Production Losses Research Articles

Spectroscopic insights into BSA-mediated deaggregation of m-THPC

Meta-tetra(hydroxyphenyl)chlorin (m-THPC) is among the most potent photosensitizers, known for its high singlet oxygen generation efficiency. However, its clinical effectiveness in photodynamic therapy (PDT) is compromised by its propensity to aggregate in aqueous solutions, adversely affecting its photophysical properties and therapeutic potential. A series of spectroscopic techniques, including UV-Vis absorption, fluorescence spectroscopy, and laser flash photolysis, revealed that m-THPC exhibits significant aggregation, particularly in MeOH-PBS mixtures with MeOH content below 30%. This aggregation adversely affects its photophysical properties leading to reduced fluorescence quantum yield and most importantly reducing its singlet oxygen quantum yield. This study introduces the use of bovine serum albumin (BSA) to counteract the aggregation of m-THPC, aiming to enhance its solubility, stability, and efficacy in physiological settings. Through advanced spectroscopic analyses we demonstrated that the m-THPC@BSA complex exhibits restored photophysical properties characteristic for monomeric form. Notably, the complex showed a significant restoration of the singlet oxygen quantum yield (ΦΔ = 0.21) compared to aggregated m-THPC. These results underscore the potential of BSA to preserve the monomeric form of m-THPC, mitigating aggregation-induced losses in singlet oxygen production. Our findings suggest that BSA-mediated delivery systems could play a crucial role in optimizing the clinical utility of hydrophobic photosensitizers like m-THPC.

Can shoe tip modifications on safety shoes reduce the braking forces in a trip-simulating, free-body shoe collision test?

Tripping often results in injury, especially in occupational settings, leading to both loss in production and increased medical expenses. Trips may occur over small perturbations, as low as 5 mm, making it almost impossible to provide effective safety precautions in many occupational settings. This explorative study evaluated the mechanical effects of collisions applied to three novel trip-reducing elements placed on the tip of a safety shoe. The assessment was conducted using a new mechanical free-body collision test, to analyse how the braking forces were affected by the trip-reducing elements. The elements tested showed a decrease of up to 83% in peak braking force and 89% in braking impulse suggesting a possible reduction in the risk of fall after tripping. Still, in-vivo studies are warranted to test if such trip-reducing elements can minimise the risk of falls in settings mimicking real life.

Evaluating Health Policy Effectiveness in Reducing the Economic Burden of Non-Communicable Diseases in Bangladesh

Non-communicable diseases (NCDs) represent a significant and growing public health challenge in Bangladesh, contributing to a substantial economic burden. Non-communicable diseases (NCDs), including cardiovascular diseases, diabetes, chronic kidney disease, cancers, and chronic respiratory conditions, represent a major health challenge in Bangladesh, contributing to substantial morbidity, mortality, and economic burden. The economic impact is profound, affecting both individuals and the broader economy through healthcare costs, loss of productivity, and long-term financial strain. This review aims to evaluate the effectiveness of health policies in mitigating the economic burden of NCDs in Bangladesh. The article begins with an overview of the prevalence and risk factors associated with NCDs, followed by an examination of the national health policies aimed at prevention, treatment, and management. The evaluation considers both successes and challenges, with a focus on policy implementation, healthcare financing, and access to care. Case studies highlight specific policy interventions that have demonstrated measurable success in reducing NCD prevalence and associated costs. The findings suggest that while significant progress has been made in policy formulation, challenges remain in ensuring comprehensive implementation and equitable access to healthcare services. Cost-effective strategies, such as scaling up preventive measures and improving healthcare infrastructure, are essential for reducing the economic burden of NCDs. The review concludes with recommendations for strengthening existing policies and exploring innovative approaches to sustain and enhance the impact of health policies on NCD management in Bangladesh.

Noninvasive Raman spectroscopy for the detection of rice bacterial leaf blight and bacterial leaf streak

Plant diseases pose significant threats to agricultural yields and are responsible for nearly 20 % of losses in total food production. Therefore, the rapid detection of plant pathogens is critically important for preventing the rapid development of plant diseases and minimizing crop damage. Raman spectroscopy (RS) has been shown to be effective for detecting living biological samples. Compared with traditional detection methods, RS is fast, sensitive, and non-destructive; it also does not require sample labeling. In this study, we used Laser tweezers Raman spectroscopy combined with convolutional neural networks to detect two closely related strains of bacteria, Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas oryzae pv. oryzicola (Xoc), exuded from bacteria-infected rice leaves. The accuracy of this technique was 97.5 %. For the application of RS in the field, we used the portable Raman spectrometer to detect mock-inoculated as well as Xoo- and Xoc-infected rice leaves at different disease courses. The identification accuracy via this technique was 87.02 % in the early stage, in which no obvious symptoms were apparent. This method also revealed spectral differences in rice leaves caused by the two bacteria, which could be leveraged for subsequent analysis of the molecular mechanism of infection. Our results indicate that RS is a promising approach for the early detection of bacterial diseases in rice in the field, as well as for in-depth single-cell analysis in laboratory settings.

Economic burden and quality of life of caregivers of patients with sickle cell disease in the United Kingdom and France: a cross-sectional study

BackgroundSickle cell disease (SCD), a genetic blood disorder that affects red blood cells and oxygen delivery to body tissues, is characterized by haemolytic anaemia, pain episodes, fatigue, and end-organ damage with acute and chronic dimensions. Caring for patients with SCD imposes a high burden on informal caregivers. This study aims to capture the impact on health-related quality of life (HRQoL) and economic burden of caregiving for patients with SCD.MethodsValidated instruments of HRQoL (EQ-5D-5L, Carer Quality of Life-7 dimensions [CarerQol-7D]) and productivity (Work Productivity and Activity Impairment Questionnaire: Specific Health Problem [WPAI: SHP]) were administered via a cross-sectional online survey to caregivers in the United Kingdom (UK) and France. Demographics, HRQoL, and economic burden data were analyzed using descriptive statistics. Economic burden was determined using country-specific minimum and average wage values. Subgroup analysis examined caregivers with and without SCD.ResultsSixty-nine caregivers were recruited (UK, 43; France, 26), 83% were female, and 22% had SCD themselves. The mean (SD) caregiver EQ-5D-5L score was 0.66 (0.28) (UK, 0.62; France, 0.73), and the mean CarerQol-7D score was 80.69 (24.40) (UK, 78.72 [25.79]; France, 83.97 [22.01]). Mental health problems were reported in 72% and 70% of caregivers measured using the EQ-5D-5L and CarerQol-7D, respectively. Financial problems were reported by 68% of caregivers, with mean annual minimum wage productivity losses of £4209 and €3485, increasing to £5391 and €9319 for average wages. Sensitivity analysis determined additional HRQoL decrements for caregivers with and without, SCD.ConclusionCaring for patients with SCD impacts the HRQoL and economic burden of caregivers. Further research to support the complex needs of SCD caregivers is required.

Integrated modelling of fertilizer and climate change scenario impacts on agricultural production and nitrogen losses in Austria

The European Commission's Farm to Fork strategy aims at reducing nutrient losses and fertilizer use, but has been criticized for its expected negative impacts on European economy, agriculture, and food supply. We apply an integrated modelling framework to analyze potential effects of fertilizer reductions on land use, nitrogen losses, and agricultural output of two fertilizer and four climate change scenarios. The fertilizer scenarios comprise a uniform 20 % reduction of mineral N fertilizer (f20) and a combination of several fertilizer restrictions (fcm). The model results indicate that the restrictions in fertilization lead to decreases in crop production of 6 to 9 %, whereas intensive and extensive grassland production increases. N losses to air, water, and soil are substantially reduced by 9 % (f20) and 20 % (fcm), yet fall short of the intended 50 % reduction. The regional heterogeneity of the model results shows that tailored measures need to be elaborated by taking climate change developments, the regional heterogeneity of prevalent farming systems, and bio-physical conditions into account. Uniform measures applied to the national policy context fall short to attain policy targets cost-effectively. N emission capping, taxes or managerial measures such as crop rotational N balancing are options to be explored in future research.

Measurement of the Direct Impact of Hematophagous Flies on Feeder Cattle: An Unexpectedly High Potential Economic Impact.

In addition to blood pathogen transmission, insects of the order Diptera affect livestock through visual and contact harassment; blood-feeders are responsible for painful bites and blood despoliation, generating behavioral modifications, anemia, and production losses. Knowledge of their economic impact is a basis for cost-effective control. Here, we measured the global impact of diptera insects by comparing two batches of six feeder cattle, one in the open air and the other protected by a mosquito net. The analytical data were insect density in the open air and, for feeder cattle, tail flick counts, hematocrit values (Ht), feed intake, feed conversion ratio (FCR), and live body weight gain (LBWG). Over a period of five months, the results showed significant losses in the LBWG of cattle exposed to insects, estimated at 8.0 ± 1.5 kg/month [2.7; 13.3], with a total loss reaching 40.0 ± 5.5 kg/head. Main diurnal insects were Stomoxys spp. and Musca crassirostris. There was a strong correlation between fly density and diurnal tail flicks. Night trapping and tail flicks showed a potentially important role of mosquitoes to be further explored. The Ht levels of exposed animals were 3-4% lower than those of controls. FCRs indicated that exposed animals needed 33% more dry matter intake/kg of LBWG. An economic assessment showed that dipterans were responsible for a 10-11% loss in LBWG during the main growing period of feeder cattle (10-15 months). A feedlot of 100 calves would register a total loss of USD 16,000 within 5 months, which appears to be an unexpectedly huge loss caused by dipterans. Investing part of this money into fly control would probably be beneficial.

BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences.

Cranial radiation therapy (RT) for brain cancers is often associated with the development of radiation-induced cognitive dysfunction (RICD). RICD significantly impacts the quality of life for cancer survivors, highlighting an unmet medical need. Previous human studies revealed a marked reduction in plasma brain-derived neurotrophic factor (BDNF) post-chronic chemotherapy, linking this decline to a substantial cognitive dysfunction among cancer survivors. Moreover, riluzole (RZ)-mediated increased BDNF in vivo in the chemotherapy-exposed mice reversed cognitive decline. RZ is an FDA-approved medication for ALS known to increase BDNF in vivo . In an effort to mitigate the detrimental effects of RT-induced BDNF decline in RICD, we tested the efficacy of RZ in a cranially irradiated (9 Gy) adult mouse model. Notably, RT-exposed mice exhibited significantly reduced hippocampal BDNF, accompanied by increased neuroinflammation, loss of neuronal plasticity-related immediate early gene product, cFos, and synaptic density. Spatial transcriptomic profiling comparing the RT+Veh with the RT+RZ group showed gene expression signatures of neuroprotection of hippocampal excitatory neurons post-RZ. RT-exposed mice performed poorly on learning and memory, and memory consolidation tasks. However, irradiated mice receiving RZ (13 mg/kg, drinking water) for 6-7 weeks showed a significant improvement in cognitive function compared to RT-exposed mice receiving vehicle. Dual-immunofluorescence staining, spatial transcriptomics, and biochemical assessment of RZ-treated irradiated brains demonstrated preservation of synaptic integrity and neuronal plasticity but not neurogenesis and reduced neuroinflammation concurrent with elevated BDNF levels and transcripts compared to vehicle-treated irradiated brains. In summary, oral administration of RZ represents a viable and translationally feasible neuroprotective approach against RICD.

Effects of Microbiota on the Soiling Process of PV Modules in Arid Zones of the Atacama Desert

Photovoltaic technology has proven to be a reliable, economical, and clean energy source that is capable of adapting to diverse geographical conditions. However, factors such as soiling overshadow these qualities, thus leading to production losses and affecting the profitability of this technology. For these reasons, soiling is a highly studied topic, which involves considering the physicochemical characterization of the deposited material, mitigation strategies, effect predictions, and cleaning mechanisms. However, there is a relatively unexplored area related to the microbiological contribution to soiling. The surface of photovoltaic modules, along with the deposited material and local atmospheric factors, fosters favorable conditions for the colonization of microorganisms. These microorganisms influence the soiling mechanisms and optical properties of photovoltaic modules. This work presents a detailed characterization of the microbial diversity present in the soiling deposited on photovoltaic modules installed in the Atacama Desert. Two study sites were defined: Antofagasta and the Solar Platform of the Atacama Desert, which have warm and cold desert climates, respectively. Mineralogical characterization tests, heavy metal analyses, TOC, and inorganic element analyses were conducted on the deposited material. Additionally, the culturable isolates and the metagenomic DNA of the soiling samples and biofilms grown on standard PV glass were characterized using next-generation sequencing. The results show that the deposited soiling contained a microbiological component that had adapted to extreme desert conditions. The presence of the genera Arthrobacter, Kocuria, and Dietzia were identified in the culturable isolates from Antofagasta, while Arthrobacter and Dietzia were obtained from the Solar Platform of the Atacama Desert. The metagenomic DNA was mainly represented by the genera Pontibacter, Noviherbaspirillum, Massilia, Arthrobacter, Hymenobacter, and Deinococcus at Antofagasta. However, at the Solar Platform of the Atacama Desert, the analyzed samples presented DNA concentrations below 0.5 ng/µL, which made their preparation unviable. At the PSDA, the biofilms formed by the genera Peribacillus and Kocuria were identified, whereas the UA showed a greater abundance of bacteria that favored biofilm formation, including those that belonged to the genera Bacillus, Sporosarcina, Bhargavaea, Mesaobacillus, Cytobacillus, Caldakalibacillus, and Planococcus. Based on these results, we propose a soiling mechanism that considers the microbiological contribution to material cementation.

Economic burden and health-related quality of life in patients with epidermolysis bullosa in Spain

Background. Epidermolysis bullosa (EB) is a rare genetic skin disorder characterized by fragility of skin with appearance of acute and chronic wounds. The aim of this study was to determine the economic burden and the health-related quality of life (HRQoL) of patients with epidermolysis bullosa (EB) in Spain from a societal perspective.Methods. We conducted a cross-sectional, retrospective study including 62 patients with EB (62% dystrophic, 9.6% junctional, 3.2% Kindler syndrome, and 26% with simplex EB). Data were collected from questionnaires completed by patients or their caregivers. The costs were estimated, including not only direct healthcare costs but also direct non-healthcare costs and productivity losses. We compared severe EB (Dystrophic, Junctional EB and Kindler syndrome) to non-severe EB (simplex EB) using as reference year 2022. HRQoL was measured by generic (EQ-5D) and specific (QoLEB) questionnaires.ResultsThe average annual cost for an EB patient was €31,352. Direct healthcare costs represented 17.2% of the total cost, direct non-healthcare costs (mainly informal care costs) 71.3% and productivity losses 11.5% of the total cost. Participants in the severe EB group had a slightly higher average cost than participants in the non-severe EB group (€31,706 vs. €30,337). Direct healthcare costs and non-healthcare costs were higher in the severe EB group (€6,205 vs. €3,024 and €23,148 vs. €20,113) while productivity losses were higher in the non-severe EB group (€7,200 vs. €2,353). The mean utility index score, where the maximum value possible is one, was 0.45 for patients with severe EB (0.76 for their caregivers) and 0.62 for those with non-severe EB (0.77 for their caregivers).Conclusions. The social economic burden of EB, resulting from the high direct non-healthcare cost of informal care, and from the loss of productivity, accentuates the importance of not restricting cost analysis to direct healthcare costs. This substantiates that EB, particularly severe EB represents a significant hidden cost that should be revealed to society and should be considered in the support programmes for people who suffer from this disease, and in the economic evaluation of new treatments.

Job Characteristic Profiles and Presenteeism Among Shift Nurses: A Latent Profile Analysis Based on the Job Demands–Resources Model

ABSTRACTAim(s)To investigate job characteristic profiles based on the job demands–resources (JD‐R) model and the association between job characteristic profiles and presenteeism.DesignCross‐sectional study.MethodsData were collected from shift nurses in South Korea in January 2023 using an online survey. This study included 544 nurses working in tertiary and general hospitals in South Korea. The participants were classified into four job characteristic profiles based on the JD‐R model using latent profile analysis. Multiple logistic and linear regression analyses were performed to examine the association between job characteristic profiles and presenteeism.ResultsFour profiles were derived from the latent profile analysis: low strain–low motivation, high strain–low motivation, low strain–high motivation and high strain–high motivation. The high strain–low motivation, low strain–high motivation and high strain–high motivation groups were 1.74, 1.37 and 3.51 times more likely to experience presenteeism than the low strain–low motivation group respectively. The number of days worked while sick and the level of reduced job productivity was also the highest in the high strain–high motivation group. In addition, general health, multimorbidities and insomnia were significant factors affecting presenteeism, number of days worked while sick and productivity loss among shift nurses.ConclusionsThis study found that even with higher levels of job resources, work environments with high levels of job demands were associated with higher rates of presenteeism.ImpactStudy findings suggest that various strategies are needed to improve the physical and mental health of shift nurses, and create a healthy organisational environment by reducing excessive job demands to reduce presenteeism and increase productivity.Reporting MethodSTROBE guidelines.Patient or Public ContributionNo patient or public contribution.

Integrated approach to determining the identity of the pollution of adjacent territories with oil products

The methodology of arranging laboratory studies of oil-contaminated soils, soils and bottom sediments to determine the source and composition of hydrocarbon contamination is described. The complex approach to laboratory analysis of samples of oil-contaminated soils, soils and bottom sediments is proposed, which allows a highly reliable identification of the potential source of contamination and/or making conclusions about the identity of the contamination of adjacent territories. The proposed complex of analytical methods includes infrared spectrometry, gas chromatography with mass-selective detection, thin-layer chromatography with flame ionization detection and elemental analysis (C, H, N, S, O). Application of the proposed integrated approach allows highly reliable determination of the nature of oil contamination of soils, estimation of the total gross content of oil products and their hydrocarbon composition, and identification of the potential source of pollution. Possible errors in the interpretation of the results of determining the identity of contamination of territories and the importance of using an integrated approach in drawing conclusions about the source (culprit) of pollution are shown using real soil samples taken from oil-contaminated objects and adjacent territories. The importance of taking into account the losses of volatile oil products at the stage of sample preparation for soil contamination with light oil fractions is demonstrated. The use of standard methods of sample preparation (drying of the samples under study) leads to errors in assessing the level of contamination of territories with volatile hydrocarbons and in the choice of methods of remediation of contaminated territories. To minimize losses of volatile hydrocarbons (petrol and naphtha fractions) at the stage of soil sampling and transportation the use of sorbent is proposed. Addition of a sorbent to the soil contaminated with oil products can reduce losses of volatile hydrocarbons by 15 – 20% in the analyzed samples. Application of the developed complex approach makes it possible to determine the features of the individual hydrocarbon composition, group and elemental composition of petroleum products and identify hydrocarbon indicators (markers) inherent only to a certain type of petroleum product.

The Contribution of Dairy Bedding and Silage to the Dissemination of Genes Coding for Antimicrobial Resistance: A Narrative Review.

Antimicrobial resistance (AMR) is a concern in the dairy industry. Recent studies have indicated that bedding serves as a reservoir for antimicrobial-resistant bacteria and antimicrobial-resistance genes (ARGs), while silage has been proposed as another possible source. The impact of AMR in dairy farming can be significant, resulting in decreased productivity and economic losses for farmers. Several studies have highlighted the safety implications of AMR bacteria and genes in bedding and silage, emphasizing the need for further research on how housing, bedding, and silage management affect AMR in farm environments. Exposure to sub-lethal concentrations of antibiotics, such as those from contaminated bedding and silage, can prompt bacteria to develop resistance mechanisms. Thus, even if antimicrobial usage is diminished, ARGs may be maintained in the dairy farm environment. By implementing proactive measures to tackle AMR in dairy farming, we can take steps to preserve the health and productivity of dairy cattle while also protecting public health. This involves addressing the prudent use of antibiotics during production and promoting animal welfare, hygiene, and management practices in bedding and farm environments to minimize the risk of AMR development and spread. This narrative review compiles the growing research, positioning the contribution of bedding and silage to the prevalence and dissemination of AMR, which can elicit insights for researchers and policymakers.

MSK ultrasound imaging–assisted clinical examination

Musculoskeletal disorders are a significant global health concern, affecting over 1.71 billion individuals worldwide, with a considerable impact on quality of life and economic burden due to healthcare costs and productivity losses. In the United Kingdom, approximately one-third of the population suffers from musculoskeletal disorders, underscoring the need for effective diagnostic and management strategies. Musculoskeletal ultrasound imaging emerges as a preferred diagnostic modality, offering a balance between technical capabilities and cost-effectiveness, owing to its non-invasive nature, portability and lack of radiation exposure. However, the operator-dependent nature of musculoskeletal ultrasound imaging necessitates specialised training for medical and healthcare professionals. The integration of musculoskeletal ultrasound imaging into traditional clinical examinations, known as ultrasound imaging–assisted clinical examination (UIACE), enhances traditional diagnostic processes by providing immediate visual feedback, facilitating a more accurate and comprehensive assessment of musculoskeletal conditions. This approach not only refines diagnosis in cases with ambiguous symptoms or overlapping signs but also significantly improves patient reassurance and management strategies. In addition, incorporating musculoskeletal ultrasound imaging into medical education through ultrasound imaging–assisted clinical examination offers students a dynamic, interactive learning experience, fostering a deeper understanding of clinical anatomy and examination skills. By advocating for its systematic inclusion in the undergraduate medical curriculum, the study highlights the potential to enhance the competence and confidence of future professionals in utilising ultrasound imaging, ultimately improving patient outcomes in musculoskeletal care.

Epidemiology and burden of chronic insomnia disorder in Europe: an analysis of the 2020 National Health and Wellness Survey

Introduction Chronic insomnia disorder (CID) is considered a significant worldwide public health concern; however, its exact burden is unknown. We estimate its prevalence across France, Germany, Italy, Spain, and the United Kingdom, and assess the economic and humanistic burden for a broader insomnia population. Methods This retrospective, cross-sectional, observational study used 2020 National Health and Wellness Survey (NHWS) data. Patients reporting insomnia were characterized to define CID. Health-related quality of life (HRQoL), work productivity, and healthcare resource use (HCRU) outcomes were assessed in four cohorts according to insomnia diagnosis and treatment status and examined using multivariable analyses according to Insomnia Severity Index categories. Results Among 62,319 respondents, 9,035 (21.2%) reported experiencing insomnia over the previous 12 months. CID prevalence rates were 5.5% to 6.7% across the five countries and 6.0% overall. HRQoL outcomes were persistently poorer in cohorts of patients diagnosed with insomnia than those with undiagnosed insomnia. Undiagnosed and treated insomnia patients reported the highest work presenteeism and total work productivity impairment and the highest number of emergency room and hospitalization visits than patients with insomnia (either treated or untreated). After adjusting for covariates, patients with severe insomnia reported significantly worse EQ-5D-5L utility scores, higher absenteeism and presenteeism rates, and more healthcare provider visits over the past 6 months than patients without insomnia (all p < 0.01). Conclusions Our prevalence rates for CID align with published literature. A diagnosis of insomnia, use of sleep medications, and severity of insomnia are associated with poor quality of life, loss of work productivity, and higher HCRU, confirming the high unmet need and substantial humanistic and economic burden of CID.

The association of emotional labour and workplace violence with health-related productivity loss

Abstract Objectives This study explored the association between emotional labour and workplace violence with health-related productivity loss (HRPL). Methods We used the initial dataset from a survey known as the Korean Work, Sleep, and Health Study, an ongoing nationwide panel study initiated in 2022. To assess emotional labour, the study included 2386 workers who worked in customer service. The Korean Workplace Violence Scale-13 and the Korean Emotional Labour Scale-11 were used to assess the level of exposure to workplace violence, and the intensity of emotional labour, respectively. The Work Productivity and Activity Impairment Questionnaire was used to measure HRPL, including absenteeism and presenteeism. We examined differences in HRPL based on workplace violence and emotional labour using generalised linear regression models. Results HRPL increased with an increase in workplace violence and emotional labour scores. Notably, the mean HRPL was highest in high-risk group of both workplace violence and emotional labour. The mean HRPL increased as the number of 'high-risk' components for workplace violence and emotional labour increased. All the workplace violence and emotional labour components exhibited higher HRPL in the 'high-risk' groups compared to the 'low-risk' groups. Conclusions Our study showed that both emotional labour and workplace violence are associated with reduced productivity.

Integrated risk management and maintenance planning in Oil and Gas Supply Chain operations under market uncertainty

The Oil and Gas Supply Chain (OGSC) is a multifaceted network comprising diverse activities and echelons. Instability or interruptions can cause economic fluctuations, impacting industries, markets, and consumers. Maintenance activities, which pause production but extend facilities' life, are recommended during non-peak demand periods to avoid production losses and meet customer demand. To mitigate these effects, decisions on operations planning, maintenance scheduling, and maintenance team assignments should be optimized in a risk management framework. The proposed model adopts a mixed-integer linear programming (MILP) framework and is solved via a sequential approach that incorporates the relax-and-fix (RF) heuristic in order to find a solution that is close to optimal. Subsequently, the solution serves as an initial solution for the CPLEX solver, which employs a branch-and-cut algorithm to attain the exact optimal solution. The practicality of this model has been showcased through its application to the supply chain in Saudi Arabia. The model efficiently schedules maintenance activities evenly and consistently across the OGSC plants over the planning period to reduce lost sales by keeping plants operational during high-demand periods. Furthermore, a sensitivity analysis was conducted to investigate the influence of the decision-maker's risk attitude on the outcomes that were obtained.

Long-term PTSD prevalence and associated adverse psychological, functional, and economic outcomes: a 12–15 year follow-up of adults with suspected serious injury

ABSTRACT Background: An increasing number of longitudinal studies investigates long-term PTSD, related outcomes and potential gender differences herein. However, a knowledge gap exists when it comes to studies following individual civilian trauma beyond a decade post-trauma. Objective: To investigate the long-term PTSD prevalence, associated adverse psychological, functional and economic outcomes related to (suspected) serious injury of 12–15 years ago in Dutch adults, as well as potential gender differences herein. Method: N = 194 trauma-exposed adults (34% women) admitted to an emergency department following suspected serious injury completed a follow-up assessment 12–15 years (M = 14.30, SD = 1.00) post-trauma. Participants completed assessments of clinician-rated PTSD symptom severity, as well as self-report questionnaires on psychological, functional and economic outcomes. Results: Nine participants (4.8%) fulfilled the DSM-5 diagnostic criteria for PTSD related to the index trauma of 12–15 years ago. Results showed that PTSD symptom severity (CAPS-5) was significantly associated with more severe symptoms of anxiety (HADS) and depression (QIDS), lower well-being (WHO-5) and (health-related) quality of life (WHOQOL; EQ-5D-5L), but not with alcohol use (AUDIT), productivity loss at work (iPCQ) and health care use (iMCQ). No significant gender differences in the long-term PTSD prevalence nor in its related psychological, functional and economic outcomes were found. Conclusions: Our findings underscore the long-term presence of PTSD and associated adverse psychological and functional outcomes in a proportion of adults who experienced (suspected) serious injury over a decade ago. PTSD is already widely recognized for its substantial impact in the aftermath of a trauma. The current study emphasizes the potential long-term consequences of individual civilian trauma, highlighting the importance of accurate screening and prevention for PTSD.

Genomic analysis of Brucella isolates from animals and humans, Türkiye, 2010 to 2020.

BackgroundBrucellosis is a bacterial zoonosis causing severe illness in humans and animals and leading to economic losses in the livestock production in Türkiye and other endemic countries.AimWe aimed at investigating genomic differences of Brucella isolates from animals and humans in Türkiye.MethodsWe used whole genome sequencing (WGS) to assess the genetic diversity of Brucella isolates from 41 provinces in Türkiye and compared with isolates from other countries. We applied allele-based typing and core genome single nucleotide polymorphism (cgSNP) determination.ResultsOf the 106 Turkish Brucella isolates included, 57 were B. abortus and 49 were B. melitensis. One B. melitensis and two B. abortus isolates were identified as vaccine strains. Most (n = 55) B. abortus isolates clustered in three major branches, with no spatial discernible pattern. Of the B. melitensis isolates, 48 were assigned to the Eastern Mediterranean lineage with no discernible patterns between host species, location and sampling date. The Turkish isolates clustered with isolates from neighbouring countries such as Greece and Syria, but some also with isolates from human patients in European countries, like Germany, Norway and Sweden, suggesting that the source may be travel-related.ConclusionSeveral B. melitensis and B. abortus lineages are circulating in Türkiye. To decrease the prevalence and prevent brucellosis in animals and humans, stricter control measures are needed, particularly in areas where humans and animals have close contact. Furthermore, illegal transportation of animals across borders should be more closely controlled and regulated.

Detachment of leading-edge vortex enhances wake capture force production

During stroke reversals, insect wings interact with their own wake flow from the preceding half-stroke, resulting in an unsteady aerodynamic mechanism known as ‘wing–wake interaction’ or ‘wake capture’. To better elucidate this mechanism, we numerically solved the incompressible Navier–Stokes equations at Reynolds numbers $10^2$ and $10^3$ . Simulations were conducted for wing planforms defined using the beta function distribution with varying aspect ratios ( $AR=2\unicode{x2013}6$ ) and radial centroid locations ( $\hat {r}_1=0.4\unicode{x2013}0.6$ ), whilst employing representative normal hovering kinematics. The wake development from the considered flapping wing planforms was investigated, and the wake capture contribution to aerodynamic force production was quantified by comparing the force generation between the fifth and first stroke cycles at multiple sections along the wingspan. Our results revealed that on the inboard wing region experiencing an attached leading-edge vortex (LEV) structure, wing–wake interaction is dominated by an unsteady downwash effect, resulting in a reduction in local force production. However, in regions closer to the wingtip experiencing detachment of the LEV, wing–wake interaction is dominated by an unsteady upwash effect, leading to an increase in local force production. Consequently, the global wake capture force production is controlled by the extent of LEV detachment, which primarily increases with the increase of wing aspect ratio. This suggests that for normal hovering flapping wings, the typical loss in translational force production due to wingtip stall is partially mitigated by wake capture effects.