Low Contrast Media Research Articles

52 - Evaluation of image quality on low contrast media with deep learning image reconstruction algorithm in prospective ECG-triggering coronary CT angiography

52 - Evaluation of image quality on low contrast media with deep learning image reconstruction algorithm in prospective ECG-triggering coronary CT angiography

Deep learning reconstruction algorithm and high-concentration contrast medium: feasibility of a double-low protocol in coronary computed tomography angiography

Abstract Objective To evaluate radiation dose and image quality of a double-low CCTA protocol reconstructed utilizing high-strength deep learning image reconstructions (DLIR-H) compared to standard adaptive statistical iterative reconstruction (ASiR-V) protocol in non-obese patients. Materials and methods From June to October 2022, consecutive patients, undergoing clinically indicated CCTA, with BMI < 30 kg/m2 were prospectively included and randomly assigned into three groups: group A (100 kVp, ASiR-V 50%, iodine delivery rate [IDR] = 1.8 g/s), group B (80 kVp, DLIR-H, IDR = 1.4 g/s), and group C (80 kVp, DLIR-H, IDR = 1.2 g/s). High-concentration contrast medium was administered. Image quality analysis was evaluated by two radiologists. Radiation and contrast dose, and objective and subjective image quality were compared across the three groups. Results The final population consisted of 255 patients (64 ± 10 years, 161 men), 85 per group. Group B yielded 42% radiation dose reduction (2.36 ± 0.9 mSv) compared to group A (4.07 ± 1.2 mSv; p < 0.001) and achieved a higher signal-to-noise ratio (30.5 ± 11.5), contrast-to-noise-ratio (27.8 ± 11), and subjective image quality (Likert scale score: 4, interquartile range: 3–4) compared to group A and group C (all p ≤ 0.001). Contrast medium dose in group C (44.8 ± 4.4 mL) was lower than group A (57.7 ± 6.2 mL) and B (50.4 ± 4.3 mL), all the comparisons were statistically different (all p < 0.001). Conclusion DLIR-H combined with 80-kVp CCTA with an IDR 1.4 significantly reduces radiation and contrast medium exposure while improving image quality compared to conventional 100-kVp with 1.8 IDR protocol in non-obese patients. Clinical relevance statement Low radiation and low contrast medium dose coronary CT angiography protocol is feasible with high-strength deep learning reconstruction and high-concentration contrast medium without compromising image quality. Key Points Minimizing the radiation and contrast medium dose while maintaining CT image quality is highly desirable. High-strength deep learning iterative reconstruction protocol yielded 42% radiation dose reduction compared to conventional protocol. “Double-low” coronary CTA is feasible with high-strength deep learning reconstruction without compromising image quality in non-obese patients.

Evaluation of image quality on low contrast media with deep learning image reconstruction algorithm in prospective ECG-triggering coronary CT angiography.

To assess the impact of low-dose contrast media (CM) injection protocol with deep learning image reconstruction (DLIR) algorithm on image quality in coronary CT angiography (CCTA). In this prospective study, patients underwent CCTA were prospectively and randomly assigned to three groups with different contrast volume protocols (at 320mgI/mL concentration and constant flow rate of 5ml/s). After pairing basic information, 210 patients were enrolled in this study: Group A, 0.7mL/kg (n = 70); Group B, 0.6mL/kg (n = 70); Group C, 0.5mL/kg (n = 70). All patients were examined via a prospective ECG-triggered scan protocol within one heartbeat. A high level DLIR (DLIR-H) algorithm was used for image reconstruction with a thickness and interval of 0.625mm. The CT values of ascending aorta (AA), descending aorta (DA), three main coronary arteries, pulmonary artery (PA), and superior vena cava (SVC) were measured and analyzed for objective assessment. Two radiologists assessed the image quality and diagnostic confidence using a 5-point Likert scale. The CM doses were 46.81 ± 6.41mL, 41.96 ± 7.51mL and 34.65 ± 5.38mL for Group A, B and C, respectively. The objective assessments on AA, DA and the three main coronary arteries and the overall subjective scoring showed no significant difference among the three groups (all p > 0.05). The subjective assessment proved that excellent CCTA images can be obtained from the three different contrast media protocols. There were no significant differences in intracoronary attenuation values between the higher HR subgroup and the lower HR subgroup among three groups. CCTA reconstructed with DLIR could be realized with adequate enhancement in coronary arteries, excellent image quality and diagnostic confidence at low contrast dose of a 0.5mL/kg. The use of lower tube voltages may further reduce the contrast dose requirement.

Study of Low kV, Low Contrast Agent Dosage, and Low Contrast Agent Flow Rate Scan in Computed Tomography Angiography of Children's Liver

Background: During computed tomography (CT) examinations, the presence of radiation material undoubtedly has a certain impact on patients, particularly children, who are more susceptible to radiation. Consequently, finding ways to minimize radiation dosage and mitigate radiation-related risks while enhancing the quality and accuracy of CT scans has become a crucial concern for medical professionals in CT equipment manufacturing companies and radiology departments to contemplate. Objectives: This study aimed to explore the feasibility of low dose and low contrast medium combined with low flow rate scanning in CT angiography (CTA) of children's liver. Patients and Methods: A total of 59 children who visited our department for liver vascular CT scans between April 2021 and December 2022 were prospectively selected and randomly divided into 2 groups: the experimental group and the control group. The experimental group consisted of 28 children who received an injection of 80 kV, automatic tube current, low contrast dose (1.5 mL/kg), and low flow rate of 20 s. The control group included 31 children who were injected with 100 kV, automatic tube current, contrast agent dose (2 mL/kg), and flow rate of 16 s. The objective and subjective image quality, radiation dose, and iodine intake in the arterial, portal, and venous phases were compared between the 2 groups. Results: During the arterial, portal, and venous phases, the experimental group exhibited lower signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) compared to the control group (P < 0.05). However, there was no significant difference in subjective quality scores between the 2 groups (P > 0.05). The effective dose (ED), volume CT dose index (CTDIvol), and dose-length product (DLP) of the experimental group were lower than those of the control group (P < 0.05). Additionally, the iodine intake in the experimental group was lower than that in the control group (P < 0.05). Conclusion: In the examination of hepatic vascular CTA in children, the use of a 3-low scanning technique can effectively decrease radiation and contrast agents while ensuring sufficient image quality for accurate clinical diagnosis.

Feasibility of Low-Dose and Low-Contrast Media Volume Approach in Computed Tomography Cardiovascular Imaging Reconstructed with Model-Based Algorithm.

Aim: To evaluate the dose reduction and image quality of low-dose, low-contrast media volume in computed tomography (CT) examinations reconstructed with the model-based iterative reconstruction (MBIR) algorithm in comparison with the hybrid iterative (HIR) one. Methods: We prospectively enrolled a total of 401 patients referred for cardiovascular CT, evaluated with a 256-MDCT scan with a low kVp (80 kVp) reconstructed with an MBIR (study group) or a standard HIR protocol (100 kVp-control group) after injection of a fixed dose of contrast medium volume. Vessel contrast enhancement and image noise were measured by placing the region of interest (ROI) in the left ventricle, ascending aorta; left, right and circumflex coronary arteries; main, right and left pulmonary arteries; aortic arch; and abdominal aorta. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were computed. Subjective image quality obtained by consensus was assessed by using a 4-point Likert scale. Radiation dose exposure was recorded. Results: HU values of the proximal tract of all coronary arteries; main, right and left pulmonary arteries; and of the aorta were significantly higher in the study group than in the control group (p < 0.05), while the noise was significantly lower (p < 0.05). SNR and CNR values in all anatomic districts were significantly higher in the study group (p < 0.05). MBIR subjective image quality was significantly higher than HIR in CCTA and CTPA protocols (p < 0.05). Radiation dose was significantly lower in the study group (p < 0.05). Conclusions: The MBIR algorithm combined with low-kVp can help reduce radiation dose exposure, reduce noise, and increase objective and subjective image quality.

Deep-learning reconstruction with low-contrast media and low-kilovoltage peak for CT of the liver

To compare images using reduced CM, low-kVp scanning and DLR reconstruction with conventional images (no CM reduction, normal tube voltage, reconstructed with HBIR. To compare images using reduced contrast media (CM), low kilovoltage peak (kVp) scanning and deep-learning reconstruction (DLR) with conventional image quality (no CM reduction, normal tube voltage, reconstructed with hybrid-type iterative reconstruction method [HBIR protocol]). A retrospective analysis was performed on 70 patients with liver disease and three-phase dynamic imaging using computed tomography (CT) from April 2020 to March 2022 at Oita University Hospital. Of these cases, 39 were reconstructed using the DLR protocol at a tube voltage of 80 kVp and CM of 300 mg iodine/kg while 31 were imaged at a tube voltage of 120 kVp with CM of 600 mg iodine/kg and were reconstructed by the usual HBIR protocol. Images from the DLR and HBIR protocols were analysed and compared based on the contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR), figure-of-merit (FOM), and visual assessment. The CT dose index (CTDI)vol and size-specific dose estimates (SSDE) were compared with respect to radiation dose. The DLR protocol was superior, with significant differences in CNR, SNR, and FOM except hepatic parenchyma in the arterial phase. For visual assessment, the DLR protocol had better values for vascular visualisation for the portal vein, image noise, and contrast enhancement of the hepatic parenchyma. Regarding comparison of the radiation dose, the DLR protocol was superior for all values of CTDIvol and SSDE, with significant differences (p<0.01; max. 52%). Protocols using DLR with reduced CM and low kVp have better image quality and lower radiation dose compared to protocols using conventional HBIR.

Beyond antioxidation: Harnessing the CeO2 nanoparticles as a renoprotective contrast agent for in vivo spectral CT angiography

It is a challenging task to develop a contrast agent that not only provides excellent image contrast but also protects impaired kidneys from oxidative-related stress during angiography. Clinically approved iodinated CT contrast media are associated with potential renal toxicity, making it necessary to develop a renoprotective contrast agent. Here, we develop a CeO2 nanoparticles (NPs)-mediated three-in-one renoprotective imaging strategy, namely, i) renal clearable CeO2 NPs serve as a one-stone-two-birds antioxidative contrast agent, ii) low contrast media dose, and iii) spectral CT, for in vivo CT angiography (CTA). Benefiting from the merits of advanced sensitivity of spectral CT and K-edge energy of Cerium (Ce, 40.4 keV), an improved image quality of in vivo CTA is successfully achieved with a 10 times reduction of contrast agent dosage. In parallel, the sizes of CeO2 NPs and broad catalytic activities are suitable to be filtered via glomerulus thus directly alleviating the oxidative stress and the accompanying inflammatory injury of the kidney tubules. In addition, the low dosage of CeO2 NPs reduces the hypoperfusion stress of renal tubules induced by concentrated contrast agents used in angiography. This three-in-one renoprotective imaging strategy helps prevent kidney injury from being worsened during the CTA examination.

Effectiveness of invention tasks and explicit instruction in preparing intellectually gifted adolescents for learning

Solving a novel problem has recently garnered some attention as a viable alternative to traditional explicit instruction in the preparation of students for learning. This study investigated the effectiveness of introducing problem-solving tasks and worked examples prior to explicit instruction, along with the use of contrast, for gifted and non-gifted adolescents. One hundred and ninety-nine students from academically selective government and Independent high schools participated in this study. The 2 × 2 × 2 research design that was used examined the effects of giftedness (i.e., gifted vs. non-gifted), instruction-type (i.e., problem-solving vs. worked examples), and structure (i.e., high vs low contrast materials) on the learning outcomes of transfer and procedural knowledge. The study also examined the impact of explicit instruction and invention-first instruction strategies on non-performance variables—self-efficacy, extraneous load, experience of knowledge gaps, and interest. The results of the study suggested that invention-first instruction may be more effective than example-first instruction in transfer, and that gifted students may benefit more from invention-first instruction than example-first instruction. The use of contrast materials was not found to affect performance. Furthermore, instruction was found to have no significant effects on the investigated non-performance variables. Collectively, these findings challenge the conventional teaching modality of explicit instruction in gifted education, and puts forward the possibility of the invention-first strategy as an effective instructional strategy for gifted students.

Preheating Temperature Control and Low-Contrast Imaging Data Analytics for Laser Powder Bed Fusion

Laser powder bed fusion (LPBF) additive manufacturing has seen widespread use for its unique advantages in achievable part complexity and processable materials. However, greater applications of this technique remain hindered by the insufficient assurance of part qualities. A major barrier to such a long-felt but not fully realized quality assurance arises from challenges in sensing and model-based control, particularly when involving materials showing low contrast under laser radiation. This article presents two advances that contribute to this vista. We 1) propose a model-based multizone heating control for minimizing the powder bed temperature deviation in the presence of part-geometry-induced cross-layer thermal disturbances and 2) create an image analytics framework for process monitoring of low-contrast material LPBF with visible light cameras. The proposed methods are developed and verified on an in-house built feedback-centric LPBF platform.

Anemia Detection with Contrast-enhanced Photon-counting CT

HomeRadiologyVol. 305, No. 2 PreviousNext CommunicationsFree AccessErratumAnemia Detection with Contrast-enhanced Photon-counting CTJonathan D. Dodd, Roisin MacDermottJonathan D. Dodd, Roisin MacDermottJonathan D. DoddRoisin MacDermottPublished Online:Oct 24 2022https://doi.org/10.1148/radiol.229023MoreSectionsPDF ToolsImage ViewerAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinked In Originally published in:https://doi.org/10.1148/radiol.221471Erratum in:https://doi.org/10.1148/radiol.229023The quote on the first page was changed to read …became clearly visible on noncontrast CT images in canine hearts. The dose-length product unit was changed to mGy ∙ cm, and the associated value was changed from 59 to 592. Reference 4 DOI was changed to https://doi.org/10.1148/radiol.220063.Article HistoryPublished online: Oct 24 2022Published in print: Nov 2022 FiguresReferencesRelatedDetailsAccompanying This ArticleAnemia Detection with Contrast-enhanced Photon-counting CTJul 26 2022RadiologyRecommended Articles Influence of Heart Rate on Image Quality and Radiation Dose Exposure in Coronary CT AngiographyRadiology2021Volume: 300Issue: 3pp. 701-703Slow and Steady Wins the Race: Lower Heart Rates Improve Diagnostic Quality for Coronary CT AngiographyRadiology2021Volume: 300Issue: 3pp. 704-705Radiation Dose Reduction by Using CT with Iterative Model Reconstruction in Patients with Pulmonary Invasive Fungal InfectionRadiology2018Volume: 288Issue: 1pp. 285-292Evaluation of Kidney Stones with Reduced–Radiation Dose CT: Progress from 2011−2012 to 2015−2016—Not There YetRadiology2017Volume: 286Issue: 2pp. 581-589MRI of Iron Oxide Nanoparticles and Myeloperoxidase Activity Links Inflammation to Brain Edema in Experimental Cerebral MalariaRadiology2018Volume: 290Issue: 2pp. 359-367See More RSNA Education Exhibits Usefulness of Spiral Flow Tube for Saline Chaser Capable of Improving Visualization Ability of Subclavian Artery in Cervical CT AngiographyDigital Posters2019Optimization of One-beat 256 Row Detector Coronary CT Angiography Using Low Contrast Media Protocols in Patients with Free Breathing under Automatic Tube Voltage SelectionDigital Posters2018Coronary CT Angiography with Wide Coverage Detector: How to Optimize Contrast Injection and Scan Protocol Based on Patient Size to Reduce Contrast and Radiation DosesDigital Posters2018 RSNA Case Collection Cardiac MyxomaRSNA Case Collection2020Chiari 1 malformation RSNA Case Collection2020Epiploic AppendagitisRSNA Case Collection2022 Vol. 305, No. 2 Metrics Altmetric Score PDF download

Image quality assessment of artificial intelligence iterative reconstruction for low dose aortic CTA: A feasibility study of 70 kVp and reduced contrast medium volume

PurposeTo investigate the image quality and feasibility of a novel artificial intelligence iterative reconstruction (AIIR) algorithm for aortic computer tomography angiography (CTA) with a low radiation dose and contrast material (CM) dosage protocol in comparison with hybrid iterative reconstruction (HIR) algorithm for standard-of-care aortic CTA. MethodsFifty consecutive patients (mean age 58 ± 14 years, mean BMI 24.5 ± 4.7 kg/m2) with aortic diseases were prospectively enrolled. All patients underwent at least twice follow-up aortic CTA examinations. Standard dose CT (SDCT) was applied in the initial follow-up examination (100 kVp, auto mAs, contrast dose 0.8 mgL/kg), images were reconstructed with HIR (SDCT-HIR). In the second follow-up examination, patients underwent scanning with low dose CT (LDCT) (70 kVp, auto mAs, contrast dose 0.5 mgL/kg), images were reconstructed with HIR (LDCT-HIR) as well as AIIR (LDCT-AIIR). Attenuation values, noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were measured for objective analysis. Subjective image quality was rated by two blinded radiologists using a 5-point scale. The effective radiation dose and CM dosage were also recorded. ResultsThe effective radiation dose (1.58 ± 0.17 mSv vs. 9.96 ± 1.05 mSv, P < 0.001) and CM dosage (34.38 ± 5.43 ml vs. 54.64 ± 8.63 ml, P < 0.001) achieved a remarkable reduction of 84.14% and 37.08% in the LDCT compared to the SDCT. The attenuation was similar among the three reconstructed images (P > 0.05). Compared to LDCT-HIR images, LDCT-AIIR showed a lower noise and higher SNR and CNR. For qualitative analysis, there were no significant differences between the LDCT-AIIR and the SDCT-HIR images among four metrics (P > 0.05). ConclusionsCompared to standard-of-care aortic CTA with HIR, the application of the AIIR algorithm allows for radiation dose and CM dosage reduction while preserving image quality on low dose aortic CTA.

The effects of contrast media on the actin cytoskeleton

Medical images (X-ray, CT, MRI, etc.) of certain tissues show some degree of contrast loss in most imaging techniques. In such cases contrast materials are very good tools to enhance the density and intensity of a vessel, body part, organ, or tissue. Pharmaceutical companies develop safer contrast agents with less side-effects, so the older ionic, high osmolality compounds have been replaced by non-ionic, low osmolality contrast materials. Nowadays, a radiologist can choose from a wide range of contrast agents and use them not only in devices using ionising radiation, but also, for example, in MRI scans with certain paramagnetic properties.

Comparison of low-dose contrast computed tomography angiography findings with surgical results in living kidney donors

Aim: To analyze the image quality and diagnostic performance of CT angiography using low dose (60 ml) contrast medium for living kidney donors and compare with surgical results.&#x0D; Material and Method: Angiographic findings of 81 renal donor candidates in 128-slice MDCT were evaluated by two independent radiologists in terms of renal artery number, early bifurcation, renal vein variations, pelvicalyceal system and ureter variations. Results were compared with intraoperative findings. The image quality, diagnostic performance and interobserver agreement of MDCT obtained with low dose contrast material were analyzed.&#x0D; Results: The mean age of the 81 living kidney donors included in the study was 49±12 (24-68) years. Left nephrectomy was performed in 71% (n=64) and right nephrectomy in 29% (n=17) of the donors. Intraoperative accessory arteries were detected in 22.2% (n:18) of the donors. The specificity, sensitivity, and accuracy for detecting accessory artery variation in MDCT were 100%, 88.9%, and 97.5%, respectively. Early bifurcation was observed in 21% (n=17) of the donors. Specificity, sensitivity and accuracy for early bifurcation detection were 98.4%, 94.1% and 97.5%, respectively. Renal vein variation was detected in 12.3% (n=10) of the donors. Specificity, sensitivity, and accuracy for renal vein variation detection were 100%. Variations of the pelvicalyceal system and ureter were observed in 3.7% (n=3) of the donors. The specificity, sensitivity, and accuracy for detecting pelvicalyceal system and ureteral variations were 100%. Interobserver agreement was excellent in detecting variations of accessory arteries, renal venous anomalies, pelvicalyceal system and ureters by MDCT (kappa: 1,000; p&lt; 0.001). It was higher in early bifurcation detection (kappa: 0.853; p&lt; 0.001).&#x0D; Conclusion: MDCT angiography with a lower dose of iodine contrast at 60 mL in kidney donors is sufficient to detect vascular anomalies and provide anatomical information. It is possible to reduce the contrast agent dose in CTA without affecting the preoperative evaluation.

Оценка зрительных функций и сумеречного зрения у пациентов после имплантации различных видов ИОЛ

Purpose. To compare NCOSIS in the distance, at an average distance and near, twilight vision and sensitivity to blinding in patients after implantation of various IOL models. Materials and methods. Сataract phacoemulsification was performed in 60 patients, Hoya iSert 250 IOL was implanted in Group I, Lentis Comfort IOL was implanted in Group II, Acrysof IQ PanOptix IOL was implanted in Group III. In the postoperative period, twilight vision and sensitivity to bright light were evaluated. Results. The threshold value with a contrast level of 1: 23 and 1: 5 without illumination was achieved in patients of all the studied groups in 100% of cases; with a contrast of 1:2 in 90% of cases in patients of group I, in 80% of cases-in patients of group II and III; with a contrast of 1:2.7 in 60% of groups I and II, in 50% in patients of group III. The threshold value with a contrast level of 1:23 was achieved in patients of all the studied groups in 100% of cases, with a contrast of 1:5 in 100% of cases in patients of groups I and III, in patients of group II in 80% of cases; with a contrast of 1:2.7 with illumination in 80% of patients of group I and 60% of patients of groups II and III; with a contrast of 1:2 and illumination in 50% of patients of group I, 40% of group II and 20% of patients of group III of the study. Conclusion. Under mesopic conditions with high contrast indicators, all three types of IOLs show equally high results of visual quality. In light conditions, monofocal IOL allows you to get a higher quality of vision in low contrast conditions, at high and medium levels, IOL indicators do not differ statistically significantly, with a significantly larger range of vision in bifocal and multifocal IOLs. Key words: cataract phacoemulsification, intraocular lenses, twilight vision.

Diagnostic performance and image quality of low-tube voltage and low-contrast medium dose protocol with hybrid iterative reconstruction for hepatic dynamic CT.

To evaluate the diagnostic performance and image quality of the low-tube voltage and low-contrast medium dose protocol for hepatic dynamic CT. This retrospective study was conducted between January and May 2018. All patients underwent hepatic dynamic CT using one of the two protocols: tube voltage, 80 kVp and contrast dose, 370 mgI/kg with hybrid iterative reconstruction or tube voltage, 120 kVp and contrast dose, 600 mgI/kg with filtered back projection. Two radiologists independently scored lesion conspicuity and image quality. Another radiologist measured the CT numbers of abdominal organs, muscles, and hepatocellular carcinoma (HCC) in each phase. Lesion detectability, HCC diagnostic ability, and image quality of the arterial phase were compared between the two protocols using the non-inferiority test. CT numbers and HCC-to-liver contrast were compared between the protocols using the Mann-Whitney U test. 424 patients (70.5 ± 10.1 years) were evaluated. The 80-kVp protocol showed non-inferiority in lesion detectability and diagnostic ability for HCC (sensitivity, 85.7-89.3%; specificity, 96.3-98.6%) compared with the 120-kVp protocol (sensitivity, 91.0-93.3%; specificity, 93.6-97.3%) (p < 0.001-0.038). The ratio of fair image quality in the 80-kVp protocol also showed non-inferiority compared with that in the 120-kVp protocol in assessments by both readers (p < 0.001). HCC-to-liver contrast showed no significant differences for all phases (p = 0.309-0.705) between the two protocols. The 80-kVp protocol with hybrid iterative reconstruction for hepatic dynamic CT can decrease iodine doses while maintaining diagnostic performance and image quality compared with the 120-kVp protocol. The 80- and 120-kVp protocols showed equivalent hepatic lesion detectability, diagnostic ability for HCC, image quality, and HCC-to-liver contrast.The 80-kVp protocol showed a 38.3% reduction in iodine dose compared with the 120-kVp protocol.

Performance evaluation of using shorter contrast injection and 70 kVp with deep learning image reconstruction for reduced contrast medium dose and radiation dose in coronary CT angiography for children: a pilot study.

Iterative reconstruction algorithms are often used to reduce image noise in low-dose coronary computed tomography angiography (CCTA) but encounter limitations. The newly introduced deep learning image reconstruction (DLIR) algorithm may provide new opportunities. We assessed the image quality and diagnostic performance of DLIR in low radiation dose and contrast medium dose CCTA of pediatric patients with 70 kVp and a shortened injection protocol. This was a prospective study. A total of 27 consecutive arrhythmic pediatric patients were enrolled in the study group and underwent CCTA using a prospective ECG-triggered single-beat protocol: tube voltage 70 kVp, automatic tube current modulation for a noise index (NI) of 22, and contrast dose of 0.4-0.6 mL/kg. Images were reconstructed with DLIR. They were compared with 27 matched patients in the control group scanned with 80 kVp, a lower NI setting (NI =19), and a higher contrast dose (0.8-1.2 mL/kg). The images in the control group were reconstructed using the adaptive statistical iterative reconstruction (ASIR-V) algorithm. The image contrast, image quality, and diagnostic confidence were assessed by 2 experienced radiologists using a 5-point scale (1: nondiagnostic and 5: excellent). The CT value and standard deviation of the aorta and perivascular tissue were measured, and the contrast-to-noise ratio (CNR) for the aorta was calculated. The contrast medium and radiation doses were compared. The study and control groups had similar image contrast scores (4.75±0.57 vs. 4.78±0.42), image quality scores (3.67±0.47 vs. 3.44±0.51), and diagnostic confidence (4.74±0.44 vs. 4.74±0.45) (all P>0.05). There was an adequate enhancement in the aorta (614.74±127.73 vs. 705.89±111.20 HU) and similar CNR (20.34±4.64 vs. 20.99±4.14) in both groups. The image noise of the study group was lower in the aorta (30.61±3.88 vs. 34.77±3.49) and similar in perivascular tissue (27.66±6.24 vs. 27.55±3.33) compared with the control group. The study group reduced the total contrast medium dose by 53% to 15.07±3.68 mL and radiation dose by 36% to 0.57±0.31 mSv. The DLIR algorithm in CCTA for children using 70 kVp tube voltage with a shortened contrast medium injection protocol maintains image quality and diagnostic confidence while significantly reducing contrast medium dose and radiation dose compared with the use of the conventional CCTA protocol.

Strong contrasting diffusivity in general oscillating domains: Homogenization of optimal control problems

The composites of materials with high contrasting properties is an interesting topic to study as it has applications. In this article, we wish to study problems in high oscillating domains, where the oscillatory part is made of two materials with high contrasting conductivities (or diffusivity). Thus the low contrast material acts as near insulation in-between the conducting materials. In the first part, we study the homogenization problem of an elliptic equation. The main discussion in this article is the study of optimal control problems based on the unfolding method. The interesting result is the difference in the limit behavior of the optimal control problem, which crucially depends on the action of the control, whether it is on the conductivity part or insulating part. In both cases, we derive the two-scale limit controls problems which are quite similar as far as analysis is concerned. But, if the controls are acting on the conductive region, a complete scale separation is available, whereas a complete separation is not visible in the insulating case due to the intrinsic nature of the problem. In this case, to obtain the limit optimal control problem in the macro scale, two cross-sectional cell problems are introduced. We do obtain the homogenized equation for the state, but the two-scale cost functional remains as it is.

Effects of tube voltage and iodine contrast medium on radiation dose of whole-body CT

Background The low-tube-voltage scan generally needs a higher tube current than the conventional 120 kVp to maintain the image noise. In addition, the low-tube-voltage scan increases the photoelectric effect, which increases the radiation absorption in organs. Purpose To compare the organ radiation dose caused by iodine contrast medium between low tube voltage with low contrast medium and that of conventional 120-kVp protocol with standard contrast medium. Material and Methods After the propensity-matching analysis, 66 patients were enrolled including 33 patients with 120 kVp and 600 mgI/kg and 33 patients with 80 kVp and 300 mgI/kg (50% iodine reduction). The pre- and post-contrast phases were assessed in all patients. The Monte Carlo simulation tool was used to simulate the radiation dose. The computed tomography (CT) numbers for 10 organs and the organ doses were measured. The organ doses were normalized by the volume CT dose index, and the 120-kVp protocol was compared with the 80-kVp protocol. Results On contrast-enhanced CT, there were no significant differences in the mean CT numbers of the organs between 80-kVp and 120-kVp protocols except for the pancreas, kidneys, and small intestine. The normalized organ doses at 80 kVp were significantly lower than those of 120 kVp in all organs (e.g. liver, 1.6 vs. 1.9; pancreas, 1.5 vs. 1.8; spleen, 1.7 vs. 2.0) on contrast-enhanced CT. Conclusion The low tube voltage with low-contrast-medium protocol significantly reduces organ doses at the same volume CT dose index setting compared with conventional 120-kVp protocol with standard contrast medium on contrast-enhanced CT.

CTMS in the study of post-EVAR endoleak in the treatment of aneurysmal dilations

Computed tomography angiography (CTA) has been widely used in diagnostic evaluation of many aortic diseases, butthere are not standardized techniques for aortic CTA. The purpose of this study is to compare two methods: biphasictechnique and split bolus. A 64-slice CT scanner has been use.There were a total of 28 patients involved in the study.The patients have been divided in two groups:- Group A: 18 patients- Group B: 10 patientsThe biphasic technique has been used on 18 patients in group A. In this protocol was used a low dose acquisitionwithout contrast medium (CM) and two contrastographic phases with CM.The split bolus technique was performed on 10 patients of group B. 120-140 ml of CM are divided in two boluses. Thefirst bolus of 55-90 ml of CM was injected at a flow of 1,5-2 ml/s, followed by 20ml of physiological solution at a flowof 1,5-2ml/s. After physiological solution the second bolus of 35-60 ml was injected at a flow of 3,5ml/s followed by20ml of Nacl at a flow of 3,5ml/s.In group A 6 patients had endoleak type I, n=2 endoleak type II, n=8 endoleak type III, n=2 endoleak type IV. (doseof 43.2 mSv).In group B 2 patients had endoleak type I, n= 4 endoleak type II, n=3 endoleak type III and n=1 endoleak type IV.(dose of 16,39 mSv).The biphasic technique has high spatial resolution and contrast resolution, reduction of acquisition times and reduction of artifacts, but an unacceptable a great amount of radiation is involvedThe split bolus technique provides results comparable to the biphasic technique but with a lower dose of radiation.

Feasibility of combined ECG-Gated and Helical acquisition mode in a pre-TAVI computed tomography angiography protocol using a fixed low-volume contrast medium injection

BackgroundTo investigate the feasibility, image quality, and clinical implications of a combined ECG-gated and helical acquisition mode in a computed tomography angiography (CTA) protocol in patients scheduled for transcatheter aortic valve implantation (TAVI) using a fixed, low-volume, contrast medium injection. MethodsBetween July and October 2019, 43 TAVI candidates underwent investigation with CTA using a 64-slice CT scanner. Images obtained were prospectively evaluated. 65 mL of low iodine dose contrast medium (CM), followed by 25 mL of saline, were administered using a fixed multiphasic injection protocol in all patients. Patients were divided into three groups based on BMI: Group 1 (n = 9) with BMI < 22 kg/m2; Group 2 (n = 22) with BMI 22−29 kg/m2; Group 3 (n = 12) with BMI > 29 kg/m2. Images were evaluated for image quality, vessel attenuation (HU), Signal-to-Noise Ratio (SNR), Contrast-to-Noise Ratio (CNR) and estimated radiation dose. Image quality of the aortic root and iliac-femoral vessels was diagnostic in all patients. ResultsVascular attenuation was > 200 HU and CNR > 3 at all vessel levels. ConclusionData from our study suggest that it is possible to image the aortic annulus and aorto-iliac anatomy and obtain high image quality in all patients by using a combined ECG-gated and helical acquisition mode in a computed tomography angiography (CTA) protocol with a fixed low-volume contrast medium injection (65 mL). This allows for accurate CT measurements of the aortic annulus, recruitment of patients for TAVI and facilitates pre-procedural planning in these high surgical risk patients.