Long-term Strategy Research Articles

Exploring the Roles, Functions, and Work Experiences of Nurse Scientists in the Veterans Health Administration.

The aim of this project was to describe nurse scientists' roles, functions, and work experiences in the Veterans Health Administration (VHA). Nurse scientists play a critical role in shaping the culture of clinical inquiry and closing the gap between knowledge and practice. A cross-sectional survey was used to collect information on sociodemographics, workload, research, clinical practice, education, and time/effort. Data were examined using descriptive statistics and χ2 analyses. One hundred forty-four nurse scientists completed the survey. These nurse scientists serve dynamic and critical roles in conducting research, implementing evidence-based practice, and reforming policy. Research effort was limited due to workload and infrastructure constraints. Better research infrastructure was associated with higher research productivity and funding. This survey highlights the needs and challenges nurse scientists experience in conducting research and advancing VHA's mission. Given the national shortage of PhD-prepared nurses, long-term strategies are needed to attract, hire, and retain nurse scientists in healthcare systems.

The worker bee’s dilemma part 2: exit strategy saboteur

Research methodology This descriptive case study is written using factual case information was obtained from an employee of the firm with their consent. All names, including the firm name, have been anonymized. Case overview/synopsis After being denied promotion, Vivienne began the first step to her long-term exit strategy by seeking another graduate degree. Her supervisor failed to supply the recommendation he’d promised for her graduate school application. Vivienne felt that his breach of trust was deliberate and now must decide what course of action to take. This case analyzes Vivienne’s organization, needs and ambition using management theories, laws and concepts. It also analyzes the phenomenon of trust, specifically vertical trust between managers and employees, and it leads to an important career crossroads for Vivienne. Complexity academic level Undergraduate. Courses: Organizational Behavior, Human Resource Management

How Meb Faber Timing Model Inspired Improving Portfolio Construction in China

Controlling risk is one of the most crucial steps when constructing investing portfolios. This paper started with tactical asset allocation (TAA), which investors would prefer compared to other long-term strategies within an acceptable range of risk. According to the report from Faber, his quantitative marketing timing model can manage risks, which means it can be applied to improve the process of portfolio construction, and the shining point of the model is that investors would choose the way that minimizes the loss if the draw-down of return is unavoidable when facing the volatility of a market. This paper evaluated Fabers timing model by applying it to Chinas capital market, where there are supposed to be more extreme cases. Also, since there are relatively few studies examining the timing effect and combining it with asset allocation as a reference in China, this paper studied one experiment in 2017 by two scholars who were familiar with the local market to prove that timing strategies also require timely adjustment of tactical asset allocation to achieve better returns. On the other hand, when there are signs that the economic environment is going to experience a recession, investors could get inspiration from this paper on how to promptly adjust the factors in the timing model to better adapt to the changing market.

Prognosis and influencing factors of ER-positive, HER2-low breast cancer patients with residual disease after neoadjuvant chemotherapy: a retrospective study

Previously, we found that patients with estrogen receptor (ER)-positive, HER2-low breast cancer are resistant to neoadjuvant chemotherapy (NACT) and have worse outcomes than those who achieve pathological complete response (pCR) after NACT. This study aimed to investigate the prognosis and influencing factors in these patients. A total of 618 patients with ER-positive breast cancer who received standard thrice-weekly NACT were enrolled, including 411 patients with ER-positive, HER2-low breast cancer. Data on the clinicopathological features of these patients before and after NACT were collected. Univariate and multivariate Cox regression analyses were used to identify the independent factors affecting 5-year disease-free survival (DFS). Among the ER-positive, HER2-low patients, 49 (11.9%) achieved a pCR after NACT. A significant difference in survival was observed between patients with and without residual disease after NACT. Additionally, changes in immunohistochemical markers and tumor stages before and after NACT were found to be significant. According to univariate and multivariate analyses, cN_stage (P = 0.002), ER (P = 0.002) and Ki67 (P = 0.023) expression before NACT were significantly associated with 5-year DFS, while pT_stage (P = 0.015), pN_stage (P = 0.029), ER (P = 0.020) and Ki67 (P < 0.001) levels after NACT were related to 5-year DFS in ER-positive, HER2-low patients with residual disease. Our study suggested that high proliferation, low ER expression and advanced stage before and after NACT are associated with a poor prognosis, providing useful information for developing long-term treatment strategies for ER-positive, HER2-low breast cancer in patients with residual disease in the future.

Epidemiology of heat-related illness in dogs under UK emergency veterinary care in 2022.

Dogs are exposed to increasing environmental risk for developing heat-related illness (HRI), with 2022 recorded as the hottest year to date in the UK and most of Europe. This study used VetCompass data to report the incidence risk, event fatality rate and canine risk factors for HRI in dogs presenting to Vets Now emergency care practices in the UK during 2022. From the clinical records of 167,751 dogs under care at Vets Now emergency clinics in 2022, 384 HRI events were identified. The 2022 incidence risk of HRI within the Vets Now caseload was 0.23% (95% confidence interval [CI]: 0.21%‒0.25%), with an event fatality rate of 26.56% (95% CI: 21.66%-32.25%). Multivariable analysis identified breed, age and sex/neuter status as risk factors for HRI. Brachycephalic dogs had 4.21 times the odds of HRI compared to mesocephalic dogs (95% CI: 3.22‒5.49, p<0.001). The clinical data used in this study were not primarily recorded for research and had some substantial levels of missing data (especially patient bodyweight). In order to protect canine welfare, improved long-term mitigation strategies are urgently needed to minimise HRI risk and associated fatality in UK dogs.

Trends in oesophageal cancer mortality in Montenegro, 1990-2018.

Oesophageal cancer (OC) is a significant public health issue, despite the decreasing trends in OC mortality rates observed globally in the past decades. The objective of our study is to analyze the pattern of OC mortality in Montenegro between 1990 and 2018 and contribute to the development of a national long-term strategy for the prevention and control of this malignancy. The data on OC death cases in Montenegro between 1990 and 2018 were collected. The mortality rates were standardized according to the World Standard Population. The Joinpoint, Linear and Poisson regressions were applied to analyze the OC mortality trend. Joinpoint regression analysis showed an increase in death rates for men and the overall level which were not statistically significant. However, the number of cases increases significantly with an average annual percentage change (AAPC) increase of 2.6% for the overall level [AAPC (95% CI)=2.6 (1.0-4.2); P = 0.002] at the expense of the increase in men, which on average was 2.6% annually [AAPC (95%CI) = 2.6 (1.2-4.1); P = 0.001]. The age groups 55-64 and 65-74 have the highest percentage of deaths cases from OC with 30.6% and 31.4%, respectively. Montenegro has witnessed a recent increase in the number of deaths from OC, although the mortality rates remain stable. National strategies to further reduce mortality rates for OC are necessary. Individuals aged 55-64 and 65-74 need specific attention during the ongoing monitoring of this cancer.

Can board funds, bank credit, and economic development improve food production? Evidence from South Asia

PurposeThis study investigates the impact of board funds, banking credit, and economic development on food production in the context of South Asian economies (India, Pakistan, Bangladesh, Sri Lanka, and Nepal).Design/methodology/approachThis study used data from the World Development Indicators covering the years 1991–2019. To investigate the relationship between the variables of the study, we employed the panel unit root test, panel cointegration test, cross-sectional dependence test, fully modified least squares (FMOLS), and panel dynamic least squares (DOLS) estimators.FindingsThe empirical results indicate that board funding significantly increase food production; however, banking credit had a negative impact. Furthermore, the findings indicate that economic development, Arable land, fertilizer consumption, and agricultural employment play a leading role in enhancing food production. The results of the Dumitrescu-Hurlin causality test also show substantiated the significance of the causal relationship among all variables.Practical implicationsSouth Asian countries should prioritize board funding, bank credit, and economic development in their long-term strategies. Ensuring financial access for farmers through micro-credit and public bank initiatives can spur agricultural productivity and economic growth.Originality/valueThis study is the first to combine board funding, banking credit, and economic development to better comprehend their potential impact on food production. Instead of using traditional approaches, this study focuses on these financial and developmental aspects as critical determinants for increasing food production, using evidence from South Asia.

A SWOT Model-Based Analysis of Marketing Strategy Taking Mixue Ice Cream and Tea as an Example

Peoples living needs have become increasingly diversified as a result of the rapid development of the economy. In recent years, the freshly-made tea beverage industry has seen a surge in popularity, with numerous tea beverage brands entering the market. The tea industry has formed a fruit-flavored tea and milk tea beverage model based on high-quality tea, gradually replacing the dominant position of tea powder preparation in the past In order to obtain a place in the fierce market competition, the majority of tea brands must fully understand the market changes and their own development status, and formulate long-term development strategies. This paper takes Mixue Ice Cream and Tea (hereinafter referred to as MIXUE) as the research object and uses the SWOT model to analyze its strengths, weaknesses, opportunities and threats. Besides, we analyze and study its own status quo in the construction of internal control. We also formulate future marketing and development strategies for MIXUE, aiming to improve its brand competitiveness and help it to achieve substantial development.

Personalized Nanovaccines Enhance Lymph Node Accumulation and Reprogram the Tumor Microenvironment for Improved Photodynamic Immunotherapy.

Tumor immunotherapy has emerged as an efficacious therapeutic approach that mobilizes the patient's immune system to achieve durable tumor suppression. Here, we design a photodynamic therapy-motivated nanovaccine (Dex-HDL/ALA-Fe3O4) co-delivering 5-aminolevulinic acid and Fe3O4 nanozyme that demonstrate a long-term durable immunotherapy strategy. After vaccination, the nanovaccine exhibits obvious tumor site accumulation, lymph node homing, and specific and memory antitumor immunity evocation. Upon laser irradiation, Dex-HDL/ALA-Fe3O4 effectively generates reactive oxygen species at the tumor site not only to induce the immunogenic cell death-cascade but also to trigger the on-demand release of full types of tumor antigens. Intriguingly, Fe3O4 nanozyme-catalyzed hydrogen peroxide generated oxygen for alleviating tumor hypoxia and modifying the inhibitory tumor microenvironment, thereby exhibiting remarkable potential as a sensitizer. The intravenous administration of nanovaccines in diverse preclinical cancer models has demonstrated remarkable tumor regression and inhibition of postoperative tumor recurrence and metastasis, thereby enabling personalized treatment strategies against highly heterogeneous tumors.

Sweet Syndrome: A Comprehensive Review of Pathogenesis, Clinical Manifestations, Diagnosis, and Management Strategies

Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is a rare and inflammatory disorder characterized by fever, neutrophilia, and tender, erythematous skin lesions. The pathogenesis of Sweet syndrome involves an exaggerated immune response, with evidence suggesting a role for cytokines, particularly granulocyte colony-stimulating factor (G-CSF). Clinical manifestations vary widely, but commonly include abrupt onset of painful, raised plaques or nodules, often on the upper limbs, face, or neck. Histopathological examination reveals dense neutrophilic infiltrates in the dermis without evidence of vasculitis. Diagnosis is primarily clinical, supported by histopathology and exclusion of other similar conditions. Treatment typically involves corticosteroids, which often lead to rapid resolution of symptoms. However, relapses are common, necessitating long-term management strategies. This review aims to provide a comprehensive overview of the pathogenesis, clinical manifestations, diagnosis, and management of Sweet syndrome, highlighting recent advancements and areas requiring further research.

ІННОВАЦІЙНІ ТРАНСФОРМАЦІЇ ОБЛІКОВО-АНАЛІТИЧНОГО ЗАБЕЗПЕЧЕННЯ УПРАВЛІННЯ БІЗНЕСОМ

Introduction. The innovative potential of business entities indicates their ability to ensure sustainable development and the availability of opportunities to maintain its achieved level in the future, which directly depends on the effectiveness of the accounting and analytical management system and the information produced by it. Changes in approaches to the formation of information at the request of users, the introduction into practice management reports, conducting activities in compliance with the principles of sustainable development, the objective need to adjust vectors of business implementation in the conditions of military operations, and the need to strengthen control over all stages of the full cycle of the economic process actualize the importance of developing an activity strategy. This applies not only to the long-term strategy, but also to the planning of current activities, which significantly increases the value of information regarding the legality of activities at each stage of the economic process. These issues require in-depth scientific research and, based on their results, the development of substantiated proposals aimed at increasing the level of accounting and analytical management support. Problem Statement. The phrase “accounting and analytical support” is quite often included in the title of scientific articles and themes of dissertations for obtaining the scientific degree of Doctor of Economic Sciences and Doctor of Philosophy in the specialty 08.00.09 - Accounting, analysis and audit (by types of economic activity). This does not indicate the exhaustiveness of the problems in the outlined field, but rather actualizes the importance of their in-depth research in the context of meeting the needs of management. The purpose is to consider modern trends in the improvement of the accounting and analytical system of business entities with the actualization of the need to expand the scope of address information at the request of users, to strengthen control over the completeness of the coverage in the process of its formation of all the facts of business practice and conducted operations, and the importance of introducing compliance procedures in this context and financial monitoring. Methods. The logical-abstract method is used, which is based on the elements of the methods of theoretical generalization, analysis, grouping, comparison, description. Results. Society's trust in the accounting institute directly depends on the quality of the information used in the process of evaluating the performance of the activity. Priority is given to summary information, summarized by the indicators of various forms of reporting. This gives reason to evaluate information from the point of view of the “purity” of reporting indicators and the initiation of the characteristic style of the accounting profession and the appropriate behavior of its representatives as managers of a high level of professional knowledge, education, culture and upbringing. It is time to develop a specific code of ethics for a professional accountant as a specialist of a new formation with powerful intellectual potential, a wide range of knowledge and skills, capable of establishing business management on the basis of financial monitoring and compliance. Conclusions. The accounting and analytical system, the components of which can change in the context of taking into account the invariance of management decisions without violating the integrity of the system, remains the informational confirmation of the transition of the business to the platform of sustainable development.

How to Make Long-Term Investments in a Stock Market? A Generic Strategy for Investors

Against the backdrop of increasingly fierce industrial competition nowadays, firms tend to have substantive business risk and/or information risk, increasing the estimation risk and limit of arbitrage for investors in their short-term investments in a stock market. It is thus important for investors to hold a long-term horizon for at least part of their investments in the stock market. This paper aims to introduce a long-term investment strategy that is practically feasible and potentially valuable to investors. To this end, we first develop a parsimonious model in which we identify the major determinants of a firm’s value. This model is used to select high-value firms from each industry for further fundamental analysis and valuation. We next expatiate on how to perform strategy analysis, accounting analysis, financial analysis, and prospective analysis, and therein apply the residual operating income valuation model, in the best possible manner to further value the selected firms and their long-term investment potential. Lastly, we expound the strategy of forming and adjusting a long-term investment portfolio in a way that potentially maximizes long-term portfolio return.

Cardiovascular Effects of Neurofeedback Course in Various Sports Adaptation Strategies: an Open Controlled Study

INTRODUCTION. Neurofeedback is effectively applied in clinical practice. Cardiovascular effects (CVEs) from different sports adaptation strategies in course-based β-rhythm neurofeedback are under-studied. AIM. To evaluate the CVEs of the neurofeedback course under different sports adaptation strategies. MATERIALS AND METHODS. The study included 1020 men (18–21 years) during the preparatory training period. Following groups were formed: 1 — cyclic sports (n = 387); 2 — speed-strength sports (n = 255); 3 — single combat (n = 31); 4 — team sports (n = 173); 5 — complex coordination sports (n = 174). The CVEs were assessed with the BOSLAB complex (Russia), with eyes open and muscles relaxed. EEG electrodes were applied bipolarly (Cz-Fz). Session types: graphic (10 minutes), game (16 minutes), where the β-rhythm level was increased and maintained. Indices of systemic pressure, cardiac activity; peripheral vessels, functional changes of the cardiovascular system (CVS) were also examined. RESULTS AND DISCUSSION. Along with improved attention, the 10th session revealed positive CVEs in the 1st, 3rd, 4th and 5th groups with CVS economization. 1st group: CVEs are a desirable response option. 2nd group: ambiguous heterochronic CVEs, with improved systemic pressure and reduced cardiac activity, indices of peripheral vessels, cardiovascular regulation index. These effects, mainly in strength sports, are caused by the long-term sports adaptation strategy, associated with hypoxia and incomplete recovery of the spent resources, causing incomplete adaptation. It is associated with mastering the β-rhythm control skill, different in the nature from the activities with the formed adaptation strategy in the long-term training process. 3rd group (10th session): changes in the brain structure (BS) function formed CVEs involving mechanisms maintaining systemic pressure, regarded as optimal. 4th and 5th groups: optimized BS and CVEs activities. CONCLUSION. The positive CVEs demonstrated expediency of the β-rhythm neurofeedback course. Ambiguous CVEs in groups of speed-strength sports are studied for neurofeedback technology modification.

A Multi-Approach and Collaborative Pathway towards Designing Climate Strategies: The Case of Trentino, a Mountainous Region in Italy

Mountainous and rural territories are considered among the most vulnerable to the effects of the Climate Crisis. Their geographical and topographical conditions, together with the complexity of the system of relations between human and natural elements, amplify the impacts and risks associated with extreme climatic events. Therefore, the consequences on the socio-economic fabric are systemic and require an immediate response from all the actors in a region. Public administration and politics can play a pivotal role within the planning framework in contrasting the impacts of the climate crisis. This paper demonstrates the multi-level and multi-stakeholder approach applied during the development process of a regional adaptation strategy. The Autonomous Province of Trento has initiated an innovative approach to understanding and managing the effects of the climate crisis on its landscape and resources and has aligned the process of definition of its long-term strategy with the guidance provided by the EU Commission and the Italian Government. The methodology used is based on the tools provided by the Climate-ADAPT platform (in particular, the Regional Adaptation Support Tool—RAST), and the “impact chains” method is specifically implemented for climate risk assessment. The RAST is applied according to a multi-stakeholder and multi-level approach to capitalise on previously established and ongoing initiatives and working groups. The research suggests that the Climate Strategy model presented in this paper needs to be at the core of the broader framework adopted by the Autonomous Province of Trento and that it can represent an important example for other regions aiming to actively involve local stakeholders in acting for climate neutrality and resilience.

Clinical Outcomes and Molecular Predictors of Pembrolizumab (Keytruda) as a PD-1 Immune Checkpoint Inhibitor in Advanced and Metastatic Cervical Cancer: A Systematic Review and Meta-Analysis

This systematic review evaluates the clinical outcomes and molecular predictors of response to pembrolizumab in patients with advanced and metastatic cervical cancer. We adhered to the PRISMA guidelines for systematic reviews, conducting a database search in PubMed, Scopus, and Embase. The eligibility criteria centered on clinical outcomes, including the overall survival (OS), progression-free survival (PFS), and immune-related biomarkers post-pembrolizumab therapy. We included both prospective and retrospective studies that detailed clinical outcomes and molecular characteristics predictive of therapeutic response. Our search yielded six studies involving 846 patients treated with pembrolizumab from 2017 to 2022. The meta-analysis of these studies showed that pembrolizumab, used as monotherapy or in combination with chemotherapy, extended the OS by a weighted median of 10.35 months and the PFS by 8.50 months. The treatment demonstrated a pooled objective response rate (ORR) of 22.39%, although the I2 test result of 67.49% showed a high heterogeneity among the studies. Notably, patients with high PD-L1 expression (CPS ≥ 10) experienced improved outcomes in terms of the PFS and OS. The most common complications were fatigue, diarrhea, and immune-related adverse events. Pembrolizumab significantly enhances clinical outcomes in metastatic cervical cancer, particularly among patients with high PD-L1 expression. The drug maintains a good safety profile, reinforcing its treatment potential for patients with advanced and metastatic cervical cancer. Future studies should explore long-term effects and strategies to integrate pembrolizumab optimally into current treatment regimens, aiming to maximize patient benefits and effectively manage side effects.

Assertive China After the Rise of Xi Jinping

In terms of China's internationalisation and economic policy, the Chinese economic miracle, which supports visions of China as a global hegemon, would correspond to a coherent long-term grand strategy. First, we analyse the key drivers along China's partial liberalisation processes. Second, the focus will shift to recent political developments in the West, as a late reaction to a more assertive China and its 'wolf diplomacy', taking into account the weakness of the free world in the face of the China threat, given the apparent strengths identified in the examination of China's strategy. Finally, a brief section will be devoted to general conclusions integrating the results of the two perspectives.

Weed Ecology: Insights for Successful Management Strategies: A Review

In crop ecosystems, the primary challenge in establishing a long-term weed management strategy arise from a lack of understanding regarding the nature of weediness and the factors that contribute to species dominance. To address this, farmers and researchers often rely on quick and efficient, yet temporary weed control methods, which can lead to long-term issues. To develop a more effective and sustainable weed management approach, it is crucial to gain a comprehensive understanding of both the biological characteristics and ecological behaviours of weeds. This can be achieved by incorporating preventive techniques, scientific knowledge and management skills, with the goal of enhancing crop production and benefiting farmers. While further information is needed in all aspects of weed management, the primary objective of weed science is to increase our knowledge of weed biology and ecology, thus fostering a better understanding of weediness. This understanding will facilitate the adoption of appropriate management strategies instead of relying solely on short-term solutions that may create or exacerbate long-term problems. The successful growth and reproduction of any species depend on a variety of conditions. In a given ecosystem, the species that can thrive more efficiently under the specific set of environmental conditions will produce the most viable offspring and become the most abundant organisms. Weed ecology, which examines the adaptive mechanisms that enable weeds to thrive in highly disturbed soil conditions, provides essential insights into the distribution and abundance of weeds in both natural and managed systems. The occurrence of a weed in a particular area is influenced by multiple factors, with climatic, soil-related (edaphic) and biotic factors being the most significant among them.

PROGRESSIVE CONTROL AND MANAGEMENT STRATEGIES IN THE ELIMINATION OF RABIES AMONG THE STRAY DOG (CANIS FAMILIARIS) POPULATION IN PAKISTAN

Stray dogs are integrally linked with rabies transmission, and a sizeable unmanaged dog population hinders rabies control program planners. Dog population management (DPM) is one of the best strategies to control rabies transmission, improve health management, and lower the population size of stray dogs. The threat of rabies is very serious due to free-roaming dogs. Foxes, skunks, groundhogs, raccoons, and house bats are rabies vector species and can carry rabies virus without showing any symptoms. Rabies is a life-threatening disease that affects thousands of losses worldwide every year. World Rabies Day is an international awareness campaign coordinated by the Global Alliance for Rabies Control (GARC). In Pakistan, there are reportedly 3 million stray dogs. More than one million dog bite cases are reported annually throughout Pakistan. About 600 dog bite cases are reported daily in the Sindh province, Pakistan. Due to an uncontrolled number of stray dogs, many serious problems arise related to public health, socio-economic, and political issues. The Animal Act of 1890 provides a specific defense against cruelty and establishes its importance in Pakistani culture. Developing long-term and supportable strategies is imperative to overcome the stray animal population worldwide. To overcome the rabies issue in Pakistan, the government should implement projects on breeding control of stray dogs through spaying and neutering surgeries. The government should also provide proper shelters for dogs and rabies vaccines. There is a need to be aware of basic preventive measures such as disinfectants and rabies vaccination. Public awareness, rabies vaccination, and dog sterilization at the national level are crucial factors in preventing rabies and managing the dog population in Pakistan.

Modeling the impact of sea level rise on endangered deer habitat

Numerous unique flora and fauna inhabit the Lower Florida Keys, including the endangered Florida Key deer, found nowhere else. In this vulnerable habitat of flat islands with low elevation, accelerated sea level rise poses a threat. Predicting the impact of sea level rise on vegetation and wildlife is crucial. This study used 5 Intergovernmental Panel on Climate Change (IPCC) sea level rise scenarios to assess their effects on No Name Key, Florida. The goal was to estimate changes in the Florida Key deer population relative to sea level rise using a lidar-derived elevation data and a vegetation map. The method used 2 cases to model the sea level rise impact. In Case 1, total non-submerged area at current sea level was determined. Using 5 IPCC scenarios, a new total non-submerged land area was estimated, and deer numbers were predicted for each scenario. In Case 2, upward migration of coastal vegetation combined with the coastal squeeze process was modeled. A distinct elevation range for each vegetation type at the current sea level was determined. Vegetation ranges were redistributed based on respective elevation ranges in the sea level rise scenarios. Areas for each vegetation type were recalculated, and Key deer numbers were estimated for each sea level rise scenario. Results under the worst emission scenario showed the following: (1) for case 1, the land area was reduced to 30 % of the current land area, corresponding to having about 27 deer, and (2) for case 2, the land area was reduced to 70 % of the current land area, having about 54 deer on No Name Key. The results indicated reduced non-submerged land area and less upland vegetation, particularly hardwoods/hammocks, by the year 2100. As less land area is available, a decline in Key deer population is expected as sea levels rise. Since Key deer favor upland vegetation, habitat affected by sea level rise will likely support a smaller deer population. The findings emphasize the need for precise, timely predictions of sea level rise impacts and long-term conservation strategies. Specifically designed measures are required to protect and maintain endangered wildlife, such as the Florida Key deer, residing on these vulnerable islands.

Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

Abstract Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease- causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein-protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration- approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.