Long-term Physical Development Research Articles

Glucocorticoid use and varying doses on the long-term outcomes of offspring born to patients with systemic lupus erythematosus.

This study aims to assess the impact of non-fluorinated glucocorticoid use and varying doses on the long-term physical, neurological, and social-emotional development outcomes of offspring born to patients with systemic lupus erythematosus (SLE). The goal is to provide guidance on the appropriate dosage of glucocorticoids during pregnancy in SLE patients. We conducted a follow-up study on the offspring of SLE patients who had pregnancies and were admitted to our obstetrics department between January 1, 2016, and September 30, 2021. Patients who received immunosuppressants and dexamethasone were excluded from the study. The SLE patients were categorized into three groups based on their glucocorticoid use during pregnancy: hormone-free group, ≤ 10mg/day group, and > 10mg/day group (equivalent to prednisone). Most patients in the three groups were used hydroxychloroquine during pregnancy. We assessed the physical development status, including weight, height (length), and other relevant factors in three groups. Additionally, we utilized the Age and Stages Questionnaires, Third Edition (ASQ-3) to evaluate the development of communication, gross motor, fine motor, problem-solving, and personal-social. The social-emotional development status was assessed using the Age and Stages Questionnaires: Social-Emotional (ASQ: SE). We standardized the weight, height (length), body mass index, and ASQ-3 domain scores of children of different ages and genders into Z-scores for comparison. The results of this study demonstrated no statistically significant differences in the long-term physical development, neurological development, and social-emotional development outcomes of the offspring of SLE patients in three groups. However, while not reaching statistical significance, it was found that the offspring of the > 10mg/day group had lower height (length) Z-scores and communication Z-scores compared to the other groups. Conclusion: The use of non-fluorinated glucocorticoids during pregnancy and varying doses did not have a significant impact on the long-term physical, neurological, and social-emotional development outcomes of offspring born to SLE patients. However, the offspring of SLE patients treated with glucocorticoids > 10mg/day during pregnancy may be necessary to strengthen the monitoring of height (length) and communication skills in the long term. What is Known: • Fetal exposure to glucocorticoids can have implications for the development of multiple systems and may persist after birth, potentially increasing the risk of neurological abnormalities and other diseases. • There is limited research on the long-term development of offspring born to SLE patients, especially the patients treated with glucocorticoids. What is New: • The use of non-fluorinated glucocorticoids during pregnancy and varying doses did not have a significant impact on the long-term outcomes of offspring born to SLE patients. • The offspring of SLE patients treated with glucocorticoids >10 mg/day during pregnancy may be necessary to strengthen the monitoring of height (length) and communication skills in the long term.

Typical weekly physical periodization in French academy soccer teams: a survey.

In elite-level youth soccer players, weekly training periodization is of paramount importance to plan for short- and long-term physical development. The present study investigated current practices for physical periodization strategies in elite male French academies. An online survey was completed by elite French academies strength and conditioning coaches to determine the typical weekly periodization with particular reference to daily training in relation to match day (MD) in youth soccer players. The survey attempted to characterize the importance of physical development compared to match result, and practices used (expected difficulty and content) for each training session according to duration, exercises, and objective. The frequency rates of the responses were compared using two-tailed Chi-square tests with the significance level set at p < 0.05. Fortyfive questionnaires were analyzed. Respondents indicated that their training sessions focused mainly on physical development (95.6%) rather than match result. Active recovery (34.2%) and aerobic conditioning exercises (40.8%) were primarily conducted on MD+1 and MD+2 using passing circuits and aerobic technical drills. Physical development was mostly pursued during sessions on MD-4 (38.8%) and MD-3 (37.3%). The number of large-sided games was highest on MD-3 (58.1%). On MD-2 and MD-1, a decrease in the training load was highlighted, with speed (40.4%) and tapering sessions (52.4%) mostly implemented. Intensive use of small-sided games (92.3%) and reactivity exercises was observed at MD-1 (100.0%). Our results revealed discrepancies between the physical objectives set for each day and the content implemented, which could potentially be more physically demanding than expected.

Statistical analysis considerations within longitudinal studies of physical qualities in youth athletes: A qualitative systematic methodological review.

BackgroundThe evaluation of physical qualities in talent identification and development systems is vital and commonplace in supporting youth athletes towards elite sport. However, the complex and dynamic development of physical qualities in addition to temporal challenges associated with the research design, such as unstructured data collection and missing data, requires appropriate statistical methods to be applied in research to optimise the understanding and knowledge of long-term physical development.AimTo collate and evaluate the application of methodological and statistical methods used in studies investigating the development of physical qualities within youth athletes.MethodsElectronic databases were systematically searched form the earliest record to June 2021 and reference lists were hand searched in accordance with the PRISMA guidelines. Studies were included if they tested physical qualities over a minimum of 3 timepoints, were observational in nature and used youth sporting populations.ResultsForty articles met the inclusion criteria. The statistical analysis methods applied were qualitatively assessed against the theoretical underpinnings (i.e. multidimensional development, non-linear change and between and within athlete change) and temporal challenges (i.e. time variant and invariant variables, missing data, treatment of time and repeated measures) encountered with longitudinal physical testing research. Multilevel models were implemented most frequently (50%) and the most appropriately used statistical analysis method when qualitatively compared against the longitudinal challenges. Independent groups ANOVA, MANOVA and X2 were also used, yet failed to address any of the challenges posed within longitudinal physical testing research.ConclusionsThis methodological review identified the statistical methods currently employed within longitudinal physical testing research and addressed the theoretical and temporal challenges faced in longitudinal physical testing research with varying success. The findings can be used to support the selection of statistical methods when evaluating the development of youth athletes through the consideration of the challenges presented.

The Impact of Prenatal Exposure to Ramadan on Child Anthropomorphic Outcomes in Pakistan.

This study analyzes the intent-to-treat effect of prenatal exposure to Ramadan (the Islamic month of fasting) on outcomes including stunting and underweight for children under age 5years in Pakistan born between 2003 and 2018. The study uses observational data from four rounds of the UN-supported Multiple Indicator Cluster Survey (MICS) data collected on 204,186 children under-5 from Punjab, Pakistan in 2007-2008, 2010-2011, 2013-2014, and 2017-2018. Excluding data on outliers and observations with incomplete data, multivariate logistic regression analysis was conducted on the appended cross-sectional data of 179,943 children under-5 to assess the risk of stunting or underweight according to the month of gestation coinciding with Ramadan. We observe a significant increase in the risk of stunting and underweight associated with exposure to Ramadan following an inverted-U pattern. The peak impact of Ramadan exposure on a child being underweight occurs in the third month of pregnancy, where the probability of being underweight is 20 percent higher as compared to children whose gestation did not coincide with Ramadan. The peak impact of Ramadan exposure on stunting occurs in the fourth month of pregnancy, where the probability of stunting is 22 percent higher as compared to children whose gestation did not coincide with Ramadan. These results vary little by gender. In contrast, exposure to Ramadan in the ninthmonth of gestation is associated with a reduction in the risk of stunting for boys and underweight for both boys and girls. Our analysis indicates that prenatal exposure to Ramadan during the first two trimesters have negative implications for children's growth. The study highlights the critical role of maternal habits during early pregnancy, especially nutritional intake, forthe long-term physical development of children.

Analysis of long-term safety and efficacy of nucleos(t)ide analogue therapy for chronic hepatitis B throughout pregnancy

BackgroundLimited data exist regarding the efficacy and long-term safety of nucleos(t)ide analogue therapy throughout pregnancy for women with chronic hepatitis B and their children. MethodsThis retrospective cohort study included 165 women in total: 91 women received telbivudine (LDT) and 74 women received tenofovir (TDF) throughout pregnancy. The virological response and safety in women were recorded, and the physical development and bone mineral density in children were evaluated up to 5 years of age. ResultsThe rate of virological breakthrough in women was 4.24% overall (7.70% in LDT group and 0% in TDF group; P < 0.05). No cases of renal injury or other obstetric adverse events occurred in either group of women. Among the children, only one child had a significantly low Z score for weight for age (<-2), and no children had a significantly low Z score for height for age or bone mineral density. No significant difference was found between the children in the two groups. ConclusionsNucleos(t)ide analogue therapy with TDF or LDT throughout pregnancy had no effect on the long-term physical development and bone development of children. In addition, the use of TDF throughout pregnancy had better long-term antiviral efficacy than LDT in women, with no evidence of renal toxicity.

Eccentric Resistance Training in Youth: Perspectives for Long-Term Athletic Development.

The purpose of this narrative review is to discuss the role of eccentric resistance training in youth and how this training modality can be utilized within long-term physical development. Current literature on responses to eccentric exercise in youth has demonstrated that potential concerns, such as fatigue and muscle damage, compared to adults are not supported. Considering the importance of resistance training for youth athletes and the benefits of eccentric training in enhancing strength, power, speed, and resistance to injury, its inclusion throughout youth may be warranted. In this review we provide a brief overview of the physiological responses to exercise in youth with specific reference to the different responses to eccentric resistance training between children, adolescents, and adults. Thereafter, we discuss the importance of ensuring that force absorption qualities are trained throughout youth and how these may be influenced by growth and maturation. In particular, we propose practical methods on how eccentric resistance training methods can be implemented in youth via the inclusion of efficient landing mechanics, eccentric hamstrings strengthening and flywheel inertia training. This article proposes that the use of eccentric resistance training in youth should be considered a necessity to help develop both physical qualities that underpin sporting performance, as well as reducing injury risk. However, as with any other training modality implemented within youth, careful consideration should be given in accordance with an individual’s maturity status, training history and technical competency as well as being underpinned by current long-term physical development guidelines.

Application and interpretation of the yo-yo intermittent recovery test to the long-term physical development of girls association football players

ABSTRACTWe aimed to evaluate short- and long-term yo-yo intermittent recovery test, level 1 (YYIRL1) performance in girls football players. Mixed-linear modelling was used to determine within-season changes in YYIRL1 performance and between- and within-player variation over four years, at four time points (July, September, December and May) in 86 players (459 observations), mean age 13 ± standard deviation 1.8 years, 0.9 ± 1.5 years from peak height velocity. Twenty-three players, tested over three consecutive years were retained for further analysis. Magnitude-based inferences were used to quantify annual change in performance on a group and individual level. Within-player correlations were used to determine the association between YYIRL1 and maturation. ‘Very likely’ small (14, ±90% confidence interval 8.1–20%) improvements were observed between July and September and ‘possibly’ trivial (5.5, 0.41–11%) differences between September and May. Within-player variation throughout the in-season period, representing the typical error of the estimate was 23%, 22–25% and between-player, 38, 33–44%. We observed ‘most likely’ moderate improvements (32, 17–49%) over three years that were moderately associated with changes in maturation (r = 0.46, 0.13 to 0.70). A minimum change of ≥44% is required to detect ‘likely’ improvements in YYIRL1 performance on an individual basis.

Long-term prognosis of neonates with necrotizing enterocolitis

To investigate the long-term prognosis of neonates with necrotizing enterocolitis (NEC). A total of 83 preterm infants with NEC who survived and were discharged between December 2014 and September 2016 were enrolled and divided into surgery group (n=57) and non-surgery group (n=26). There were 0, 33 and 24 cases of stage I, II and III NEC respectively in the surgery group and 7, 19 and 0 cases respectively in the non-surgery group. The physical development and neurodevelopmental outcomes of the infants were followed up after discharge. Of the 83 infants, the mean corrected age at the end of follow-up was 21±6 months. Of the 83 infants, 31 (37%) had subnormal body weight, and the surgery group had a higher rate of subnormal body weight than the non-surgery group (P<0.05). Twenty-two infants (27%) had subnormal body length and 14 children (17%) had subnormal head circumference among the 83 infants. Eighteen infants (22%) had motor developmental delay/developmental disorders, and the surgery group had a higher incidence rate of the disorders than the non-surgery group (28% vs 8%; P<0.05). Five infants (6%) were diagnosed with cerebral palsy, among whom 4 were in the surgery group and 1 was in the non-surgery group. Long-term physical development and neurodevelopmental outcomes may be adversely affected in neonates with NEC, in particular in those with severe conditions who need surgical treatment, suggesting that long-term follow-up should be performed for neonates with NEC.

Youth Resistance Training: The Good, the Bad, and the Ugly-The Year That Was 2017.

The good news is that a growing body of evidence recognizes resistance training as foundational to long-term physical development. Original research and reviews published in 2017 conclude that early exposure to developmentally appropriate resistance training can improve markers of health, increase muscular fitness, enhance physical literacy, and reduce the risk of injury in young athletes. Although the papers discussed in the commentary add to our understanding of the pleiotropic benefits of youth resistance training, they also raise concerns. As measures of muscular strength and power have been found to track from childhood to adulthood, the bad news is that youth with low levels of muscular fitness tend to become weak adults who are at increased risk for functional limitations and adverse health outcomes. Furthermore, global participation in youth resistance training is falling far short of public health recommendations, and these ugly trends will likely impact the health and well-being of future generations. A change in current attitudes and common practices is urgently needed to educate parents, practitioners, and clinicians about the potential benefits of resistance training for all children and adolescents, not only young athletes.

Dynamic-MFA examination of Chilean housing stock: long-term changes and earthquake damage

The dynamics and metabolism of the built environment are important for understanding the construction, renovation and demolition activities that characterize its long-term physical development. Previous research on building stock development is limited, particularly for developing countries. As one of the most seismically active countries in the world, Chile's built environment is constantly subjected to losses. This study included earthquake vulnerability and damage in a dynamic material flow analysis (MFA) of the Chilean housing stock. Stock and flows of residential floor area were modelled using population and life style parameters. Demolition was modelled assuming a constant demolition rate. By characterizing the building stock according to vulnerability classes and establishing a mass balance per class, the effects of different typology distributions on the overall damage to the stock caused by earthquakes could be assessed. Scenarios with different trends in typology distribution for new construction and renovation suggest that significant potential exists for reducing future earthquake damage in the Chilean housing stock. This is best achieved by gradually reducing the vulnerability of buildings to earthquakes. Legislation, building standards and financial instruments could be used to ensure such reductions in earthquake damage and thereby provide socio-economic benefits in the future.

Quantification of the typical weekly in-season training load in elite junior soccer players

We examined the typical weekly training load experienced by elite junior soccer players during the in-season competitive period. Altogether, eight under-14 (U14), eight under-16 (U16) and eight under-18 (U18) players were monitored over a 2-week period during the first month of the 2010–11 competitive season. This time period included one competitive match per week. Physiological loading was monitored using heart rate (HR) and ratings of perceived exertion (RPE). Training and match loads were calculated by multiplying the global session RPE and duration (session-RPE). Total weekly training load (training and match) increased with age (U14, 2524 ± 128 arbitrary units [AU]; U16, 2919 ± 136 AU; U18, 3948 ± 222 AU; P < 0.05). Differences in the daily training load across the training week were also evident in the older age group relative to both U14 and U16. The amount of time engaged in low (<50% HRmax) and high (>90% HRmax) intensity activity during training and match-play was significantly lower and higher respectively in the U18 compared to the U14 group (P < 0.05). When comparing activity, the intensity (% HRmax) of field training (U18, 69 ± 2%; U16, 74 ± 1%; U14, 74 ± 2%) was significantly lower compared to match-play (U18, 81 ± 3%; U16, 84, ± 2%; U14, 83 ± 2) across all age groups (P < 0.05). Findings demonstrate that age related differences in the volume and intensity of weekly in-season training load are evident amongst elite professional junior soccer players. These differences may reflect a systematic approach to the long-term physical development of elite junior players.

Effects of G207, a conditionally replication-competent oncolytic herpes simplex virus, on the developing mammalian brain

Viral oncolytic therapy for malignant brain tumors involves local intratumoral delivery of a genetically engineered virus with tumor cell-specific lytic activity. Promising preliminary results have been achieved in preclinical models with G207, a replication-competent herpes simplex virus type 1 constructed with multiple directed mutations. Although the safety of G207 has been demonstrated in adults, application of viral oncolytic therapy to children with brain tumors has been delayed because of previous lack of data concerning the impact of a replication-competent oncolytic virus on the developing mammalian brain. In this study there was no significant difference in long-term physical development, cognitive performance, or exploratory behaviors between mice that received intracerebral inoculation of G207 or control saline at 4 days of age. However, histological examination and magnetic resonance imaging revealed frequent unilateral ventriculomegaly ipsilateral to the site of injection in only the G207 group. These results suggest that although it is unlikely that G207 will have significant adverse effects on neurodevelopmental outcomes of pediatric patients with brain tumors, an initial study of G207 in children should exclude those patients with tumors in or near the ventricular system as well as patients less than 2 years of age. Furthermore, patients in such a study will need to be closely monitored for the development of hydrocephalus.

Child Health and Household Resources in South Africa: Evidence from the Old Age Pension Program

This paper presents nonparametric evidence on the effects of the expansion of the Old Age Pension program in South Africa on child health. Did this increase in household resources improve child health and nutrition? Does the gender of the recipient of the pension affect its impact? The answers to these questions have very important policy implications. There is evidence that inadequate nutrition during childhood (and even in utero) affects long-term physical development, as well as the development of cognitive skills. This in turn affects productivity later in life (see Partha Dasgupta, 1993; John Strauss and Duncan Thomas, 1998; T. Paul Schultz, 1999). In the United States, the evidence suggests that monetary transfers to the poor have very little impact on child welfare (Janet Currie, 1995; Susan Mayer, 1997). However, the effects of parental income and monetary transfers on child outcomes are likely to be of greater magnitude among poor households in developing countries. The South African Pension program provides an unusual opportunity to evaluate the possible effects of such a monetary transfer. This paper exploits the rapid increase in the coverage and benefits of the Old Age Pension program in South Africa which took place in the early 1990’s (Anne Case and Angus Deaton, 1998). At the end of the apartheid era, the government committed to achieving parity of benefits and eligibility requirements between whites and Africans. This was achieved mostly by increasing the benefits received by the Africans. In 1993, 80 percent of African women above age 60 and 77 percent of African men above 65 received the pension. The maximum benefit of 370 rands per month (aproximately $3 per day) was equal to half of the minimum wage, and about twice the median income per capita in rural areas. Due to living arrangements inherited from the apartheid era, close to onethird of African children under the age of 5 currently live with a pension recipient. Children who live with a pension recipient tend to come from relatively disadvantaged backgrounds. As a consequence, they tend to be smaller than other children their age. To estimate the effect of receiving a pension on the anthropometric status of children, this paper exploits the fact that height reflects accumulated investments in child nutrition. The larger the proportion of her life during which a child is well-nourished, the taller she will be, given her age. Due to the expansion of the program in the early 1990’s, individuals of qualified age became more likely to receive a pension, and the benefits became substantially larger. Thus, children born after the expansion of the program are more likely to have spent a larger fraction of their lives wellnourished, if they live with a pension recipient, to the extent that the pension resulted in improved nutrition. In this paper, I present nonparametric evidence of the program’s effect on nutrition based on this observation.