Low Amniotic Fluid Index Research Articles

Improving Amniotic Fluid Index with L-Arginine Supplementation

Background: Oligohydramnios, characterized by a low Amniotic Fluid Index (AFI), is associated with adverse pregnancy outcomes, including fetal growth restriction, preterm labor, and low birth weight. Effective interventions for improving AFI are critical, particularly in resource-limited settings. L-Arginine, a nitric oxide precursor, has shown promise in enhancing uteroplacental circulation and increasing AFI. This study aimed to evaluate the efficacy of L-Arginine supplementation in improving AFI and associated maternal and neonatal outcomes in pregnant women with oligohydramnios in Bangladesh. Methods: This study was conducted at Islami Bank Hospital over one year (July 2023 to June 2024), involving 90 pregnant women diagnosed with oligohydramnios. Participants received daily L-Arginine supplementation, and AFI was measured before and after the intervention. Maternal and neonatal outcomes, including gestational age at delivery, birth weight, and neonatal intensive care unit (NICU) admissions, were recorded. Statistical analysis was performed using paired t-tests, with p < 0.05 considered statistically significant. Results: The mean AFI increased significantly from 5.4 cm (SD ±1.7) before the intervention to 8.6 cm (SD ±2.1) after supplementation, with a mean difference of 3.2 cm (p < 0.001). Low birth weight was observed in 20% of the neonates, while 17.78% required NICU admission. There was a notable improvement in neonatal outcomes with L-Arginine supplementation. Conclusion: L-Arginine supplementation significantly improved AFI and neonatal outcomes, making it a viable intervention for managing oligohydramnios in pregnant women. Further research is recommended to confirm these findings in larger populations.

Impact of perinatal factors on meconium aspiration syndrome in full-term newborns and the construction of a column chart prediction model: An observational study.

To explore the influence of perinatal-related factors on meconium aspiration syndrome (MAS) in full-term neonates and construct a nomogram prediction model for risk stratification of neonatal MAS and adoption of preventive measures. A total of 424 newborns and their mothers who were regularly examined at our hospital between January 2020 and December 2023 who had meconium-contaminated amniotic fluid during delivery were retrospectively selected as participants. Neonates were divided into MAS and non-MAS groups based on whether MAS occurred within 3 days after birth. Data from the 2 groups were analyzed, and factors influencing MAS were screened using multivariate logistic regression analysis. The R3.4.3 software was used to construct a nomogram prediction model for neonatal MAS risk. Receiver operating characteristic (ROC) curve analysis and the Hosmer-Lemeshow goodness-of-fit test were used to evaluate the performance of the model, and its clinical effectiveness was evaluated using a decision curve. Among the 424 neonates with meconium-stained amniotic fluid, 51 developed MAS within 3 days of birth (12.03%). Multivariate logistic regression analysis showed that a low amniotic fluid index before delivery (OR = 2.862, P = .019), advanced gestational age (OR = 0.526, P = .034), cesarean section (OR = 2.650, P = .013), severe amniotic fluid contamination (OR = 4.199, P = .002), low umbilical cord blood pH (OR = 2.938, P = .011), and low neonatal Apgar 1-min score (OR = 3.133, P = .006) were influencing factors of MAS in full-term neonates. Based on the above indicators, a nomogram prediction model for MAS risk of full-term newborns was constructed. The area under the ROC curve of the model was 0.931. The model was also tested for goodness-of-fit deviation (χ2 = 3.465, P = .903). Decision curve analysis found that the model was clinically effective in predicting the net benefit of MAS risk in neonates with meconium-stained amniotic fluid. The construction of a column chart prediction model for neonatal MAS risk based on prenatal amniotic fluid index, gestational age, delivery method, amniotic fluid contamination level, newborn umbilical blood pH value, and Apgar 1-min score has a certain application value.

Low amniotic fluid index at term as a predictor of adverse perinatal outcome.

Objective: To assess the prevalence of adverse perinatal outcomes in antenatal women with low amniotic fluid index at term. Study Design: Observational Cross-sectional Analysis. Setting: Department of Gynaecology and Obstetrics Hayatabad Medical Complex, Peshawar. Period: 2nd February 2020, to 5th February 2021. Methods: The study involved a total of 165 patients, in 37 to 40-weeks of gestation period, the research included antenatal women with a low amniotic fluid index, with any parity, gravidity, and 18-35 years of age. While Excluded patients with any medical disorders during pregnancy (e.g., PIH, anemia, cardiac disease etc.), and those with gestational period <37 weeks from the study. Thorough history, clinical examination and ultrasound were carried out of all the women included in the study from OPD and emergency department, to confirm a low amniotic fluid index. Patient follow-up was extended to their arrival in the Obstetric suite during established labor, APGAR scores were calculated and recorded at birth, and at the 5-minute of birth for the neonate. Adverse Perinatal Outcome was considered positive if the APGAR Score was <7/10 at five minutes of life of neonate. Data analysis was performed using SPSS 23. Results: Out of 165 patients 57% of the patients were induced while 43% spontaneously delivered, similarly 66.7% were delivered vaginally while 33.3% were delivered via C Section. Low neonatal APGAR score was recorded in 67.9% patients which is a significant percentage, hence our study results showed positive correlation of low AFI with adverse perinatal outcome. We also observed that probability of satisfactory values of AFI is 1.5 times more in spontaneous deliveries (p=0.04, OR=1.5), however no such relation exists for period of gestation or number of parity. Similarly, there is a significant relation of mode of delivery with satisfactory values of AFI (p=0.00), however no such relation exists for period of gestation or number of parity. However, the probability of vaginal deliveries is 1.6 times more with an increased in number of para (p=0.02, OR=1.6). Conclusion: Reduced amniotic fluid index is linked with significant Unfavorable Perinatal Outcomes proved by low APGAR score (<7/10 at five minutes).

Impact of Low Amniotic Fluid Index at Term Pregnancy on Perinatal Outcome

Impact of Low Amniotic Fluid Index at Term Pregnancy on Perinatal Outcome

Evaluation of Perinatal Outcomes in Pregnant Women With Low Amniotic Fluid Index.

The outcomes and management of low amniotic fluid index (AFI) in pregnancy are controversial. The purpose of this study was to determine the relationship between low AFI and perinatal outcomes. This prospective study was conducted on 420 uncomplicated singleton pregnant women with a gestational age of over 28 weeks who referred to Al-Zahra Hospital in Rasht (Iran) for routine perinatal care. Pregnant women were divided into 3 groups of 140 patients based on the AFI and were followed up until delivery. Three groups included normal (8<AFI≤25 cm), borderline (5<AFI≤8 cm) and oligohydramnios (AFI≤5cm) AFI. The three adverse outcomes of respiratory distress, hospitalization in NICU, and length of hospitalization were statistically significantly different between the two groups with normal and borderline AFI and in the borderline group was more than the normal group. Adverse outcomes including; low birth weight (LBW), small for gestational age (SGA), respiratory distress, 1- min APGAR scores<7, hospitalization in NICU and its duration were statistically significantly different between the two groups with normal AFI and oligohydramnios, and it was more in the oligohydramnios group than the normal group. The three adverse outcomes of LBW, SGA and1- min APGAR scores<7 in the two borderline and oligohydramnios groups had statistically significant differences and were more in the oligohydramnios group than the borderline group. Consideration to the AFI in perinatal care to predict adverse perinatal outcomes and perform necessary interventions to improve these outcomes is necessary.

Amniotic Fluid Index and its relationship with Poor Apgar Score in Term Pregnancy

Background: The Amniotic Fluid Index (AFI) is an essential indicator of fetal well-being during pregnancy. Abnormalities in AFI, such as oligohydramnios (low AFI) or polyhydramnios (high AFI), can have significant implications on neonatal outcomes. The Apgar score, a quick assessment of a newborn's health post-delivery, may be influenced by these variations in AFI. Objective: This study aimed to investigate the relationship between AFI measurements and Apgar scores in term pregnancies, emphasizing the potential impact of amniotic fluid volume variations on neonatal health. Methods: Conducted at the Department of Obstetrics and Gynecology, Cantt General Hospital Rawalpindi, this descriptive study spanned six months, from October 2022 to March 2023. It involved 224 pregnant women aged 20-40 years, with gestational ages ranging from 37 to 42 weeks. Exclusion criteria included congenital abnormalities, intrauterine growth restriction, multiple gestations, and high-risk pregnancies. A non-probability purposive sampling technique was used. Ultrasonography was performed to measure AFI, categorizing it into two groups: AFI &lt;50mm and AFI &gt;50mm. Apgar scores were assessed at birth, with scores less than 6 categorized as poor. Results: The mean age of participants was 31.03±6.18 years, and the mean gestational age was 39.26±1.70 weeks. Of the 224 subjects, 74 (33.0%) had AFI &lt;50mm, and 150 (67.0%) had AFI &gt;50mm. Poor Apgar scores were observed in 61 (40.7%) newborns from the low AFI group and 5 (6.8%) from the high AFI group. The overall incidence of poor Apgar scores was 29.5%, with a significant statistical correlation (p-value = 0.00) between low AFI and poor Apgar scores. Conclusion: The study demonstrated a significant association between low AFI (&lt;50mm) in full-term pregnancies and poor Apgar scores. These findings highlight the necessity for diligent monitoring and management of amniotic fluid levels to improve neonatal outcomes.

Adverse Fetal Outcomes in Patients with Low Amniotic Fluid Index: Presenting Care Hospital Setting

Background: Pregnancy is a critical period where various physiological parameters are monitored to ensure the well-being of both mother and fetus. Amniotic fluid index (AFI) is one such measure, with deviations from the norm, particularly low AFI, being associated with adverse fetal outcomes. This study delves into the correlation between low AFI and fetal well-being in a tertiary care setting. Objective: The aim of this study was to investigate the association between low AFI and adverse fetal outcomes and to quantify the impact of low AFI on fetal health during delivery in a tertiary care hospital. Methods: A prospective study was conducted on 100 pregnant women attending the Obstetrics and Gynecology Department of Khyber Teaching Hospital, Peshawar, from June 28 to September 27, 2023. AFI was measured using ultrasonography, with a particular focus on participants with an AFI of less than 5 cm. The study also included a systematic sample of patients across various gestational ages and recorded outcomes such as intrauterine growth restriction (IUGR), oligohydramnios-associated deformations, cord compression, variable decelerations in fetal heart rate, and the presence of meconium-stained amniotic fluid. Statistical analysis was performed using chi-square and t-tests, with a significance level set at p&lt;0.05. Results: The mean AFI was 8.7 cm (SD = 1.5). Low AFI (&lt;5 cm) was observed in 15% of the participants. Adverse outcomes included 6 cases of IUGR (6%), 4 cases of oligohydramnios-associated deformations (4%), 3 cases of cord compression (3%), 5 cases of variable decelerations in fetal heart rate (5%), and 8 cases of meconium-stained amniotic fluid (8%). A significant association was found between low AFI and adverse fetal outcomes (χ² = 8.43, p &lt; 0.01). Conclusion: The study confirmed a significant correlation between low AFI and the presence of adverse fetal outcomes, emphasizing the importance of vigilant fetal monitoring and management in pregnancies with low AFI.

Maternal Outcome in Patients with Abruptio Placenta: A Comprehensive Analysis in A Tertiary Care Hospital

Background: Abruptio placenta is a critical obstetric condition characterized by the premature detachment of the placenta from the uterine wall, leading to significant maternal and fetal risks. Despite its rarity, the condition demands prompt diagnosis and intervention due to the high morbidity and mortality associated with it. Prior research has established a link between maternal hypertension and increased risk of severe complications such as hemorrhagic shock, disseminated intravascular coagulation (DIC), and organ failure. Objective: This study aimed to analyze the maternal outcomes of patients with Abruptio placenta in a tertiary care setting, with a specific focus on the association between hypertension and maternal complications. Methods: A prospective cohort study was conducted over a three-month period at the Obstetrics and Gynecology Department of Khyber Teaching Hospital, Peshawar. A sample size of 100 patients was determined based on the anticipated frequency of cases. Inclusion criteria were patients diagnosed with Abruptio placenta during antenatal care or at admission for delivery. Comprehensive data on demographics, medical history, clinical presentation, and management strategies were collected using standardized forms. Ethical approval was obtained from the institutional review board, and informed consent was secured from all participants. The statistical analysis was performed using SPSS version 25, with a significance level set at p &lt; 0.05. Results: The study included 105 patients with a mean age of 28.6 years; 64.8% were multiparous, and 40.0% had hypertension. Clinical presentation included vaginal bleeding (92.4%), abdominal pain (83.8%), and fetal distress (72.4%). The majority (59.0%) were diagnosed during antenatal care, while 41.0% were diagnosed at admission. Emergency Cesarean section was performed in 93.3% of cases. Blood transfusions were required for 23.8% of patients, and 28.6% presented with a low amniotic fluid index. The mean gestational age at delivery was 34.2 weeks. The analysis revealed a significant association between hypertension and the incidence of haemorrhagic shock (12 cases with hypertension, 2 without), DIC (5 cases with hypertension, 2 without), and organ failure (3 cases with hypertension, 1 without). Conclusion: The study affirms the heightened risk of severe maternal complications associated with hypertension in patients with Abruptio placenta. The high rate of emergency Cesarean sections and blood transfusions underscores the urgency and complexity of managing this condition. These findings highlight the necessity for vigilant antenatal monitoring and rapid intervention strategies in tertiary care settings.

FETOMATERNAL OUTCOME IN PREGNANT WOMEN AT TERM WITH LOW AMNIOTIC LIQUID

To determine the fetomaternal outcome in pregnant women at term with low amniotic liquid. A cross-sectional study was carried out on 120 pregnant women aged 18 to 40 years, gestational age 37 to 40 weeks, and low amniotic fluid &lt; 5 cm on ultrasonography. Fetomaternal outcomes were assessed in all women. Chi-Square test was used for association keeping P value &lt; 0.05 as significant. The mean age was 28.71±6.56 years. Caesarean section was carried out on 65% of patients, a low APGAR score was noted in 61.7% of neonates, low birth weight was seen in 64.2% of neonates, while 15% of neonates required NICU admission. Our study observed that caesarean section, low APGAR score at 5 minutes, low birth weight, and NICU admission are the most commonly associated fetomaternal outcome of the low amniotic fluid index in pregnant women at term.

Study of low amniotic fluid index and its effect on perinatal outcome

AFI may be an important predictor for deciding timing of delivery and adverse maternal and fetal outcome. Hence, we aimed at determining whether an antepartum low amniotic fluid index (AFI) is a predictor of adverse perinatal outcome in normal pregnancy and to determine a threshold level of AFI that could predict an adverse outcome. This study was conducted as an observational study on a total of 100 antenatal females presenting with term pregnancy at Department of Obstetrics and Gynecology, Lord Mahavir Civil Hospital, Ludhiana during study period. Detailed history and clinical examination was done. AFI was assessed with help of USG. The study was conducted on a total of 100 antenatal females. AFI was &amp;#60;5 in 38%. Low AFI was associated with LSCS and negative fern test was statistically significant (p&amp;#60;0.05). We observed a significant association of low AFI with low birth weight, poor APGAR score at 1 as well as 5 minutes and higher risk of NICU admission (p&amp;#60;0.05). The area under the curve and sensitivity as well as specificity at cutoff (4.5) was maximum for NICU admission followed by LSCS (p&amp;#60;0.05). AFI is an important determinant of adverse maternal and fetal outcome. AFI &amp;#60;5 is associated with adverse maternal outcome in the form of higher operative delivery and adverse fetal outcome i.e. low birth weight, meconium stained liquor, low APGAR score and higher NICU admission. Intensive intrapartum care along with fetal surveillance may help in minimizing adverse perinatal outcomes.

Assessment of Correlation between Amniotic Fluid Index (AFI) and Feto-maternal Outcomes of In-term Pregnancies

Background: Amniotic fluid plays a crucial role in providing basic life support to the fetus. This clear, slightly yellowish liquid that surrounds the fetus is helpful in the development of fetal systems by providing thermally controlled and a non-restricted sterile environment for fetal growth. During labour, amniotic fluid helps in providing an adequate cushion for umbilical cord. It is this mechanical function of the cushion which aids in preventing compression of cord in-between fetus and uterine wall during uterine contractions and fetal movements. Therefore, helps to prevent fetal distress. It protects fetus from any kind of injury and helps in preventing infection by its bacteriostatic properties. This study aims to estimate the effect of decreased amniotic fluid index (AFI) on maternal and fetal outcomes in term pregnancy.&#x0D; Materials and Methods: This will be a Prospective cross sectional observational study conducted in OBGY dept. of AVBRH, Wardha. Pregnant women will be enrolled and divided into 3 groups as per Amniotic Fluid Index. Group A with low amniotic fluid index (AFI&lt; 5 cm) Group B with borderline amniotic fluid index (AFI&gt;5cm and &lt;8cm)and Group C with normal amniotic fluid index (AFI 8cm-24cm). Data will be collected, analysed and compared between the groups in terms of the ultrasonographic findings and feto-maternal outcomes of in term pregnancy.&#x0D; Expected Results: Significant correlation is expected between AFI and feto-maternal outcomes.&#x0D; Conclusion: Unexpected adverse outcomes can be minimized by estimation of AFI and timely antepartum treatment in mothers with decreased AFI.

Prediction of meconium aspiration syndrome by data available before delivery.

To identify risk factors associated with the occurrence of meconium aspiration syndrome (MAS) among neonates. A retrospective case-control study in a university affiliated tertiary medical center, including all neonates born with meconium stained amniotic fluid (MSAF) between March 2011 and March 2020. Patients were categorized by the occurrence of MAS. Demographic, pregnancy and delivery characteristics were compared between the two groups. Risk factors for MAS were analyzed. Of 90579 singleton deliveries, a total of 11856 with MSAF were included. Of these newborns, 78 (0.66%) were diagnosed with MAS Four factors were independently associated with MAS: delivery at <38 0/7weeks (aOR [95% CI]: 3.48 (1.02-11.84), P=0.046); higher body mass index (aOR [95% CI]: 1.09 (1.02-1.16), P=0.003); lower amniotic fluid index (aOR [95% CI]: 0.99 (0.98-0.99), P=0.032); higher white blood cell count (aOR [95% CI]: 1.11 (1.02-1.20), P = 0.009). The presence of one, two and three of the above-mentioned risk factors yielded a risk for MAS of 0.8%, 2.5% and 100%, respectively. We identified independent risk factors for MAS and developed a risk score calculator. This tool may assist physicians in the management of deliveries complicated by MSAF.

OEIS Syndrome: Omphalocele, Exstrophy of the Cloaca, Imperforate Anus, and Spinal Defects

OEIS Syndrome: Omphalocele, Exstrophy of the Cloaca, Imperforate Anus, and Spinal Defects

Relationship of Amniotic Fluid Index (AFI) Between Maternal and Perinatal in Patients

Background: Alcohol amniotic, a protecting fluid that surround the embryo. It protects from concussion, pressure, desiccation, reminiscent of the aquatic origin of life. Adequate amount of amniotic fluid is essential requirement for the normal development and it acts like a cushion against trauma, agitation and accidental impulsions. It has also bacteriostatic properties and prevents the infection of many bacterial infections.&#x0D; Aim: To assess the maternal and fetal outcome in cases with normal and abnormal Amniotic Fluid Index levels.&#x0D; Results: The mode of delivery was spontaneous vaginal delivery followed by Assisted VD, Elective CS, Emergency CS respectively. It was affected by amount of liquor since, low AFI group 35 (75%) patients ended up in cesarean section for fetal distress. While in control group 63(18.3%) patients had caesarean section.&#x0D; Conclusion: Early neonatal death was seen in 0.2%, 4.5% and 70.5% newborns were born to pregnant women with normal AFI, oligohydramnios respectively. 70.5% neonates born to pregnant women with oligohydramnios had NICU admission. All cases were admitted in NICU because of respiratory distress.

Perinatal outcome in pregnant females at term having low amniotic fluid index.

Objectives: To determine the frequency of perinatal outcome in pregnant females at term having low amniotic fluid index. Study Design: Descriptive, Case Series study. Setting: Department of Obstetrics &amp; Gynecology, Independent University Hospital, Faisalabad. Period: 1st October 2019 to 31st March 2020. Materials &amp; Methods: A total of 90 women having singleton pregnancy with cephalic presentation having 37-40 weeks of gestation with AFI &lt;8cm, 20 to 35 years of age were included. Patients with multiple pregnancy, ruptured membrane, fetal anomaly, gestational diabetes and Rh Incompatibility were excluded. Cesarean delivery, meconium stained liquor, low birth weight, NICU admission and APGAR score &lt;7 at 5 min were assessed by consultant gynecologist. Results: Age range in this study was from 20 to 35 years with mean age of 28.92 + 4.45 years. Majority of the patients 43 (47.77%) were between 31 to 35 years of age. Mean gestational age was 38.31 + 1.20 weeks. Mean parity was 2.72 + 1.02. In this study, frequency of perinatal outcome in pregnant females at term having low amniotic fluid index was as follows; cesarean section was performed in 60 (66.67%), low birth weight was observed in 58 (64.44%) patients, APGAR score &lt;7 at 5 minutes in 56 (62.22%), meconium stained liquor in 24 (26.67%) and NICU admission in 17 (18.89%) patients. Conclusion: This study concluded that proper antenatal monitoring and management should be done in these high risk patients in order to reduce the morbidity and mortality of the fetus.

The effects of oligohydramnios on perinatal outcomes after preterm premature rupture of membranes

Objective Amniotic fluid plays a vital protective role in fetal growth and development. Low amniotic fluid index (AFI) during pregnancy increases risk of adverse perinatal outcomes. Prior studies reported association of oligohydramnios (AFI&lt;5 cm) with shorter latency period and inconsistent correlation with chorioamnionitis after preterm premature rupture of membranes (PPROM). We studied effects of oligohydramnios on perinatal outcomes after PPROM. Methods A retrospective cross-sectional study was performed at our medical center on women with PPROM between 23 to 34 weeks during 2014 to 2016. The primary predictor variable was AFI of &lt;5 cm or ≥5 cm in relationship to perinatal outcomes. Results From a total of 117 PPROM cases reviewed, 46 women had AFI&lt;5 cm and 71 had AFI≥5 cm. Length of stay (LOS) in neonatal intensive care unit (NICU) was 42 days for AFI&lt;5 cm versus 26.5 days for AFI&gt;5 cm (p&lt;0.007). The mean neonatal Apgar scores at 1 and 5 minutes (5.2 and 7.4 respectively) were lower in the AFI&lt;5 cm group compared to AFI≥5 cm (6.9 at 1 minute and 8.4 at 5 minutes, p&lt;0.001). Conclusion Oligohydramnios after PPROM is associated with adverse perinatal outcomes such as lower Apgar scores and longer LOS in the NICU. No association was observed with latency period and chorioamnionitis.

Effect of Low Amniotic Fluid Index in Perinatal Outcome of Term Low-Risk Pregnancy

Effect of Low Amniotic Fluid Index in Perinatal Outcome of Term Low-Risk Pregnancy

Branch pulmonary artery Doppler parameters predict early survival-non-survival in premature rupture of membranes.

Preterm premature rupture of membrane (pPROM) leads to high neonatal mortality due in part to severe lung hypoplasia (LH). In other causes of severe LH, fetal echo-based parameters of smaller branch pulmonary arteries (PA), shorter acceleration to ejection time ratio (AT/ET), increased peak early diastolic reverse flow (PEDRF), and higher pulsatility index (PI) are predictive of worse neonatal outcome. We sought to determine whether these parameters correlated with worse clinical outcome in pPROM. Twenty-five pregnancies complicated by pPROM were prospectively recruited. Fetal echocardiography was used to evaluate branch PA diameters and Doppler parameters. Clinical records were reviewed. Fetal echo findings were compared between early survivors and non-survivors. Of 25 pPROM cases, 5 had early neonatal demise (≤3 days) due to respiratory insufficiency. While gestational age at pPROM, fetal echo, and at birth did not differ, amniotic fluid index (AFI) was significantly lower in early non-survivors compared to survivors (p = 0.05). No difference was observed in PA diameter, PEDRF, or PI; however, branch PA AT/ET was significantly shorter in non-survivors (right PA median 0.12 (0.11-0.16) vs. survivors 0.17 (0.14-0.21), p = 0.046 and left PA 0.12 (0.09-0.13) vs. survivors 0.16 (0.11-0.21), p = 0.042). We found a significantly lower AFI and shorter fetal bilateral branch PA AT/ET to be associated with early neonatal demise following pPROM.

Factors associated with neonatal outcomes in preterm prelabor rupture of membranes after cervical cerclage.

To evaluate risk factors associated with neonatal morbidity and mortality in pregnant women with preterm prelabor rupture of membranes (PPROM) after cervical cerclage. A retrospective cohort study of singleton pregnancies with cervical insufficiency was conducted at a tertiary referral center in Taiwan from May 1, 2000 to July 31, 2017. Patients with PPROM after cerclage and delivered between 20 0/7days and 36 6/7days were recruited. Logistic and linear regression analyses were performed to evaluate various risk factors. Overall, 109 women were included. Mothers with a higher white blood cell count, a higher C-reactive protein (CRP) level, a lower amniotic fluid index, and chorioamnionitis were significantly associated with neonatal morbidity. Neonatal mortality was related to oligohydramnios (adjusted odds ratio [aOR] 2.98, 95% confidence interval [CI] 1.11-8.01) and chorioamnionitis (aOR 3.17, 95% CI 1.03-9.69). An elevated CRP level was associated with a shorter PPROM to delivery latency (adjusted B -16.64, 95% CI -29.88 to -3.41), but cerclage retention more than 12hours after PPROM was associated with a prolonged latency (adjusted B 17.21, 95% CI 3.25-31.18). Oligohydramnios and chorioamnionitis are associated with neonatal mortality.

A Comparative Study of Perinatal Outcomes in Patients with Oligohydramnios (Low Amniotic Fluid Index)

A Comparative Study of Perinatal Outcomes in Patients with Oligohydramnios (Low Amniotic Fluid Index)