Low Content Group Research Articles

Prognostic significance of collagen content in solitary fibrous tumors of the central nervous system

PurposeWe aimed to explore the prognostic significance of collagen content in solitary fibrous tumors (SFTs) of the central nervous system (CNS) and preliminarily investigate its relationship with magnetic resonance imaging (MRI) features of SFTs.MethodsCollagen content was identified using Masson’s trichrome staining, and quantitatively assessed. Radiomic methods were applied to extract quantitative MRI features of SFTs, which were then analyzed in relation to collagen content.ResultsThe collagen content in CNS SFTs was categorized into high- and low-content groups, with a cutoff value of 6%. Survival analysis indicated a positive correlation between collagen content and overall survival (OS). In multivariate Cox regression analysis, incorporating factors such as mitosis, necrosis, Ki67, and collagen content and other indicators, collagen content emerged as an independent prognostic factor. Collagen content demonstrated a negative correlation with tumor histological phenotype, Ki67, WHO grade, mitosis, necrosis, and brain invasion. Additionally, the signal intensity of SFTs on T2-weighted imaging (T2WI) decreased with increasing collagen content. Radiomics analysis identified 1,702 features from each patient’s region of interest, with 12 features showing significant differences between the high and low collagen content groups. Among the quantitative parameters and radiomic models, the combined T1- and T2WI models exhibited the highest diagnostic performance.ConclusionThese findings suggest that collagen content is an independent prognostic risk factor for OS. Furthermore, combined radiomic models based on T1-and T2WI sequences may offer a more comprehensive, objective, and accurate assessment of collagen content in CNS SFTs.

Critical evaluation of YouTube videos regarding the all-on-4 dental implant treatment concept: A content-quality analysis

Statement of problemRehabilitation of complete edentulous arches by using the all-on-4 dental implant treatment concept is a well-established procedure. Considering the popularity of YouTube as a source for health-related information, a thorough investigation of the content-quality and reliability of videos regarding the all-on-4 concept is lacking. PurposeThe purpose of this cross-sectional analysis was to critically appraise the content-quality and reliability of YouTube videos regarding the all-on-4 dental implant treatment concept as a source of information for patients, students, and dentists. Material and methodsA comprehensive search was performed on the YouTube website using the specific keyword “All-on-4,” which was identified as the most appropriate search term by the Google Trends website. Only English language videos regarding the all-on-4 dental implant treatment concept were included for systematic analyses. Following the eligibility criteria, the included videos were assessed for their demographic characteristics and quality-content. Based on the content score, the videos were categorized as low content (LC) and moderate + high content (MHC) groups. Further, qualitative analyses were performed by using the DISCERN tool and a global quality (GQ) scale. Statistical analyses were conducted by using the Mann-Whitney U test and the Spearman correlation analysis (α=.05). ResultsOf 250 screened videos, only 73 were eligible for final analyses. The included videos presented an average 123 846 (range, 4 to 3 182 404) views with a mean duration of 528 (range, 12 to 1699) seconds. In addition, the average number of likes was 1122 (range, 0 to 3300), but, remarkably, none of the included videos received any dislikes. Overall, the mean content-quality score was 6.2 ±3.8, thus indicating low-quality content. The average DISCERN and GQ scores were 47.73 ±9.94 and 3.41 ±0.95, with the Spearman rank correlation test showing a strong positive correlation (r=.732; P<.001) among the total obtained scores. Moreover, statistically significant differences were reported between the LC and MHC groups for both DISCERN and GQ scores (P<.001). ConclusionsThe reliability of YouTube videos regarding the all-on-4 dental implant treatment concept is questionable, as they exhibit poor content-quality, thus making them an unreliable source for patients, students, and dentists seeking accurate information.

Analyzing biomimetic dentistry YouTube videos' quality and content

Aim: This study evaluated the quality and content of YouTube videos about biomimetic dentistry. Methodology: A keyword search for "biomimetic dentistry" was conducted on YouTube. It used only publicly available Internet data from searching YouTube with the default filter “Biomimetic Dentistry” on April 3, 2023. Of the 200 examined videos, only 91 fit the inclusion criteria; those 91 videos underwent a content quality evaluation. The videos' viewing rates were determined after their demographic characteristics were assessed. The information quality index (VIQI) and the Global Quality Scale (GQS) were used to evaluate the video quality. For the statistical analysis, the Shapiro–Wilk, Kruskal–Wallis, Mann–Whitney U, Chi-square, and Fisher's exact tests were used. Results: Most of the videos (n = 59) were labeled "low content," and healthcare practitioners uploaded the majority (91.2%) of them to YouTube. The most discussed subject was advantages and disadvantages (87.9%), followed by the definition of biomimetic dentistry (76.9%). The high-content video group's GQS and VIQI scores were significantly higher than low-content group. There was a statistically significant positive correlation between the VIQI and GQS (p &lt; 0.05) (p = 0,001) and a positive correlation between the overall content, total VIQI, and total GQS scores. Conclusion: The material in YouTube videos about biomimetic dentistry is insufficient for use as a patient information tool. Biomimetic dentistry-related YouTube videos' quality and content were typically poor. Health practitioners should be aware of the content of video-sharing platforms and take responsibility for enriching video content. How to cite this article: Erdem Hepşenoğlu Y, Değirmencioğlu D, Topbaş C. Analyzing biomimetic dentistry YouTube videos' quality and content. Int Dent Res 2023;13(S1):44-49. https://doi.org/10.5577/idr.2023.vol13.s1.7 Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

Does YouTube provide adequate information about orthodontic pain?

To evaluate the content and quality of information about orthodontic pain on YouTube. YouTube was searched using the keywords "orthodontic pain" and "brace pain." A total of 65 videos were chosen for the final analysis. Videos were classified into high- and low-content groups using an eight-point scoring system and reviewed according to selected orthodontic pain-related topics. Video quality was rated by the Video Information and Quality Index (VIQI) and Global Quality Scale (GQS). Statistical data analysis was performed using SPSS 28.0 software, Mann-Whitney U-tests, χ2 tests, and Spearman correlation coefficients. Most YouTube videos related to orthodontic pain were low content (86.2%), and a few were high content (13.8%). Pharmacological pain relief was the most prevalent topic (50.8%), followed by duration of pain (32.3%) and influence of pain on patient quality of life (29.2%). The least-mentioned topic was possible location of pain (7.7%). Most of the videos were uploaded by laypeople (64.6%). Videos uploaded by dental professionals had significantly higher means of GQS scores (P = .035), flow of information (P < .001), information quality (P = .008), and total VIQI (P < .001). Compared with low-content, high-content videos had a higher mean of flow of information (P = .037). There was a weak correlation between total content and GQS scores and a strong correlation between GQS and VIQI scores (r = 0.740; P < .01). Overall, YouTube was found to be an inadequate source of information on orthodontic pain.

Assessment of the content and quality of YouTube videos related zygomatic implants: A content-quality analysis.

This study aimed to evaluate the content and quality of YouTube videos of zygomatic implants. According to Google Trends (2021), "zygomatic implant" was the most preferred keyword related to the topic. Therefore, in this study "zygomatic implant" was used as a keyword for the video search. Demographic characteristics such as the number of views, likes/dislikes, comments, video duration, number of days after upload, uploaders, and target audiences of the videos were evaluated. To evaluate the accuracy and content quality of videos (available from YouTube), the video information and quality index (VIQI) and global quality scale (GQS) were used. Statistical analyses were performed using the Kruskal-Wallis test, Mann-Whitney U test, chi-square test, Fisher's exact chi-square test, Yates continuity correction, and Spearman correlation analysis (p < 0.05). A total of 151 videos were searched; 90 met all inclusion criteria. According to the video content score, 78.9% of the videos were identified as low content, 20% as moderate, and 1.1% as high content. There was no statistical difference between the groups in video demographic characteristics (p> 0.001). Conversely, information flow, accuracy of information, video quality and precision, and total VIQI scores were statistically different between the groups. The moderate-content group had a higher GQS score than the low-content group (p < 0.001). The videos were mainly uploaded (40%) from hospitals and universities. Most videos were targeted toward professionals (46.75%). Low-content videos had higher ratings than the moderate- and high-content videos. Most YouTube videos on zygomatic implants showed low-content quality. This implies that YouTube is not a reliable source of information on zygomatic implants. Dentists, prosthodontists, and oral and maxillofacial surgeons should be aware of the content of video-sharing platforms and take responsibility for enriching video content.

Association Between Mitochondrial DNA Copy Number and Head and Neck Squamous Cell Carcinoma: A Systematic Review and Dose-Response Meta-Analysis

BackgroundThe association between mitochondrial DNA (mtDNA) copy number and head and neck squamous cell carcinoma (HNSCC) risk remains unclear. Therefore, we aimed to evaluate the relationship between mtDNA copy number and HNSCC risk.Material/MethodsWe searched PubMed, Web of Science, and EMBASE until August 2020. Studies that assessed the association between mtDNA copy number and HNSCC as the outcome of interest were included. We performed a 2-class and dose-response meta-analysis to assess the association between cancer risk and mtDNA.ResultsEight articles (2 cohort studies and 6 case-control studies) with a total of 3913 patients were included in our meta-analysis. The overall results showed that mean mtDNA copy number level from 9 studies was 0.71 higher in patients with cancer than in non-cancer controls (the standardized mean differences (SMD) 0.71, 95% CI: 0.28–1.15, P<0.001). However, when 4 studies were pooled by dichotomizing mtDNA copy number at the median value into high- and low-content groups, no significant association between mtDNA content and overall cancer risk was found (odds ratio (OR)=0.87, 95% CI: 0.52–1.44, P=0.584). Furthermore, we observed a non-linear association from 3 studies between increased mtDNA copy number levels (P for nonlinearity <0.001).ConclusionsThe elevated mtDNA copy number could predict the risk of HNSCC as a biomarker. Moreover, there was non-linear relationship of risk between HNSCC and mtDNA copy number.

Quality and Content of YouTubeTM Videos Related to Sinus Lift Surgery

ObjectiveIn the interest of supplying medical information to YouTubeTM videos, this study aimed to assess the quality and content of the information provided that is related to sinus lift surgery. MethodsIn this cross-sectional study, YouTubeTM videos were searched using the search term “sinus lift surgery”. The first 140 videos were reviewed and analyzed by two independent researchers, after which 103 of them were included in the study. A 13-point scale was used to classify the videos by low- and high-content. Each video was evaluated on content quality using the video information and quality index (VIQI). ResultsNinety-four (94.28%) and nine (8.72%) videos were included in the high-content and low-content groups, respectively. The high-content video group covered more topics than the low-content group, such as the definition of the procedure, its contraindications and advantages, and what to expect after the surgery (P < 0.05). The total VIQI scores of the high-score group were significantly higher than those of the low-score group. There was a positively strong correlation between total content score and VIQI (r = 0.777, P < 0.05). ConclusionThe quantity and quality of the YouTubeTM videos that feature sinus lift surgery are limited for professionals but may be sufficient for patients and non-specialist health care providers. Medical professionals, such as periodontists and oral surgeons, should play more of an active role in providing high-quality information by directing patients toward alternative sources that more clearly explain their surgeries.