Abstract: In order to better understand how altering one's ideas might improve one's self-esteem and help one cope with substance misuse issues, this study looked at the relationship between automatic thoughts and self-esteem in adult substance users. In order to participate in the study, a sample of 95 persons who use drugs filled out self-report questionnaires measuring their automatic thought patterns and self-esteem. The findings showed that among adults who use drugs, automatic thoughts and levels of self-esteem are significantly correlated. In particular, people with greater levels of self-esteem were more likely to report having good automatic thoughts, whereas people with lower levels of self-esteem were more likely to report having negative automatic thoughts. Additionally, the results indicated that treating and changing automatic negative beliefs could be a useful intervention technique for enhancing self-worth and supporting the treatment of substance misuse problems.