Two unique facilities for isothermal low-cycle fatigue (LCF) and in-phase (IP) or out-of-phase (OP) thermo-mechanical fatigue (TMF) testing of tubular specimens under boiling water reactor (BWR) and pressurized water reactor (PWR) coolant conditions were set up and successfully tested. The systems allow both strain- and stress-controlled fatigue experiments with very small strain amplitudes or complex stress/strain profiles with superimposed rather rapid temperature changes (100°C to 340°C) under flowing conditions. The present article introduces the new test facility and briefly discusses the first results of these experiments. In contrast to air, a strong effect of temperature on LCF and TMF lives was observed in deoxygenated and hydrogenated high-temperature water environment, where both lives decrease with increasing temperature above 100°C. The TMF life is between that of the isothermal LCF tests at minimum and maximum temperature. The IP TMF life is shorter than that of OP TMF and close to the LCF l...