain reference value for this similar condition.

Impact of input volume on red cell quality in deglycerolized RBCs using a modified ACP-215 protocol.

The ACP 215 automated cell processor is used to glycerolize and deglycerolize red cell concentrates (RCCs). Its primary advantage over the COBE 2991, previously used to cryopreserve RCCs, is that it maintains a closed system enabling extended post-thaw expiry. However, it was observed that post-deglycerolization hematocrits (Hct) of units processed with the LN236 kit are markedly lower than those processed using the COBE 2991. Therefore, we intended to determine whether a modified process using a smaller volume deglycerolization kit (LN235) could increase the final Hct with limited deleterious effects on product characteristics. Two proof-of-concept (POC) studies, conducted to determine the feasibility of using the LN235 processing kit for deglycerolization, identified the necessary modifications to the pre- and post-deglycerolization process, after which a two-part study characterized the modified protocol. The impact of pre-cryopreservation storage duration (7-21 days), input red cell mass, and the type of CPD/SAGM RCC production method (red cell filtration and whole blood filtration) were investigated. Using the LN235 kit in conjunction with a volume reduction step for RCCs with a red cell mass exceeding 180 mL allowed for an ~8% increase in Hct. As expected, slightly lower recoveries were seen for large RCCs due to volume reduction; however, there were no other detrimental outcomes on product quality. Leveraging the LN235 kit, recommended by Haemonetics for units with a red cell mass of ≤180 mL, can be used to increase the post-deglycerolization Hct of RCCs that exceed this volume.

Reversing protonation of weakly basic drugs greatly enhances intracellular diffusion and decreases lysosomal sequestration.

For drugs to be active they have to reach their targets. Within cells this requires crossing the cell membrane, and then free diffusion, distribution, and availability. Here, we explored the in-cell diffusion rates and distribution of a series of small molecular fluorescent drugs, in comparison to proteins, by microscopy and fluorescence recovery after photobleaching (FRAP). While all proteins diffused freely, we found a strong correlation between pKa and the intracellular diffusion and distribution of small molecule drugs. Weakly basic, small-molecule drugs displayed lower fractional recovery after photobleaching and 10- to-20-fold slower diffusion rates in cells than in aqueous solutions. As, more than half of pharmaceutical drugs are weakly basic, they, are protonated in the cell cytoplasm. Protonation, facilitates the formation of membrane impermeable ionic form of the weak base small molecules. This results in ion trapping, further reducing diffusion rates of weakly basic small molecule drugs under macromolecular crowding conditions where other nonspecific interactions become more relevant and dominant. Our imaging studies showed that acidic organelles, particularly the lysosome, captured these molecules. Surprisingly, blocking lysosomal import only slightly increased diffusion rates and fractional recovery. Conversely, blocking protonation by N-acetylated analogues, greatly enhanced their diffusion and fractional recovery after FRAP. Based on these results, N-acetylation of small molecule drugs may improve the intracellular availability and distribution of weakly basic, small molecule drugs within cells.

Water Recovery of brine water treatment from a small-scale desalination system in Nakhon Ratchasima

This study aims to recover water from treating brine water of a small-scale desalination using a solar still. The design focuses on keeping temperatures inside at conditions suitable for water evaporation from the brine water basin. Water vapor rises and condenses into water droplets on the transparent glass cover, moving down the slope into a channel and collecting outside. The solar still is 1.0 m x 1.0 m x 0.5 m (width x depth x height) with a 25-degree slope for a transparent glass cover on top. This slope allows the water droplet to move down without reentering into the brine water basin below. The brine water was placed on top of the carbonized rice hull. The black residues can absorb heat energy by being a dark color, locally available, environmentally friendly, and stable. The test results during rainy and early winter months showed that the prototype solar still produced the average recovery water of 150 mL/day/set, with the hourly temperatures inside the chamber ranging from 30 to 70.1 Celsius. The highest inside temperature occurred at 2 PM, with an average of 70.1 Celsius. A correlation was observed between temperature and the amount of distilled water. Water recovery from the prototype ranged from 1,090 to 1,256 mL/day. Low recovery occurred in the rainy months. Estimation of water recovery rates in Nakhon Ratchasima ranged from 45 to 55 mL/m2/day. The solar still provides an alternative to recover water and mitigate the direct impact of brine water discharge from the small-scale desalination in Nakhon Ratchasima from possible effect of salinity water discharge. The method is economical, less burdensome to the caretaker, and low budget. The recovery water is freshwater; thus, it can be reused and has no long-term impact. The use of solar still is an auxiliary device that can be used with small-scale desalination in areas with saline water.

Intercostal bypass graft pseudoaneurysm repaired with percutaneous glue embolization utilizing CT needle guidance: A case report.

Pseudoaneurysm formation in connective tissue patients postoperatively can be a challenging and life-threatening problem to treat. Repair of an aorta to intercostal bypass graft pseudoaneurysm post open thoracoabdominal aortic aneurysm repair by percutaneous glue embolization utilizing Dyna CT Needle Guidance technology is a safe, minimally invasive method with low morbidity and short post-procedural recovery. A 30-year-old male with suspected connective tissue disorder who developed a Type B aortic dissection complicated by limb threatening right lower extremity ischemia treated with left-to-right fem-fem bypass and RLE fasciotomies. His thoracic aortic dissection subsequently was repaired urgently for persistent chest pain and rapid aortic expansion by open thoracoabdominal aortic aneurysm repair with aorta to intercostal bypass graft. Seven weeks postop patient presented with hemoptysis and was noted to have an enlarging T9 intercostal pseudoaneurysm requiring repair. Post discharge follow-up thoracic CTA performed showed complete resolution of the T9 intercostal pseudoaneurysm. Therefore, percutaneous NBCA glue embolization with iGuide technology is a viable alternative to open thoracic pseudoaneurysm repair and offers distinct advantages over other imaging modalities for localization.

A Review on the Water Invasion Mechanism and Enhanced Gas Recovery Methods in Carbonate Bottom-Water Gas Reservoirs

Carbonate gas reservoirs are crucial in gas field development, with carbonate bottom-water gas reservoirs being a significant subset. However, the development of these reservoirs often faces challenges such as water invasion, leading to a low gas recovery rate. Enhancing gas recovery is a primary goal for researchers in this field. This study provides a systematic review of the mechanisms, identification, and dynamic prediction of water invasion in these gas reservoirs. The technical adaptability and application range of different enhanced recovery methods are summarized, and their application effects are evaluated. The results indicate that carbonate gas reservoirs have diverse types of storage and permeability spaces, with a wide distribution of pore size scales, leading to various types of enclosed gas caused by water invasion. The prediction accuracy of water invasion models for bottom-water gas reservoirs with fractures and vugs is relatively low. Therefore, numerical simulation research on the basis of fine reservoir characterization is the key technology. The control of bottom-water invasion and the rescue measures after the bottom-water invasion are the keys to improving gas recovery, which can be divided into four types: drainage gas recovery, water control production, active drainage, and injection medium. Gas production by drainage is the main technology for improving gas recovery, among which foam drainage is the most widespread. The optimization of development parameters in production by water control has a good effect in the early stages of development. The active drainage technology on the water invasion channel is the bottom-up technology for the effective development of strong water-flooded gas reservoirs. CO2 injection may have great potential to improve the recovery of bottom-water gas reservoirs, which is one of the important research directions under the background of “carbon peaking and carbon neutrality”. The research provides theoretical and technical reference significance for enhanced recovery of carbonate bottom-water gas reservoirs.

Banana Ripening Plant with a Low Global Warming Potential Refrigerant and Heat Recovery for the Romanian Climate

Banana Ripening Plant with a Low Global Warming Potential Refrigerant and Heat Recovery for the Romanian Climate

Hospital-Acquired Pressure Ulcers and Long-Term Motor Score Recovery in Patients With Acute Cervical Spinal Cord Injury

Pressure ulcers (PUs) are (1) prevalent secondary complications after spinal cord injury (SCI), (2) present with elevated systemic inflammatory tone, and (3) may interfere with healing processes underlying neurological recovery (disrepair). To investigate whether PUs acquired during initial hospitalization are associated with neurological and functional long-term outcome and survival after SCI. Multicenter cohort study at 20 centers of the prospective SCI Model Systems (SCIMS) Database (Birmingham, AL). Patients with acute traumatic cervical SCI with relevant motor impairment (ie, American Spinal Injury Association [ASIA] impairment scale [AIS] A, B, and C) were enrolled from January 1996 to September 2006 and followed up until June 2016. Data were analyzed from April 2021 to September 2024. PUs acquired during surgical or first rehabilitative SCI care. The change in the ASIA motor score at 1 year after SCI was the primary end point. Secondary end points included the recovery of functional independence measure (FIM) motor score at 1 year after SCI and mortality up to 10 years. ASIA and FIM motor score were analyzed applying linear mixed models with random intercept adjusted for baseline neurological level, AIS, and sociodemographic factors. Mortality was analyzed using Cox regression. The study included 1282 patients with a mean (SD) age of 38.0 (15.7) years and consisted of 1028 (80.2%) male patients. Regarding race and ethnicity, 349 of 1249 (27.9%) were African American patients, 1139 of 1273 (89.5%) were non-Hispanic patients, and 834 of 1249 (66.8%) were White patients. During initial hospitalization, 594 patients (45.7%) acquired PUs. Exposure to PUs was associated with impaired motor recovery 1 year after SCI compared with unexposed patients (-9.1 ASIA motor score points; 95% CI, -12.3 to -6.0; P < .001). In addition, PUs were associated with lower recovery of physical independence 1 year after SCI (-8.3 FIM motor score points; 95% CI: -11.1 to -5.5; P < .001). Cox regression confirmed PUs as a risk marker for death up to 10 years after SCI (hazard ratio, 1.41; 95% CI, 1.09 to 1.82; P = .01). In this cohort study, PUs acquired during initial hospitalization after SCI were independently associated with poor long-term neurofunctional outcome. PUs constitute a modifiable factor associated with risk for worse long-term disability (recovery confounder) and elevated mortality.

Enhanced analysis of PAHs in tea using GC–MS/MS with hydrogen carrier gas

A green multiresidue method for PAH analysis was developed using hydrogen as the carrier gas, avoiding harmful solvents and integrating waste-reducing strategies such as µSPE. The use of hydrogen carrier gas in gas chromatography coupled with tandem mass spectrometry (GC–MS/MS) was explored for the enhanced detection of polycyclic aromatic hydrocarbons (PAHs) in black tea. The study demonstrated that hydrogen, as a carrier gas, offers better chromatographic properties than helium or nitrogen. This leads to improved separation of critical pairs using a short run time method. A fast extraction method using micro solid-phase extraction (µSPE) as a clean-up step was developed to analyze 24 PAHs. The extraction method was optimized using a 4 mL 1:1 mixture of ethyl acetate and acetone. The method was validated and demonstrated good recoveries, ranging from 73 % to 113 % for most PAHs, with lower recoveries (50–63 %) observed for high molecular weight PAHs. Reproducibility was also high, with relative standard deviation (RSD) values below 15 %. Linearity and matrix effects were also evaluated, yielding excellent results, with no PAH exhibiting strong matrix effects. Real sample analysis of black tea from various brands and origins revealed the presence of multiple PAHs with concentrations ranging 9.5–39.2 µg/Kg, some exceeding the maximum residue levels set by the European Union. These findings highlight the need for efficient methodologies to monitor PAHs in food products.

Sparse Vector and Low Rank Recovery Phase Transitions: Uncovering the Explicit Relations

Sparse Vector and Low Rank Recovery Phase Transitions: Uncovering the Explicit Relations

Reduction Disintegration Behavior and Crystallographic Transformation of Vanadium-Titanium Magnetite Pellets during Hydrogen-based Reduction

：There are many advantages of the smelting of vanadium-titanium magnetite pellets by hydrogen-based shaft furnace pre-reduction and electric arc furnace process, including high reduction efficiency, low carbon dioxide emission and high recovery of titanium and so on. The preparation of qualified vanadium-titanium magnetite pellets with low reduction disintegration index (RDI) is prerequisite of this process. The reduction disintegration behavior of vanadium-titanium magnetite pellets during hydrogen-based reduction was systematically investigated in this work, and the crystallographic transformations during the reduction were dig into as well. The RDI+6.3 mm of vanadium-titanium magnetite pellets reached 43.28% after 60 minutes of reduction at 500 °C in a Midrex atmosphere (36% CO, 5% CO2, 55% H2, and 4% CH4). During the reduction of trigonal titano-hematite [(Fe,Ti)2O3] to cubic titano-magnetite, both the single unit cell volume and the total number of unit cells increased dramatically. The total titanium-iron oxide cell volume expanded nearly sevenfold, from 8.75×1022 ų to 5.99×1023 ų, causing considerable pellet swelling. Conversely, the reduction of rhombohedral Fe2TiO5 to trigonal FeTiO3 resulted in a decrease in cell volume. Studying the crystalline transformation is crucial for developing effective methods to inhibit low-temperature reduction disintegration, thereby enhancing the comprehensive utilization of vanadium-titanium magnetite resources.

Numerical investigation on motion responses of high-speed self-propelled submersible subject to internal solitary wave

Internal solitary waves (ISWs) pose a significant threat to underwater submersibles. Unlike low-speed submersibles in the ISW field, the high-speed submersibles form a large pitching angle, which is more dangerous for submersible maneuverability. However, the mechanisms behind the interaction between ISWs and high-speed submersibles still remain unexplored. In this work, the three-dimensional numerical model for ISW–structure interaction is used to investigate the motion response characteristics of high-speed submersibles in the ISW field. Based on the extended Korteweg–de Vries (eKdV) theory, the ISW is generated in a two-layer numerical tank by enforcing velocity inlet boundaries. The ISW evolution is obtained by solving the Navier–Stokes equations. The motion of the self-propelled submersible is simulated by solving the equation of motion of the submersible. Using this model, numerical investigation on the ISW and high-speed submersible interaction is performed. The effects of submersible depth, self-recovery stiffness, and ISW amplitude on the motion response of the high-speed submersible are analyzed systematically. When the initial position of the submersible is above the ISW trough and the initial depth is close to the trough depth, the submersible may pierce through the ISW surface, which further results in the formation of a large pitching angle, motion stall and “falling deep.” It is difficult for the submersibles with the low recovery stiffness to maintain or control the navigation trajectory. They would undergo the large pitching angle and even impact on the seabed.

Segregating Laterals for Efficient Gas Re-Injection in Shale Plays Using Smart Completion

There is a strong global demand for oil and gas resources, and forecasts indicate robust growth in oil demand in the coming years. Meeting this demand necessitates the exploitation of unconventional resources and enhancing the recovery of existing oil and gas fields. Field trials indicate that traditional gas injection in shale wells has low sweeping efficiency. Emerging technologies play an exceedingly significant role in solving the challenges of gas EOR in shale and tight formations. Among these advancements, smart or intelligent well technology has emerged as a promising solution to enhance field development outcomes. This study focuses on improving gas flooding efficiency in the Bakken formation by utilizing smart completions to reduce the gas–oil ratio (GOR) and increase oil recovery. An economic assessment of gas re-injection is conducted, considering both gas storage and enhanced oil recovery, with analysis incorporating capital expenditures, operating costs, and revenue from increased production. Reservoir simulations were employed to determine the most effective gas injection scenarios for maximizing recovery and storage efficiency. Simulation results demonstrate that 20% of perforated laterals account for 80% of the injected gas. To address this challenge, this work proposes using smart completions to segregate lateral sections, thereby optimizing gas injection efficiency, and unlocking additional oil in tight formations. Segregating horizontal laterals for gas re-injection using smart completion technology can achieve gas injection efficiencies of up to 0.25 barrels per Mcf of gas injected, with lower incremental gas production. The optimal injection rate is between 1 MMcfd and 3 MMcfd, with an injection period ranging from one to three years. It was also found that injecting gas into the toe section results in high bottom hole pressure but lower oil recovery due to reduced gas injection efficiency. From an economic perspective, the project yielded favorable outcomes, with a positive net present value (NPV) at a 7% discount rate. Even at lower oil prices (USD 50 per barrel), the Internal Rate of Return (IRR) was calculated to be 170%, indicating strong potential profitability.

Experimental Study on Enhanced Oil Recovery of Shallow Super-Heavy Oil in the Late Stage of the Multi-Cycle Huff and Puff Process

The shallow, thin super-heavy oil reservoir demonstrates certain characteristics, such as shallow reservoir depths, low-formation temperature, and high crude oil viscosity at reservoir temperatures. In the current production process, the central area of P601 is undergoing high-frequency huff and puff operations, facing certain problems such as decreasing production, low recovery rates, and rapid depletion of formation pressure. Through physical simulation experiments, the various elements of HDNS-enhanced oil recovery technology were analyzed. Nitrogen plus an oil-soluble viscosity reducer can improve the thermal recovery and development effect of super-heavy oil. With the addition of the viscosity-reducing slug, the recovery rate of steam flooding was 58.61%, which was 23.32% higher than that of pure steam flooding; after adding the 0.8 PV nitrogen slug, the recovery rate increased to 76.48%. With the increased nitrogen injection dosage, the water breakthrough time was extended, the water cut decreased, and the recovery rate increased. Nitrogen also plays a role in profile control and plugging within the reservoir; this function can effectively increase the heating range, increase steam sweep efficiency, and reduce water cut. So, the synergistic effects of steam, nitrogen, and viscosity-reducing agents are good. This technology enhances the development of shallow-layer heavy oil reservoirs, and subsequent development technologies are being compared and studied to ensure the sustainable development of super-heavy oil reservoirs.

Cooperative effects of quaternary ammonium salt collectors and cationic polyacrylamide on flotation separation of diaspore and kaolinite: Experimental study and simulation

In the presence of depressant cationic polyacrylamide (CPAM), three quaternary ammonium salt as collectors were used in the flotation separation of diaspore and kaolinite, respectively. The flotation results of single minerals showed that the high recovery of the kaolinite and the low recovery of diaspore were gained, which indicated that the floatability of kaolinite was hardly affected while the floatability of diaspore was obviously weakened by using Gemini collector and CPAM under the conditions of pulp pH value of 6. The mass ratio of Al2O3 to SiO2 (A/S) was also increased from 4.86 to 8.90. FTIR spectra, adsorption capacity of collectors and zeta potential analysis illustrated that the maximum difference value in adsorption capacity of Gemini collector on the surface of kaolinite and diaspore was obtained because of the differences of the collectors in the presence of CPAM. This phenomenon was further supported by molecular dynamics simulation analysis and XPS analysis. The opinion can be provided that the difference between kaolinite and diaspore was enlarged by regulating the cooperation of the collector and the depressant for increasing the flotation separation of minerals.

Coupled Electrolysis–Microfiltration System for Efficient Phosphorus Removal and Recovery in the Form of Iron Phosphate Compounds from Wastewater

Electrochemical technology presents a promising approach for phosphorus recovery from wastewater. Nevertheless, its application in industry is hindered by relatively low phosphorus recovery efficiency, high energy consumption and complex reactor configurations. In this study, a coupled electrolysis and microfiltration system was designed for phosphorus recovery in the shape of iron phosphate compounds with the use of steel pickling wastewater as the iron source. In the electrolysis unit, the anode diffusion layer was extracted from the porous anode surface with the production of an acid effluent and an alkaline effluent. The alkaline effluent was mixed with the stainless steel acid washing wastewater generated from the steel pickling process and then introduced into the microfiltration unit to intercept the iron phosphate crystals. The filtered effluent was finally introduced into the air aeration unit to further reduce the phosphorus content in the water. And the extracted acid solution could be reused in the pickling step of the iron and steel manufacturing process. The experimental results show that the coupled system achieved phosphorus recovery of 42~80% at a current density of 5~20 mA cm−2, accompanying energy consumption of 5.78~9.15 kWh (kg P)−1 and current efficiency of 79~43%, when the phosphorus concentration was 3 mM and the iron–phosphorus molar ratio was 1.5. After the microfiltration treatment, the residual phosphorus could be further reduced to 0.5 mg L−1 within 30 min at an aeration rate of 80 mL min−1, which met the discharge standard. The presence of interfering ions (HCO3− and SiO42−) posed inhibited effects on phosphorus recovery. Generally, this study provides a green and environmentally friendly way to efficiently recover phosphorus resources from wastewater.

Characterization and Processing of Low-Grade Middle Group 2 Chromite Ore by Gravity Shaking Table and a Comparative SLon Magnetic Separation: A Case Study

Chromite is considered a strategic mineral in the global economy. It is mainly used as an essential raw material in the production of stainless steel and other metal alloys due to its corrosion and heat resistance properties. High-grade chromite resources are gradually depleting; with the increasing chromite demand in metallurgical applications, studies have focused on exploring low-grade and alternative chromite sources. This study proposes a cost-effective processing flowsheet for the low-grade middle group 2 (MG2) chromite layer, a poorly explored chromatite seam within the South African bushveld igneous complex (BIC). The study involved mineralogical characterization followed by gravity and magnetic separation of the low-grade MG2 ore at 18.18% Cr2O3. Characterization by XRD and Auto-SEM revealed that the ore mainly consists of pyroxene, chromite, and feldspar, with other minerals in trace quantities. The gravity separation test by shaking table upgraded the chromite (Cr2O3) to 42.0% at high chromite recoveries, whereas the laboratory Slon wet high-intensity magnetic separation method (SLon WHIMS) upgraded the chromite in the feed to 42.95% grade at lower chromite recoveries. Desliming the sample before the gravity and magnetic separation tests significantly improved the separation. The magnetic separation tests further demonstrated that chromite within the MG2 layer is sensitive to magnetic separation due to its high iron content. The adapted flowsheet is proposed as a cost-effective flowsheet for processing the low-grade MG2 layer. The flow sheet can be optimized by conducting the SLon WHIMS tests at high intensities followed by fine gravity tests by spiral circuits to maximize the chromite recovery while achieving commercial chromite grades and a Cr:Fe ratio greater than 1.5.

GlycoPCT: Pressure Cycling Technology-Based Quantitative Glycoproteomics Reveals Distinctive N-Glycosylation in Human Liver Biopsy Samples of Nonalcoholic Fatty Liver Disease.

Protein N-glycosylation is vital in the human liver and influences functions such as lipid metabolism, apoptosis, and inflammation. However, site-specific N-glycosylation patterns and variations in liver biopsy samples between healthy individuals and those with nonalcoholic fatty liver disease (NAFLD) remain incompletely characterized, primarily due to the limitations of current clinical glycoproteomic methods, including a large demand for clinical samples, low efficiency of tissue protein extraction, and a low recovery rate of intact N-glycopeptides (IGPs). To address this issue, we developed GlycoPCT, a quantitative glycoproteomic method based on pressure cycling technology. It enables efficient recovery of IGPs and accurate analysis of trace liver biopsy samples. Our research revealed a total of 4,459 unique IGPs and 361 glycans from 758 glycoproteins. High-mannose type, complex type, fucosylation type, and sialylation type N-glycans were significantly upregulated in the NAFLD group (p < 0.001, t test). Notably, we also identified 182 upregulated IGPs from 67 proteins (p < 0.05, FC > 1.50) and 108 downregulated IGPs from 44 proteins (p < 0.05, FC < 0.67) in the NAFLD group. Furthermore, we highlighted an essential acute phase glycoprotein, alpha-1-acid glycoprotein 1 (A1TA), which is synthesized in the liver and plays a significant role in NAFLD progression. These novel glyco-signatures provide crucial clues for the diagnosis and pathogenesis of NAFLD.

Recovery Capital and Subsequent Overdose Risk and Addiction Treatment Engagement Among Emergency Department Patients at High Risk of Opioid Overdose

Background Emergency department (ED) visits are an opportunity to provide prevention services to people at high risk of overdose. Considering patients’ resources to initiate and sustain recovery ("recovery capital”) may be useful for tailoring ED services, although its relevance in this population is unknown. Methods This secondary analysis used data from ED patients at high risk of opioid overdose enrolled in a randomized controlled trial in Rhode Island (2018–2021). We assessed baseline recovery capital using the Brief Assessment of Recovery Capital (BARC-10), dichotomized as a total score <47 versus ≥47. Post-discharge addiction treatment engagement within 30 days and non-fatal opioid overdose and fatal overdose within 18 months were assessed using statewide administrative data. We used modified Poisson regression and Cox proportional hazards models to estimate the association between recovery capital and (1) treatment engagement and (2) overdose risk, respectively, adjusting for potential confounders. Results Among 543 participants, 32.2% had a baseline BARC-10 total score of ≥47, 32.6% engaged in treatment within 30 days, and 25.6% had a non-fatal opioid overdose and 4.2% had a fatal overdose within 18 months. BARC-10 total score was not associated with treatment engagement within 30 days (adjusted relative risk = 0.79, 95% confidence interval [CI] = 0.60–1.05) or non-fatal opioid overdose (adjusted hazard ratio [aHR] = 0.83, 95%CI = 0.57–1.20) or fatal overdose (aHR = 0.45, 95%CI = 0.14–1.40) within 18 months. Conclusion The majority of ED patients at high risk of opioid overdose had a BARC-10 total score of <47, suggesting low recovery capital. BARC-10 total score was not associated with post-discharge treatment engagement or overdose risk.