Today, the service of Voice over Internet Protocol or (VoIP) is one of the most used service around the globe in many fields, especially with video conferencing applications. Different applications and also many communications companies around the world use the VoIP service. Communication stakeholders aim to keep old customers happy and attract new customers. There was a need for some kind of service quality measures. Metrics are used to quantify the quality of transmission link are known Quality of Service (QoS). Whereas, user satisfaction level is identified by using Quality of Experience (QoE). This paper conducted a simulation model for VoIP service over heterogeneous, using OPNET modeler. This work aims to compare the user satisfaction level of the VoIP service by using different coding schemes in the application level of the User Equipment (UE). The measured QoS parameters over the heterogeneous transmission link were IP packet delay, IP Packet jitter, IP packet loss, MAC layer delay, PHY layer throughput in the network. Additionally, in this simulation model the use of E-Model to assess QoE level using Mean Opinion Score (MOS) metric in predicting the VoIP call quality. The results using the vocoder G.729A during the (30) sec of the voice call simulation time were as follows: Delay 0.57 mSec, Throughput of 290 Kbits/sec, Jitter of 0.02 uSec, MOS value of 3.76. The results using the vocoder G.711 during the same aforementioned time were as follows: Delay 0.25 mSec, Throughput of 70 Kbits/sec, Jitter of 0 Sec), MOS value of 3.08.