The article considers the basis of scientific research in the field of electric power industry the issues of transition to 20 kV voltage in the distribution power grids of Uzbekistan. The main advantages of this method are analysed, as well as the factors affecting power and energy losses in electrical systems and networks. The paper presents a schematic diagram of an electric network section, on which a comparative calculation and analysis of voltage, energy and power losses in 6/10/20 kV networks is carried out. Special attention is paid to the peculiarities of calculation of these parameters, as well as the basic expressions for their calculation and the resulting graphical relationships. From the analysis it can be concluded that it is reasonable to use 20 kV voltage in distribution networks. It allows to reduce power and energy losses, which is an important factor in the efficient operation of electric power systems, to increase line capacity and service range. However, when selecting the optimal voltage for certain conditions, it is necessary to take into account a number of factors, such as the length of transmission lines, the type of wires and transformers used, and the load level of the network.