Tropical region is characterised by high outdoor solar radiation and temperature. These radiations penetrate into the interior particularly through the window glazing, thereby raising the indoor temperature with a resultant effect on high cooling energy demand (for comfortable indoor living condition). Of the identified three sustainable approaches towards inhibiting direct incoming indoor solar penetration in the tropical city of Ogbomoso, Nigeria, this study, through computer-based simulation technique, compared performance effectiveness of varying design interventions on the window composition/material adopted. Through multiple/iterative building performance simulation tool, DesignBuilder, the methodology involves virtual model of a three-bedroom residential building, typical of the prevailing building typology in the study area. This particular model served as the experimental control model. Three (3) variants of the control model, each with either externally mounted shading devices on the building envelope, or improved thermally resistant multilayer window glazing (i.e., double glazing) or low-emissivity coated window glazing material, were generated for individual performance effectiveness evaluation. All the four models were subjected to a twelve-month simulation cycle, to experience a year-round thermal conditions and evaluations individually. The results show that double-glazing window installation proved to be the most effective approach, with about 13.1 % improvement (i.e., solar radiation inhibition) on the indoor thermal gains. This is followed by the externally mounted shading devices (i.e., 11.1 % improvement) and the least inhibition (i.e., 5.0 %) was observed in the case of low-emissivity coated window glazing material. Adoption of double or more layers of glass panes in window fabrication for controlling indoor solar radiation penetration is therefore advised. Alternatively, integration of external window shading elements could be adopted. This study is directed towards reduction of cooling energy consumption in tropical buildings through efficient and sustainable indoor cooling mechanism capable of inhibiting solar gains into the building, with a focus on the performance roles and composition of windows in particular.