Displacement Of Loop Research Articles

Complete genome characterization of foot-and-mouth disease virus My-466 belonging to the novel lineage O/ME-SA/SA-2018

Foot-and-mouth disease virus (FMDV), the causative agent of the foot-and-mouth disease of cattle population possesses a rapid evolutionary rate. In Bangladesh, the first circulation of the O/ME-SA/SA-2018 lineage as a novel sublineage, MYMBD21 was reported from our laboratory. The first whole genome sequence of an isolate, BAN/MY/My-466/2021 (shortly named My-466) of the SA-2018 lineage is characterized and represented in this study. The genome is 8216 nucleotides long with 6996 nucleotides open reading frame flanked by 5ꞌ UTR (1–1100) and 3ꞌ UTR (8097–8216). VP1 was found to be highly variable among the structural proteins with crucial mutations in the major antigenic region, G-H loop. Structural variations of the VP1 against both field and proposed local vaccine strains were evidenced by the G-H loop displacement in a superimposed 3D model. The complete genome information of the isolate would be valuable for undertaking proper control measures needed to limit the spread of the newly emerged FMDV strain.

Kink Waves in Twisted and Expanding Magnetic Tubes

We study kink and fluting waves in expanding and twisted magnetic flux tubes. We use the thin-tube and zero-beta plasma approximations. The equilibrium magnetic field is force free with a constant proportionality coefficient between the electrical current and the magnetic field. We derive the equation governing the kink and fluting waves in a tube. Using this equation we study the propagation of kink waves in a particular case of a magnetic tube homogeneous in the axial direction. We show that while there is only one propagating kink wave with the phase speed equal to the kink speed in an untwisted tube, in a twisted tube there are two wave modes, accelerated and decelerated. The phase speed of the accelerated wave exceeds the kink speed, while the phase speed of the decelerated wave is less than the kink speed. We also show that the standing modes are defined by the same eigenvalue problem as that in the case of an untwisted tube. Hence, the frequencies of the standing-wave modes are not affected by the twist. This implies that the seismological results based on the observation of the standing-wave mode frequencies remain valid when the twist is taken into account. The only effect of twist is the variation of the direction of polarisation of the coronal magnetic-loop displacement along the loop. As a result, an apparent node can be detected near the loop apex if only one component of the loop displacement is observed. This can lead to an incorrect conclusion that the observed coronal loop kink oscillation was the first overtone, while in fact it was the fundamental mode.

Biomechanical Comparison of 1.2-mm Suture Tape, 2.0-mm Suture Tape, and 0.5-mm Suture Using Various Arthroscopic Knot Techniques.

The biomechanical properties of the 1.2-mm suture tape have outperformed conventional sutures in previous studies. To compare the loop and knot security of 2 tape-type and 1 cord-type sutures using different arthroscopic knot techniques. Controlled laboratory study. The biomechanical characteristics of the 1.2-mm tape, 2.0-mm tape, and 0.5-mm No. 2 suture were compared using 4 different knot types: 2 sliding knots (Samsung Medical Center [SMC] and Tennessee) and 2 nonsliding knots (2-throw surgeon's and 2-throw square) with 2 and 3 additional reverse half-hitches on alternating posts (RHAPs) in a closed-loop system on a materials testing device. Each configuration was tested for loop security (maximal load applied between 0 and 3 mm of displacement), knot security (ultimate failure load), and failure mode with cyclical loading (30 N load for 20 cycles at 1 cycle per sec until failure). Loop and knot security among the configurations were compared using an analysis of variance. With 2 RHAPs, the 2.0-mm tape showed significantly greater loop security than the 1.2-mm tape and suture (P = .001). With 3 RHAPs, the loop security of the suture was significantly superior compared with the 1.2-mm tape (P = .010). Regarding knot security, with 2 RHAPs, the 2.0-mm tape was significantly better than the 1.2-mm tape and suture (P < .001), while with 3 RHAPs, the suture was significantly superior to the 1.2-mm tape (P = .012). Using a square knot with 2 RHAPs, the 2.0-mm tape had significantly greater loop security (P = .001) and better knot security (P = .001) to the 1.2-mm tape and suture. Using the Tennessee knot with 2 RHAPs, the 1.2-mm tape had less loop security (P = .011) and knot security (P = .005) than the suture. Using the SMC knot with 3 RHAPs, the 2.0-mm tape and suture were significantly superior in loop security (P = .001) and knot security (P < .001) to the 1.2-mm tape. There was no significant difference in the failure mode between tapes and sutures with 2 and 3 RHAPs. With 2 RHAPs, the 2.0-mm tape demonstrated greater resistance to suture loop displacement and better knot security compared with the 1.2-mm tape and suture. However, with 3 RHAPs, the 1.2-mm tape manifested weaker loop and knot security compared with the suture.

Monte Carlo simulation of a magnetic nanoparticles system under an external rotating magnetic field

The magnetic response of an identical magnetic nanoparticles (MNP) system to a rotating external field (RMF) is studied via Monte Carlo simulations. The field of amplitude H0 and frequency ω, was applied in the y−z plane rotating clockwise. The energy was modeled by the Stoner–Wohlfarth scheme for fixed or random orientations of the anisotropy, and is in contact with a thermal bath at a temperature T. Interparticle dipolar interactions were also considered.In the non-interacting system and for low temperature, hysteresis is observed in the z magnetization component Mz for both orientations of the anisotropy axis and only in the y component (My) for the random case. Furthermore, the loop areas were estimated, and increased with ω for all orientations and (My,Mz) components. At higher temperatures the superparamagnetic state is observed, so both the blocking temperatures TB and loop areas were estimated. The values of TB were close from the room temperature TR=300K for all components, and the areas decreased with T but they are practically not zero at TB.When dipolar interactions are included a new scenario is revealed. In the low temperature regime, the blocked state is present for both My and Mz for all anisotropy orientations, and extends beyond the interval of amplitudes H0 estimated theoretically for the model without interactions and fixed anisotropy. The loops are displaced with respect to the origin of the magnetization-external field plane. When the temperature is raised, the blocked state extends for a larger range than the model without interactions, and the loop displacement decreases with T. These behaviors could be explained by observing that the average dipolar field per particle produces an effective field – the sum of both dipolar and external field – that is asymmetric with respect to the zero field line at low temperatures, becomes half-wave symmetric at higher temperatures, so the the centered character of the loops is restored . In addition, the loop areas show a peak for all orientations of the anisotropy axes in an intermediate range of temperatures. This result can be associated with a dominance of the anisotropy induced by the dipolar field.Finally, by comparing the areas of the loops of the models with and without interactions, it was found that the non-interacting model have larger areas at low temperatures that vanish near the room temperature, unlike the areas of the model with interactions due to the extension of the blocked state.

Asymmetric Magneto-Optical Rotation in Magnetoplasmonic Nanocomposites

The results of the asymmetric magneto-optical rotation in the magnetoplasmonic nanocomposite study are presented. The asymmetry is observed in spectra of magneto-optical rotation when a magneto-optical medium with a plasmonic subsystem is magnetized along or against the radiation wave vector. The asymmetry is observed as vertical displacement of a magneto-optical hysteresis loop too. Such asymmetry is detected in magnetoplasmonic nanocomposite, which consists of a magneto-optical layer of Bi substituted iron-garnet intercalated with a plasmonic subsystem of gold self-assembled nanoparticles. It is shown that the physical reason for the asymmetric magneto-optical rotation is the manifestation of the Cotton–Mouton birefringence effect when the normal magnetization of the sample to a radiation wave vector appears due to the magnetic component of the electromagnetic field of resonating nanoparticles. This effect is additive to the basic magneto-optical Faraday Effect.

A High Fidelity and High Frequency Physical Simulator for Mitral Annulus Kinematics

Cardiovascular medical devices that operate within the heart are subjected to millions of loading cycles that can compromise the structural integrity of the implant over time. Accelerated structural testing is a major challenge in the design of implantable cardiac devices, particularly in the emerging realm of catheter-based devices used to treat conditions like mitral valve regurgitation (MR). In this work, we design a bench-top simulator for accelerated structural testing of devices that operate in or near the mitral valve. We first use four-dimensional computed tomography (4DCT) data to create a molded replica of the mitral valve and identify the most deformation-inducing time points in the cardiac cycle. We then kinematically analyze the motion of the mitral annulus using screw theory and create an electromechanical simulation device that mimics this motion at high frequencies. The final apparatus allows for multiple patient-specific scenarios and accurate closed loop displacement control of the screw-based kinematics of the mitral annulus. The test apparatus operates with less than 1 dB of passband ripple up to its 25.7 Hz bandwidth. The proposed device moves toward a desirable paradigm in accelerated structural testing that is less reliant on computational models, animal models, and high-risk early feasibility clinical trials.

A Lumenal Loop Associated with Catalytic Asymmetry in Plant Vacuolar H+-Translocating Pyrophosphatase.

Membrane-integral inorganic pyrophosphatases (mPPases) couple pyrophosphate hydrolysis with H+ and Na+ pumping in plants and microbes. mPPases are homodimeric transporters with two catalytic sites facing the cytoplasm and demonstrating highly different substrate-binding affinities and activities. The structural aspects of the functional asymmetry are still poorly understood because the structure of the physiologically relevant dimer form with only one active site occupied by the substrate is unknown. We addressed this issue by molecular dynamics (MD) simulations of the H+-transporting mPPase of Vigna radiata, starting from its crystal structure containing a close substrate analog (imidodiphosphate, IDP) in both active sites. The MD simulations revealed pre-existing subunit asymmetry, which increased upon IDP binding to one subunit and persisted in the fully occupied dimer. The most significant asymmetrical change caused by IDP binding is a ‘rigid body’-like displacement of the lumenal loop connecting α-helices 2 and 3 in the partner subunit and opening its exit channel for water. This highly conserved 14–19-residue loop is found only in plant vacuolar mPPases and may have a regulatory function, such as pH sensing in the vacuole. Our data define the structural link between the loop and active sites and are consistent with the published structural and functional data.

Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation

Human immunodeficiency virus-1 (HIV-1), the causative agent of AIDS, impacts millions of people. Entry into target cells is mediated by the HIV-1 envelope (Env) glycoprotein interacting with host receptor CD4, which triggers conformational changes allowing binding to a coreceptor and subsequent membrane fusion. Small molecule or peptide CD4-mimetic drugs mimic CD4’s Phe43 interaction with Env by inserting into the conserved Phe43 pocket on Env subunit gp120. Here, we present single-particle cryo-EM structures of CD4-mimetics BNM-III-170 and M48U1 bound to a BG505 native-like Env trimer plus the CD4-induced antibody 17b at 3.7 Å and 3.9 Å resolution, respectively. CD4-mimetic-bound BG505 exhibits canonical CD4-induced conformational changes including trimer opening, formation of the 4-stranded gp120 bridging sheet, displacement of the V1V2 loop, and formation of a compact and elongated gp41 HR1C helical bundle. We conclude that CD4-induced structural changes on both gp120 and gp41 Env subunits are induced by binding to the gp120 Phe43 pocket.

Application of the mixing of the field of low amplitude AC bias with a strong field of linear slow varying to investigate the magnetic properties of materials

The paper presents a new experimental method of the magnetic hysteresis loop investigation and the constructed measurement instrument. The principle of operation is to mix two magnetic fields: the first of these fields has a very low amplitude, a shape of sine wave (AC bias) and the frequency range order of 10–104 Hz. The second field has a very low frequency (order 10−2 Hz), a high amplitude and forms approximately a triangle wave. The presented, dedicated system is different in comparison to commonly used hystographs and it consists of coreless coils only. The measurement method gives the opportunity of obtaining more detailed measurements of the initial cycles in the material magnetizing process. In a special case, the magnetic field strength changes in the B(H) curve can be stopped at any operating point and then it is possible to investigate local properties using AC bias field for various frequencies. The results revealed a successive displacement of the hysteresis loop and approaching to the steady state position.

Implementation of Dahl\u2019s dynamic friction model to contact mechanics of elastic solids

This study presents an analytical method for the solution of dynamic frictional contact problem between a rigid punch and an isotropic elastic solid. Rigid flat punch moves over the isotropic elastic solid at a constant subsonic speed and friction force develops based on Dahl’s friction law instead of Coulomb’s dry friction law. Dahl’s dynamic friction model is adopted since this model is one of the well-known dynamic friction models in the literature. According to this model, friction force depends only on a displacement rather than the speed of the punch since viscous effects are ignored. Influences of the parameters describing Dahl’s friction model on contact stress at slow and high speed sliding cases are examined. Analytical solution is conducted by means of Galilean and Fourier transformations. Friction force is computed numerically by the use of 4th order Runge–Kutta method for various displacements of the punch. Formulation for the contact problem is reduced to a singular integral equation and normal stress over the surface of elastic half-plane is determined. Obtained contact stresses are compared with those generated through finite element method and results display a high degree of accuracy. The influences of direction of motion, Coulomb’s coefficient of friction, pre-sliding displacement, asperity stiffness and shape factor of hysteresis loop upon contact stresses and stress intensity factors are revealed.

Recognizing the Ultrasound Patterns of Mesenteric Panniculitis.

Mesenteric panniculitis (MP) is a rare, benign, and nonspecific chronic fibrosing inflammation of the mesenteric adipose tissue. Abdominal pain is the most frequent presentation.The objective was to recognize ultrasound (US) features in MP. A retrospective 9-year review of computed tomography- (CT) or US-diagnosed cases of MP recorded in the radiology department was performed. The inclusion criteria included an US recorded in PACS imaging data base within 10 days before CT, to compare and evaluate the correlation of MP diagnosis.The prevalence of MP on CT was 2.8%. The 120 selected patients had an abdominal US 10 days before CT. Male-to-female ratio was 4:1. Fifty-three percent of MP was suggested by US. The US finding was increased volume with fatty mass in the mesentery root (98%). The fatty mesenteric mass had oval shape or convex anterior border in 94%, central abdominal location in 91%, and focal mesenteric increased echogenicity in 95%. Lateral bowel loop displacement was observed in 59%. Detection of lymph nodes was less frequent (55%).In conclusion, MP is an entity to be considered in the differential diagnosis of abdominal pain. Knowledge and recognition of the US findings of MP and central abdominal compression may improve detection during the abdominal US examination.

Kink Oscillations in Solar Coronal Loops with Elliptical Cross Sections. I. The Linear Regime

Abstract The cross sections of solar coronal loops are suggested to be rarely circular. We examine linear kink oscillations in straight, density-enhanced, magnetic cylinders with elliptical cross sections by solving the three-dimensional magnetohydrodynamic equations from an initial-value-problem perspective. Motivated by relevant eigenmode analyses, we distinguish between two independent polarizations, one along the major axis (the M-modes) and the other along the minor one (the m-modes). We find that, as happens for coronal loops with circular cross sections, the apparent damping of the transverse displacement of the loop axis is accompanied by the accumulation of transverse Alfvénic motions and the consequent development of small scales therein, suggesting the robustness of the concepts of resonant absorption and phase mixing. In addition, two stages can in general be told apart in the temporal evolution of the loop displacement: a Gaussian time dependence precedes an exponential one. For the two examined density ratios between loops and their surroundings, the periods of the M-modes (m-modes) tend to increase (decrease) with the major-to-minor-half-axis ratio, and the damping times in the exponential stage for the M-modes tend to exceed their m-mode counterparts. This is true for the two transverse profiles we examine. However, the relative magnitudes of the damping times in the exponential stage for different polarizations depend on the specification of the transverse profile or the density contrast. The applications of our numerical findings are discussed in the context of coronal seismology.

Abstract 17087: Mesenchymal Stem Cell-Derived Extracellular Vesicle Therapy Delivered in a Hydrogel Preserves Hemodynamic Function Following Myocardial Infarction

Introduction: Mesenchymal Stem Cell (MSC)-derived Extracellular Vesicles (EVs) are an emerging regenerative therapy for treatment of ischemic cardiomyopathy. In this study, we determine the efficacy of MSC-EV therapy in a shear-thinning hydrogel (STG) delivered via intramyocardial injection to the border zone of rat hearts following myocardial infarction (MI). Hypothesis: MSC EV-loaded STGs will preserve hemodynamic function and minimize ventricular scar formation in a rat model of acute MI. Methods: EVs were isolated from MSCs by PEG precipitation, and the EV proteome was characterized by MaxQuant 1.5.1.2 and Metacore analysis software. Varying concentrations of EVs were administered to rats following induction of acute MI by ligation of the left anterior descending artery. EVs were delivered in either sterile phosphate buffered saline (PBS) or STG for sustained EV release. Chronic injury was assessed at 4 weeks post-MI through transthoracic echocardiography, intraventricular pressure-volume loop displacement, and histology. Results: MSC EV proteomic analysis highlighted upregulation of VEGF angiogenic cascades and ILK-mediated proliferative pathways. The mean left ventricle ejection fraction (LVEF) for each treatment group at four weeks is displayed in Table 1. A 20 ug dose of MSC EVs in STG improved LVEF by 19.12% (p&lt;0.05) compared to PBS, with a 90 ug dose of MSC EVs in STG increasing LVEF by 23.56% (p&lt;0.01) (Fig. 1). Conclusions: Intramyocardial injection of MSC EVs in STG post-MI showed concentration dependent improvements in hemodynamics. These findings show that high doses of MSC EV in STG may have potential as a therapy for ischemic cardiomyopathy. Proteomic analysis revealed that angiogenesis, recruitment of cardiac progenitor cells, and immune modulation may be mechanistic drivers of MSC-EV therapy.

Influences of compressor displacement ratio on dual-loop heat pump system for ventilation heat recovery

The performance of heat pump ventilation heat recovery system can be effectively improved using multiple-loop independent compression cycle. The influence of the DR change on the performance of dual-loop system was predicted through calculation to explore the influence of the change in displacement ratio (DR) on the performance of the system and the direction of further improving the performance of the system. The optimum DR in dual-loop system was calculated. The performance differences of two dual-loop heat pump systems with different DR values were compared by experiments. Results show that the optimum DR is between 0.8040 and 0.9206, and this optimum DR maximizes the COP of the system. Experimental results show that, compared with the COP of the system with the DR of 2, that of the system with the DR of 0.5 can be increased by 14.8%. Compared with the overall COP of the triplex loop system with the same displacement in each loop, that of the system with the DR of 0.5 is even higher under certain test conditions. The comparison results of COP changes are in accordance with the prediction of simulation calculation. Therefore, a reasonable increase in the displacement of the low-pressure loop in the multi-loop heat recovery heat pump system will improve the system performance.

Conformational gating in ammonia lyases

BackgroundAmmonia lyases are enzymes of industrial and biomedical interest. Knowledge of structure-dynamics-function relationship in ammonia lyases is instrumental for exploiting the potential of these enzymes in industrial or biomedical applications. MethodsWe investigated the conformational changes in the proximity of the catalytic pocket of a 3-methylaspartate ammonia lyase (MAL) as a model system. At this scope, we used microsecond all-atom molecular dynamics simulations, analyzed with dimensionality reduction techniques, as well as in terms of contact networks and correlated motions. ResultsWe identify two regulatory elements in the MAL structure, i.e., the β5-α2 loop and the helix-hairpin-loop subdomain. These regulatory elements undergo conformational changes switching from ‘occluded’ to ‘open’ states. The rearrangements are coupled to changes in the accessibility of the active site. The β5-α2 loop and the helix-hairpin-loop subdomain modulate the formation of tunnels from the protein surface to the catalytic site, making the active site more accessible to the substrate when they are in an open state. ConclusionsOur work pinpoints a sequential mechanism, in which the helix-hairpin-loop subdomain of MAL needs to break a subset of intramolecular interactions first to favor the displacement of the β5-α2 loop. The coupled conformational changes of these two elements contribute to modulate the accessibility of the catalytic site. General significanceSimilar molecular mechanisms can have broad relevance in other ammonia lyases with similar regulatory loops. Our results also imply that it is important to account for protein dynamics in the design of variants of ammonia lyases for industrial and biomedical applications.

Mutational landscape screening of methylene tetrahydrofolate reductase to predict homocystinuria associated variants: An integrative computational approach

Methylene tetrahydrofolate reductase (MTHFR) is a flavoprotein, involved in one-carbon pathway and is responsible for folate and homocysteine metabolism. Regulation of MTHFR is pivotal for maintaining the cellular concentrations of methionine and SAM (S-adenosyl methionine) which are essential for the synthesis of nucleotides and amino acids, respectively. Therefore, mutations in MTHFR leads to its dysfunction resulting in conditions like homocystinuria, cardiovascular diseases, and neural tube defects in infants. Among these conditions, homocystinuria has been highly explored, as it manifests ocular disorders, cognitive disorders and skeletal abnormalities. Hence, in this study, we intend to explore the mutational landscape of human MTHFR isoform-1 (h.MTHFR-1) to decipher the most pathogenic variants pertaining to homocystinuria. Thus, a multilevel stringent prioritization of non-synonymous mutations in h.MTHFR-1 by integrative machine learning approaches was implemented to delineate highly deleterious variants based on its pathogenicity, impact on structural stability and functionality. Subsequently, extended molecular dynamics simulations and molecular docking studies were also integrated in order to prioritize the mutations that perturbs structural stability and functionality of h.MTHFR-1. In addition, displacement of Loop (Arg157-Tyr174) and helix α9 (His263-Ser272) involved in open/closed conformation of substrate binding domain were also probed to confirm the functional loss. On juxtaposed analysis, it was inferred that among 126 missense mutations screened, along with known pathogenic mutations (H127 T, A222 V, T227 M, F257 V and G387D) predicted that W500C, P254S and D585 N variants could be potentially driving homocystinuria. Thus, uncovering the prospects for inclusion of these mutations in diagnostic panels based on further experimental validations.

Observation of spin glass behavior in chiral Mn48Fe34Si18 with a β-Mn related structure

The ternary silicide system Fe-Mn-Si exhibits several complex magnetic phases and the chemical similarity of Fe and Mn enables these two elements to be mutually substituted over a wide compositional range. Because this substitution results in chemical disorder and often causes competing magnetic exchange interactions, frustrated spin glass ordering is expected to occur for some Fe-Mn-Si phases. However, the observation of a spin glass state within these alloys has been elusive to date. This paper reports magnetization and ac susceptibility measurements on Mn48Fe34Si18. The compound crystallizes in a Mn3IrSi-type structure, which is closely related to that of β-Mn. Typical spin glass behavior is observed at low temperatures. This comprises a bifurcation of field-cooled and zero-field-cooled magnetization, a displacement of the field-cooled hysteresis loop, magnetic relaxation, a memory effect, and a sharp, frequency-dependent cusp in the ac susceptibility at the freezing temperature. Mn48Fe34Si18 is demonstrated to be a canonical spin glass.

Structural Basis of MRG15-Mediated Activation of the ASH1L Histone Methyltransferase by Releasing an Autoinhibitory Loop

Human ASH1L is the catalytic subunit of the conserved histone methyltransferase (HMTase) complex AMC that dimethylates lysine 36 in histone H3 (H3K36me2) to promote gene transcription in mammals and flies. Unlike AMC, ASH1L alone shows poor catalytic activity, because access to its substrate binding pocket is blocked by an autoinhibitory loop (AI loop) from the postSET domain. We report the crystal structure of the minimal catalytic active AMC complex containing ASH1L and its partner subunit MRG15. The structure reveals how binding of theMRG domain of MRG15 to a conserved FxLP motif inASH1L results in the displacement of the AI loop to permit substrates to access the catalytic pocket of the ASH1L SET domain. Together, ASH1L activation by MRG15 therefore represents a delicate regulatory mechanism for how a cofactor activates an SET domain HMTase by releasing autoinhibition.

МОДЕЛИРОВАНИЕ ПЛАСТИЧЕСКОГО ДЕФОРМИРОВАНИЯ ПОЛИКРИСТАЛЛИЧЕСКИХ КОНСТРУКЦИОННЫХ СПЛАВОВ ПРИ БЛОЧНЫХ НЕСИММЕТРИЧНЫХ РЕЖИМАХ МЯГКОГО МАЛОЦИКЛОВОГО НАГРУЖЕНИЯ

Processes of plastic deformation of polycrystalline structural alloys under block-type nonstationary regimes of soft low-cycle loading are considered. Modified Korotkikh's thermal-plasticity model pertaining to the class of yield theories with translation-isotropic hardening is used as defining relations of plasticity. The modification of Korotkikh's model consists in using a different formulation of evolutionary equations for the displacement of the yield surface center (the micro-stress tensor), used for block-type nonstationary regimes of low-cycle loading for describing effects of setting under a hard loading regime (controlled strains) and ratcheting under a soft loading regime (controlled stresses) of the plastic hysteresis loop. Determining the material parameters and scalar functions of the plastic deformation model, assessing its adequacy and scope of application was done based on the experimental studies of the deformation process of laboratory specimens made of stainless steels of the austenite (SS316L, SS304) and ferrite (20MnMoNi5-5) classes in the conditions of uniaxial and multiaxial, proportional and non-proportional regimes of soft block-type cyclic loading. Comparison of the numerical results with the experimental data indicates that the developed plasticity model qualitatively and quantitatively, accurately enough for engineering purposes, describes the main effects of plastic deformation (displacements of the plastic hysteresis loops and decreasing strain amplitudes) under block-type nonstationary nonsymmetrical regimes of soft low-cycle loading.

Non-damping oscillations at flaring loops

Context. Quasi-periodic oscillations are usually detected as spatial displacements of coronal loops in imaging observations or as periodic shifts of line properties (i.e., Doppler velocity, line width and intensity) in spectroscopic observations. They are often applied for remote diagnostics of magnetic fields and plasma properties on the Sun. Aims. We combine the imaging and spectroscopic measurements of available space missions, and investigate the properties of non-damping oscillations at flaring loops. Methods. We used the Interface Region Imaging Spectrograph (IRIS) to measure the spectrum over a narrow slit. The double-component Gaussian fitting method was used to extract the line profile of Fe XXI 1354.08 Å at the “O I” spectral window. The quasi-periodicity of loop oscillations were identified in the Fourier and wavelet spectra. Results. A periodicity at about 40 s is detected in the line properties of Fe XXI 1354.08 Å, hard X-ray emissions in GOES 1−8 Å derivative, and Fermi 26−50 keV. The Doppler velocity and line width oscillate in phase, while a phase shift of about π/2 is detected between the Doppler velocity and peak intensity. The amplitudes of Doppler velocity and line width oscillation are about 2.2 km s−1 and 1.9 km s−1, respectively, while peak intensity oscillates with amplitude at about 3.6% of the background emission. Meanwhile, a quasi-period of about 155 s is identified in the Doppler velocity and peak intensity of the Fe XXI 1354.08 Å line emission, and AIA 131 Å intensity. Conclusions. The oscillations at about 40 s are not damped significantly during the observation; this might be linked to the global kink modes of flaring loops. The periodicity at about 155 s is most likely a signature of recurring downflows after chromospheric evaporation along flaring loops. The magnetic field strengths of the flaring loops are estimated to be about 120−170 G using the magnetohydrodynamic seismology diagnostics, which are consistent with the magnetic field modeling results using the flux rope insertion method.