Longitudinal Increments Research Articles

Variation of segment joint opening of underwater shield tunnel during long operational period

Segment joint is the main water leakage channel in underwater shield tunnels, and joint deformation influences tunnel waterproof capacity greatly. Real-time structure health monitoring is a great way to investigate the joint opening and to offer early warnings for abnormality, such as data outlier and joint properties degradation. This study investigated the variation of joint opening, provided early warning indexes and evaluated the joint mechanical properties degradation using the field monitoring data of an underwater shield tunnel over 10 years, which is rarely seen in the literature. Study results show that: (1) Field monitoring data reveals that the distribution of joint opening increments obeys a heavy-tailed distribution rather than the normal distribution. The exponential distribution model and the log normal distribution model can fit the longitudinal joint increments and circumferential joint increments much better. (2) The early warning index is determined based on the statistic theory and 0.999 quantile is set as the warning value. The obtained warning values of the studied underwater tunnel are 0.005 mm and 0.08 mm for the longitudinal and circumferential joint respectively. The small warning value means that small abnormality can be identified and the early warning would be more efficient. (3) A mechanical model is proposed to evaluate the joint mechanical properties degradation based on monitoring data. Results show that normal stiffness of circumferential joint decreases from 18.3 GPa/m to 14.7 GPa/m. Results of this study provides valuable reference for early-warning and joint degradation evaluation of under water shield tunnel.

Lower plasma linoleic acids as a risk factor for gout: an integrated analysis of population-based cohort and genetic data.

Background: Gout is a nutrition-related, highly prevalent inflammatory arthritis with undesirable effects on the quality of life. The relationships between circulating fatty acids (FAs) and gout remain poorly understood. Method: We included 268 174 participants with plasma FAs measured using nuclear magnetic resonance at the baseline (2006-2010) from the UK Biobank, of which 15 194 participants had repeated measures of FAs between 2012 and 2013. Cox proportional hazards models were used to assess the association of the baseline and longitudinal changes in relative levels of plasma FAs (% total FAs) with incident gout. Mendelian randomization (MR) analyses were conducted to assess the potential causality of the examined association. Results: Over a median follow-up of 12.8 years, 5160 incident cases of gout occurred. Baseline polyunsaturated fatty acids (PUFAs), n-6 PUFAs, and linoleic acids (LAs) were inversely associated with incident gout (all P-trend values < 0.0001). Baseline monounsaturated fatty acids (MUFAs), n-3 PUFAs, and docosahexaenoic acids (DHAs) were positively associated with incident gout (all P-trend values < 0.0001). Longitudinal increments of n-6 PUFAs and LAs were associated with a lower risk of subsequent gout, whereas an increment of n-3 PUFAs was associated with a higher risk. In two-sample MR analyses, genetically determined higher levels of PUFAs, n-6 PUFAs, and LAs were associated with a decreased risk of gout (all P values < 0.05). Conclusions: Our findings consistently indicate a causal relationship of elevated levels of n-6 PUFAs, especially LAs, with a reduced risk of gout.

Baseline Values of Circulating IL-6 and TGF-β Might Identify Patients with HNSCC Who Do Not Benefit from Nivolumab Treatment.

The immunotherapy of head and neck cancer induces a limited rate of long-term survivors at the cost of treating many patients exposed to toxicity without benefit, regardless of PD-L1 expression. The identification of better biomarkers is warranted. We analyzed a panel of cytokines, chemokines and growth factors, hereinafter all referred to as 'cytokines', as potential biomarkers in patients with head and neck cancer treated with nivolumab. A total of 18 circulating cytokines were analyzed. Samples were gathered at baseline (T0) and after 3 courses of nivolumab (T1) in patients with relapsed/metastatic disease. The data extracted at T0 were linked to survival; the comparison of T0-T1 explored the effect of immunotherapy. A total of 22 patients were accrued: 64% current heavy smokers, 36% female and 14% had PS = 2. At T0, ROC analysis showed that IL-6, IL-8, IL-10 and TGF-β were higher in patients with poor survival. Cox analysis demonstrated that only patients with the IL-6 and TGF-β discriminate had good or poor survival, respectively. Longitudinal increments of CCL-4, IL-15, IL-2 and CXCL-10 were observed in all patients during nivolumab treatment. In this small population with poor clinical characteristics, this study highlights the prognostic role of IL-6 and TGF-β. Nivolumab treatment is associated with a positive modulation of some Th1 cytokines, but it does not correlate with the outcome.

Assessment of Wound Recovery and Radial Growth 10 Years after Forest Operations in Hardwood Stands

Damage to the residual stand caused by forest operations can have detrimental impacts on the biological processes of stand growth. This study shows the details from monitoring damages related to manual motor ground-based timber operations in a mountain mixed hardwood forest. The harvesting system was cut-to-length, and logs were extracted by wheeled cable-skidders. Data were collected from the remaining trees immediately after logging and 10 years after the logging session. The parameters assessed included stem injury, radial growth increment and wound healing rate for five hardwood species of commercial interest. The number of injured trees represented 15% of the residual stand, 23% of the wounds were related to the felling operation and 76% to extraction. Wound height, wound size and damage to bark, due to felling, were larger than those in extraction, while wound width and damages to cambium and wood caused by extraction were larger than those triggered by felling. Ten years after harvesting, average longitudinal and radial growth increments were reduced by 38% and 24%, respectively. Wound healing rates ranged from 12.90 mm yr−1 for extraction wounds to 19.70 mm yr−1 for felling ones within 10 years. On average 73% of all wounds were still unrecovered and 17% of these were decayed, while only 10% were fully healed within a 10-year recovery period. The analysis showed that the best recovering performance among damaged trees was mostly achieved in shade-intolerant species with a diameter less than 40 cm, located in the dominant canopy layer with a wound size smaller than 100 cm2. In addition to the significant effect on log quality, the ecological longevity of residual trees has major implications for pre-planning harvesting operations that can preserve the quality and value of residual trees. Understanding the damage inflicted upon residual trees is essential to reduce economic losses, improve planning of harvest operations and, ultimately, ensure a sustainable harvest of mixed hardwood stands in mountain regions.

Evaluation of a new immunochemestry analyzer Atelica® Solution

Although alanine aminotransferase (ALT) is well known to be associated with metabolic syndrome (MetS), prospective data on longitudinal increments in ALT activities and incident cases of MetS are limited. We analyzed the impact of longitudinal increments of ALT on MetS based on a health check-up population in China.A total of 4491 subjects free of MetS who completed at least two annual health examinations during March 2010 to April 2016 were enrolled in this cohort study. The MetS was defined according to the Joint Interim Statement criteria 2009. The RRs of incident MetS were estimated by using the Cox model and the Joint model in R software.The cumulative incidence of MetS was 18.55% during the 7 years of follow-up. In the Cox model, the estimated RR of developing MetS was 1.751 (95% CI =1.532–2.000) for 1 unit augmented in LNALT-0 level. In the Joint model, the estimated RR of developing MetS was 3.626 (95% CI = 2.721–4.831) for 1 unit augmented in LNALT activity longitudinally.The longitudinal increment of individuals' ALT activity over time increased the incidence risk of MetS and the effects generated by longitudinal increments of ALT on MetS was higher than that generated by baseline ALT.

The longitudinal increments of serum alanine aminotransferase increased the incidence risk of metabolic syndrome: A large cohort population in China

BackgroundAlthough alanine aminotransferase (ALT) is well known to be associated with metabolic syndrome (MetS), prospective data on longitudinal increments in ALT activities and incident cases of MetS are limited. We analyzed the impact of longitudinal increments of ALT on MetS based on a health check-up population in China. MethodsA total of 4491 subjects free of MetS who completed at least two annual health examinations during March 2010 to April 2016 were enrolled in this cohort study. The MetS was defined according to the Joint Interim Statement criteria 2009. The RRs of incident MetS were estimated by using the Cox model and the Joint model in R software. ResultsThe cumulative incidence of MetS was 18.55% during the 7 years of follow-up. In the Cox model, the estimated RR of developing MetS was 1.751 (95% CI =1.532–2.000) for 1 unit augmented in LNALT-0 level. In the Joint model, the estimated RR of developing MetS was 3.626 (95% CI = 2.721–4.831) for 1 unit augmented in LNALT activity longitudinally. ConclusionsThe longitudinal increment of individuals' ALT activity over time increased the incidence risk of MetS and the effects generated by longitudinal increments of ALT on MetS was higher than that generated by baseline ALT.

Turbulence laws in natural bed flows

Characterization of turbulence in natural bed streams is one of the most fascinating problems of fluid dynamics. In this study, a statistical description of turbulence in a natural pebble bed flow is presented applying the laws of turbulence. A laboratory experiment was conducted to measure the three-dimensional instantaneous velocity components in a flow over heterogeneous coarse sediments that simulated a natural bed. The analysis reveals that the spectra (in Fourier space) show a power-law scaling,$E(k)\sim k^{{\it\alpha}}$, suggesting the presence of inertial range turbulence. The exponent${\it\alpha}$is slightly shallower than the Kolmogorov$5/3$scaling law, with this deviation possibly due to the bed roughness heterogeneity and to fluctuation anisotropy. The Taylor frozen-in approximation is broken at smaller scales towards the roughness crest level; therefore, a new statistical tool for the validation of this approximation is proposed. The Kolmogorov$4/5$-law for the longitudinal increments and simultaneously the Monin–Yaglom$4/3$-law for the nonlinear normal fluxes (both in physical space) are preserved, providing an accurate estimation of the turbulent kinetic energy dissipation rate. The heterogeneity of the bed acts to induce the transport of finite kinetic helicity to the outer layer through persistently prolonged vortices. An associated$2/15$-law for the cascade of helicity has been locally found. These findings open a new direction in turbulence research for flows over highly rough beds.

Age, growth and population structure of jumbo flying squid Dosidicus gigas off the Peruvian Exclusive Economic Zone based on beak microstructure

The beak is a hard structure of cephalopods with relatively constant shape, which records a lot of biological and ecological information. Based on samples collected by Chinese squid jigging vessels off the Peruvian Exclusive Economic Zone from July to October 2013, we explored the feasibility of age estimation and growth pattern with the upper beak of Dosidicus gigas. The internal rostral axis and longitudinal increments could be clearly identified on the upper beak rostrum sagittal sections of this species. Checks and abnormal structure were observed in some beaks. Ages estimated were from 123 to 298 days for females and from 106 to 274 days for males. Back-calculated hatching dates were from December 2012 to May 2013. All of the samples were from the austral summer/autumn spawning cohort. Hatching peak occurred between January and March. Growth in mantle length (ML) and body weight were best described by exponential functions and there were no significant differences between females and males. The maximum absolute daily growth rate and instantaneous growth rate of ML were 2.12 mm/day and 0.59/day, respectively. This study suggests that the upper beak could be used for estimating age, growth and population structure of D. gigas.

Introduction of longitudinal and transverse Lagrangian velocity increments in homogeneous and isotropic turbulence

Based on geometric considerations, longitudinal and transverse Lagrangian velocity increments are introduced as components along, and perpendicular to, the displacement of fluid particles during a time scale τ. It is argued that these two increments probe preferentially the stretching and spinning of material fluid elements, respectively. This property is confirmed (in the limit of vanishing τ) by examining the variances of these increments conditioned on the local topology of the flow. These longitudinal and transverse Lagrangian increments are found to share some qualitative features with their Eulerian counterparts. In particular, direct numerical simulations at up to 300 show that the distributions of are negatively skewed at all τ, which is a signature of time irreversibility in the Lagrangian framework. Transverse increments are found more intermittent than longitudinal increments, as quantified by the comparison of their respective flatnesses and scaling laws. Although different in nature, standard Cartesian Lagrangian increments (projected on fixed axis) exhibit scaling properties that are very close to transverse Lagrangian increments.

Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging

We investigated whether individuals with impaired glucose tolerance (IGT) in midlife subsequently show regionally specific longitudinal changes in regional cerebral blood flow (rCBF) relative to those with normal glucose tolerance (NGT). Sixty-four cognitively normal participants in the neuroimaging substudy of the Baltimore Longitudinal Study of Aging underwent serial 15O-water positron emission tomography scans (age at first scan, 69.6 ± 7.5 years) and oral glucose tolerance tests 12 years earlier (age at first oral glucose tolerance test, 57.2 ± 11.1 years). Using voxel-based analysis, we compared changes in rCBF over an 8-year period between 15 participants with IGT in midlife and 49 with NGT. Significant differences were observed in longitudinal change in rCBF between the IGT and NGT groups. The predominant pattern was greater rCBF decline in the IGT group in the frontal, parietal, and temporal cortices. Some brain regions in the frontal and temporal cortices also showed greater longitudinal increments in rCBF in the IGT group. Our findings suggest that IGT in midlife is associated with subsequent longitudinal changes in brain function during aging even in cognitively normal older individuals.

Dating branch growth units in a tropical tree using morphological and anatomical markers: the case of Parkia velutina Benoist (Mimosoïdeae)

In tropical areas, studies based on the retrospective analysis of tree development have focused principally on growth ring research. The interpretation of primary growth markers is overlooked although it opens perspectives to provide long time-series on tree-crown development. This study focused on Parkia velutina, an emergent tree of neotropical rain forests. Our objectives were (1) to characterize the phenological cycle of this species, and (2) to identify temporally interpretable morphological and anatomical markers. We collected dominant branches in 14 adult trees and identified growth markers that limit longitudinal and radial increments. We coupled this approach with a 2-year phenological survey of 20 trees. Leaf shedding, growth unit elongation and growth ring formation define the phenological cycle. At tree scale, this cycle is synchronous and affects all axes. At population scale, trees can be desynchronized. This cycle is annual despite some slight variability. Successive growth units and growth rings are easily identifiable. Dating a branch by counting the number of growth units or growth rings is possible in many years with a reasonable error. Nevertheless, estimating their precise month of formation in order to study climatic influences remains difficult.

Hydraulic constraints limit height growth in trees at high altitude

• Low temperatures limit the fixation of photosynthates and xylogenesis. Here, we hypothesized that reduced longitudinal growth in trees at high altitude is related to the lower hydraulic efficiency of the transport system. • Apical buds of Norway spruce (Picea abies) trees at high and low elevation were heated during 2006 and 2007. At the end of the experiment, trees were felled. Longitudinal increments and tracheid lumen areas were measured along the stem. Apical hydraulic conductivity (k) was estimated from anatomical data. • Before heating, high-altitude trees showed fewer (P = 0.002) and smaller (P = 0.008) apical conduits, and therefore reduced k (P = 0.016) and stem elongation (P < 0.0001), in comparison with trees at low elevation. After 2 yr of heating, k increased at both high (P = 0.014) and low (P = 0.047) elevation. Only high-altitude trees showed increased stem elongation, which reached the same magnitude as that of controls at low elevation (P = 0.735). Heating around the apical shoots did not appear to induce significant changes in conduit dimension along the rest of the stem. • The total number and size of xylem elements at the stem apex are strongly constrained by low temperatures. Trees at high altitude are therefore prevented from building up an efficient transport system, and their reduced longitudinal growth reflects strong hydraulic limitations.

Unified multifractal description of velocity increments statistics in turbulence: Intermittency and skewness

The phenomenology of velocity statistics in turbulent flows, up to now, relates to different models dealing with either signed or unsigned longitudinal velocity increments, with either inertial or dissipative fluctuations. In this paper, we are concerned with the complete probability density function (PDF) of signed longitudinal increments at all scales. First, we focus on the symmetric part of the PDFs, taking into account the observed departure from scale invariance induced by dissipation effects. The analysis is then extended to the asymmetric part of the PDFs, with the specific goal to predict the skewness of the velocity derivatives. It opens the route to the complete description of all measurable quantities, for any Reynolds number, and various experimental conditions. This description is based on a single universal parameter function D ( h ) and a universal constant R ∗ .

Joint multi-scale statistics of longitudinal and transversal increments in small-scale wake turbulence

We analyse the relationship of longitudinal and transversal increment statistics measured in isotropic small-scale turbulence. This is done by means of the theory of Markov processes leading to a phenomenological Fokker–Planck equation for the two increments from which a generalized Kármán equation is derived. We discuss in detail the analysis and show that the estimated equation can describe the statistics of the turbulent cascade. A remarkable result is that the main differences between longitudinal and transversal increments can be explained by a simple rescaling symmetry, namely the cascade speed of the transverse increments is 1.5 times faster than that of the longitudinal increments. Small differences can be found in the skewness and in a higher order intermittency term. The rescaling symmetry is compatible with the Kolmogorov constants and the Kármán equation and gives new insight into the use of extended self-similarity (ESS) for transverse increments. Based on the results we propose an extended self-similarity for the transverse increments (ESST).

Baleen as a biomonitor of mercury content and dietary history of North Atlantic Minke Whales ( Balaenopetra acutorostrata): combining elemental and stable isotope approaches

Baleen is an incrementally-growing tissue of balaenopteran whales which preserves relatively well over time in museums and some archeological sites, and, therefore might be useful for studies examining long-term changes of metal levels in whales. This study examined Hg and stable C and N isotopic composition of baleen plates of the North Atlantic minke whale ( Balaenoptera acutorostrata), which continues to be a food source for people in Greenland and elsewhere. We compared the Hg levels and stable isotopes of major tissues (kidney, liver and muscle) with those of baleen plates to see whether baleen could be used as a biomonitor of variations of Hg intake and diet both between individuals and within individuals over time. Mercury was significantly correlated with concentrations in all tissues (kidney, liver and muscle). Stable C and N isotopes in baleen were generally similar to those of muscle, which reflects the recent (approximately one month) feeding of the whale, but in some individuals there were significant differences between baleen and muscle. Sectioning of baleen into 1 cm longitudinal increments showed that these differences were due to marked dietary shifts by some individuals over time that had been recorded in the baleen but were lost from the muscle record. Whole baleen C and N isotopes were better correlated with tissue Hg levels, suggesting that baleen may provide a more reliable indicator of long-term average diet, which in turn may be better related to Hg accumulation in tissues than the shorter-term diet record contained in muscle.

Integrated Aeropropulsive Computational Fluid Dynamics Methodology for the Hyper-X Flight Experiment

Computational e uid dynamics tools have been used extensively in the analysis and development of the X-43A Hyper-X Research Vehicle. A signiecant element of this analysis is the prediction of integrated vehicle aeropropulsive performance,which includes an integration of aerodynamic and propulsion eoweelds. Thedevelopment of the Mach7X-43Arequiredapree ightassessmentoflongitudinalandlateral-directionalaeropropulsivecharacteristics nearthetargeteight-testcondition.Thedevelopmentofthispree ightdatabasewasaccomplishedthroughextensive aerodynamic wind-tunnel testing and a combination of three-dimensional inviscid airframe calculations and cowlto-tail scramjet cycle analyses togenerate longitudinal performance increments between mission sequences. These increments were measured directly and validated through tests of the Hyper-X e ight engine and vehicle e owpath simulator in the NASA Langley Research Center 8-Foot High Temperature Tunnel. Predictions were reened with tip-to-tailNavier‐Stokescalculations,which alsoprovidedinformation onscramjetexhaustplumeexpansion inthe aftbody region. A qualitative assessment of lateral-directional stability characteristics was made through a series of tip-to-tail inviscid calculations, including a simulation of the powered scramjet eight-test condition. Additional comparisons with wind-tunnel forceand momentdataas well as surfacepressuremeasurements from theHyper-X e ight engine and vehicle eowpath simulator model and wind-tunnel testing were made to assess solution accuracy.

A statistical estimator of turbulence intermittency in physical and numerical experiments

The velocity increments statistic in various turbulent flows is analysed through the hypothesis that different scales are linked by a multiplicative process, of which multiplier is infinitely divisible. This generalisation of the Kolmogorov-Obukhov theory is compatible with the finite Reynolds number value of real flows, thus ensuring safe extrapolation to the infinite Reynolds limit. It exhibits a sestimator universally depending on the Reynolds number of the flow, with the same law either for Direct Numerical Simulations or experiments, both for transverse and longitudinal increments. As an application of this result, the inverse dependence Rλ = ƒ(s) is used to define an unbiased Rλ value for a Large Eddy Simulation from the resolved scales velocity statistics. However, the exact shape of the multiplicative process, though independent of the Reynolds number for a given experimental setup, is found to depend significantly on this setup and on the nature of the increment, longitudinal or transverse. The asymmetry of longitudinal velocity increments probability density functions exhibits similarly a dependence with the experimental setup, but also systematically depends on the Reynolds number.

Inverse energy cascade in two-dimensional turbulence: deviations from gaussian behavior

High-resolution numerical simulations of stationary inverse energy cascade in two-dimensional turbulence are presented. Deviations from Gaussian behavior of velocity differences statistics are quantitatively investigated. The level of statistical convergence is pushed enough to permit reliable measurement of the asymmetries in the probability distribution functions of longitudinal increments and odd-order moments, which bring the signature of the inverse energy flux. No measurable intermittency corrections could be found in their scaling laws. The seventh order skewness increases by almost two orders of magnitude with respect to the third, thus becoming of order unity.

Three-component vorticity measurements in a turbulent grid flow

All components of the fluctuating vorticity vector have been measured in decaying grid turbulence using a vorticity probe of relatively simple geometry (four X-probes, i.e. a total of eight hot wires). The data indicate that local isotropy is more closely satisfied than global isotropy, the r.m.s. vorticities being more nearly equal than the r.m.s. velocities. Two checks indicate that the performance of the probe is satisfactory. Firstly, the fully measured mean energy dissipation rate 〈ε〉 is in good agreement with the value inferred from the rate of decay of the mean turbulent energy 〈q2〉 in the quasi-homogeneous region; the isotropic mean energy dissipation rate 〈εiso〉 agrees closely with this value even though individual elements of 〈ε〉 indicate departures from isotropy. Secondly, the measured decay rate of the mean-square vorticity 〈ω2〉 is consistent with that of 〈q2〉 and in reasonable agreement with the isotropic form of the transport equation for 〈ω2〉. Although 〈ε〉≃〈εiso〉, there are discernible differences between the statistics of ε and εiso; in particular, εiso is poorly correlated with either ε or ω2. The behaviour of velocity increments has been examined over a narrow range of separations for which the third-order longitudinal velocity structure function is approximately linear. In this range, transverse velocity increments show larger departures than longitudinal increments from predictions of Kolmogorov (1941). The data indicate that this discrepancy is only partly associated with differences between statistics of locally averaged ε and ω2, the latter remaining more intermittent than the former across this range. It is more likely caused by a departure from isotropy due to the small value of Rλ, the Taylor microscale Reynolds number, in this experiment.

Wave Processes in the Hypersonic Shock Layer on a Flat Plate

An electron-beam fluorescence technique is used to investigate the properties of density waves in the shock layer on a flat plate placed in a hypersonic stream (Mx=21) at zero incidence; the Reynolds number based on the longitudinal coordinate and the freestream parameters is Rex=(2.7–3)·105. Transverse profiles of the mean density and the overall and spectral levels of the density fluctuations are obtained, the longitudinal and lateral phase velocities of the waves and the correlation scales are determined, and the longitudinal increments of the waves are derived. The data are compared with the experimental results obtained at Rex=(2.6–7)10·4.