The optimization of a contact-less magnetoelastic sensing setup designed to detect substances/agents accumulating in its environment is presented. The setup is intended as a custom-built, low-cost yet effective magnetoelastic sensor for pest/bug detection in constrained places (small museums, labs, etc.). It involves a short, thin, and flexible polymer slab in a cantilever arrangement, with a short Metglas® 2826 MB magnetoelastic ribbon attached on part of its surface. A mobile phone both supports and supplies low-amplitude vibration to the slab’s free end. When vibrating, the magnetoelastic ribbon generates variable magnetic flux, thus inducing voltage in a contact-less manner into a pick-up coil suspended above the ribbon. This voltage carries specific characteristic frequencies of the slab’s vibration. If substances/agents accumulate on parts of the (suitably coated) slab surface, its mass distribution and, hence, characteristic frequencies change. Then, simply monitoring shifts of such frequencies in the recorded voltage enables the detection of accumulating substances/agents. The current work uses extensive testing via various vibration profiles and load positions on the slab, for statistically evaluating the sensitivity of the mass detection of the setup. It is shown that, although this custom-built substance/agent detector involves limited (low-cost) hardware and a simplified design, it achieves promising results with respect to its cost.