Long-term Outcome Of Obsessive-compulsive Disorder Research Articles

Predictors of the 6-year outcome of obsessive-compulsive disorder: Findings from the Netherlands Obsessive-Compulsive Disorder Association study.

Obsessive-compulsive disorder is characterized by a chronic course that can vary between patients. The knowledge on the naturalistic long-term outcome of obsessive-compulsive disorder and its predictors is surprisingly limited. The present research was designed to identify clinical and psychosocial predictors of the long-term outcome of obsessive-compulsive disorder. We included 377 individuals with a current diagnosis of obsessive-compulsive disorder, who participated in the Netherlands Obsessive Compulsive Disorder Association study, a multicenter naturalistic cohort study. Predictors were measured at baseline using self-report questionnaires and clinical interviews. Outcome was assessed using the Yale-Brown Obsessive Compulsive Scale at 2-, 4- and 6-year follow-up. The overall course of obsessive-compulsive disorder was characterized by two prominent trends: the first reflected an improvement in symptom severity, which was mitigated by the second, worsening trend in the long term. Several determinants affected the course variations of obsessive-compulsive disorder, namely, increased baseline symptom severity, late age of onset, history of childhood trauma and autism traits. The long-term outcome of obsessive-compulsive disorder in naturalistic settings was characterized by an overall improvement in symptom severity, which was gradually halted to the point of increased worsening. However, after 6 years, the severity of symptoms remained below the baseline level. While certain determinants predicted a more favorable course, their effect diminished over time in correspondence to the general worsening trend. The results highlight the importance of a regular and continuous monitoring for symptom exacerbations as part of the management of the obsessive-compulsive disorder, regardless of the presence of putative predictors.

Course and outcome of obsessive-compulsive disorder.

Obsessive–compulsive disorder (OCD) is generally believed to follow a chronic waxing and waning course. The onset of illness has a bimodal peak – in early adolescence and in early adulthood. Consultation and initiation of treatment are often delayed for several years. Studies over the past 2–3 decades have found that the long-term outcomes in OCD are not necessarily bleak and that at least half the treatment-seeking patients with OCD show symptomatic remission over long term. A short duration illness, of low severity that is treated early and intensively, with continued maintenance treatment over long term possibly has a good outcome. Recent studies have also identified neuroimaging and neuropsychological correlates of good outcome, but these need further replication. This paper presents an overview of conceptual issues and studies on long-term outcome of OCD and predictors of outcome.

Long-term outcome of obsessive-compulsive disorder in adults: a meta-analysis.

To study the long-term rate and predictors of remission in adults with obsessive-compulsive disorder (OCD), using meta-analysis. The MEDLINE database was searched to May 2013 using the search terms obsessive-compulsive disorder, prospective, outcome study, clinical course, remission, prognosis, follow-up, and long-term and limits for language (English), species (humans), and age (adults). This was supplemented by manual bibliographic cross-referencing. English-language studies from peer-reviewed journals on adults with DSM-III-R, DSM-IV, DSM-IV-TR, ICD-9, or ICD-10 diagnosis of OCD followed up for ≥ 1 year and treated with serotonin reuptake inhibitors and/or cognitive-behavioral therapy that reported rate of remission (Yale-Brown Obsessive Compulsive Scale [YBOCS] score < 16 at longest follow-up) were included. Data were gathered as numbers/means/percentages/categories on sample size, study design, follow-up duration, age at assessment, illness duration, age at illness onset, gender, marital status, inpatient/outpatient status, family history, baseline YBOCS score, comorbidities, and remission. Seventeen studies (pooled N = 1,265) fit the selection criteria and were used for the meta-analysis. The pooled sample had a mean follow-up duration 4.91 years and was predominantly male and outpatient and had onset of illness in the second decade, illness duration more than 10 years, and moderate-to-severe OCD. Pooled remission rate was 53% (95% CI, 42%-65%). Prospective studies showed higher pooled remission rate than retrospective studies (55% [95% CI, 45%-65%] vs 50% [95% CI, 27%-73%], P < .001). Indian studies showed higher pooled remission rate than others (71% [95% CI, 59%-83%] vs 48% [95% CI, 37%-59%], P < .001). Age at onset (t = -7.08, P = .019), illness duration (t = -8.13, P = .015), baseline YBOCS score (t = -6.81,P = .021), and male gender (t = -5.92, P = .027) had significant negative association with remission on meta-regression. A high long-term remission rate found in this meta-analysis is contrary to generally held beliefs about poor outcome of individuals with OCD. Multicenter, prospective, long-term studies should systematically examine course and outcome in larger samples, emphasizing symptomatic and functional recovery.

Neuroanatomical Correlates of Naturalistic Long-Term Outcome of Obsessive-Compulsive Disorder Treated With Selective Serotonin Reuptake Inhibitors

Neuroanatomical Correlates of Naturalistic Long-Term Outcome of Obsessive-Compulsive Disorder Treated With Selective Serotonin Reuptake Inhibitors

CLINICAL PREDICTORS OF LONG-TERM OUTCOME IN OBSESSIVE-COMPULSIVE DISORDER

The purpose of this study was to investigate demographic and clinical factors associated with the long-term outcome of obsessive-compulsive disorder (OCD). A hundred ninety-six previously untreated patients with DSM-IV criteria OCD completed a 12-week randomized open trial of group cognitive-behavioral therapy (GCBT) or fluoxetine, followed by 21 months of individualized, uncontrolled treatment, according to international guidelines for OCD treatment. OCD severity was assessed using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) at different times over the follow-up period. Demographics and several clinical variables were assessed at baseline. Fifty percent of subjects improved at least 35% from baseline, and 21.3% responded fully (final Y-BOCS score < or = 8). Worse prognosis was associated with earlier age at onset of OCD (P = 0.045), longer duration of illness (P = 0.001) presence of at least one comorbid psychiatric disorder (P = 0.001), comorbidity with a mood disorder (P = 0.002), higher baseline Beck-Depression scores (P = 0.011), positive family history of tics (P = 0.008), and positive family history of anxiety disorders (P = 0.008). Type of initial treatment was not associated with long-term outcome. After correction for multiple testing, the presence of at least one comorbid disorder, the presence of a depressive disorder, and duration of OCD remained significant. Patients under cognitive-behavioral or pharmacological treatment improved continuously in the long run, regardless of initial treatment modality or degree of early response, suggesting that OCD patients benefit from continuous treatment. Psychiatric comorbidity, especially depressive disorders, may impair the long-term outcome of OCD patients.

An 11- to 13-Year Follow-Up of 75 Subjects With Obsessive-Compulsive Disorder

There is a paucity of data on the long-term course and outcome of obsessive-compulsive disorder (OCD). Available data suggest that OCD runs a chronic course with waxing and waning severity. However, most previous studies included severely ill patients who were often clinically referred and hospitalized. The present study reports the course and outcome of OCD in patients who were largely outpatient, self-referred, and drug-naive. Seventy-five of the 105 subjects (71%) with DSM-IV-diagnosed OCD were followed up 11 to 13 years after initial consultation in 1991 and 1992 at a major psychiatric hospital in India. A majority were self-referred (N = 63, 84%), drug-naive (N = 54, 72%), and outpatients (N = 60, 80%). The follow-up evaluations were carried out by experienced clinicians using various scales and structured instruments. The course and outcome were determined according to predefined criteria. Multinomial logistic regression analysis was performed to identify potential predictors of outcome. A majority of subjects were adequately treated with medications (N = 57, 76%). Out of 75 subjects, only 18 subjects (24%) had clinical OCD. Overall, 57 subjects (76%) had a favorable outcome: 32 subjects (43%) had no OCD and 25 (33%) had subclinical OCD. Mixed OCD and any Axis I lifetime comorbidity predicted "clinical OCD" outcome. Outcome of OCD is better than generally assumed, and the findings of this study offer a new perspective on the long-term outcome of OCD. Poor outcome in previous studies may have been due to the inclusion of severely and chronically ill patients.

Long-term outcome and prognosis of obsessive-compulsive disorder with onset in childhood or adolescence.

The aim of the catch-up follow-up study is to describe the long-term outcome of obsessive-compulsive disorder (OCD) with onset in childhood and adolescence. The psychiatric morbidity in adulthood including personality disorders was assessed and predictors in childhood for the course of obsessive-compulsive symptoms were examined. The total study group consisted of the entire patient population treated for OCD at our departments for child and adolescent psychiatry between 1980 and 1991. We reassessed 55 patients personally by way of structured interviews. The mean age of onset of OCD was 12.5 years and the mean follow-up time was 11.2 years. At the follow-up investigation 71% of the patients met the criteria for some form of psychiatric disorder, while 36% were still suffering from OCD. Of the patients with a present diagnosis of OCD 70% had at least one further clinical disorder (especially anxiety and affective disorders). The most frequent personality disorders diagnosed were obsessive-compulsive (25.5%), avoidant (21.8%), and paranoid (12.7%) personality disorders. In-patient treatment, terminating treatment against advice and tics in childhood or adolescence significantly correlated with more severe OC symptoms in adulthood.

Long-Term Outcome of Obsessive-Compulsive Disorder with Psychotic Features

Long-Term Outcome of Obsessive-Compulsive Disorder with Psychotic Features

Long-Term Outcome of Obsessive-Compulsive Disorder in Childhood

A review of the records of one psychiatric clinic over a 16-year period revealed 17 cases who met the criteria for a diagnosis of severe obsessive-compulsive neurosis. Retrospective review of these cases revealed that 82% of the children's parents themselves suffered from severe psychiatric or medical impairment, and that 29% of the children suffered from serious medical illnesses. All 17 cases had been treated, most with “intensive” psychotherapy. Fifteen patients could be located for follow-up, of whom 10 agreed to a structured interview. Seven of the 10 still suffered from obsessive-compulsive symptoms, and all reported serious problems with social life and peer relationships. We hypothesize that the obsessive-compulsive symptoms of the children served as a defense against anxiety generated by their extremely stressful life situations. The children's intellectual cognitive style and the availability in some instances of obsessive-compulsive parental models may have contributed to their choice of an obsessive-compulsive defense.