Low Category Research Articles

Association of physical activity and screen time with cardiovascular disease risk in the Adolescent Brain Cognitive Development Study.

According to the Physical Activity Guidelines Advisory Committee Scientific Report, limited evidence is available on sedentary behaviors (screen time) and their joint associations with physical activity (steps) for cardiovascular health in adolescence. The objective of this study was to identify joint associations of screen time and physical activity categories with cardiovascular disease (CVD) risk factors (blood pressure, hemoglobin A1c, cholesterol) in adolescence. This study analyzed data from the Adolescent Brain Cognitive Development (ABCD) Study, comprising a diverse sample of 4,718 U.S. adolescents aged 10-15 years between 2018 and 2021. Steps were measured by a Fitbit wearable device and levels were categorized as low (1,000-6,000), medium (> 6,000-12,000), and high (> 12,000) averaged daily step counts. Self-reported recreational screen time hours per day were classified as low (0-4), medium (> 4-8), and high (> 8) hours per day. CVD risk factors including blood pressure, hemoglobin A1c, and cholesterol (total and HDL) were measured. The analytical sample averaged 6.6h of screen time per day and 9,722 steps per day. In models including both screen time and steps, the high screen time category was associated with a 4.27 higher diastolic blood pressure percentile (95% CI 1.83-6.73) and lower HDL cholesterol (B= -2.85, 95% CI -4.77 to -0.94mg/dL) compared to the low screen time category. Medium (B = 3.68, 95% CI 1.24-6.11) and low (B = 7.64, 95% CI 4.07-11.20) step categories were associated with higher diastolic blood pressure percentile compared to the high step category. The medium step category was associated with lower HDL cholesterol (B= -1.99, 95% CI -3.80 to -0.19mg/dL) compared to the high step category. Findings were similar when screen time and step counts were analyzed as continuous variables; higher continuous step count was additionally associated with lower total cholesterol (mg/dL). Combinations of low screen time and high steps were generally associated with favorable cardiovascular health markers including lower diastolic blood pressure and higher HDL cholesterol, which can inform future adolescent health guidelines.

Achievement of Physical Education Learning Results Based on Gender Review and Learning Motivation on High School Students in the Yogyakarta Region, Indonesia

This research aims to examine differences in Physical Education (PE) learning outcomes for high school students based on gender and learning motivation. The sample in this research was 84 high school students in Yogyakarta and was taken using a simple random sampling system. Data analysis used descriptive statistics and inferential factorial two-way anova. The mean score for male students in the low learning motivation category was 86.29 and female students in the low learning motivation category was 83.71. The mean score for male students in the moderate learning motivation category was 83.21 and female students in the moderate learning motivation category was 84.14. The mean score for male students in the high learning motivation category is 85.64 and female students in the high learning motivation category is 82.64. The results of the Anova test on the learning motivation factor variable value Sig. 0.42 < 0.05 means that there is a significant difference or influence between students' learning motivation (low, medium and high) on PE learning outcomes. In the gender factor variable, the Sig. value 0.001 < 0.05 means that there is a significant difference or influence between gender (male and female) on PE learning achievement. Next, on the variables of learning motivation and gender, the Sig. value 0.000 < 0.05 means that there is an influence or interaction between learning motivation factors and gender on students' PE learning outcomes. The conclusion is that PE design needs to take into account the specifics of gender and type of sport. This is so that male and female students have the right to exercise according to their portion in order to benefit from the PE program at school. Apart from that, it is also to provide maximum enjoyment and achievement for students in various games and sports activities in PE without any pressure. The conclusion is that motivational factors and gender significantly interact and influence students' PE learning outcomes. Therefore, it is important for teachers to consider these two factors in designing and implementing effective PE learning, paying special attention to the specific needs and conditions of each student based on their respective learning motivation and gender. Keywords: Achievement, Learning Results, Physical Education, Students, Gender, Learning Motivation

청소년 어머니의 정서지능 기반 부모교육 참여경험 내러티브 탐구

Objectives This study was conducted to explore in-depth the actual participation experience of a mother with adolescents participating in emotional intelligence-based parent education and the meaning of the experiences. Methods To this end, emotional intelligence-based parent education was conducted from September to November 2023, and data were collected through face-to-face interviews three times by selecting one parent participant with adolescents. It was analyzed in the three-dimensional narrative inquiry’s space proposed by Clandinin & Connelly(2000) to interpret vivid experiences and their meanings in the context of the participant's life stories naturally and spontaneously. Results There were 3 experience domains and 1 semantic domains and 15 lower categories. The first domain were ‘desperate desire to become an expert and be comfortable from a empty heart’ as the motivation. The sec-ond domain were ‘I'm afraid I'm going to be hurt’, ‘I'm desperate to fill my childhood parent position’, ‘the moment when a spark bursts while doing my best to play the role of a parent’, ‘mother constantly cracking down on me for fear of being told that I raised my child wrong’, ‘I'm living a hard life without a break and collapsing because of my emotions,’ and ‘I pretend to be okay outside and I'm acting like a comedian.’ The third domain were ‘the joy of warm support and care toward me’, ‘the courage to experience deep inner fears’, and ‘the person who grows into true self-understanding’. Conclusions In the process of recognizing and understanding oneself, who unilaterally controlled and demanded change in relationships with children, it led to inner growth. The meaning of the participation experience in emo-tional intelligence parental education became an inflection point not only for the relationship with the children but also for the change in one's own growth through true meeting with oneself.

Physical training and external load management for young athletes

Football today is more intense and demanding than ever before and these increasing physical demands have a direct impact on grassroots players, leading to ever greater interest in determining the external load variables using GPS in lower categories. The objective of this study is to observe and analyse the mean figures for the variables Distance(m), High Acc(m) and High Dec(m), HSR Abs(m), HMLD(m) and MAX Speed (km·h-1) per player aged 15, 16 and 17 based on their position in a competitive match. We also aim to determine if U16 players are able to compete in a U17 and U18 category team. A total of 57 male players, between 15 and 17 years old, participated in the study, divided by team corresponding to their age, and members of farm teams of a professional football club in the Community of Madrid. The results obtained for the mentioned variables show that some players could play at a higher category, specifically U16 Centre-Backs and Forwards and U17 Wing-Backs, Midfielders and Wingers. However, it must be noted that these results may be influenced by factors such as biological age of the players, the minutes of play, the style of play, the rival in the match, the pitch conditions and weather. Keywords: Grassroots Football, External Load, GPS, Distance(m), High Acc(m)/Dec(m), HSR Abs(m), HMLD(m), MAX Speed(km·h-1)

The landscape of liver transplantation for patients with Alcohol-associated liver disease in USA.

Indications for liver transplants have expanded to include patients with alcohol-associated liver disease (ALD) over the last decade. Concurrently, the liver allocation policy was updated in February 2020 replacing the Donor Service Area with Acuity Circles (AC). The aim is to compare the transplantation rate, waitlist outcomes, and post-transplant survival of candidates with ALD to non-ALD and assess differences in that effect after the implementation of the AC policy. Scientific Registry for Transplant Recipients data for adult liver transplant (LT) candidates was reviewed from the post-AC era (2/4/2020 - 3/1/2022) and compared with an equivalent length of time before AC were implemented. The adjusted transplant rates were significantly higher for those with ALD pre-AC, and this difference increased after AC implementation (transplant rate ratio comparing ALD to non-ALD=1.20, 1.13, 1.61, and 1.32 for MELD categories 37-40, 33-36, 29-32, 25-28, respectively, in the post-AC era, p <0.05 for all). The adjusted likelihood of death/removal from the waitlist was lower for ALD patients across all lower MELD categories (aSHR=0.70, 0.81, 0.84, 0.70 for MELD categories at list 25-28, 20-24, 15-19, 6-14, respectively, p <0.05). Adjusted post-transplant survival was better for those with ALD (aHR=0.81, p <0.05). Waiting list and post-transplant mortality tended to improve more for those with ALD since the implementation of AC but not significantly. ALD is a growing indication for liver transplantation. Although ALD patients continue to have excellent post-transplant outcomes and lower wait list mortality, candidates with ALD have higher adjusted transplant rates, and these differences have increased after AC implementation.

Morphologic patterns observed in prostate biopsy cases with discrepant grade group and molecular risk classification.

Molecular-based risk classifier tests are increasingly being utilized by urologists and radiation oncologists to guide clinical decision making. The Decipher prostate biopsy test is a 22-gene RNA biomarker assay designed to predict likelihood of high-grade disease at radical prostatectomy and risk of metastasis and mortality. The test provides a risk category of low, intermediate, or high. We investigated histologic features of biopsies in which the Grade Group (GG) and Decipher risk category (molecular risk) were discrepant. Our institutional urologic outcomes database was searched for men who underwent prostate biopsies with subsequent Decipher testing from 2016 to 2020. We defined discrepant GG and molecular risk as either GG1-2 with high Decipher risk category or GG ≥ 3 with low Decipher risk category. The biopsy slide on which Decipher testing was performed was re-reviewed for GG and various histologic features, including % Gleason pattern 4, types of Gleason pattern 4 and 5, other "high risk" features (e.g., complex papillary, ductal carcinoma, intraductal carcinoma [IDC]), and other unusual and often "difficult to grade" patterns (e.g., atrophic carcinoma, mucin rupture, pseudohyperplastic carcinoma, collagenous fibroplasia, foamy gland carcinoma, carcinoma with basal cell marker expression, carcinoma with prominent vacuoles, and stromal reaction). Follow-up data was also obtained from the electronic medical record. Of 178 men who underwent prostate biopsies and had Decipher testing performed, 41 (23%) had discrepant GG and molecular risk. Slides were available for review for 33/41 (80%). Of these 33 patients, 23 (70%) had GG1-2 (GG1 n = 5, GG2 n = 18) with high Decipher risk, and 10 (30%) had GG ≥ 3 with low Decipher risk. Of the 5 GG1 cases, one case was considered GG2 on re-review; no other high risk features were identified but each case showed at least one of the following "difficult to grade" patterns: 3 atrophic carcinoma, 1 collagenous fibroplasia, 1 carcinoma with mucin rupture, and 1 carcinoma with basal cell marker expression. Of the 18 GG2 high Decipher risk cases, 2 showed GG3 on re-review, 5 showed large cribriform and/or other high risk features, and 10 showed a "difficult to grade" pattern. Of the 10 GG ≥ 3 low Decipher risk cases, 5 had known high risk features including 2 with large cribriform, 1 with IDC, and 1 with Gleason pattern 5. In GG1-2 high Decipher risk cases, difficult to grade patterns were frequently seen in the absence of other known high risk morphologic features; whether these constitute true high risk cases requires further study. In the GG ≥ 3 low Decipher risk cases, aggressive histologic patterns such as large cribriform and IDC were observed in half (50%) of cases; therefore, the molecular classifier may not capture all high risk histologic patterns.

Training Impact Assessment: Evaluating PAMETI's Programs for Punjab's Extension Personnel

The study was undertaken with the objective of finding the level of effectiveness of the training programmes for extension personnel. The sample consists of trainees from various competency development training programmes organised by Punjab Agricultural Management and Extension Training Institute (PAMETI) in 2017–2018. In total 5 trainings and 24 trainees from each trainings were selected by purposive and random sampling respectively. Thus, a sample of 120 trainees from PAMETI, Ludhiana were taken for the study. Most of the trainees belonged to the high category of ‘applicability and utility’, ‘knowledge, attitude and skill’ and conviction of the training programmes whereas most belonged to medium category of relevance, timeliness and ‘improvement in job performance and satisfaction’ of training programmes. It was found that average training effectiveness index is highest for applicability and utility of the training programmes whereas lowest for job performance and satisfaction. Most of the trainees perceived to lie in the medium category of the overall training effectiveness index followed by high and low category.

Assessment of hydrological baseline condition and its alteration in Athabasca River Basin, Canada

Study regionAthabasca River Basin (ARB), Canada. Study focusThis study aimed to characterize the flow regime of the ARB, a basin with diverse hydroclimatic and geological characteristics. Forty-two different flow indicators from the Indicators of Hydrological Alteration (IHA) and Cold regions Hydrological Indicators of Change (CHIC) were employed. The natural range of these indicators was established for the baseline period (1961–1990), and subsequent alterations during the recent period (1991–2020) were systematically examined. Principal Component Analysis (PCA) was applied to identify pivotal indicators shaping the basin's flow regime. In addition, trends of key indicators were examined at eight distinct locations within the basin. New hydrological insights for the study regionThe findings indicate spatiotemporal variation between the basin's upper and lower parts. The upstream region exhibited an earlier peak flow (9 days), an earlier ice break-up (17 days), and a shorter ice cover duration (22 days) compared to the downstream region. Increased winter and spring flow have led to an augmentation of annual flow by 3.8 % in the upper region. In contrast, downstream flow experienced a decline throughout the year (11.38 %), which was found to be statistically significant at a rate of 3.24 m3/s/year. Alteration analysis revealed a shift toward the 'low category' (below their defined baseline range) for most indicators in the recent period, underscoring a transition towards a diminishing flow regime, with an overall alteration ranging at low to moderate levels (19–38 %). Late summer flow reduction (8–25 %) can have critical implications, given the rising water demand in the basin. The study identified eleven key indicators encapsulating the basin's flow regime variability range. It was found that ice cover, its break-up, and spring freshet significantly influence the flow regime of the basin. The findings from this study will assist decision-makers in making more informed decisions for the holistic management of water resources in the basin.

Impact of bariatric surgery on maternal gestational weight gain and pregnancy outcomes in women with obesity: A population-based cohort study from Qatar.

Bariatric surgery is performed in obese women of reproductive age to help achieve a healthy prepregnancy weight to reduce the complications associated with obesity in pregnancy. However, these procedures can impact maternal nutrition and gestational weight gain (GWG). This study evaluates the maternal and neonatal outcomes in women with prepregnancy bariatric surgery and determines the impact on GWG. This study included 24 weeks gestation or more pregnancies, with a maternal BMI at delivery of 30 kg/m2 or more. It was categorized into two groups based on whether they had prepregnancy bariatric surgery (exposed) or not (unexposed). The outcomes included gestational diabetes (GDM), gestational hypertension (GHT), mode of delivery, preterm birth (PTB), GWG, birthweight (BW) and customized BW centiles, low birthweight (LBW), congenital anomalies, and admission to the neonatal intensive unit (NICU). Categorization was also done based on the adequacy of GWG (low, adequate, and excess). A total of 8,323 women were included in the study, 194 of whom had prepregnancy bariatric surgery. After adjusting for confounders, the exposed group had a mean GWG 1.33 kg higher than the unexposed group (95% CI 0.55-2.13, p=0.001). The exposed group had higher odds of PTB (aOR 1.78, 95% CI 1.16-2.74, p=0.008), CD (aOR 6.52, 95% CI 4.28-9.93, p<0.001), LBW in term babies (aOR 2.60, 95% CI 1.34-5.03, p=0.005), congenital anomalies (aOR 2.64, 95% CI 1.21-5.77, p=0.015), low APGAR score (aOR 3.75, 95% CI 1.12-12.5, p=0.032) and 80.4g lesser birthweight (95% CI -153.0, -5.8; p=0.034). More women in the low GWG category had LBW babies (28.6% versus 6.7% in the high GWG group, p=0.033), lowest mean BW and median BW centiles (2775 grams versus 3289 grams in the high GWG group, p=0.004 and 57.5% versus 74.5% in the high GWG group, p=0.040, respectively). The findings of this study highlight differences in perinatal outcomes such as preterm birth, low birth weight, congenital anomalies, cesarean deliveries, and gestational weight gain between post-bariatric women and controls. These insights can help inform the planning and provision of appropriate maternity care to enhance patient safety and outcomes. The results of this study can also guide the counseling of reproductive age-group women who are planning to undergo bariatric surgery.

Mastery concepts and misconceptions in biotechnology courses with a three tier diagnostic test

This research aims to determine the mastery of concepts and misconceptions of students in the Biology Education Study Program wich is in Pekanbaru. This type of research is survey research with a porpusive sampling type. The population of the study was all students who had taken biotechnology courses, while the research sample was 6th semester students who had just completed biotechnology courses in the previous semester. The total research sample was 32 students. The instrument used to measure mastery of concepts and misconceptions is a diagnostic test with 20 multiple choice questions accompanied by reasons and level of belief. The questions are given using a Google form and students work on the questions during class and are given 90 minutes.The research data were analyzed descriptively. Based on the results showed that for indicator 1 30.01% of students understood the basic concepts of biotechnology well and 55.63 had misconceptions. In indicator 2, only 5% of students understood the concept of biotechnology process while 64.38% had misconceptions and 29.38 did not understand the concept. Indicator 3, as many as 10.63% of students understand the concept of conventional and modern biotechnology characteristics and 59.38% of students have misconceptions and 25.63% do not understand the concept while indicator 4 as many as 30.63% of students understand the examples of biotechnology products while still 43.13% have misconceptions and 22.50% still do not understand the concept. Students' mastery of concepts in biotechnology courses is in a very low category and while more than half of the students still experience misconceptions and do not understand the concepts.

Kompetensi Literasi Digital Mahasiswa Program Studi Pendidikan Geografi FKIP Universitas Lambung Mangkurat

The development of science and technology (IPTEK) which is very massive has a very broad influence on all aspects of human life. One of them is education and teaching that can facilitate the exchange of information so that it is not bound by space and time. This is of course very useful, especially for students, groups who always need information as reference material for their daily assignments. Therefore, students really need information literacy skills, to support the lectures they follow. There are several models used to measure a person's literacy ability, one of which is the Empowering 8 model, where this model was produced from a workshop conducted in Sri Lanka in 2004. The purpose of this study was to analyze the digital literacy competence of students of the geography education study program, FKIP Lambung Mangkurat University. This study uses a descriptive method with a quantitative approach. Based on the results of research that has been carried out, digital digital literacy students of geography education FKIP Lambung Mangkurat University are at a good or mastered level. Where from the respondents' answers, 17% were very dominant, 71% controlled, 11% did not master, and 1% did not master. Respondents who are very mastering, not mastering, and very not mastering are in the low category, respondents who are mastering are in the high category.

PSI-9 Relationship of body condition measures and boar reproductive performance

Abstract In the swine industry, boar nutritional requirements are not well characterized; thus, boars are typically fed to maintain a specific body condition score (BCS). Assessing body condition with subjective scoring can lead to over or underfeeding, which may have repercussions on sperm production and(or) quality. There are objective tools to assess body condition in live boars, like backfat (BF) thickness measured with real-time ultrasound, the Knauer caliper, and flank-to-flank (F2F) length. The relationship of sperm production and quality with BCS has not been reported in modern genetics and modern boar studs. The purpose of this study was to evaluate the relationship of body condition measures with boar reproductive performance. Data collected in March 2023 on commercial boars (n = 147) included a BCS ranging from 2.25 to 3.5, ultrasound backfat (13.7 ± 4.37 mm) performed by a trained technician, body weight (BW; 222 ± 30.2 kg) estimated using heart girth and body length from poll to tailhead, F2F length (106.03 ± 5.94 cm) and Knauer caliper score (17.5 ± 2.37). Additional variables considered were boar genetic line, age, and collection frequency. Sperm production data (total motility, 92.1 ± 7.22%; concentration, 36.7 ± 12.10 mil/mL; ejaculate volume, 231.1 ± 73.72 mL; normal cells, 83.4 ± 11.27%) were obtained from the six collections immediately prior to body condition evaluation. Data were evaluated with the glmmTMB package of R Statistical Software using a generalized linear mixed model. There were no significant relationships between motility or ejaculate volume and boar body condition. Backfat depth was related to percentage of normal cells (P = 0.029) and inversely related to sperm concentration (P = 0.035). There was a tendency for boars with greater F2F to have greater sperm concentration (P = 0.090). Generally, the percentage of normal cells decreased with increasing BCS, though due to the low number of observations in the lower categories, only BCS 3.25 and BCS 3.5 boars were found to have a significant relationship with the trait (P = 0.004 and P = 0.022, respectively). Caliper measure was not related with any sperm parameters. While accessible tools are necessary for consistent management of boars, BF thickness measured by ultrasound was the only objective tool in this study with a significant relationship to any sperm parameters assessed. Measuring BF with ultrasound may not be practical for everyday use. More research should be done to further assess body condition measurements, objective measuring tools, and boar sperm production.

THE INFLUENCE OF TEACHER COMPETENCY ON STUDENT LEARNING ACHIEVEMENT (SURVEY ON ECONOMICS SUBJECT CLASS XII MA MA'ARIF NU CIMANGGU CILACAP DISTRICT )

The objectives of this study were: 1) To determine the competence of class XII economic teachers at MA Ma'Arif NU Cimanggu, 2) To determine the learning achievement of economic subjects in class XII at MA Ma'Arif NU Cimanggu, 3) To determine the effect of competence teachers towards student achievement in class XII in economic subjects at MA Ma'Arif NU Cimanggu.This type of research used in this research is quantitative research. The method used is a survey method. The techniques used to carry out the analysis using simple regression techniques, From the results of the study, the following conclusions were obtained: (1) The category of economic teacher competence at MA Ma'Arif NU Cimanggu, Cilacap Regency which was in the low category was 2 respondents or 15.4%, in the moderate category as many as 10 respondents or 76.9 % and in the high category as much as 1 respondent or equal to 7.7%. (2) The descriptive results of determining the predicate of the value of the 13 respondents obtained the results: 1 or 7.7% of the students got the very good category, as many as 4 or as much as 30 , 7% of students scored in the good category, as many as 8 or 61.6% of students scored in the sufficient category and there were no students who scored in the poor predicate. (3) There was an influence between the competence of economic teachers on learning achievement in economic subjects with a significance value of 0.000. The regression equation can be written: Y = 28,448 + 1,072X. The R value or the correlation value between variables is 0.469 or 46.9%. Meanwhile, the R Square value of 0.355 implies that the effect of economic teacher competence on learning achievement in economic subjects in class XII MA Ma'arif Cimanggu, Cilacap Regency is 35.5%. Keywords: Teacher Competence, Learning Achievement, Economics Subjects

GAMBARAN EFIKASI DIRI DENGAN KETERAMPILAN KOMUNIKASI PESERTA DIDIK KELAS XI DI SMA

This study aims to analyze the relationship between self-efficacy and communication skills of class XI students at SMA Negeri 10 Palembang. This research uses quantitative methods with correlational design. The total population in this study was 605 students and a sample of 86 students using simple random sampling techniques. Data analysis was performed using the Pearson Product Moment formula in the SPSS version 16.0 application. The results of the analysis obtained by most students had self-efficacy dominant is in the low category, namely 31 students while in the variable communication skills dominant is the medium category, namely 32 students then obtained a correlation coefficient of sebesar = 0,559 which is where = 0,559 &gt; 0,214 so that the research hypothesis Ha is accepted, namely there is a positive relationship between self- efficacy and communication skills of class XI students at SMA Negeri 10 Palembang, which means that the higher the self-efficacy, the higher the communication skills.

Abstract PO1-14-02: Real world application of a 21-gene recurrence score in a Swiss single center breast cancer population. A comparative analysis of treatment administration before and after TAILORx

Abstract PO1-14-02: Real world application of a 21-gene recurrence score in a Swiss single center breast cancer population. A comparative analysis of treatment administration before and after TAILORx

Abstract GS01-02: Phase 3 study of neoadjuvant pembrolizumab or placebo plus chemotherapy, followed by adjuvant pembrolizumab or placebo plus endocrine therapy for early-stage high-risk ER+/HER2− breast cancer: KEYNOTE-756

Abstract Background: KEYNOTE-756 (NCT03725059) is a global phase 3 study of neoadjuvant pembrolizumab or placebo + chemotherapy followed by adjuvant pembrolizumab or placebo + endocrine therapy (ET) in patients with early-stage high-risk ER+/HER2– breast cancer. Here, we report primary pCR results and residual cancer burden (RCB) outcomes. Methods: Eligible patients with T1c-2 (≥2 cm) cN1-2 or T3-4 cN0-2, centrally confirmed, grade 3, invasive ductal ER+/HER2− breast cancer were randomized 1:1 to receive neoadjuvant pembrolizumab 200 mg Q3W or placebo, both given with paclitaxel QW for 12 weeks, then 4 cycles of doxorubicin or epirubicin + cyclophosphamide (neoadjuvant treatment). After definitive surgery (± radiation therapy), patients received pembrolizumab or placebo for 9 cycles + standard ET. Stratification factors include region (Eastern Europe, China, or Other), tumor PD-L1 status (CPS ≥1 [positive] vs CPS &amp;lt; 1 [negative]), nodal involvement (positive vs negative), ER positivity (≥10% vs &amp;lt; 10%) and anthracycline schedule (Q3W vs Q2W). Dual primary endpoints are pCR (ypT0/Tis ypN0) and EFS. Secondary endpoints include OS, pCR defined as ypT0 ypN0 and ypT0/Tis and safety. RCB was an exploratory endpoint and was assessed by a local pathologist at the time of surgery. RCB-0, -1, -2, and -3 denote increasingly larger residual disease. Results: 1278 patients were randomized to pembrolizumab + chemotherapy (n=635) or placebo + chemotherapy (n=643). At the final pCR analysis (May 25, 2023, first interim analysis data cutoff), median follow-up was 33.2 mo (range, 9.7-51.8). In the ITT population, pembrolizumab + chemotherapy showed a statistically significant improvement in pCR (ypT0/Tis ypN0) vs placebo + chemotherapy: 24.3% (95% CI, 21.0-27.8) vs 15.6% (95% CI, 12.8-18.6); estimated difference, 8.5 percentage points (95% CI, 4.2-12.8); P=0.00005; results were consistent for the secondary pCR definitions, ypT0 ypN0 (21.3% vs 12.8%) and ypT0/Tis (29.4% vs 18.2%). The benefit of pembrolizumab + chemotherapy on pCR was generally consistent in the prespecified subgroups. There were more patients with RCB-0 (24.7% vs. 15.6%) and RCB-1 (10.2% vs 8.1%) and fewer patients in the RCB-2 (40.8% vs. 45.3%) and RCB-3 categories (20.5% vs. 28.9%) in the pembrolizumab group versus the placebo group. In the neoadjuvant phase, grade ≥3 treatment-related AE rates were 52.5% with pembrolizumab + chemotherapy and 46.4% with placebo + chemotherapy, with 1 death in the pembrolizumab arm due to acute myocardial infarction. EFS results are still immature and continue to be evaluated. Conclusions: The addition of pembrolizumab to chemotherapy significantly increased the pCR rate and shifted RCB to lower residual disease categories in patients with early-stage high-risk ER+/HER2− breast cancer. Safety was consistent with the known profiles of each regimen. Citation Format: Fatima Cardoso, Joyce O'Shaughnessy, Heather McArthur, Peter Schmid, Javier Cortés, Nadia Harbeck, Melinda Telli, David Cescon, Peter A. Fasching, Zhimin Shao, Delphine Loirat, Yeon Hee Park, Manuel Gonzalez Fernandez, Gabor Rubovszky, Seock-Ah Im, Rina Hui, Toshimi Takano, Fabrice André, Hiroyuki Yasojima, Zhenzhen Liu, Yu Ding, Liyi Jia, Vassiliki Karantza, Konstantinos Tryfonidis, Aditya Bardia. Phase 3 study of neoadjuvant pembrolizumab or placebo plus chemotherapy, followed by adjuvant pembrolizumab or placebo plus endocrine therapy for early-stage high-risk ER+/HER2− breast cancer: KEYNOTE-756 [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr GS01-02.

Abstract PS09-01: Individual patient data meta-analysis of clinical and translational biomarkers for prediction of pathological complete response (pCR) after de-escalated therapy in HER2+ breast cancer in four trials of the West German Study Group

Abstract Background Introduction of anti-HER2 therapies substantially improved outcomes for HER2-positive early breast cancer (HER2+ eBC). However, a considerable proportion of patients (pts) may still be overtreated with systemic chemotherapy (CTx) combinations. Establishing safe de-escalation strategies to avoid toxicities requires precise patient selection. Therefore, we set out to determine predictors for efficacy and survival in the unique setting of four de-escalation trials investigating short (12-week) neoadjuvant treatments (NAT) in HER2+ eBC. We investigated the prognostic ability of clinical and translational biomarkers for pCR to identify pts with the best prognosis after de-escalated systemic CTx-free NAT. Methods 756 pts who received de-escalated NAT were analyzed: trastuzumab + pertuzumab (T + P, n=92) and T + P + paclitaxel (pac, n=42) in ADAPT-HR-/HER2+ (NCT01817452); trastuzumab emtansine (T-DM1, n=118), T-DM1 + endocrine therapy (ET, n=125), and T + ET (n=129) in ADAPT-HR+/HER2+ (NCT01779206), T + P + pac (n=107) and T + P + ET (n=100) in TP-II (NCT03272477); and T + P + pembrolizumab (n=43) in Keyriched-1 (NCT03988036) in HER2-enriched (HER2-E) subtype by PAM50. The primary endpoint of each trial was pCR (ypT0/is ypN0). Survival was a secondary endpoint in all trials but Keyriched-1; survival data for TP-II are pending. Baseline gene expression was analyzed by BC360 assay; intrinsic molecular subtypes were determined using the PAM50 predictor. Stromal tumor infiltrating lymphocytes (sTILs) were evaluated at baseline and at week 3 of NAT. sTILs were categorized using a 30% threshold and the low cellularity category ( &amp;lt; 500 invasive tumor cells) at week 3. Prognostic markers for pCR were identified with univariate and multivariable logistic regression models with backstep algorithm excluding variables with p≥0.1; considered variables included age, sTILs (baseline, 3-weeks), cT, cN, grade, hormone receptor and HER2 status, intrinsic subtype, and standardized ERBB2 and ESR1 gene expression. These analyses were performed separately for NAT involving systemic CTx (i.e. containing pac, n=149) and systemic CTx-free NAT (n=607). Results Overall pCR rate was 39.1% (CTx: 66.4%; CTx-free: 32.5%). Multivariable analysis identified predictors of pCR after CTx-free NAT: low cellularity at week 3 (vs &amp;lt; 30% sTILs: OR 3.21, 95%CI 1.85-5.57), ERBB2 (OR 1.90, 95%CI 1.41-2.55), HER2 3+ (vs 1+/2+ and ISH+: OR 8.01, 95%CI 1.65-38.99), LumA/LumB/Basal subtype (vs HER2-E: OR 0.57, 95%CI 0.34-0.97), cT2 (vs 1: OR 0.54, 95%CI 0.33-0.89), and cN1-3 (vs 0, OR 0.46, 95%CI 0.27-0.78). In CTx-containing NAT, only ERBB2 (OR 2.08, 95%CI 1.28-3.40) and additionally ESR1 (OR 0.38, 95%CI 0.23-0.61) were prognostic for pCR. Updated analysis including expanded gene expression data from ADAPT-HR+/HER2+ and a prognostic score for pCR after CTx-free NAT developed using machine learning methods will be presented at the meeting. Conclusions This pooled analysis demonstrated a 66% pCR rate after a short (12-week) de-escalated NAT in HER2+ eBC. In one-third of patients (with mainly stage I cancer, higher HER2 expression by immunohistochemistry and gene expression analysis, and low cellularity at 3 weeks), pCR can be achieved without systemic CTx. Identified biomarkers could pave the way for developing new patient selection strategies to spare CTx-associated acute and late toxicities in a clinically meaningful number of patients. Citation Format: Monika Graeser, Oleg Gluz, Christine zu Eulenburg, Sherko Küemmel, Raquel von Schumann, Matthias Christgen, Rachel Wuerstlein, Enrico Pelz, Hans-Heinrich Kreipe, Peter Schmid, Marc Thill, Michael Braun, Jochem Potenberg, Claudia Schumacher, Joke Tio, Andreas Hartkopf, Marianne Just, Christian Schem, Kerstin Lüdtke-Heckenkamp, Eva-Maria Grischke, Felix Hilpert, Angela Kentsch, Ronald Kates, Ulrike Nitz, Nadia Harbeck. Individual patient data meta-analysis of clinical and translational biomarkers for prediction of pathological complete response (pCR) after de-escalated therapy in HER2+ breast cancer in four trials of the West German Study Group [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PS09-01.

Interpretasi Material Pada Rancang Bak Ukur Skala Laboratorium Dengan Pendekatan Konfigurasi Wenner, Wenner – Schlumberger dan Dipole-dipole

Geoelectric measurements have been carried out using multichannel ResistivityMeter (Geores) tools with Wenner, Wenner-Schlumberger, and Dipole-dipole Configuration approaches on the influence of materials arranged in a laboratory-scale measuring tub design with dimensions of 194x184x80 cm. The measured method is the variation in resistivity value against each trajectory of the material. The method used is the variation of resistivity values for each path of the material that has been arranged in a laboratory scale measuring design. Geoelectric measurements were carried out on 7 lines (5 line in the West-East direction and 2 line in the North-South direction). The spacing between the electrodes of each line is 10 cm with 16 electrodes in one line so that each line has a length of 160 cm or 1.6 m which corresponds to the length and width dimensions of a laboratory scale measuring design. The electrode arrangement parameters are constant with respect to changes in the configuration selected from the geores parameters during geoelectric measurements. The measurement results showed that the identified depth reached 31.2 cm. The low resistivity value category has an interval of 374-4,397 ohm.meters at a depth of 0-12.5 cm, which is the influence of building sand material containing water and soil, while the depth interval is 12.5 - 31.2 cm ohm.meters (material category that is influenced by 2 iron rods, tin tailings sand, granite, gravel) with resistivity values ranging from 12,378–67,498 ohm.meters. From experiments on the influence of the resistivity values of the three Wenner, Wenner-Schlumberger, and Dipole-dipole configurations, it was obtained that the smallest absolute error resistivity value in the Wenner configuration was 5.01% against the overall average absolute error resistivity value of 10.16%.

Assessing the mangrove community structure and aquatic environmental factors of the mangrove ecosystem in Jangkaran Village

Coastal areas have the potential for damage caused by abrasion, strong winds, and tsunamis. Seeing the high potential for damage that might occur, the appropriate approach is to conserve mangrove forests, one of which is found in Jangkaran Village, Temon District, Kulon Progo Regency. This study aims to identify mangrove community structure and aquatic environmental factors in Jangkaran Village. Mangrove community structure was analyzed using the importance value index and the Shannon-Wiener diversity index. Aquatic environmental factors were analyzed using temperature, pH, dissolved oxygen, and salinity parameters. Data collection was carried out in three locations in Jangkaran Village. Mangrove vegetation data were taken from each transect using the 10 m x 10 m quadrat transect method. Data on aquatic environmental factors were taken directly at the location using a refractometer, DO meter, and pH meter. The results of this study are species with the highest importance index value in location 1, namely Rhizophora apiculata (117.094%), location 2, Avicennia marina (207.203%), and location 3, Avicennia marina (97.0362%). Shannon Wiener diversity indexes in the three locations are 0.6943, 0.4056, and 0.6841. The results of measurements of aquatic environmental factors are temperature 25.7-30.3 °C; pH 7.2-7.7; salinity 25-34; and dissolved oxygen 6.5-6.7. Thus mangrove diversity in Jangkaran village is included in the low category and the aquatic environmental factors is favorable for mangrove growth so that the mangrove ecosystem can be further developed.

ANCA Kidney Risk Score (AKRiS) performance in a German Cohort of Patients with Histologically Confirmed ANCA-Associated Renal Vasculitis.

Predicting the outcome of ANCA-associated vasculitis (AAV) is a difficult task. One of the most promising prognostic scores, the ANCA Renal Risk Score (ARRS), has recently been updated and renamed to ANCA Kidney Risk Score (AKRiS). We wanted to test its performance in our population. 164 patients were included and categorized in subgroups analogous to that of both scores. Multivariable logistic regression analysis was applied to assess the risk of renal failure. Additionally, baseline data and outcome were compared between the subgroups of each score to retrieve useful clinical information. Stratified by AKRiS risk category, the proportions of patients who developed end-stage kidney disease (ESKD) at 36 months were 9.8%, 29.1%, 63.0%, and 83.3%, respectively (p < 0.001).Those belonging to the higher risk groups showed more pronounced proteinuria and anemia at diagnosis (p=0.001, p<0.001, respectively). Although our patients exhibited a more severe disease phenotype than those of AARS and AKRiS, both scores performed equally well: The Harrell´s C Index was similar (0.8381 vs. 0.8337). Beyond that, we found differences and similarities in the risk associations between the subgroups of both scores and disease activity or patient outcome, with some of them being described for the first time. For example, there was a higher risk of renal failure with anemia but not with C-reactive protein and the Birmingham Vasculitis Activity Score (BVAS) and an increased incidence of relapsing disease in the lower risk categories of ARRS. Here, we present the first external AKRiS validation confirming the improved ESKD prediction of the revised score in our cohort. Furthermore, we highlighted associations between risc score categories and patient mortality or vasculitis relapse.