Long-term Results Of Combined Treatment Research Articles

Gene Expression Profile-Guided Personalized Intraperitoneal Chemotherapy for Gastric Cancer Peritoneal Carcinomatosis.

Peritoneal carcinomatosis (PC) is one of the most unfavorable sites of metastasis for malignant tumors of various localizations, especially gastric cancer (GC). According to the literature, synchronous PC in GC is common in 15-52% of patients. The purpose of this study was to examine the long-term results using personalized systemic and intraperitoneal chemotherapy as part of the combined treatment of stomach cancer presenting with synchronous PC. Cytoreductive surgical treatment was performed for 70 patients at the first stage. The control group (n = 35) received standard postoperative chemotherapy according to the FOLFOX scheme. Personalized postoperative systemic and intraperitoneal chemotherapy was administered in the basic group (n = 35), based on the expression levels of the eight genes in the primary tumor, lymph node, and peritoneal metastases. The median progression-free survival was 14.9 months in the basic group, and in the control group it was 11.2 months (P < 0.001). The median life expectancy in the basic group was 16.8 (13.7 - 18.8) months, in the control group it was 12.5 (11.3 - 13.1) months (P < 0.001). Developing algorithms of personalized systemic and intraperitoneal chemotherapy in patients with GC with synchronous carcinomatosis, based on the analysis of molecular genetic characteristics of the tumor and metastases, allows to improve the long-term results of combined treatment.

Combined treatment for cancer of the ampulla of Vater

Aim : comparative study of the immediate and long-term results of combined treatment of patients with pancreatobiliary cancer of the ampulla of Vater. Materials and methods . From 2001 to 2019 21 patients with pancreatobiliary cancer of the ampulla of Vater underwent curative treatment. It included preoperative radiotherapy, extended Wipple procedure and adjuvant chemotherapy as indicated (main group). In 48 cases of pancreatobiliary cancer of the ampulla of Vater extended Wipple procedure and adjuvant chemotherapy according to indications was performed (comparison group). In 43 cases of intestinal cancer of the ampulla of Vater extended Wipple procedure and adjuvant chemotherapy according to indications was performed. Results. Postoperative complication and mortality in the study group and the comparison group were 14.3% and 35.4% ( p = 0.07), 4.8% and 6.3% ( p = 0.8). Overall 5-year survival rate, median survival were 50.7% and 9.8% ( p = 0.01), 51 (36.5–115) mo. and 10 (4–29) mo. ( p = 0.0008). Overall 5-year survival rate, median survival in the group of intestinal cancer of the ampulla of Vater accounted for 61.3 % and 44 (17–85.5) mo. One-year disease-free survival in patients with adenocarcinoma of the ampulla of Vater who have undergone curative treatment was 77.8%, 3-year survival – 51.0%, 5-year survival – 35.2%, median is 22 (9–54) mo. Conclusion . Preoperative radiotherapy in curative treatment of pancreatobiliary cancer of the ampulla of Vater did not result to a change in the nature and an increase in the postoperative complications rate. Combination treatment for pancreatobiliary cancer of the ampulla of Vater significantly improved long-term survival.

Long-term results of combined treatment of patients with locally advanced gastric cancer with the inclusion of neoadjuvant chemoradiotherapy.

ntroduction. Gastric cancer remains one of the most common malignant neoplasms. In the world, including Russia, high incidence rates and low efficacy rates of long-term treatment outcomes remain. The use of neoadjuvant therapy is now increasingly seen as a standard therapy approach for locally advanced gastric cancer and cardioesophageal junction.&#x0D; Materials and methods. This work presents the results of treatment using a new method – combined treatment of locally advanced stomach cancer (neoadjuvant chemoradiotherapy in the regime of accelerated hyperfraction with daily dose splitting up to SOD 46 Gy against the background of modified polychemotherapy according to the Xelox scheme). The structure of the development of locoregional relapses and metastases, the indicators of overall and relapse-free survival, depending on various clinical and morphological factors, were described. In total, the results were analyzed in 43 patients diagnosed with gastric cancer.&#x0D; Results and discussion. At the time of this analysis, 22 patients died, 21 patients continued to be observed or were lost from the observation. Life expectancy ranged from 6.1 to 122 months. According to the multivariate analysis, two factors were identified that have a statistically significant independent effect on overall survival: the macroscopic type of growth according to Borrmann (P≤0.009) and the degree of therapeutic pathomorphism (P≤0.015). In 3 cases, a complete therapeutic tumor pathomorphism was registered. Patients continue observation for up to 6 years. Local recurrence was not detected in any case. Regional recurrence was detected and morphologically confirmed in one patient. Peritoneal metastases, the development of which more often occurred in the case of low-grade forms of gastric cancer, were observed in 12 cases.&#x0D; Conclusion. All in all, the annual survival rate was 80.5 ± 6.2%, three-year 55.5 ± 7.8%, and five-year 45.0 ± 7.9%. The results show that combined treatment of locally advanced gastric cancer, using a new technique of neoadjuvant chemoradiotherapy, contributes to an increase in overall and relapse-free survival.

Анализ отдаленных результатов комбинированного лечения пеллюцидной дегенерации роговицы

Анализ отдаленных результатов комбинированного лечения пеллюцидной дегенерации роговицы

Yüzeyel Femoral Arterin İzole Total Oklüzyonunda Rotasyonel Aterektomi ve İlaç Kaplı Balon Kombine Kullanımının Uzun Dönem Sonuçları

Aim: In this study, we aimed to evaluate the long-term results of combined treatment with rotational atherectomy (RA) and drug-coated balloon (DCB) in isolated total occlusion of the superficial femoral artery (SFA). Materials and Methods: The retrospective study was conducted between February 2016 and January 2018 and included a total of 23 limbs of 20 patients with isolated total occlusion of the SFA. Patient data on demographic and clinical characteristics were obtained from the hospital records. The stage of the disease was classified according to the Rutherford classification. The ankle–brachial index was measured pre- and postoperatively. Results: Of the patients, 19 (95%) were male and one (5%) was female. The mean patient age was 67.40±7.50 (49–77) years. The patient distribution according to the preoperative Rutherford classification was as follows: stage 5, four (17.40%) patients; stage 4, eight (34.80%) patients; stage 3, eleven (47.80%) patients. The rates of one- and two-year freedom from target lesion revascularization were 82.61% and 69.57%, respectively. Discussion and Conclusion: Our study results showed that combined treatment with RA and DCB was an effective method in SFA lesions with a high calcified plaque burden, providing high rates of primary patency and freedom from target lesion revascularization as well as low rates of complication.

Long-term results of combined treatment of a patient with cancer of the upper ampullary rectum Complicated by bleeding

The clinical observation the results of combined treatment of a patient with locally advanced rectal cancer complicated by bleeding with the use of selective chemooil embolization of the superior rectal artery have been presented (1 figure, bibliography: 4 refs).

Long-term results of combined treatment of triple-negative breast cancer

The most dangerous immunohistochemical type of breast cancer is the triple-negative type. This subtype is detected in 10-20 % of breast cancer cases and is characterized by an aggressive clinical course with high proliferative activity and growth rate, which leads to more active surgical tactics and systemic treatment.The aim of the study was to study the long-term results of the combined treatment of triple-negative type of breast cancer in comparison with other immunohistochemical types.Materials and methods. The treatment results of 140 women with breast cancer who underwent radical surgery and were available for contact after 6 months and more after the operation were analyzed depending on the initial clinical and pathological parameters and treatment features using the methods of descriptive statistics, χ2 criterion and correlation analysis, survival tables and the Kaplan-Meier method.Results. During the analyzed period, distant metastases were detected in 5 (3.6 %), locoregional recurrence in 15 (10.7 %), 12 (8.6 %) patients died. Long-term results with triple-negative type of breast cancer are worse than with luminal forms. A significant dependence of survival on neoadjuvant chemotherapy was revealed. Radiation therapy, the volume of surgery (radical resection or radical mastectomy), breast reconstruction did not significantly affect the long-term result of treatment.Conclusion. Triple-negative type of breast cancer has the worst long-term results with an increase in the frequency of distant and locoregional metastases and a decrease in overall and relapse-free survival compared with luminal types. After neoadjuvant chemotherapy, the frequency of locoregional relapses decreases and the life expectancy of patients increases

Ways to improve long-term results of combined treatment of patients with colorectal cancer liver metastases

Ways to improve long-term results of combined treatment of patients with colorectal cancer liver metastases

Odległe wyniki skojarzonego leczenia chorych z wczesnym rakiem piersi po leczeniu oszczędzającym

Odległe wyniki skojarzonego leczenia chorych z wczesnym rakiem piersi po leczeniu oszczędzającym

244 Hepatocellular carcinoma: Long-term results of combined treatment with percutaneous radiofrequency ablation and transcatheter arterial chemoembolization

244 Hepatocellular carcinoma: Long-term results of combined treatment with percutaneous radiofrequency ablation and transcatheter arterial chemoembolization

Excision and cryosurgery in the treatment of conjunctival malignant epithelial tumours.

To evaluate the long-term results of combined treatment with excision and cryosurgery for malignant epithelial tumours of the conjunctiva. We retrospectively reviewed the medical records of patients diagnosed with conjunctival malignant epithelial tumours and treated with excision and cryosurgery between 1980 and 1998. The demographic features of the patients, characteristics of the tumours, and the peculiarities of the recurrences were recorded. The SPSS V 9.05 computed program was used for the statistical analysis of the results. Kaplan-Meier plots were used to determine the recurrence-free survival, and the logrank test was used to compare the recurrences according to histological classification. A total of 55 subjects (57 eyes), 19 female and 36 male, were included in the study. Their ages ranged between 15 and 82 years (mean 55+/-14 years). Histological diagnosis was conjunctival intraepithelial neoplasia (CIN) in 26 (46%) and invasive squamous cell carcinoma (SCC) of the conjunctiva in 31 eyes (54%). All eyes were treated with excision and cryosurgery with nitrous oxide probe. During the follow-up period of 6 months to 15 years, seven (12.3%) recurrences were observed. The success rate for patients with CIN and invasive SCC was 88.5 and 87.1%, respectively. There was no difference for recurrence rates between CIN and invasive SCC groups according to logrank test (P=0.68). Over the long-term follow-up, cryosurgery following excision is a successful method in the treatment of conjunctival intraepithelial tumours and invasive squamous cell carcinoma of conjunctiva with favourable outcome and minimal complications.