Low-density Cholesterol Values Research Articles

Asociación de la expresión de genes con metabolitos sanguíneos y perfil de ácidos grasos en corderos

Some agricultural byproducts can be used as viable alternatives in animal feed. Therefore, the effect of the inclusion of avocado meal and sunflower oil on the profile of fatty acids, blood metabolites and the expression of genes associated with lipid metabolism in lambs was evaluated. Three treatments were evaluated: 0 % control, 10 % avocado meal and 10 % sunflower oil for 84 days. It was found that including avocado meal in the diet increased the amount of blood glucose and also globulin, but decreased creatinine and Glutamic Oxaloacetic Transaminase, compared to the addition of sunflower oil where the content of cholesterol, triglycerides, and VLDL decreased. and R A/G. There was no difference for muscle fat percentage. The concentration of fatty acids C20:0, C20:1 and C23:0 was lower with avocado meal, without affecting the MUFA and UFA values, the UFA/SFA ratio and the saturation index. The inclusion of avocado meal caused a change in the expression of the ACACA, FASN, SCD, FASBP3, PPARG and SREBF1 genes in the Longisimus thoracis muscle, there was a positive association between glucose and the FASBP3 gene, also of HDL with the PPARG gene, MUFA, proteins and indices of desaturation of fatty acids were associated with genes such as SCD, FASN, SREBF1 and ACACA The inclusion of avocado meal is an alternative to modify genetic expression, also to reduce very low density cholesterol values in the blood.

Effect of Dietary Lipid Sources on Feed Utilization, Growth Efficiency and Carcass Composition of Clarias gariepinus Juveniles

This study was designed to investigate plant and animal lipid that can enhance feed utilization, growth, and survival of Clarias gariepinus Juveniles. Juveniles with mean weight 32.50±0.5g were stocked randomly to seven tanks replicated thrice, with each tank having seven fish each and were fed with the prepared diets with varied lipid. 40% crude protein and isocaloric diets with digestible energy of 2,933.76Kcal were formulated and labelled Diet 1-7 with different sources of plant and animal lipids. Diet 1, 2 and 3 contained palm oil, Groundnut oil and soybean oil respectively, while diet 4, 5 and 6 contained Pork lard, Cod Liver oil and Beef tallow. Diet 7 (Control diet without any lipid source).
 The result showed that there was no significant difference (P>0.05) in Feed conversion ratio (FCR) and survival rates among the diets. The mean weight gain was highest in fish fed with pork lard (22.12g) while the lowest value of 15.36g was recorded in fish fed with soybean oil. Relative weight gains and feed intake showed no significant difference (P>0.05) between fish fed lipids of plant origin. However, there was significant difference (P<0.05) among fish fed lipids from animal origin. The Highest Total Cholesterol (28.18 mg/dl) was recorded in fish fed beef tallow as lipid sources while the least value of low-density cholesterol (value of 2.26 mg/dl) was recorded in fish fed with soybean oil. In conclusion, C. gariepinus was able to utilize animal-based lipid sources more in terms of growth and feed utilization while the lipid profile result of the individual carcass after the culture period showed that C. gariepinus fed lipid from plant sources had a slightly better cholesterol level than those fed lipid of animal sources.

Correlation of lipid profile among patients with hypothyroidism and type 2 diabetes mellitus

BACKGROUND: Dyslipidemia is common metabolic abnormality in thyroid disorders overt or subclinical and diabetes mellitus (DM) with a marked increase in circulating low-density lipoprotein (LDL-C). OBJECTIVES: This study was carried out to find variations in dyslipidemic patterns in type 2 DM (T2DM) with hypothyroidism (HY). METHODS: Total cholesterol (TC), triglycerides (TG), very low-density cholesterol (VLDL), low-density cholesterol (LDL), and high-density cholesterol (HDL) were compared among the three study groups at a tertiary care teaching hospital of Bihar in eastern India. Group A: T2DM. Group B HY, and Group C: having both T2DM and HY and control group. RESULTS: The lipid profile of patients with diabetes showed TC (316.18 ± 4.299 mg/dl), TG (358.36 ± 5.544 mg/dl), LDL (214.70 ± 4.192 mg/dl), VLDL (71.67 ± 1.109 mg/dl), and HDL (29.80 ± 0.348 mg/dl). Mean lipid profile values in HYs were TC (314.38 ± 1.739 mg/dl), TG (322.46 ± 2.429 mg/dl), LDL (208.69 ± 1.665 mg/dl), VLDL (64.29 ± 0.5591 mg/dl), and HDL (41.20 ± 0.3647 mg/dl). Patients suffering from both diabetes and HY had TC (337.92 ± 4.793 mg/dl), TG (350.02 ± 5.127 mg/dl), LDL (236.17 ± 4.093 mg/dl), VLDL (70.01 ± 1.026 mg/dl), and HDL (31.74 ± 0.285 mg/dl). LDL value was markedly high in diabetic HY patients. All the lipid profile parameters were significantly increased except HDL among the patients with diabetes and HY patients. Increase was more in cholesterol and LDL values among patients suffering from both diabetes and HY. HDL levels were lowest among the patients with diabetes and also decreased among the diabetic HYs. CONCLUSIONS: In this study, on patients with diabetes and HY, dyslipidemia was more in two variables, namely, cholesterol and LDL; there was a distinct difference in lipid profile patterns between single and dual morbidities.

Use of serum cholesterol/triglyceride ratio to discern for which individuals the Friedewald formula can be used confidently

The values of low-density lipoprotein cholesterol obtained according to the Friedewald formula (Clin Chem 1972; 18:499-502), or by the De Long transformation (J Am Med Assoc 1986;256:2372-7), were compared with the values obtained when the individual cholesterol/triglyceride ratio of very-low-density lipoprotein was used for estimating the contribution of this lipoprotein to the total cholesterol. We found that these formulas gave the greatest errors for individuals with a low serum cholesterol/triglyceride ratio. We propose criteria for deciding when the numerically calculated value of low-density cholesterol is appropriate, and when it is not.