Longer Reaction Research Articles

Acute Effects of Sprint Interval Training and Chronic Effects of Polarized Training (Sprint Interval Training, High Intensity Interval Training, and Endurance Training) on Choice Reaction Time in Mountain Bike Cyclists.

This study evaluated the acute effects of sprint interval training and chronic effects of polarized training on choice reaction time in cyclists. Twenty-six mountain bike cyclists participated in the study and were divided into experimental (E) and control (C) groups. The cyclists trained for 9-weeks and performed five training sessions each week. Types of training sessions: (1) sprint interval training (SIT) which consisted of 8-16, 30 s repetitions at maximal intensity, (2) high-intensity interval training (HIIT) included 5 to 7, 5-min efforts at an intensity of 85-95% maximal aerobic power (Pmax), and (3) endurance training (ET) performed at an intensity of 55-60% Pmax, lasting 120--180 min. In each week the cyclists performed: in group E a polarized training program, which included 2 × SIT, 1 × HIIT and 2 × ET, while in group C 2 × HIIT and 3 × ET. Before (acute effects) and after the 9-week training period (chronic effects) participants performed laboratory sprint interval testing protocol (SITP), which consisted of 12 maximal repetitions lasting 30 s. During SITP maximal and mean anaerobic power, as well as lactate ion concentration and blood pH were measured. Choice reaction time (RT) was measured 4-times: before and immediately after the SITP test-before and after the 9-week training period. Evaluated the average choice RT, minimal choice RT (shortest reaction), maximal choice RT (longest reaction), and the number of incorrect reactions. Before the training period as acute effects of SITP, it was observed: a shorter average choice RT (F = 13.61; p = 0.001; η2 = 0.362) and maximal choice RT (F = 4.71; p = 0.040; η2 = 0.164), and a decrease the number of incorrect reactions (F = 53.72; p = 0.000; η2 = 0.691), for E and C groups. After the 9-week training period, chronic effects showed that choice RT did not change in any of the cyclists' groups. Only in the E group after the polarized training period, the number of incorrect reactions decreased (F = 49.03; p = 0.000; η2 = 0.671), average anaerobic power increased (F = 8.70; p = 0.007; η2 = 0.274) and blood pH decreased (F = 27.20; p = 0.000; η2 = 0.531), compared to the value before the training period. In conclusion, a shorter choice RT and a decrease in the number of incorrect reactions as acute effects of SITP, and a decrease in the number of incorrect reactions and higher average power as chronic effects of the polarized training program are beneficial for mountain bike cyclists.

Smartphone-based behavioral monitoring and patient-reported outcomes in adults with rheumatic and musculoskeletal disease

BackgroundRheumatic and musculoskeletal diseases (RMD) are associated with depression, fatigue, and disturbed sleep – symptoms that often impact behavior and activity. Patient reported outcomes (PROs) are a way of collecting information on the patient symptom experience directly from the individual. The purpose of this study was to measure and compare user smartphone sensor and activity data in adults with RMDs and assess associations with PROs.MethodsWe invited adults with RMDs enrolled in the FORWARD Databank to participate by installing a custom app on their smartphone and answering PROs (pain, global, HAQ-II) questions daily and weekly over 3 years. Passive data collected included mobility distance, unique calls and text messages, call durations, and number of missed calls. Confounders included sociodemographic, clinical, passive phone behavior, and seasonal factors. Kappa statistics between PRO and flares were computed to measure agreement. The agreement between daily and weekly VAS pain was estimated using the intraclass (ICC) correlation of a two-way random effect model. The relationship between the weekly PRO outcomes and the passive phone data was analyzed with a linear mixed-effect model (LMM), including a random intercept for participant and slope for time in the study with an unstructured covariate structure.ResultsOf the 446 participants, the mean (SD) age was 54 (12) years, most (65.5%) had rheumatoid arthritis (RA), the vast majority (91%) were female, and the US Northeast has the least representation (12%). Longer reaction times, interaction diversity, and higher mobility were associated with worse PROs while longer text messages were associated with better PROs. Participants in this study showed good levels of adherence which holds promise for future interventions using passive behavior measures in self-management and clinical follow-up.ConclusionThis is the first study to examine passive smartphone behavior with PROs in RMDs and we found significant associations between these behaviors and important health outcomes of pain and function. As smartphone usage continues to change, future studies should validate and expand on our findings with a goal of finding changes in patient symptoms passively through mobile device monitoring.

Attentional bias toward pictures related to circumscribed interests in children with autism spectrum disorder

Background Circumscribed interests (CIs) are regarded as one of the common symptoms for individuals with autism spectrum disorder (ASD). Although some studies have found attentional bias toward CI-related stimuli for individuals with ASD, few studies have directly explored the reasons for these findings. Method Children with ASD (n = 15) and age-matched typically developing (TD) children (n = 15) completed a Stroop-like task and a modified dot-probe task, and their reaction times were measured. The stimuli of these tasks included neutral objects and objects related to CI for individuals with ASD. Results Children with ASD had longer reaction times to name colors of CI-related stimuli than neutral stimuli in the Stroop-like task. Similarly, in the modified dot-probe task, if the CI-related stimulus was presented simultaneously with the neutral stimulus, children with ASD responded faster to the target that appeared in the previous location of the CI-related stimulus (i.e. congruent condition) than to the neutral stimulus (i.e. incongruent condition). Importantly, the reaction times of children with ASD in the incongruent condition were significantly slower than in the baseline condition, where both neutral stimuli were displayed simultaneously with stimulus-onset asynchrony (SOA) of 500 ms. In contrast, there was no significant difference in reaction times to CI-related stimuli and neutral stimuli in both tasks for TD children. Conclusions These findings suggest children with ASD have attentional bias toward CI-related stimuli, because of difficulty disengaging attention from CI-related stimuli with SOA of 500 ms.

Neuropsychological exponents for the driving ability in remitted bipolar patients

BackgroundBipolar disorder (BD) is associated with cognitive deficits regardless of the phase of the disease. Medications used in treatment are an additional factor that may affect cognitive performance. Poor cognitive performance can significantly affect a patient's ability to drive.Aim of the studyThis study aims to explore cognitive functions relevant for safe driving in the group of remitted bipolar patients.MethodPatients with BD in remission (n = 33) and healthy volunteers (n = 32) were included. Selected psychometric tests for drivers were carried out using computer software: called Specialistic Diagnostic Platform (SPD): The Cross-over Test (COT) version with free tempo (COT-F) and tempo of 50 tasks per minute (COT-50) and the Signal Test (ST). Moreover, the following neuropsychological tests were used: Rey Auditory Verbal Learning Test (RAVLT), Stroop Color-Word Test (SCWT) part A and B, and Trail Making Test (TMT) version A and B.ResultsIn comparison with healthy controls bipolar patients in remission had poorer outcomes for some cognitive parameters and longer reaction times in both tests for drivers and neuropsychological tests. Additionally, we found a significant correlation between the time of performance of neuropsychological tests and the time of psychometric tests for drivers.ConclusionPatients with BD performed worse in several cognitive domains assessed by tests for drivers and neuropsychological tasks. These deficits can affect the speed of the patient's motor reactions while driving.

Recognition of Affective Faces of Different Age Groups

It has been found that valence and arousal are the core affect dimensions in emotional structure. In this study, we hypothesized that there might be differences between different age groups in emotional structure using six facial expression stimuli (angry, disgusted, fearful, neutral, happy, and sad) of three age groups (young, middle-aged, and old). Unlike previous studies asking participants to rate subjective ratings or similarities between stimuli, participants in this study were required to determine whether stimulus pairs were the same or different emotions and reaction time and accuracy were measured for further analyses. We assumed that it would be harder when the stimulus pair is similar whereas it would be easier when the pair is different. The results showed that for the same emotion pair condition, the sad-sad pair had the lowest accuracy and the longest reaction time, while the happiness-happiness pair had the highest accuracy and the shortest reaction time. For the different emotion pairs, angry-disgusted and disgusted-sad was the lowest accuracy and the longest reaction time. For age of the stimuli effect, responses to the old faces had the lowest accuracy and the longest reaction time. The results suggest that identification of emotional stimuli might be affected by emotion category and age. Further study may need to recruit various age groups, because participants in the current study were mostly young adults.

The online processing of the ambiguous null object in Mandarin among patients with Broca’s aphasia

ABSTRACT Background: Research on how patients with Broca’s aphasia and concomitant agrammatism process dependency structures online offers a window into the understanding of how language is organized in the mind. Previous studies have shown that patients evince differential performances on dependency structures generated at different levels of linguistic representation. The present study extends this line of research to investigate patients’ online processing of referential dependencies involving ambiguous pronominal interpretations. Aims: Mandarin, unlike English, allows the object to be missing (null) in some contexts, rendering these null pronominal forms as ambiguous between two interpretations (strict vs. sloppy), which are generated in different levels of linguistic representation. This study examined Mandarin-speaking healthy and agrammatic aphasic participants’ processing of the two interpretations of the null pronominal form such as Zhangsan qile ta de ma, Lisi ye qile e “literally: Zhangsan rode his horse and Lisi rode, too”, where Lisi rode either Zhangsan’s horse (strict) or Lisi’s horse (sloppy). Methods & Procedures: Two experiments, employing a Cross-Modal Picture Priming paradigm, manipulated three probe picture conditions (strict, sloppy, control) and two probe positions (at the verb phrase offset and 400 ms afterwards). Experiment 1 tested neurologically unimpaired controls in order to establish the time course of processing as a standard of comparison. Experiment 2 tested patients with agrammatic aphasia. Outcomes and Results: Immediately at the verb phrase offset where the null object is structurally licensed, unimpaired individuals primed both the strict and the sloppy interpretations, with no significant difference in reaction times between the two conditions. At the position 400 ms after the verb phrase offset; however, unimpaired participants did not show priming of either of the two interpretations. Patients showed the opposite pattern: at verb phrase offset, they did not show threshold-level priming of either of the two interpretations; 400 ms afterwards, they showed priming of both the strict and sloppy interpretations, with the strict interpretation eliciting significantly longer reaction times than the sloppy interpretation. Conclusions: Patients’ delay in priming both the strict and the sloppy interpretations shows that patients evince a temporal delay when processing dependency structures, which may arise from patients’ deficit with lexical integration. Additionally, patients spent significantly longer reaction times on the strict interpretation relative to the sloppy interpretation, which confirms the prediction that that the former, which is generated in the level of discourse, is computationally more costly than the latter, which is generated in the level of semantics.

The application of electrochemical processes in oily wastewater treatment: a review

Oily wastewater is becoming a concern worldwide due to its quantities and the presence of contaminants and its sustainable treatment should be cost-effective and meet all requirements so the contaminants are not transferred to the environment. The paper reviews the state-of-the-art in the oily wastewater treatment by electrochemical processes such as electrochemical advanced oxidation processes and electrocoagulation. Efficiency of oily wastewater treatment has been thoroughly investigated with its expression as a function of the main technological (process) parameters. Fe and Al electrodes, as well as their combination have proven to be very effective in oily wastewater treatment with slightly better performance of Al electrodes. Higher current densities and longer reaction times result with higher COD, TOC, turbidity, phenol and oil and grease removal efficiencies, but with resulting increase in wastewater temperature and energy consumption, so there is a strong need for the process optimization. There is a need for further research on the treatment efficiencies of different contaminants (heavy metals, total hydrocarbons, organic halogens, cyanides, etc.). A lack of research is presented on the treatment efficiency with electrodes of different materials as well as the analyses of the sludge production and its further treatment and use or disposal.

The synthesis and characterization of phenolic resin with a high content of dimethylene ether bridges

Phenolic resins were synthesized using sodium montmorillonite (MMT) as a catalyst at a concentration of 3%, 5%, and 10%, the reaction time was 24 and 48 h, respectively. The phenolic resin yield was up to 69%. The chemical structure of the resins was determined by NMR, the thermal properties were determined by DSC and TGA, and molar masses were determined by SEC. The resins could not be easily classified as resol or novolac because the most common type of bonding between the aromatic rings was dimethylene ether (DME) bridges. Due to near neutral pH (6.7–7.1), some methylol groups were also present in the structure. Increasing the MMT concentration increased the molar mass of the resin; however, no influence of reaction time was observed. Increased MMT concentration, as well as longer reaction time, decreased the glass transition temperatures, which were very low, in the range of 8–24 °C. Increased content of DME increased the thermal stability of the resins.

A wearable ring-shaped inertial system to identify action planning impairments during reach-to-grasp sequences: a pilot study

BackgroundThe progressive ageing of the population is leading to an increasing number of people affected by cognitive decline, including disorders in executive functions (EFs), such as action planning. Current procedures to evaluate cognitive decline are based on neuropsychological tests, but novel methods and approaches start to be investigated. Reach-to-grasp (RG) protocols have shown that intentions can influence the EFs of action planning. In this work, we proposed a novel ring-shaped wearable inertial device, SensRing, to measure kinematic parameters during RG and after-grasp (AG) tasks with different end-goals. The aim is to evaluate whether SensRing can characterize the motor performances of people affected by Mild Neurocognitive Disorder (MND) with impairment in EFs.MethodsEight Individuals with dysexecutive MND, named d-MND, were compared to ten older healthy subjects (HC). They were asked to reach and grasp a can with three different intentions: to drink (DRINK), to place it on a target (PLACE), or to pass it to a partner (PASS). Twenty-one kinematic parameters were extracted from SensRing inertial data.ResultsSeven parameters resulted able to differentiate between HC and d-MND in the RG phase, and 8 features resulted significant in the AG phase. d-MND, indeed, had longer reaction times (in RG PLACE), slower peak velocities (in RG PLACE and PASS, in AG DRINK and PLACE), longer deceleration phases (in all RG and AG DRINK), and higher variability (in RG PLACE, in AG DRINK and PASS). Furthermore, d-MND showed no significant differences among conditions, suggesting that impairments in EFs influence their capabilities in modulating the action planning based on the end-goal.ConclusionsBased on this explorative study, the system might have the potential for objectifying the clinical assessment of people affected by d-MND by administering an easy motor test. Although these preliminary results have to be investigated in-depth in a larger sample, the portability, wearability, accuracy, and ease-of use of the system make the SensRing potentially appliable for remote applications at home, including analysis of protocols for neuromotor rehabilitation in patients affected by MND.

The long-term associations between parental behaviors, cognitive function and brain activation in adolescence

Parenting behavior has a vital role in the development of the brain and cognitive abilities of offspring throughout childhood and adolescence. While positive and aggressive parenting behavior have been suggested to impact neurobiology in the form of abnormal brain activation in adolescents, little work has investigated the links between parenting behavior and the neurobiological correlates of cognitive performance during this age period. In the current longitudinal fMRI study, associations between parenting behaviors and cognitive performance and brain activation across mid- and late-adolescence were assessed. Observed measures of maternal aggressive and positive behavior were recorded in early adolescence (12 years) and correlated with fMRI activation and in-scanner behavioral scores on the multi-source interference task (MSIT) during mid- (16 years; 95 participants) and late-adolescence (19 years; 75 participants). There was a significant reduction in inhibitory-control-related brain activation in posterior parietal and cingulate cortices as participants transitioned from mid- to late-adolescence. Positive maternal behavior in early-adolescence was associated with lower activation in the left parietal and DLPFC during the MSIT in mid-adolescence, whereas maternal aggressive behavior was associated with longer reaction time to incongruent trials in late-adolescence. The study supports the notion that maternal behavior may influence subsequent neurocognitive development during adolescence.

Effects of Structured Solids on Regioselectivity of Dibromination of Naphthalene

The influence of structured solids (amorphous, lamellar and 3D crystalline) on the regioselectivity of the dibromination of naphthalene using bromine at room temperature has been investigated. The more acidic amorphous catalysts and an acidic clay give rapid reactions and lead to a large preponderance of 1,4-dibromonaphthalene over the 1,5-dibromo compound, while calcined KSF clay, a bentonite material, after a short reaction time gives a small predominance of the 1,5-isomer. Longer reaction times lead to the equilibration of reaction mixtures, which means that the 1,4-isomer eventually predominates in all cases. Based on these observations, it has been possible to devise synthetically useful preparative procedures, involving direct room temperature reactions of bromine with naphthalene, for either 1,4-dibromonaphthalene or 1,5-dibromonaphthalene based on the use of different solids, namely Synclyst 13 and KSF clay, respectively.

In Situ Generated Nickel Phosphide Based Catalysts for Hydroprocessing of Levulinic Acid

This article describes the production of unsupported nickel phosphide\t\t\t\t\tcatalysts generated in situ in а reaction mixture from water-soluble and\t\t\t\t\toil-soluble precursors during the hydroconversion of levulinic acid. These\t\t\t\t\tcatalysts contain crystalline phases, specifically\t\t\t\t\t\tNi12P5 and\t\t\t\t\t\tNi(PO3)2. During the\t\t\t\t\thydrogenation of levulinic acid in toluene in the presence of NiP–TOP, a lower\t\t\t\t\ttemperature and a shorter reaction time contribute to the formation of\t\t\t\t\tγ-valerolactone (100% selectivity). A higher temperature and a longer reaction\t\t\t\t\ttime favor the formation of valeric acid (94% selectivity). In the hydrogenation\t\t\t\t\tof levulinic acid in ethanol in the presence of\t\t\t\t\t\tNiP–H3PO2, the main reaction\t\t\t\t\tproduct is ethyl levulinate (95% selectivity).

Measuring sexual interest in persons who have sexually offended against children: investigating the Choice Reaction Time task using the Virtual People Set

ABSTRACT Identifying pedophilic sexual interest among persons who have sexually offended against children (PSOCs) is important for risk assessment because not all PSOCs are pedophilic. Existing physiological and self-report methods have several limitations. In the present study, sexual interest was assessed indirectly by means of a computer task: the Choice Reaction Time (CRT) task in 49 extrafamilial PSOCs and 25 persons without a history of sexual offences against children (control group). The results showed that PSOCs, the participants with a DSM-IV diagnosis of pedophilia or with a high score on pedophilic interest (measured by the SSPI-2) performed equally fast in the different age category stimuli. In other words, no effect of sexual orientation towards children was found. The control group however, showed longer reaction times for the adult and adolescent stimuli compared to the child stimuli, indicative that they did not have a sexual orientation towards children. The present study found only partial evidence for the validity of the CRT paradigm, as it was effective in discriminating age orientation in the control group but not in the group of PSOCs.

Recognizing Your Hand and That of Your Romantic Partner.

Although the hand is an important organ in interpersonal interactions, focusing on this body part explicitly is less common in daily life compared with the face. We investigated (i) whether a person’s recognition of their own hand is different from their recognition of another person’s hand (i.e., self hand vs. other’s hand) and (ii) whether a close social relationship affects hand recognition (i.e., a partner’s hand vs. an unknown person’s hand). For this aim, we ran an experiment in which participants took part in one of two discrimination tasks: (i) a self–others discrimination task or (ii) a partner/unknown opposite-sex person discrimination task. In these tasks, participants were presented with a hand image and asked to select one of two responses, self (partner) or other (unknown persons), as quickly and accurately as possible. We manipulated hand ownership (self (partner)/other(unknown person)), hand image laterality (right/left), and visual perspective of hand image (upright/upside-down). A main effect of hand ownership in both tasks (i.e., self vs. other and partner vs. unknown person) was found, indicating longer reaction times for self and partner images. The results suggest that close social relationships modulate hand recognition—namely, “self-expansion” to a romantic partner could occur at explicit visual hand recognition.

Production of biodiesel from waste cooking oil using heterogeneous catalysts KI/γ-Al2O3

Biodiesel is a promising alternative fuel that can be produced from vegetable oil through the esterification process. Conventional homogeneous acid or base catalysts result in a lower biodiesel yield and a longer reaction time and require separation from the product, which lead to inefficient production. This research was aimed at utilising the heterogeneous catalyst potassium iodide (KI)/γ-aluminium oxide (γ-Al2O3) for esterification of waste cooking oil into biodiesel. The catalyst was prepared using the impregnation method in which calcination was conducted at 500°C for 3 h. The esterification operation condition was set to a temperature of 65°C for 3 h and a molar ratio of oil to methanol of 1:14. Moreover, the heterogeneous catalyst was compared with a homogeneous catalyst with respect to the yield of biodiesel. The results showed that at a 2% (g catalyst/g oil) catalyst concentration, the esterification using the catalyst KI/γ-Al2O3 produced a higher yield of biodiesel (88·03%) compared with using γ-aluminium oxide (58·86%) and a conventional catalyst (82·23%). The reusability study of the catalyst KI/γ-Al2O3 showed that after the first reuse, the catalyst could still produce biodiesel with a yield of 61·30%. After the second reuse, the yield of biodiesel was 52·61%, and the third reuse produced a yield of 21·50%.

Prosodic influence in face emotion perception: evidence from functional near-infrared spectroscopy

Emotion is communicated via the integration of concurrently presented information from multiple information channels, such as voice, face, gesture and touch. This study investigated the neural and perceptual correlates of emotion perception as influenced by facial and vocal information by measuring changes in oxygenated hemoglobin (HbO) using functional near-infrared spectroscopy (fNIRS) and acquiring psychometrics. HbO activity was recorded from 103 channels while participants (hbox {n} = 39, hbox {age} = 20.37 hbox {years}) were presented with vocalizations produced in either a happy, angry or neutral prosody. Voices were presented alone or paired with an emotional face and compared with a face-only condition. Behavioral results indicated that when voices were paired with faces, a bias in the direction of the emotion of the voice was present. Subjects’ responses also showed greater variance and longer reaction times when responding to the bimodal conditions when compared to the face-only condition. While both the happy and angry prosody conditions exhibited right lateralized increases in HbO compared to the neutral condition, these activations were segregated into posterior-anterior subdivisions by emotion. Specific emotional prosodies may therefore differentially influence emotion perception, with happy voices exhibiting posterior activity in receptive emotion areas and angry voices displaying activity in anterior expressive emotion areas.

Performance of discrete, reciprocal, and cyclic movements of the ipsilesional upper limb in individuals after stroke.

Aiming movements of the upper limbs can be classified either as discrete, or reciprocal, or cyclic. The control of these movements after a stroke can be affected. The aim of this experimental, cross-sectional study was to characterize the performance of these movements after the right and left hemisphere chronic stroke. Thirty-six individuals aged between 40 and 70years, right-handed, were allocated into three groups (control, right stroke, and left stroke). Participants were asked to perform aiming movements on a tablet. Individuals after stroke performed the tasks only with their ipsilesional limb, while the control group performed movements with both limbs. The reaction and movement times, peak velocity, and the variability and error of the endpoint were analyzed. Individuals after stroke presented a worse performance in all movement classes as expected, but differently depending on the damaged hemisphere. Participants with right hemisphere damage showed larger endpoint errors, while those with left hemisphere damage had longer reaction and movement times. Both differences were seen consistently in discrete and reciprocal, but not in cyclic movements. Cyclic movements presented shorter latencies, were faster, and showed greater endpoint errors when compared to discrete and reciprocal movements. These results suggest that stroke affects differently the performance of discrete and reciprocal movements according to the hemisphere lesion side, but not in cyclic movements. Different levels of motor control among the three classes of movements by the nervous system may justify these results.

Differences in executive function of the attention network between athletes from interceptive and strategic sports

The differences in the executive attention network and the related blood oxygen characteristics of the right frontal-parietal network brain area between athletes from interceptive and strategic sport were investigated. Strategic athletes had higher accuracy and longer reaction time (RT) compared with interceptive sports athletes, lower flanker conflict effects on accuracy compared to the other two group. It was accompanied by significant activation of the rdLPFC and the rIFG. Strategic athletes had higher flanker conflict effects on RT compared with interception athletes under the invalid cue condition, which was accompanied by significant activation of the right IFG. The strategic athletes complete the task under the condition of invalid clues indicating top-down control, and which is closely related to the activation of the right frontal-parietal network.

How do worry and clinical status impact working memory performance? An experimental investigation

BackgroundPrevious research has suggested that worry is negatively associated with working memory performance. However, it is unclear whether these findings would replicate across different worry levels and in individuals with anxiety and depressive disorders (i.e. clinical statuses).MethodOne-hundred-thirty-eight participants performed a two-block working memory task (150 trials per block). Based on participants` current clinical status, four groups were considered (generalised anxiety disorder group: n = 36; clinical group with another anxiety or mood disorders: n = 33; subclinical group: n = 27; control group: n = 42). Trait worry levels were collected from all of the participants. Working memory performance was measured as accuracy and reaction time.ResultsDuring the first block, higher worry scores were significantly associated with longer reaction times. Moreover, the generalised anxiety disorder group, clinical group, and subclinical groups demonstrated significantly longer reaction times compared to the control group in Block 1, when age was controlled for. From Block 1 to Block 2, all of the participants demonstrated a significant decrease in accuracy and reaction time, regardless of worry level or clinical status.ConclusionThe results indicate that higher worry levels negatively impact WM processing efficiency. Moreover, when age was controlled for, we found participants` clinical status to be linked with WM impairments. The results highlight the relevance of investigating the impact of different worry levels on cognitive processes across clinical and non-clinical populations.

Mono-endo-6-N,N-diethylcarbamoyl and bis-endo,endo-6,12-N,N-diethylcarbamoyl derivatives of Tröger’s base. Synthesis and exo-endo isomerization study

An efficient synthetic route to the mono-endo-6- and bis-endo,endo-6,12-N,N-diethylcarbamoyl derivatives of Troger’s base (TB), endo-7 and endo-8, is reported. Studies of reaction time, proton source, and additive allowed establishment of optimized conditions for the conversion of exo-7 into the corresponding isomer endo-7. With a longer reaction time, the exo,exo-6,12 bis-carbamoyl derivative exo-8 was converted into the corresponding endo,endo-bis-carbamoyl product endo-8. Single crystal X-ray crystallographic analysis confirmed the structural and stereochemical assignments made on the basis of 1H NMR, mechanistic, and calculational studies. Deuterium quench experiments using LDA, CD3ONa/CD3OD and DCl/CD3OD conditions of both exo-7 and exo-8 afforded exo-7d1 and exo-8d2, respectively (> 95% deuterium incorporation), supporting an enolate mechanism for the isomerization. In contrast, when repeating the experiment with DCl/CD3OD, no deuterium was incorporated, suggesting the traditional ring-opening mechanism involving an iminium ion. (Less)