The utilization of UiO-66 MOF-based photocatalytic materials has achieved significant attention for their potential in hydrogen generation, owing to their remarkable stability and porous crystalline structure. Recent studies have disclosed enhanced light absorption capabilities in UiO-66 through both pre and post-synthetic modifications. These modifications also play a significant role in mitigating the recombination of photogenerated charge carriers by facilitating electron transfer in hybrid or derived materials. Designing of MOF-based modified improved photocatalyst includes, integration with other low band gap semiconductors, incorporation of noble metals as co-catalysts, surface engineering, inclusion of defects or introduction of heteroatom in the framework. MOF-COF hybridization, dye sensitization etc., further reinforced photocatalytic hydrogen yield. The above-mentioned comprehensive investigations have researched into aspects such as morphology, hydrogen generation efficiency, and the underlying mechanisms. It reveals that the creation of heterojunctions at interface channelizes the separation and smooth flow of electrons resulting in suppression of recombination reaction and favorable photocatalytic properties. The synergy between the components often results in enhanced performance. The present article provides a comprehensive review of modified UiO-66 MOF-based materials investigated for photocatalytic hydrogen generation.