A few-moded silica-based optical fiber fabricated from core materials that possess intrinsically low optical nonlinearities is reported. Specifically, the 8-μm core, 125-μm cladding diameter silicate fiber was composed of a strontium aluminosilicate oxyfluoride core with a fused silica cladding and was fabricated using the molten core method. Relative to conventional optical fibers, reductions of ∼6.3 dB in Brillouin gain coefficient (gB ), ∼0.9 dB in Raman gain coefficient (gR), and ∼2.2 dB in thermo-optic coefficient were realized as was a “silica-like” nonlinear refractive index (n2) with a value of ∼3 × 10 –20 m2/W. The role of each core material constituent on parameters that drive optical nonlinearities is discussed to provide a materials solution route for low nonlinearity fiber systems. Materially addressing optical nonlinearities represent a simpler and more effective approach to mitigating power-scaling limits in high energy fiber laser systems compared to the geometric approaches employed using microstructured fibers.