Loss Mechanisms Research Articles

Factors related to preoperative anxiety in older patients with sensory impairment: A cross-sectional study.

To identify the factors related to preoperative anxiety in older adults with sensory impairment. Descriptive quantitative research design. Study participants were 120 older adults admitted to a tertiary hospital in Seoul, South Korea to undergo eye or ear surgery. Data were collected from 11 February to 30 April 2023. The collected data were analysed using descriptive statistics, t-tests, ANOVA, and multiple regression analysis using SPSS 28.0. The study was reported following the STROBE checklist. Preoperative anxiety differed significantly according to gender (p = .002), average monthly household income (p < .001), subjective health status (p = .003), subjective vision loss (p = .004), one-sided or both-sided eye discomfort (p = .002), use of glasses (p = .010), subjective hearing loss (p = .022) and anxiety coping mechanisms (p < .001). The results of a multiple regression analysis on the significant variables identified that gender (β = .178, p = .036) and anxiety coping mechanisms (β = .336, p < .001) had the most significant effect on preoperative anxiety, with an explanatory power of 34.5%. The development and practical application of tailored nursing interventions catering to specific genders and anxiety coping mechanisms would contribute to reducing preoperative anxiety and providing efficient nursing care for older adults with sensory impairment.

Systematic Review and Meta-analysis of the Impact of Metabolic Surgery on Hepatic Stiffness.

Bariatric surgery is one of the effective therapeutic options for people with obesity and obesity-related co-morbidities. In addition to weight-related co-morbid diseases, including diabetes, hypertension, and hypercholesterolemia, non-alcoholic fatty liver disease (NAFLD) is common in patients with morbid obesity. Bariatric surgery is one of the therapeutic options in the management of NAFLD. Hence, this review focused on the potential role of bariatric surgery on hepatic elasticity measured through shear wave elastography. A systematic literature search was performed, and the studies regarding heterogeneity were evaluated using the random-effects model. The meta-analysis on 6 trials (3-12 months follow-up) including 350 participants showed a significant reduction of liver elasticity after surgery (WMD: -1.149, 95% CI: -1.767, -0.532, p < 0.001; I2:81.55%). Bariatric surgery is associated with decreased liver elasticity. This improvement could be related to weight loss or other mechanisms of bariatric surgery.

Corrosion and wear mechanisms of rare earth (Gd, Sc, Y)-doped Zr-based amorphous alloys

Rare-earth elements have been utilized in the design and development of new amorphous alloys to improve the corrosion and wear resistance of Zr-based amorphous alloys. In this study, a rare-earth doped Zr-based amorphous alloy (Zr-BMG(RE)) was prepared by the copper mold casting method, which was investigated by corrosion and wear experiments. The results show that Zr-BMG(RE) has a completely amorphous structure, and the doping of rare earths Gd and Y raises the crystallization transition temperature of the amorphous. The addition of rare earth elements Gd and Sc increases the microhardness of Zr-based amorphous alloys, while rare earth element Y causes a slight decrease in microhardness. Gd and Sc will make Zr-based amorphous materials corrosion current density increases, the material pitting and localized corrosion, acid corrosion resistance is reduced. Y doping improves the self-corrosion potential of Zr-based amorphous alloys, reduces the corrosion current density, the surface passivation film is the densest, and the degree of charge transfer on the metal surface is the most difficult, Zr-BMG(Y) has a better corrosion resistance compared with other alloy materials. Zr-BMG(Gd) has the smallest friction rate (1.72×10-7mm3N-1mm-1), and the wear rates of the rare earth doped Zr-based amorphous alloys are all smaller than that of Zr-BMG, and the main loss mechanism of Zr-based amorphous alloys is the interaction of adhesive wear, abrasive wear, oxidative wear and fatigue wear. The mechanism of corrosion and wear resistance of rare earth to Zr-based amorphous alloys is discussed, which provides a new idea for the design of amorphous alloys.

The synergistic effects on the magnetic CoNi and Fe3O4 nanoparticles co-embedded porous carbon toward enhanced microwave absorbing performance

Abstract Lightweight and environmentally friendly three-dimensional biomass-derived porous carbon (3D BPC) holds great potential as a highly effective material for microwave absorption (MA) applications. However, the high complex permittivity and lack of magnetic loss in a single 3D BPC lead to impedance mismatching and a limited absorption bandwidth. Developing 3D BPC–based absorbers with multiple loss mechanisms and excellent impedance matching remains a notable yet challenging task. In this study, inspired by a synergistic composition and microstructure design, 3D BPC co-embedded with magnetic cobalt–nickel (CoNi) and iron(III) oxide (Fe3O4) nanoparticles (3D BPC@CoNi@Fe3O4) was developed. 3D BPC@CoNi@Fe3O4 exhibited consistently low complex permittivity, primarily due to the suppression of conductive loss, whereas the introduction of magnetic phases (CoNi and Fe3O4) enhanced the magnetic loss. Optimised impedance matching, achieved through the synergistic regulation of the electromagnetic parameters, emerged as the key mechanism for improving the MA properties. The as-synthesised 3D BPC@CoNi@Fe3O4 composite, with only 20 wt.% loading demonstrated a wide effective absorption bandwidth (reflection loss [RL] &lt; −10 dB) of 6.08 GHz and an impressive minimum RL value of −40.08 dB. These findings offer valuable insights into the development of high-performance 3D BPC–based microwave absorbers through composition and microstructure optimisation.

Plasma-Fluid Energy Transfers in Plasma Assisted Ignition

ABSTRACT A three-dimensional model of plasma-fluid coupling is developed, including the Navier-Stokes, the drift-diffusion, and the radiative transfer equations, to investigate the energy transfers between plasma and fluid in repetitive-pulsed discharge ignition. A modal decomposition of the energy transfer is performed to determine the contributions of plasma to the mechanical coupling and pressure losses during ignition. The detailed model is validated against experiments and compared against a well-known empirical approximation. The main findings are that the modal coupling is dependent on the geometry of the electrodes and flat electrodes provide the strongest mechanical transfer into the acoustic modes. Uniform flow conditions decrease the extent of the mechanical coupling due to the decreased pressure velocity correlations in shear flows. Water vapor production reduces the entropic mode of the energy coupling.

Bremsstrahlung radiation power in fusion plasmas revisited: towards accurate analytical fitting

Abstract In fusion plasmas, where electron temperatures $T_e$ range from keV to hundreds of keV, Bremsstrahlung radiation constitutes a significant energy loss mechanism. While various thermal average fitting formulas exist in the literature, their accuracy is limited, particularly for $T_e \leq 20$ keV with error $&gt;10\%$. Additionally, non-relativistic fitting formulas become invalid for $T_e \geq 50$ keV. The accurate calculation of Bremsstrahlung radiation is important for fusion gain study, especially of advanced fuels fusion. In this work, we develop new but still simple fitting formulas that are valid for electron temperatures ranging from small ($\lesssim0.1$ keV) to extreme relativistic range, with errors of less than 1\% even for high atomic number ions (e.g., $Z=30$), which could be sufficient for fusion plasma applications. Both electron-ion (e-i) and electron-electron (e-e) Bremsstrahlung radiations are considered. Both polynomial fitting with truncated ($t=k_BT_e/m_ec^2\leq10$) and one-fit-all formulas are provided. Additionally, we offer fitting formulas for e-i and e-e specifically for electron energies, which could prove useful in non-Maxwellian Bremsstrahlung radiation studies.

Interlayer growth of magnetic nanocomponent in Ti3C2Tx MXene EMW absorbers for periodic electromagnetic synergetic network

Transition metal carbides/carbonitrides (MXene) exhibit huge potential as electromagnetic wave (EMW) absorbers in dealing with electromagnetic radiation problem that rise due to the rapid development of 5G era. The incorporation of magnetic materials can effectively mitigate the impedance mismatch and singular loss mechanisms inherent in pure MXenes (PMs). However, challenges persist due to issues such as random distribution, complex preparation processes, and inadequate interaction. In this study, Ti3C2Tx/Ni hybrids were synthesized using a one-pot method, wherein Ni, derived from molten salt, replaces Al layer of MXene, facilitating the in-situ growth of Ni nanocomponents within the interlayered region. The periodic electromagnetic synergetic network of “MXene-Ni-MXene-Ni-MXene” provides substantial magnetic resonance, eddy current loss, interface polarization, defect polarization, and dipole polarization, enriching the loss mechanism. By regulating the concentration of Ni, the intrinsic poor impedance matching of MXene was improved. Consequently, Ti3C2Tx/Ni hybrid exhibited exceptional electromagnetic wave absorption (EMA) performance, achieving a reflection loss (RL) of −64.51 dB and an effective absorption bandwidth (EAB) of 4.96 GHz at a matching thickness of 1.98 mm. Additionally, the super radar cross-section (RCS value = −15.73 dB m2) endow it potential in practical application. This work provides a facile method for achieving unique electromagnetic synergetic loss mechanism, thus paving the way for exploring high-efficient MXene-based EMW absorbers.

Significance of the proton energy loss mechanism to gold nanoparticles in proton therapy: a Geant4 simulation

The biological effectiveness in proton therapy is only slightly greater than of the treatment by X-ray and hence, many researches have suggested the use of gold nanoparticles for increasing the ionization interactions to produce more secondary electrons and elevate the yield of DNA damage. But the ionization interactions also lead to protons energy loss inside the nanoparticles. The present study shows that, the protons slowed-down by High-Z nanoparticles are responsible for dose enhancement rather than the produced secondary electrons. To this purpose, using Geant4 Monte Carlo tool, one million nanoparticles distributed in a proton irradiated volume and variation of the proton’s spectra and the dose related to this variation has been demonstrated. It was found that, the elevation in proton’s LET values when passing through the gold nanoparticles will lead to a more significant dose enhancement than the increased dose due to the extra secondary electrons. Also, it was found that, the mechanism of protons slowing-down by gold nanoparticles has another useful aspect in proton therapy in which, the dose leakage to surrounding healthy tissues will be reduced which must be considered in future investigations more precisely.

Frequency Domain-Based Super Resolution Using Two-Dimensional Structure Consistency for Ultra-High-Resolution Display

Recent advancements in the field of super resolution (SR) have seen the adoption of generative adversarial networks (GANs) for realistic images. In this case, when performing with low-resolution (LR) images, several challenges arise due to the loss of high-frequency details from high-resolution (HR) images, potentially leading to unwanted distortions in the generated SR images. Our paper presents a novel solution by using two-dimensional structure consistency (TSC) for image analysis. The TSC serves as a mask, enabling adaptive analysis based on the unique frequency characteristics of different image regions. Furthermore, a mutual loss mechanism, which dynamically adjusts the training process based on the results filtered by the TSC-based mask, is introduced. Additionally, the TSC loss is proposed to enhance our model capacity to generate precise TSC in high-frequency regions. As a result, our method effectively reduces distortions in high-frequency areas while preserving clarity in regions containing low-frequency components. Our method outperforms other SR techniques, demonstrating superior results in both qualitative and quantitative evaluations. Quantitative measurements, including PSNR, SSIM, and the perceptual metric LPIPS, show comparable PSNR and SSIM values, while the perceptual SR quality is notably improved according to the LPIPS metric.

Using an ensemble Kalman filter method for a soil nitrogen transport model in the real rice field

The overuse of nitrogen fertilizer in rice field of China leads to nitrogen loss and serious water pollution, so it is vital to accurately predict soil nitrogen transport in rice field. But the prediction errors of soil nitrogen transport are great due to complex chemical and reactive conditions and uncertain parameters in real rice fields. In this study, a prediction model of soil nitrogen transport in a rice field was established via modifying the HYDRUS-1D source code, and a data assimilation method called the ensemble Kalman filtering (EnKF) was coupled, based on the observed NH4+-N and NO3–-N concentrations at different depths in a real rice field. Study results for two different protocols of assimilating observed NH4+-N and NO3–-N concentrations simultaneously and separately were compared. It indicated the predictions accuracy of NH4+-N and NO3–-N concentrations was improved significantly via the EnKF method, and the former protocol is better than the latter. Moreover, for the latter protocol, observations of NO3–-N concentrations were more efficient than NH4+-N to improve the predictions accuracy of NH4+-N and NO3–-N concentrations at different depths. Inversed parameters of urea hydrolysis, NH4+-N volatilization, soil adsorption of NH4+-N, nitrification and denitrification increased over time. On the whole, the inversed model parameters were more stable at deep soil than shallow soil, which were different at different depths. With soil depths increase, parameters of the NH4+-N adsorption and NO3–-N denitrification increased, while parameters of urea hydrolysis, NH4+-N volatilization and nitrification decreased. This study improved the model predictions accuracy and inversed the model parameters, revealing the mechanism of nitrogen loss in real rice fields, which can provide scientific basis to reduce serious environmental problems caused by the overuse of nitrogen fertilizer.

A novel high-Q Lamé mode bulk acoustic resonator

This study introduces a novel high-Q Lamé mode MEMS resonator, optimized through support beam structures and etching hole distributions to minimize anchor losses and thermal elastic dissipation (TED). Fabricated using a Silicon-On-Insulator (SOI) process, the resonators achieved Q values of 129,200 and 102,100 in different designs, demonstrating significant improvements in vacuum conditions and highlighting air damping as a key loss mechanism. Nonlinear analysis revealed material nonlinearity dominance. These findings offer valuable guidelines for developing high-end MEMS devices, such as low phase noise oscillators and high-resolution sensors, by showcasing substantial reductions in energy dissipation and enhanced Q factors through structural optimizations.

Study of nonequilibrium regenerative heat exchange in positive displacement compressors

BACKGROUND: An important task in the design of thermal engines is the evaluation of power losses in different processes to determine the installation efficiency. One of the processes that generates power losses in the compressor is the process of nonequilibrium regenerative heat exchange (NRHE) of the compressed gas with the working cavity walls. This heat exchange occurs at a significant temperature difference, which can lead to noticeable power losses. Modern compressor design methods do not consider losses from nonequilibrium regenerative heat exchange and do not describe them separately from other types of losses. AIM: This study investigates the mechanism of losses during regenerative heat exchange between the gaseous working flow out and the working cavity walls and evaluates the scale of these losses. METHODS AND RESULTS: This work provides a qualitative description of the mechanism for the formation of losses from NRHE. As a result of solving the problem of unsteady thermal conductivity, an analytical expression for calculating such losses is derived based on the Gouy-Stodola theorem. CONCLUSIONS: The study revealed that power losses from NRHE account for a significant share in the overall balance of machine losses. Parameters influencing the magnitude of these losses were also determined, and recommendations were developed to reduce them.

Carbon nanolayer-mounted single metal sites enable dipole polarization loss under electromagnetic field.

Surface modulation strategies have spurred great interest with regard to regulating the morphology, dispersion and flexible processability of materials. Unsurprisingly, customized modulation of surfaces is primed to offer a route to control their electronic functions. To regulate electromagnetic wave (EMW) absorption applications by surface engineering is an unmet challenge. Thanks to pyrolyzing surface-anchored metal-porphyrin, here we report on the surface modulation of four-nitrogen atoms-confined single metal site on a nitrogen-doped carbon layer (sM(N4)@NC, M = Ni, Co, Cu, Ni/Cu) (sM=single metal; NC= nitrogen-doped carbon layer) that registers electromagnetic wave absorption. Surface-anchored metal-porphyrins are afforded by attaching them onto the polypyrrole surface via a prototypical click reaction. Further, sM(N4)@NC is experimentally found to elicit an identical dipole polarization loss mechanism, overcoming the handicaps of conductivity loss, defects, and interfacial polarization loss among the current EMW absorber models. Importantly, sM(N4)@NC is found toexhibit an effective absorption bandwidth of 6.44 and reflection loss of -51.7 dB, preceding state-of-the-art carbon-based EMW absorbers. This study introduces a surface modulation strategy to design EMW absorbers based on single metal sites that enable fine-tunable and controlled absorption mechanism with atomistic precision.

Challenges and opportunities in high efficiency scalable and stable perovskite solar cells

Perovskite solar cells (PSCs) are the fastest-growing photovoltaic (PV) technology and hold great promise for the photovoltaic industry due to their low-cost fabrication and excellent efficiency. To achieve commercial readiness level, the most important factor would be yield beyond 95% at the PSC module levels. The current essential requirements for PSCs are reproducibility of high efficiency devices, scalability, and stability. The reported certified high efficiency (24–26%) results are based on the use of FAPbI3 perovskites with a bandgap of Eg≈ 1.5 eV, and the typical device's active area ranges from ≈ 0.1 cm2 to a maximum of 1 cm2. However, relatively higher bandgap PSCs are essential, especially in tandem solar cell applications. Hence, optimization of higher bandgap PSCs is a necessity. As the bandgap of the perovskites increases, the efficiency goes down due to reduced JSC and increased VOC loss. Therefore, understanding the loss mechanism and corresponding solutions need to be developed. Scaling up the device's active area without compromising the fill factor and, hence, efficiency is non-trivial. So, understanding the loss mechanism in large area devices is crucial. The stability analysis reported in the literature is inconsistent, preventing data comparison and identifying various degradation factors or failure mechanisms. Moreover, how the accelerated tests would be useful in predicting the real lifetime of the solar cells is yet to be developed. So, understanding the knowledge and the technological gaps between laboratory and industry-scale production is crucial for further development. Therefore, in this review article, we discuss the challenges and opportunities for scalable and stable high efficiency PSCs.

Post Harvest Management Techniques of Few Selected Crops in Assam, India

Reducing agricultural loss or waste is the ultimate goal of post-harvest management techniques. Post-harvest management has become crucial in the present environment of growing population and declining agricultural land and other resources. Ensuring food security in a manner that is safe for both humans and the environment is currently the world's top priority. The FAO estimates that in order to feed the nine billion people on the planet by 2050, food production would need to rise by seventy percent. Therefore, a deep comprehension of the roles played by agro-ecosystems is necessary. A vast number of agricultural products has been produced in recent years, yet there has been a lack of advancement and uptake of post-harvest technologies, leading to significant post-harvest losses. Agricultural crops have 16–36% post-harvest losses each year due to microbiological, physiological, and mechanical losses. Because most products are highly perishable, they require much more care and strategies to ensure that value addition and processing are encouraged. The value chain for processing has become essential to enhancing national food security and promoting food safety. The value chain in agriculture crops post-harvest management includes pre-harvest variables, harvesting, market preparation (pre-cooling, sorting, grading, packaging, and on-farm storage), transportation, storage, value addition/processing, and by-product waste management. The chapter focuses mostly on few selected fruit, vegetable, and cereal crops while discussing current advancements in post-harvest technology and food crop value addition.

Substantial oxygen loss and chemical expansion in lithium-rich layered oxides at moderate delithiation.

Delithiation of layered oxide electrodes triggers irreversible oxygen loss, one of the primary degradation modes in lithium-ion batteries. However, the delithiation-dependent mechanisms of oxygen loss remain poorly understood. Here we investigate the oxygen non-stoichiometry in Li1.18-xNi0.21Mn0.53Co0.08O2-δ electrodes as a function of Li content by using cycling protocols with long open-circuit voltage steps at varying states of charge. Surprisingly, we observe substantial oxygen loss even at moderate delithiation, corresponding to 2.5, 4.0 and 7.6 ml O2 per gram of Li1.18-xNi0.21Mn0.53Co0.08O2-δ after resting at upper capacity cut-offs of 135, 200 and 265 mAh g-1 for 100 h. Our observations suggest an intrinsic oxygen instability consistent with predictions of high oxygen activity at intermediate potentials versus Li/Li+. In addition, we observe a large chemical expansion coefficient with respect to oxygen non-stoichiometry, which is about three times greater than those of classical oxygen-deficient materials such as fluorite and perovskite oxides. Our work challenges the conventional wisdom that deep delithiation is a necessary condition for oxygen loss in layered oxide electrodes and highlights the importance of calendar ageing for investigating oxygen stability.

A simplified coaxial ion trap mass analyzer: Characterization of the simplified toroidal ion trap with a rectilinear ion guide

A new miniature coaxial ion trap mass analyzer with a rectilinear ion guide has been constructed using a combination of planar and cylindrical electrodes. The results reported here focus on characterizing the performance of the rectilinear ion guide and simplified toroidal ion trap components. The simplified toroidal ion trap was found to have an ion capacity in excess of 105 ions and mass spectral resolution of 0.5–0.6 when used as a mass analyzer. The ion storage efficiency within the toroidal trapping region was evaluated and found the stored ion population decreased exponentially with storage time. Ion losses depended slightly on the stored βz condition. Ion losses within the toroidal region are attributed primarily to field instabilities at the intersection point of the two components while charge exchange reactions were observed but considered a minor loss mechanism. The ability to mass selectively ejection ions of a specific mass from the toroidal trapping region was characterized and found to approach 100 % efficiency under appropriate ejection conditions.

Impact of Loss Mechanisms on Linear Spectra of Excitonic and Polaritonic Aggregates.

The presence of loss mechanisms governed by empirical timescales can profoundly affect the dynamics in molecular systems, leading to changes in their spectra. However, incorporation of these effects along with the system's interaction with the thermal dissipative environments proves to be challenging. In this work, we demonstrate the possibility of utilizing the recently developed path integral Lindblad dynamics (PILD) method to study the linear spectra of molecular aggregates. PILD presents a uniquely powerful simulation technique for retaining the effects of the vibrations in a numerically exact manner through the Feynman-Vernon influence functional while incorporating the effects of losses in an empirical manner using the Lindbald master equation. As illustrations of this technique, we provide examples taken from chiral excitonic and polaritonic aggregates for which we simulate both the absorption spectra and circular dichroism (CD) spectra. We demonstrate that the effect of loss on particular states can differ not just on the basis of the symmetries of the state but also on the basis of complicated "interactions" of the structured dissipative environments with the system and its loss mechanisms. Due to the different selection rules between the absorption and CD spectra and the relative intensities and broadening of the peaks, the two linear spectra together give an interesting insight into the contributions of the various eigenstates to the correlation functions. While the focus here is on linear spectroscopy, it should be possible in the future to use PILD to study multidimensional spectra under loss mechanisms as well.

Low-intensity pulsed ultrasound regulates bone marrow mesenchymal stromal cells differentiation and inhibits bone loss by activating the IL-11-Wnt/β-catenin signaling pathway

BackgroundOsteoporosis (OP) is a common metabolic bone disease. Low-intensity pulsed ultrasound (LIPUS) can effectively promote bone formation and fracture healing. The Wnt/β-catenin signaling pathway is crucial for regulating bone homeostasis and bone diseases, and its downregulation is one of the main mechanisms of osteoporosis pathogenesis. Interleukin-11 (IL-11), which is regulated by mechanical stress, is a key factor in bone remodeling. Here, we investigated the optimal intervention parameters for LIPUS, the relationships among LIPUS, IL-11, and the Wnt/β-catenin signaling pathway, and the effects of LIPUS on bone loss and potential molecular mechanisms in ovariectomized (OVX) mice. MethodsBone marrow mesenchymal stromal cells (BMSCs) were subjected to LIPUS intervention for 0, 10, or 20 min to determine the optimal intervention time. The mediating role of IL-11 in LIPUS intervention was explored through IL-11 knockdown and overexpression. Finally, animal experiments were conducted to investigate the in vivo therapeutic effects of LIPUS. ResultsThe optimal intervention time for LIPUS was 20 min. LIPUS promoted IL-11 expression and upregulated the Wnt/β-catenin signaling pathway, thereby promoting osteogenic differentiation and inhibiting adipogenic differentiation of BMSCs. IL-11 mediates the regulation of the Wnt/β-catenin signaling pathway by LIPUS. Additionally, LIPUS effectively improved the bone microstructure in ovariectomized mice, inhibited bone loss, promoted IL-11 expression in bone tissue, and activated the Wnt/β-catenin signaling pathway in the femur. ConclusionLow-intensity pulsed ultrasound can regulate BMSCs differentiation and inhibit bone loss by promoting IL-11 expression and activating the Wnt/β-catenin signaling pathway.

Aging Skeletal Muscles: What Are the Mechanisms of Age-Related Loss of Strength and Muscle Mass, and Can We Impede Its Development and Progression?

As we age, we lose muscle strength and power, a condition commonly referred to as sarcopenia (ICD-10-CM code (M62.84)). The prevalence of sarcopenia is about 5–10% of the elderly population, resulting in varying degrees of disability. In this review we emphasise that sarcopenia does not occur suddenly. It is an aging-induced deterioration that occurs over time and is only recognised as a disease when it manifests clinically in the 6th–7th decade of life. Evidence from animal studies, elite athletes and longitudinal population studies all confirms that the underlying process has been ongoing for decades once sarcopenia has manifested. We present hypotheses about the mechanism(s) underlying this process and their supporting evidence. We briefly review various proposals to impede sarcopenia, including cell therapy, reducing senescent cells and their secretome, utilising targets revealed by the skeletal muscle secretome, and muscle innervation. We conclude that although there are potential candidates and ongoing preclinical and clinical trials with drug treatments, the only evidence-based intervention today for humans is exercise. We present different exercise programmes and discuss to what extent the interindividual susceptibility to developing sarcopenia is due to our genetic predisposition or lifestyle factors.