To disclose the application value of cold plate with transverse layout used in thermal management system, a novel dimensionless factor, Comprehensive Index of Thermal Management System (CITMS), is proposed, which involves three most important parameters: pumping power Etol, temperature dispersion Tσ and maximum temperature Tmax. Results show that compared to 15 types of mini-channels (longitudinal parallel, serpentine, bifurcated, u-turn, annular, zigzag, cobweb, elm leaf, diverged, rhombus spoiler, gridding, wave, honeycomb, multistage tesla-valve, pease types), transverse parallel mini-channel shows superior CITMS, which declines by an average of 80.26 % to 99.61 % under weighting coefficient w = 1 and expected operating temperature Texp = 320.15 K. Meanwhile, zigzag, wave, pease and multistage tesla-valve mini-channels with transverse layout show significantly better CITMS than longitudinal layout, which decline by an average of 78.61 % to 89.03 %. This is mainly due to the decline in Tσ and Etol. Furthermore, based on CITMS, an appropriate mass flow rate can be achieved for a specific cold plate. Under w = 30 and Texp = 298.15 K, the optimal value of CITMS for transverse parallel mini-channel occurs at 0.5 g/s. In view of better comprehensive performance and same process difficulty, transverse layout could undoubtedly become an effective design concept.