Low-frequency Pure Tones Research Articles

Experiments on the peculiar region and threshold of oppressive or vibratory sensation caused by low-frequency pure tones

Experiments on the peculiar region and threshold of oppressive or vibratory sensation caused by low-frequency pure tones

The effect of motion frequency and sound source frequency on steady-state auditory motion evoked potential

The ability of humans to perceive motion sound sources is important for accurate response to the living environment. Periodic motion sound sources can elicit steady-state motion auditory evoked potential (SSMAEP). The purpose of this study was to investigate the effects of different motion frequencies and different frequencies of sound source on SSMAEP. The stimulation paradigms for simulating periodic motion of sound sources were designed utilizing head-related transfer function (HRTF) techniques in this study. The motion frequencies of the paradigm are set respectively to 1-10 Hz, 15 Hz, 20 Hz, 30 Hz, 40 Hz, 60 Hz, and 80 Hz. In addition, the frequencies of sound source of the paradigms were set to 500 Hz, 1000 Hz, 2000 Hz, 3000 Hz, and 4000 Hz at motion frequencies of 6 Hz and 40 Hz. Fourteen subjects with normal hearing were recruited for the study. SSMAEP was elicited by 500 Hz pure tone at motion frequencies of 1-10 Hz, 15 Hz, 20 Hz, 30 Hz, 40 Hz, 60 Hz, and 80 Hz. SSMAEP was strongest at motion frequencies of 6 Hz. Moreover, at 6 Hz motion frequency, the SSMAEP amplitude was largest at the tone frequency of 500 Hz and smallest at 4000 Hz. Whilst SSMAEP elicited by 4000 Hz pure tone was significantly the strongest at motion frequency of 40 Hz. SSMAEP can be elicited by periodic motion sound sources at motion frequencies up to 80 Hz. SSMAEP also has a strong response at lower frequency. Low-frequency pure tones are beneficial to enhance SSMAEP at low-frequency sound source motion, whilst high-frequency pure tones help to enhance SSMAEP at high-frequency sound source motion. The study provides new insight into the brain's perception of rhythmic auditory motion.

Hearing in African pygmy hedgehogs (Atelerix albiventris): audiogram, sound localization, and ear anatomy.

The behavioral audiogram and sound localization performance, together with the middle and inner ear anatomy, were examined in African pygmy hedgehogs Atelerix albiventris. Their auditory sensitivity at 60dB SPL extended from 2 to 46kHz, revealing a relatively narrow hearing range of 4.6 octaves, with a best sensitivity of 21dB at 8kHz. Their noise-localization acuity around the midline (minimum audible angle) was 14°, matching the mean of terrestrial mammals. The African pygmy hedgehog was not able to localize low-frequency pure tones or a 3-kHz amplitude-modulated tone when forced to rely on the interaural phase-difference cue, a trait shared by at least nine other mammals. The middle ear of Atelerix has a configuration including an ectotympanic which is not fused to the surrounding bones, a substantial pars flaccida, a synostosed malleo-ectotympanic articulation and a 'microtype' malleus. The hearing and sound localization of A. albiventris is compared to that of a broad range of other mammals. It is shown that a malleus morphology like that of Atelerix, including a stiff articulation with the ectotympanic, is a consistent feature of other mammals that do not hear frequencies below 400Hz.

High-resolution temporal weighting of interaural time differences in speech.

Previous studies have shown that for high-rate click trains and low-frequency pure tones, interaural time differences (ITDs) at the onset of stimulus contribute most strongly to the overall lateralization percept (receive the largest perceptual weight). Previous studies have also shown that when these stimuli are modulated, ITDs during the rising portion of the modulation cycle receive increased perceptual weight. Baltzell, Cho, Swaminathan, and Best [(2020). J. Acoust. Soc. Am. 147, 3883-3894] measured perceptual weights for a pair of spoken words ("two" and "eight"), and found that word-initial phonemes receive larger weight than word-final phonemes, suggesting a "word-onset dominance" for speech. Generalizability of this conclusion was limited by a coarse temporal resolution and limited stimulus set. In the present study, temporal weighting functions (TWFs) were measured for four spoken words ("two," "eight," "six," and "nine"). Stimuli were partitioned into 30-ms bins, ITDs were applied independently to each bin, and lateralization judgements were obtained. TWFs were derived using a hierarchical regression model. Results suggest that "word-initial" onset dominance does not generalize across words and that TWFs depend in part on acoustic changes throughout the stimulus. Two model-based predictions were generated to account for observed TWFs, but neither could fully account for the perceptual data.

Neural Responses to Signals for Behavior Change: Greater Within‐Person Variability is Associated With Risk Factors for Substance Dependence

An impaired ability to change behavior in the face of cues indicating a need for change is one means of defining risk for substance dependence. The present study used a cognitive task administered in a laboratory as a model of this process. It focused on 2 known and related correlates of risk (conduct disorder, borderline personality disorder) and examined their associations with reactivity to cues requesting a change in motor behavior. A total of 224 teenagers, 14 to 19years of age, performed a task during which white noise bursts were used to cue a requirement to reverse the mapping of right and left key press responses onto high- and low-frequency pure tones during a subsequent trial block. The amplitude of the P300 electroencephalographic (EEG) response to each cue was summarized by calculating its across-trial average as well as its intertrial variability (ITV). In addition, the number of motor response reversal failures (perseveration errors) was calculated. The ITV of the P300 response to cues for behavior change was superior to its average amplitude in revealing associations with risk: It was significantly greater among teenagers with more conduct problems and more borderline personality disorder symptoms in comparison with their less-affected peers. ITV was also positively correlated with perseveration errors. No group differences were found in P300 amplitude averaged over trials. The findings suggest that the measurement of intertrial variability in brain activity may be more valuable than the average level for revealing neurophysiological differences associated with impulsivity and personality risk factors for dependence. EEG measures may be particularly valuable in this context because they offer superior temporal resolution and signal-to-noise characteristics.

The effects of age and sex on the detection of pure tones by adult CBA/CaJ mice (Mus musculus).

Age-related hearing loss (ARHL) is a neurodegenerative disorder characterized by a gradual decrease in hearing sensitivity. Previous electrophysiological and behavioral studies have demonstrated that the CBA/CaJ mouse strain is an appropriate model for the late-onset hearing loss found in humans. However, few studies have characterized hearing in these mice behaviorally using longitudinal methodologies. The goal of this research was to utilize a longitudinal design and operant conditioning procedures with positive reinforcement to construct audiograms and temporal integration functions in aging CBA/CaJ mice. In the first experiment, thresholds were collected for 8, 16, 24, 42, and 64kHz pure tones in 30 male and 35 female CBA/CaJ mice. Similar to humans, mice had higher thresholds for high frequency tones than for low frequency pure tones across the lifespan. Female mice had better hearing acuity than males after 645days of age. In the second experiment, temporal integration functions were constructed for 18 male and 18 female mice for 16 and 64kHz tones varying in duration. Mice showed an increase in thresholds for tones shorter than 200ms, reaching peak performance at shorter durations than other rodent species. Overall, CBA/CaJ mice experience ARHL for pure tones of different frequencies and durations, making them a good model for studies on hearing loss. These findings highlight the importance of using a wide range of stimuli and a longitudinal design when comparing presbycusis across different species.

Stream biasing by different induction sequences: Evaluating stream capture as an account of the segregation-promoting effects of constant-frequency inducers

Stream segregation for a test sequence comprising high-frequency (H) and low-frequency (L) pure tones, presented in a galloping rhythm, is much greater when preceded by a constant-frequency induction sequence matching one subset than by an inducer configured like the test sequence; this difference persists for several seconds. It has been proposed that constant-frequency inducers promote stream segregation by capturing the matching subset of test-sequence tones into an on-going, pre-established stream. This explanation was evaluated using 2-s induction sequences followed by longer test sequences (12-20 s). Listeners reported the number of streams heard throughout the test sequence. Experiment 1 used LHL- sequences and one or other subset of inducer tones was attenuated (0-24 dB in 6-dB steps, and ∞). Greater attenuation usually caused a progressive increase in segregation, towards that following the constant-frequency inducer. Experiment 2 used HLH- sequences and the L inducer tones were raised or lowered in frequency relative to their test-sequence counterparts (ΔfI = 0, 0.5, 1.0, or 1.5 × ΔfT ). Either change greatly increased segregation. These results are concordant with the notion of attention switching to new sounds but contradict the stream-capture hypothesis, unless a "proto-object" corresponding to the continuing subset is assumed to form during the induction sequence.

Effects of induction sequences on the tendency to segregate auditory streams: Exploring the stream biasing effects of constant- and alternating-frequency inducers

The extent of stream segregation for a test sequence comprising high- (H) and low-frequency (L) pure tones, presented in a galloping rhythm (e.g., LHL-LHL-…), is much greater when preceded by a constant-frequency induction sequence matching one subset of the constituent tones (e.g., L-L-L-L-…) than by an inducer of the same duration configured like the test sequence. This difference persists for several seconds after the test sequence begins. The origin of this effect was explored using short (2 s) induction sequences followed by long (16-20 s) test sequences. In experiment 1, LHL- sequences were used and one or other subset of the inducer tones was attenuated (0-24 dB in 6-dB steps, and ∞). Greater attenuation of either subset led to a progressive increase in the segregation of the subsequent test sequence, towards that following the constant-frequency inducer. In experiment 2, HLH- sequences were used and the frequency of the L-subset of inducer tones was raised or lowered relative to their test-sequence counterparts. Either change increased subsequent stream segregation. These outcomes support the notion of stream biasing—that constant-frequency inducers promote segregation by capturing the matching subset of test-sequence tones into an on-going, pre-established stream. [Work supported by Aston University.]

Influence of interaural time differences on the loudness of low-frequency pure tones at varying signal and noise levels

Influence of interaural time differences on the loudness of low-frequency pure tones at varying signal and noise levels

On the relation between pitch and level

Pitch is the perceptual dimension along which musical notes are ordered from low to high. It is often described as the perceptual correlate of the periodicity of the sound's waveform. Previous reports have shown that pitch can depend slightly on sound level. We wanted to verify that these observations reflect genuine changes in perceived pitch, and were not due to procedural factors or confusion between dimensions of pitch and level. We first conducted a systematic pitch matching task and confirmed that the pitch of low frequency pure tones, but not complex tones, decreases by an amount equivalent to a change in frequency of more than half a semitone when level increases. We then showed that the structure of pitch shifts is anti-symmetric and transitive, as expected for changes in pitch. We also observed shifts in the same direction (although smaller) in an interval matching task. Finally, we observed that musicians are more precise in pitch matching tasks than non-musicians but show the same average shifts with level. These combined experiments confirm that the pitch of low frequency pure tones depends weakly but systematically on level. These observations pose a challenge to current theories of pitch.

Effects of Interaural Differences on the Loudness of Low-Frequency Pure Tones

The loudness related to a sound may vary according to the localization of its source. This phenomenon is described as directional loudness and has been mainly observed for high-frequency sounds and for sources located in the horizontal plane. Because of the acoustic shadow of the head, the left and right ear pressures are modified depending on the source azimuth and the global loudness resulting from a summation process may vary accordingly. But directional loudness has also been reported to occur at 400 Hz, where shadowing effects are usually rather small. It might therefore be suspected that directional loudness effects could be influenced by other parameters involved in the localization process. In a previous study, a small but significant increase of loudness with increasing interaural time difference (ITD) was shown for low-frequency pure tones (200 and 400 Hz) at a low loudness level (40 phon). The present study aimed at getting insight into the potential cause and extent of this effect by assessing the loudness of similar pure tones lateralized with headphones by applying an interaural level difference (ILD) in addition to an ITD and by measuring the effect of ITD at the hearing threshold. It showed significant effects of both ILD and ITD on loudness, and no interaction between these factors. As the effects added even when the factors were contradictory, it supports the hypothesis that the effect is caused by the ITD itself and is not related to the localization process. However, the ITD effect was not significant at the hearing threshold.

Specificity of the Human Frequency Following Response for Carrier and Modulation Frequency Assessed Using Adaptation.

The frequency following response (FFR) is a scalp-recorded measure of phase-locked brainstem activity to stimulus-related periodicities. Three experiments investigated the specificity of the FFR for carrier and modulation frequency using adaptation. FFR waveforms evoked by alternating-polarity stimuli were averaged for each polarity and added, to enhance envelope, or subtracted, to enhance temporal fine structure information. The first experiment investigated peristimulus adaptation of the FFR for pure and complex tones as a function of stimulus frequency and fundamental frequency (F0). It showed more adaptation of the FFR in response to sounds with higher frequencies or F0s than to sounds with lower frequency or F0s. The second experiment investigated tuning to modulation rate in the FFR. The FFR to a complex tone with a modulation rate of 213 Hz was not reduced more by an adaptor that had the same modulation rate than by an adaptor with a different modulation rate (90 or 504 Hz), thus providing no evidence that the FFR originates mainly from neurons that respond selectively to the modulation rate of the stimulus. The third experiment investigated tuning to audio frequency in the FFR using pure tones. An adaptor that had the same frequency as the target (213 or 504 Hz) did not generally reduce the FFR to the target more than an adaptor that differed in frequency (by 1.24 octaves). Thus, there was no evidence that the FFR originated mainly from neurons tuned to the frequency of the target. Instead, the results are consistent with the suggestion that the FFR for low-frequency pure tones at medium to high levels mainly originates from neurons tuned to higher frequencies. Implications for the use and interpretation of the FFR are discussed.

Loudness of low-frequency pure tones lateralized by interaural time differences.

Directional loudness is that phenomenon by which the loudness of a sound may vary according to the localization of its source. This phenomenon has been mainly observed for high-frequency sounds, for sources located in the horizontal plane. Because of the acoustic shadow of the head, the left and right ear pressures are modified depending on the source azimuth and the global loudness resulting from a summation process may vary accordingly. Directional loudness has also been reported to occur at 400 Hz, where shadowing effects are usually rather small. It might therefore be suspected that directional loudness effects could be influenced by other parameters involved in the localization process. This study assessed the loudness of low-frequency pure tones (200 and 400 Hz) lateralized with headphones by applying an interaural time difference (ITD) but no interaural level difference. It showed small but significant variations of loudness with respect to ITD at a low loudness level (40 phon): ITD values associated with virtual azimuths of ±60° and ±90° led to a small but significant increase in loudness (up to 1.25 dB). However, there was no such effect at a moderate loudness level (70 phon).

Directional sound sensitivity in utricular afferents in the toadfish Opsanus tau.

The inner ear of fishes contains three paired otolithic end organs, the saccule, lagena and utricle, which function as biological accelerometers. The saccule is the largest otolith in most fishes and much of our current understanding on auditory function in this diverse group of vertebrates is derived from anatomical and neurophysiological studies on this end organ. In contrast, less is known about how the utricle contributes to auditory functions. In this study, chronically implanted electrodes were used, along with neural telemetry or tethers to record primary afferent responses from the utricular nerve in free-ranging and naturally behaving oyster toadfish Opsanus tau Linnaeus. The hypothesis was that the utricle plays a role in detecting underwater sounds, including conspecific vocalizations, and exhibits directional sensitivity. Utricular afferents responded best to low frequency (80-200 Hz) pure tones and to playbacks of conspecific boatwhistles and grunts (80-180 Hz fundamental frequency), with the majority of the units (∼75%) displaying a clear, directional response, which may allow the utricle to contribute to sound detection and localization during social interactions. Responses were well within the sound intensity levels of toadfish vocalization (approximately 140 SPL dBrms re. 1 µPa with fibers sensitive to thresholds of approximately 120 SPL dBrms re. 1 µPa). Neurons were also stimulated by self-generated body movements such as opercular movements and swimming. This study is the first to investigate underwater sound-evoked response properties of primary afferents from the utricle of an unrestrained/unanesthetized free-swimming teleost fish. These data provide experimental evidence that the utricle has an auditory function, and can contribute to directional hearing to facilitate sound localization.

Middle Ear Implant versus Hybrid Cochlear Implant for High‐Frequency Sensorineural Hearing Loss

Objectives:Profound SNHL responds well to a standard cochlear implant (CI) with rewarding results. However, if the individual has residual hearing in the low frequencies there is a reasonable chance that the pure tones will be lost. Hybrid cochlear implants have been suggested as a solution for this problem. Unfortunately, there continues to be a loss of the low frequency pure tones in a large number of these patients.Methods:One solution would be to use a middle ear implant instead of a hybrid CI. The Maxum middle ear implant has the advantage of being a minimally invasive surgical procedure that can be performed under local anesthesia. A small magnet is attached to the stapes through a transcanal approach.Results:After 3 weeks an integrated processor coil (IPC) is inserted into the external auditory canal. The IPC has an electromagnet driver. By driving the stapes directly it is possible to obtain as much as 60 dB of functional gain in the high frequencies without distortion, acoustic feedback, or the sensation of occlusion.Conclusions:For these reasons the author believes a Maxum should be considered in these patients before a Hybrid Cochlear Implant. If the SNHL progresses, then a CI can still be performed at a later date. This sequence of events delays the invasion of the cochlea and in some cases prevents the need for a CI altogether.

On the localization of complex sounds: temporal encoding based on input-slope coincidence detection of envelopes.

Behavioral and neural findings demonstrate that animals can locate low-frequency sounds along the azimuth by detecting microsecond interaural time differences (ITDs). Information about ITDs is also available in the amplitude modulations (i.e., envelope) of high-frequency sounds. Since medial superior olivary (MSO) neurons encode low-frequency ITDs, we asked whether they employ a similar mechanism to process envelope ITDs with high-frequency carriers, and the effectiveness of this mechanism compared with the process of low-frequency sound. We developed a novel hybrid in vitro dynamic-clamp approach, which enabled us to mimic synaptic input to brain-slice neurons in response to virtual sound and to create conditions that cannot be achieved naturally but are useful for testing our hypotheses. For each simulated ear, a virtual sound, computer generated, was used as input to a computational auditory-nerve model. Model spike times were converted into synaptic input for MSO neurons, and ITD tuning curves were derived for several virtual-sound conditions: low-frequency pure tones, high-frequency tones modulated with two types of envelope, and speech sequences. Computational models were used to verify the physiological findings and explain the biophysical mechanism underlying the observed ITD coding. Both recordings and simulations indicate that MSO neurons are sensitive to ITDs carried by spectrotemporally complex virtual sounds, including speech tokens. Our findings strongly suggest that MSO neurons can encode ITDs across a broad-frequency spectrum using an input-slope-based coincidence-detection mechanism. Our data also provide an explanation at the cellular level for human localization performance involving high-frequency sound described by previous investigators.

Experimental study on hearing thresholds for low-frequency pure tones

Experimental study on hearing thresholds for low-frequency pure tones

Electric-acoustic pitch comparisons in single-sided-deaf cochlear implant users: Frequency-place functions and rate pitch

Eight cochlear implant users with near-normal hearing in their non-implanted ear compared pitch percepts for pulsatile electric and acoustic pure-tone stimuli presented to the two ears. Six subjects were implanted with a 31-mm MED-EL FLEXSOFT electrode, and two with a 24-mm medium (M) electrode, with insertion angles of the most apical contacts ranging from 565° to 758°. In the first experiment, frequency-place functions were derived from pure-tone matches to 1500-pps unmodulated pulse trains presented to individual electrodes and compared to Greenwood's frequency position map along the organ of Corti. While the overall median downward shift of the obtained frequency-place functions (−0.16 octaves re. Greenwood) and the mean shifts in the basal (<240°; −0.33 octaves) and middle (−0.35 octaves) regions were statistically significant, the shift in the apical region (>480°; 0.26 octaves) was not. Standard deviations of frequency-place functions were approximately half an octave at electrode insertion angles below 480°, increasing to an octave at higher angular locations while individual functions were gradually leveling off.In a second experiment, subjects matched the rates of unmodulated pulse trains presented to individual electrodes in the apical half of the array to low-frequency pure tones between 100 Hz and 450 Hz. The aim was to investigate the influence of electrode place on the salience of temporal pitch cues, for coding strategies that present temporal fine structure information via rate modulations on select apical channels. Most subjects achieved reliable matches to tone frequencies from 100 Hz to 300 Hz only on electrodes at angular insertion depths beyond 360°, while rate-matches to 450-Hz tones were primarily achieved on electrodes at shallower insertion angles. Only for electrodes in the second turn the average slopes of rate-pitch functions did not differ significantly from the pure-tone references, suggesting their use for the encoding of within-channel fine frequency information via rate modulations in temporal fine structure stimulation strategies.

Further examination of complex pitch perception in the absence of a place--rate match

Oxenham et al. [Proc. Nat. Acad. Sci. 101, 1421-1425 (2004)] reported that listeners cannot derive a "missing fundamental" from three transposed tones having high carrier frequencies and harmonically related low-frequency modulators. This finding was attributed to complex pitch perception requiring correct tonotopic representation but could have been due to the very high modulator rate difference limens (DLs) observed for individual transposed tones. Experiments 1 and 2 showed that much lower DLs could be obtained for bandpass-filtered pulse trains than for transposed tones with repetition rates of 100 or 300 pps; however, DLs were still larger than for low-frequency pure tones. Experiment 3 presented three pulse trains filtered between 1375 and 1875, 3900 and 5400, and 7800 and 10 800 Hz simultaneously with a pink-noise background. Listeners could not compare the "missing fundamental" of a stimulus in which the pulse rates were, respectively, 150, 225, and 300 pps, to one where all pulse trains had a rate of 75 pps, even though they could compare a 150 + 225 + 300 Hz complex tone to a 75-Hz pure tone. Hence although filtered pulse trains can produce fairly good pitch perception of simple stimuli having low repetition rates and high-frequency spectral content, no evidence that such stimuli enable complex pitch perception in the absence of a place-rate match was found.

Temporal weighting for interaural time differences in low-frequency pure tones

In contrast to envelope-based interaural time differences (ITD) at high frequencies, where sound onsets play a dominant role, the reliability and salience fine-structure ITD at low frequency (&amp;lt;1500 Hz) suggests uniform sensitivity to information across periods of an ongoing stimulus waveform. Several past studies, however, have demonstrated low-frequency ITD thresholds to improve sub-optimally with increasing sound duration [e.g. Houtgast &amp; Plomp 1968, JASA 44:807-12], suggesting that the initial periods of a brief tone play a greater role in ITD processing than do later periods. Here, we measured the temporal profile of ITD sensitivity in pure tones ranging from 250-1000 Hz. Sounds were presented with ITD that either remained fixed over the sound duration (condition RR) or progressed linearly to eliminate the ITD cue from either the beginning (condition 0R) or end (R0) of the sound. Durations varied from 40-640 ms, including 20 ms ramps applied diotically to minimize envelope cues. ITD detection thresholds demonstrated (a) suboptimal improvement with duration and (b) greater sensitivity to ITD available early (R0) rather than late (0R) in the stimulus, a pattern nearly identical to that observed for high-frequency envelope ITD. [Supported by NIH R01 DC011548.]