Low Likelihood Of Coronary Disease Research Articles

Implications for single phase prospective CT coronary angiography for the diagnosis of significant coronary stenoses in clinical practice

CT coronary angiography (CTA) with 64 slice multi-detector CT (64-MDCT) has assumed an increasing role in clinical practice; however the high radiation dose associated with retrospective ECG-gated CTA has led to suggestions that a low dose prospectively gated strategy may be more appropriate. This study aims to assess the feasibility of this proposed strategy amongst standard referral for CTA in our centre. We retrospectively analyzed 200 consecutive clinical CTA studies assessing the number of cardiac phases required to allow full diagnostic visualisation of the coronary tree. We assessed whether the pre-test likelihood of coronary disease, heart rate, heart rate variability and range, current beta-blockers use, coronary calcium score, breathing artefact or study quality affected the number of phases required. 125/200 patients (62.5%) required only a single phase for full diagnostic visualisation of the coronary tree [most commonly 65% of the R-R interval-109/125 (87.2%)]. A successful diagnostic single cardiac phase was most likely in patients with a low heart rate (Heart rate < 70 bpm OR = 2.64; p = 0.003 and heart rate < 60 bpm OR = 4.81; p < 0.001 respectively) and low likelihood of coronary disease [OR = 1.97 95% CI (1.09, 3.58) p = 0.025]. High image quality is possible using single phase analysis in those patients with low likelihood of coronary disease, low heart rates and full cooperation with inspiratory breath hold. In patients with HR of <60, prospective ECG-gated acquisitions reduce radiation dose but may be non-diagnostic in as many as one third. Careful patient selection is therefore essential.

Rapid Detection of Myocardial Infarction by Subsecond, Free-Breathing Delayed Contrast-Enhancement Cardiovascular Magnetic Resonance

An ultrafast, delayed contrast-enhancement cardiovascular magnetic resonance technique that can acquire subsecond, "snapshot" images during free breathing (subsecond) is becoming widely available. This technique provides myocardial infarction (MI) imaging with complete left ventricular coverage in < 30 seconds. However, the accuracy of this technique is unknown. We prospectively compared subsecond imaging with routine breath-hold delayed contrast-enhancement cardiovascular magnetic resonance (standard) in consecutive patients. Two cohorts with unambiguous standards of truth were prespecified: (1) patients with documented prior MI (n=135) and (2) patients without MI and with low likelihood of coronary disease (lowest Framingham risk category; n=103). Scans were scored masked to identity and clinical information. Sensitivity, specificity, and accuracy of subsecond imaging for MI diagnosis were 87%, 96%, and 91%, respectively. Compared with the standard technique (98%, 100%, 99%), the subsecond technique had modestly reduced sensitivity (P=0.0001), but specificity was excellent. Missed infarcts were generally small or subendocardial (87%). Overall, regional transmural extent of infarction scores were highly concordant (2083/2294; 91%); however, 51 of 337 regions (15%) considered predominantly infarcted (> 50% transmural extent of infarction) by the standard technique were considered viable (< or = 25% transmural extent of infarction) by the subsecond technique. Quantitative analysis demonstrated moderately reduced contrast-to-noise ratios for subsecond imaging between infarct and remote myocardium (12.0+/-7.2 versus 20.1+/-6.6; P<0.0001) and infarct and left ventricular cavity (-2.5+/-2.7 versus 3.6+/-3.7; P<0.0001). MI can be rapidly detected by subsecond delayed contrast-enhancement cardiovascular magnetic resonance during free breathing with high accuracy. This technique could be considered the preferred approach in patients who are more acutely ill or unable to hold their breath. However, compared with standard imaging, sensitivity is mildly reduced, and the transmural extent of infarction may be underestimated.

Dyspnea and Risk in Suspected Coronary Disease

Stress testing for the detection of coronary artery disease is most useful in patients considered on clinical grounds to be at intermediate risk.1 The patient's age and sex and the nature of chest pain can be used to provide a simple estimate of the probability of coronary artery disease.2 Because the absence of chest pain has traditionally been interpreted to indicate a low likelihood of coronary disease — and, indeed, a low long-term risk — functional testing has been thought to contribute little to the evaluation of patients without angina.3 Basing a selection strategy for stress testing on the evaluation . . .

Improved coronary disease detection with quantitative attenuation-corrected Tl-201 images

Background. The normal distribution of myocardial tracer activity is different in attenuation-corrected images compared with uncorrected images. We therefore postulated that quantitation of attenuation-corrected thallium 201 images with direct comparison to a database of healthy subjects could improve detection of coronary artery stenoses. Methods and Results. In 49 patients with angiographic evidence of coronary artery disease and 69 patients with a less than 5% likelihood of coronary artery disease, tomographic Tl-201 myocardial imaging was performed by means of a triple-headed camera with fan-beam collimators and the images were processed with attenuation correction, with attenuation and Compton scatter correction, and without correction. Images were subjectively interpreted in a blinded manner. From the group of 69 patients with a low likelihood of coronary disease, scintigraphic data from the first 20 men and the first 20 women were used to generate normal reference ranges for each of the 3 image-processing methods. Data from the 49 patients with angiographic coronary disease and from the remaining 29 patients with a low likelihood of coronary disease were then analyzed quantitatively in comparison to the gender-matched normal databases. With visual interpretation, attenuation-corrected images yielded an improved detection rate compared with uncorrected images (79% vs 46%, P = .008) for 70% or greater left anterior descending coronary artery stenoses. Attenuation-corrected images also provided an improved normalcy rate for the right coronary artery territory (91% vs 75%, P = .006) and an improved normalcy rate when the images were analyzed overall by patient (88% vs 74%, P = .009). With quantitative analysis, attenuation correction yielded an improved detection rate for patients with a significant coronary artery stenosis compared with uncorrected images (90% vs 71%, P = .016). Defect extent was also increased by attenuation correction. Compared with attenuation correction alone, the addition of scatter correction yielded no incremental improvement in detection rate or normalcy rate. Attenuation-scatter correction did produce a nonsignificant trend toward detection of more of the total number of stenotic arteries compared with uncorrected images (60 vs 48 of 79 arteries). Conclusions. With the use of a triple-headed camera with fan-beam collimation, visual analysis of attenuation-corrected Tl-201 images improved detection of left anterior descending coronary artery disease without loss of detection in other coronary territories. Furthermore, quantitative analysis of attenuation-corrected Tl-201 images improved the overall detection rate for coronary artery disease in patients without compromise of the normalcy rate. (J Nucl Cardiol 2002;9:52-61.)

Evaluation of an attenuation correction method for thallium-201 myocardial perfusion tomographic imaging of patients with low likelihood of coronary artery disease

Background. Image artifacts caused by nonuniform photon attenuation are a source of error in interpretation of images during myocardial perfusion single photon emission computed tomography (SPECT). A newly introduced attenuation correction method was evaluated for improvement in image homogeneity during 201TI SPECT. The method was assessed with a cardiac phantom and in examinations of 42 patients (29 men) with a low likelihood of coronary disease. Methods and Results. Simultaneous transmission-emission SPECT was performed with a moving collimated 153Gd line source synchronized with a moving electronic acquisition window for transmission imaging and a novel variable-width electronic exclusion window for emission imaging designed to avoid transmission-to-emission cross talk. The resulting uncorrected and corrected polar maps were analyzed visually and divided into 31 segments for quantitative analysis. Visual analysis of the color-coded mean polar maps showed clear improvement in homogeneity after correction among the phantom, male patients, female patients, and 42 patients combined at stress and redistribution. The male and female mean polar maps showed very little differences in regional count distribution after correction. Quantitative analysis of the mean polar maps showed the following mean segmental counts (%SD) before and after attenuation correction: phantom 88 (9) to 90 (7.5), P = .00005; men at stress 83 (10) to 88 (6), P = .0007, and at redistribution 84 (8) to 88 (6), P = .01; women at stress 86 (7) to 90 (5), P = .0002, and at redistribution 87 (5) to 88 (7), P = .3; patients combined at stress 84 (8) to 88 (6), P = .0004, and at redistribution 85 (7) to 87 (7), P = .03. Inferior/anterior count ratio for men at stress increased after correction from 0.82 to 0.99 and septal/lateral count ratio from 0.94 to 1.02. Inferior/anterior count ratio for men at redistribution increased from 0.86 to 1.06 and septal/lateral count ratio from 0.97 to 1.04. Inferior/anterior count ratio for women at stress increased from 0.95 to 1.03 and septal/lateral count ratio from 0.93 to 1.00. Inferior/anterior count ratio for women at redistribution increased from 1.04 to 1.10, and septal/lateral count ratio decreased from 1.02 to 1.00. Conclusion. Improvement in image homogeneity was demonstrated with this attenuation correction method with a cardiac phantom and for patients with low likelihood of coronary artery disease. The slight relative increase in inferior wall counts at redistribution was most likely caused by scatter from the relatively higher liver activity compared with the situation during stress and emphasizes the need for scatter correction. The close similarity in count distribution for the mean male and female polar maps supports use of a sex-independent normal database for quantitative analysis. The reduced variation in corrected images from patient to patient implies increased accuracy for detection of myocardial defects.

Use of electrocardiographic-thallium exercise testing in clinical practice

Although there is a great deal of data on the accuracy of combined electrocardiographic-thallium exercise testing, little is known about the use of these tests in clinical practice. A quantitative likelihood system was employed to characterize referral patterns for such testing, and the impact of test results on the likelihood of coronary artery disease was examined. Two hundred thirteen subjects consecutively referred for the purpose of establishing or excluding the presence of coronary artery disease were studied. No subject had a history of a prior myocardial infarction. By historical evaluation, 96 had a low likelihood of coronary disease (less than or equal to 0.20), 88 an intermediate likelihood (0.21 to 0.80) and 29 a high likelihood (greater than 0.80). As anticipated from theoretical analyses, testing produced the greatest shifts in disease likelihood in subjects with an intermediate pretest disease likelihood, and confirmed the historical evaluation in patients at the extremes of pretest disease likelihood. Therefore, although electrocardiographic-thallium stress testing is best suited for subjects with intermediate pretest disease likelihood, the majority of referrals had either a high or low likelihood. Clinicians appear to value confirmatory results in patients at the extremes of pretest disease likelihood. Electrocardiographic exercise testing would serve a similar purpose.