Long-term Instability Research Articles

Cost-Effectiveness of Temporary Financial Assistance for Veterans Experiencing Housing Instability.

The US Department of Veterans Affairs (VA) partners with community organizations (grantees) across the US to provide temporary financial assistance (TFA) to vulnerable veterans through the Supportive Services for Veteran Families (SSVF) program. The goal of TFA for housing-related expenses is to prevent homelessness or to quickly house those who have become homeless. To assess the cost-effectiveness of the SSVF program with TFA vs without TFA as an intervention for veterans who are experiencing housing insecurity. This study used a Markov simulation model to compare cost and housing outcomes in a hypothetical cohort of veterans enrolled in the SSVF program. Enrollees who are homeless receive rapid rehousing services, while those who are at risk of becoming homeless receive homelessness prevention services. The SSVF program with TFA for veterans who are experiencing housing insecurity. The effectiveness measure was the incremental cost-effectiveness ratio (ICER) with quality-adjusted life-years (QALYs). The model was parameterized using a combination of inputs taken from published literature and internal VA data. The model had a 2-year time horizon and a 1-day cycle length. In addition, probabilistic sensitivity analyses were conducted using 10 000 Monte Carlo simulations. The base case analyses found that the SSVF program with TFA was more costly ($35 814 vs $32 562) and yielded more QALYs (1.541 vs 1.398) than the SSVF program without TFA. The resulting ICER was $22 676 per QALY, indicating that TFA is the preferred strategy at a willingness-to-pay threshold of $150 000 per QALY. This ICER was $19 114 per QALY for veterans in the rapid rehousing component of the SSVF program and $29 751 per QALY for those in the homelessness prevention component of the SSVF program. At a willingness-to-pay threshold of $150 000 per QALY, probabilistic sensitivity analyses showed that TFA was cost-effective in 8972 of the 10 000 Monte Carlo simulations (89.7%) for rapid rehousing and in 8796 of the 10 000 Monte Carlo simulations (88.0%) for homelessness prevention only. This economic evaluation suggests that TFA is a cost-effective approach (ie, yields improved health benefits at a reasonable cost) for addressing housing insecurity for veterans enrolling in the SSVF program. Future research could examine the cost effectiveness of large, nationwide housing interventions such as this one among subpopulations of veterans such as those with certain comorbidities including severe mental illness or substance use disorders, those with chronic diseases, or those experiencing long-term housing instability vs acute loss of housing.

Efficacy of Diagnostic In-Office Shoulder Ultrasound in the Surgical Treatment of Full-Thickness Rotator Cuff Tears.

Early surgical management of full-thickness traumatic rotator cuff tears (RCTs) may optimize functional outcomes, prioritizing timely diagnoses. Ultrasound and magnetic resonance imaging (MRI) are highly sensitive and specific modalities for RCT diagnosis, yet MRI remains the gold standard diagnostic tool despite increased costs and potential delays in care. Ultrasound can provide same-day diagnosis, thus possibly expediting care. The use of diagnostic shoulder ultrasound alone in the orthopaedic surgeon's office could increase the efficiency of diagnosis and care of traumatic full-thickness RCTs compared with MRI. Cohort study; Level of evidence, 3. A retrospective chart review of patients with full-thickness traumatic RCT diagnosed via ultrasound or MRI who subsequently underwent rotator cuff repair with 1 of 2 ultrasound-trained surgeons between January 1, 2014, and December 31, 2019, was performed. Inclusion criteria included patients ≥18 years old, documentation of a first-time traumatic event, and the patient's desire to have immediate surgical management. Revision surgeries, long-term shoulder instability, and nontraumatic injuries were excluded. Basic demographic data were collected, and the number of preoperative office visits and the timing from initial evaluation to diagnosis and surgery were calculated for the ultrasound and the MRI cohorts. A power analysis of 0.8 with an alpha of .05 required 38 patients per group. Overall, 133 patients were diagnosed via MRI compared with 76 via ultrasound. Besides body mass index, there were no significant differences in demographic variables or insurance status. Compared with the MRI cohort, patients in the ultrasound cohort received their diagnosis almost 2 weeks faster (P < .0001), were scheduled for surgery almost 3 weeks faster (P < .0001), and underwent surgery 2 weeks faster after initial evaluation (P < .0001) while requiring nearly half as many clinical visits (P < .0001). Regression analysis confirmed that ultrasound significantly reduced time to imaging, scheduling, and surgery after initial evaluation while requiring fewer clinical visits (P < .05). The study findings indicated that ultrasound was a time-saving alternative diagnostic modality for traumatic RCT compared with MRI without compromising standard of care. These results were achieved independent of patient insurance status, disability index, or other demographic variables.

Measuring instability in chronic human intracortical neural recordings towards stable, long-term brain-computer interfaces.

Intracortical brain-computer interfaces (iBCIs) enable people with tetraplegia to gain intuitive cursor control from movement intentions. To translate to practical use, iBCIs should provide reliable performance for extended periods of time. However, performance begins to degrade as the relationship between kinematic intention and recorded neural activity shifts compared to when the decoder was initially trained. In addition to developing decoders to better handle long-term instability, identifying when to recalibrate will also optimize performance. We propose a method, "MINDFUL", to measure instabilities in neural data for useful long-term iBCI,without needing labels of user intentions. Longitudinal data were analyzed from two BrainGate2 participants with tetraplegia as they used fixed decoders to control a computer cursor spanning 142 days and 28 days, respectively. We demonstrate a measure of instability that correlates with changes in closed-loop cursor performance solely based on the recorded neural activity (Pearson r = 0.93 and 0.72, respectively). This result suggests a strategy to infer online iBCI performance from neural data alone and to determine when recalibration should take place for practical long-term use.

Absolutely Structural Disorder Boosting Bandwidth toward Full-Spectrum White Light from Single Occupancy of Activator.

Achieving single-phase full-spectrum white light (SFWL) phosphors is a central goal in theoptical field because they simplify white-LEDs assembly and avoid long-term color instability. Despite many approaches are developed, current SFWL phosphors still suffer from chromaticity drift due to inconsistent thermal quenching of multiple emitting centers. Herein, an absolutely structural disorder strategy is established to develop a single-emitting center-based SFWL phosphor. Precisely controlling the flux added induces a structural translation from the absolutely ordered Y0.75Ta0.25O1.75:Bi3+ to the absolutely disordered Y0.785Ta0.215O1.715:Bi3+, as directly identified by STEM-HAADF analyses. Structural disorder enables Y0.785Ta0.215O1.715:Bi3+ to produce SFWL with the FWHM of 6194cm-1 (175nm) by employing a single activator site, a 1352cm-1 increase compared to the cyan-emitting Y0.75Ta0.25O1.75:Bi3+ despite Bi3+ occupies two lattice positions. This single-emitting center-based SFWL, coupled with minimal thermal expansion of the unit cell and inapparent spectral overlap of excitation and emission bands, ensure zero-chromaticity shift with elevated temperature. A prototype white-LEDs using Y0.785Ta0.215O1.715:Bi3+ as a single luminescent layer generates warm white light without perceptible CIE coordinates shift under various currents or after extremely long-term continuous operation. This work highlights the potential of structural disorder in designing SFWL phosphors with exceptional color stability.

Redox Concomitant Formation Method for Fabrication of Cu(I)-MOF/Polymer Composites with Antifouling Properties.

Marine biofouling, which is one of the technical challenges hindering the growth of the marine economy, has been controlled using cuprous oxide (Cu2O) nanoparticles due to the exceptional antifouling properties of Cu(I) ions. However, Cu2O nanoparticles have encountered bottlenecks due to explosive releases of Cu+ ions, high toxicity at elevated doses, and long-term instability. Here, we present a novel method called Redox Concomitant Formation (RCF) for fabricating a hierarchical Cu(I) metal-organic framework polypyrrole (Cu(I)-MOF/PPy) composite. This method enables in-situ phase transition via successive redox reactions that change the chemical valence state and coordination mode of Cu(II)-MOF, resulting in a new structure of Cu(I)-MOF while creating a PPy layer surrounded by the hierarchical structure. Owing to the steady release of Cu+ ions from the Cu(I) sites and photothermal properties of PPy, Cu(I)-MOF/PPy exhibits superior and broad-spectrum resistance to marine bacteria, algae, and surface-adhered biofilms in complex biological environments, as well as long-term stability, resulting in 100% eradication efficiency under solar-driven heating. Mechanistic insights into successive structural redox reactions and formation using the RCF method are provided in detail, enabling the fabrication of novel MOFs with the desired composition and structure for a wide range of potential applications.

Development of Efficient Ink Dispersion Process for Solid-State Electrolyte and Electrode Manufacturing

All-solid-state lithium batteries (ASSBs) have several advantages over lithium-ion batteries (LIBs) such as higher safety thresholds associated with solid electrolytes (SEs) and the possibility of using lithium metal or silicon anodes to achieve comparatively higher energy and power density. The SE can also prevent chemical interactions with dissolved active materials, and thus solve the issue of long-term instability of LIBs. However, there are also challenges associated with ASSBs manufacturing, such as local stress and contact-loss between SE and active materials in cathodes due to active material “breath”, poor contact and high ionic resistance at the SE-cathode interface, difficulty in fabricating thin SEs, and the absence of scalable and cost-effective manufacturing processes (J. Janek and W.G. Zeier, Nature Energy 8 (2023): 230-240). A key to tackling these issues begins with ink formulation for electrolyte and cathode coating, including ink compositions and rheological properties.In this study, we report the influence of ink preparation methods and conditions on the solid-state electrolyte and cathode coating qualities, where lithium lanthanum zirconium oxide (LLZO) and lithium nickel manganese cobalt oxide (NMC) are used as model systems. Various mixing methods, such as acoustic wave mixing, high-speed off-axis mixing, and thin film mixing, are compared. Their influence on ink viscosity and particle dispersion, coating thickness and microstructure uniformity, and electrolyte and electrode electrochemical properties will be discussed.

Mechanisms and influential factors of soil chromium long-term stability by an accelerated aging system after chemical stabilization

Chemical stabilization is one of the most widely used remediation strategies for chromium (Cr)-contaminated soils by reducing Cr(VI) to Cr(III), and its performance is affected by human and natural processes in a prolonged period, challenging long-term Cr stability. In this work, we established a method for evaluating the long-term effectiveness of remediation of Cr-contaminated soils, and developed an accelerated aging system to simultaneously simulate acid rain leaching and freeze-thaw cycles. The mechanisms and influencing factors of long-term (50-year) change in soil Cr speciation were unravelled after stabilization with Metafix®. Chemical stabilization remarkably decreased the contents of Cr(VI)soil, Crtotal-leach and Cr(VI)leach, among which the removal rate of Cr(VI) in soil was up to 89.70 %, but it also aggravated soil Cr instability. During the accelerated aging process, Crtotal-leach change rates in chemically stabilized soil samples were 0.0462–0.0587 mg/(L·a), and soil Cr became instable after 20-year accelerated aging. The proportion of Cr bound to organic matter and residual Cr increased in soil, and exchangeable Cr decreased. Linear combination fitting results of XANES also showed that Cr(VI) and Cr3+ were transformed into OM-Cr(III), Fh-Cr(III) and CrFeO3 after restoration. During the accelerated aging process, acid rain leaching activated Cr(III) and dissolved Cr(VI), whereas freeze-thaw cycle mainly affected OM-Cr. Chemical stabilization, acid rain leaching and aging time were the major factors influencing the stability of soil Cr, and the freeze-thaw cycle promoted the influence of acid rain leaching. This study provided a new way to explore the long-term effectiveness and instability mechanisms at Cr-contaminated site after chemical stabilization.

A new hybrid approach for cold load restoration using deep learning

After an extended outage in a power system, restoration of feeders with high penetration levels of thermostatically controlled loads (TCLs) will be a challenging problem. By restoring these feeders, the demand will increase several times the normal conditions which is called the cold load pick-up (CLPU) phenomenon. This can lead to overload of equipment such as power transformers in transmission substations. In order to increase the reliability of network load supply, in transmission substations, usually several transformers are used which can be operated in parallel by closing circuit breakers on the secondary side called bus section (BS). When the restoration process is long and the loads are cold, more loads can be restored by closing the BSs and paralleling the transformers. On the other hand, it is not possible to close all the BSs simultaneously because paralleling all the transformers at the same time increases the short circuit level on the secondary side. Furthermore, in power systems, some loads are voltage-dependent and by reducing the voltage, their demand can be decreased and therefore the restoration process is expedited. Due to the increase in demand caused by CLPU, additional stress is applied to the power system, which can lead to operational constraints violation and even long-term voltage instability. Therefore, at the time of restoration of each feeder, the settings of voltage control devices are updated to avoid the violation of operational constraints and the occurrence of wider events. In this paper, in order to reduce cold load restoration time, closing the bus sections and voltage reduction are used simultaneously. Also, short circuit and operational constraints are considered. The cold load restoration problem is formulated as a mixed integer nonlinear programming and is solved using the pattern search algorithm. Since there are many decision variables and solving the problem is time-consuming, a combination of deep learning networks, pattern search algorithm and parallel computing is used to accelerate the computations.

The Buford Complex Redefined: A Pathologic Morphology in Sheep's Clothing.

Considered a normal anatomic variant, the Buford complex has not been studied in children. A Buford complex is not a normal anatomic variant and would, therefore, be present at a lower rate than that seen in the adult population. Cross-sectional study; Level of evidence, 3. Measurements were recorded from magnetic resonance imaging performed over 13 years in children aged ≤11 years for various pathologies unrelated to glenohumeral instability. Interrater reliability was determined to identify Buford complexes, sublabral foramens and tears, and normal shoulders via 16 preadolescent and adolescent patients with confirmed arthroscopic correlation. The Buford complex and labral foramen rates were then compared with a published rate in adults using a binomial probability test. A total of 122 children (62 girls; mean age, 6.4 years [age range, 2 months-10.9 years]) were evaluated. Interrater reliability was 0.846 (95% CI, 0.56-1) to identify anterosuperior labral variants. The expected sublabral foramen count was 23 children, but only 1 was identified (P < .001). The expected Buford complex count was 8 children, but none could be identified (P < .001). The absence of Buford complexes and the significant reduction in sublabral foramen abundance in younger children suggest that these anatomic variants are more likely to be developmental than congenital. The distinct possibility that these previously considered normal variants are truly pathologic findings cannot be ignored. Evidence of a Buford complex could potentially signify an underlying, long-term shoulder instability issue to the treating provider that warrants further investigation or management.

Lake Kinneret and Hula Valley Ecosystems under Climate Change and Anthropogenic Involvement

The long-term record of ecological, limnological and climatological parameters that were documented in the Kinneret drainage basin was statistically evaluated. The dependent relations between environmental parameters and a change in climate conditions open a consequence dispute between three optional definitions: long-term instability, climate change impact and ecosystem resiliency. The Kinneret drainage basin during the Anthropocene era is marked by intensive anthropogenic involvement: Increase in population size, drainage of the wetlands and old lake Hula, agricultural development, enhancement of lake Kinneret utilization for water supply, hydrological management, fishery and recreation. Therefore, the impact of a combination of natural and anthropogenic environmental factors confounded each other, and the uniqueness of climate change is unclear.

Ultrasonic-assisted green extraction and incorporation of Spirulina platensis bioactive components into turmeric essential oil-in-water nanoemulsion for enhanced antioxidant and antimicrobial activities

The utilization of essential oils as natural antioxidants and preservatives is limited by high volatility, poor water solubility, and long-term instability. To address this, a novel ultrasonic-assisted method was used to prepare and stabilize a nanoemulsion of turmeric essential oil-in-water, incorporating bioactive components extracted from Spirulina platensis. Ultrasonic treatment enhanced the extraction efficacy and nanoemulsion stability. Algal biomass subjected to ultrasonic treatment (30 min at 80% amplitude) yielded a dry extract of 73.66 ± 3.05%, with the highest protein, phenolic, phycocyanin, and allophycocyanin content, as well as maximum emulsifying activity. The resulting nanoemulsion (5% oil, 0.3% extract, 10 min ultrasonic treatment) showed reduced particle size (173.31 ± 2.24 nm), zeta potential (−36.33 ± 1.10 mV), low polydispersity index, and enhanced antioxidant and antibacterial properties. Rheology analysis indicated shear-thinning behavior, while microscopy and spectroscopy confirmed structural changes induced by ultrasonic treatment and extract concentration. This initiative developed a novel ultrasonic-assisted algal-based nanoemulsion with antioxidant and antibacterial properties.

Short-term profitability of stakeholders and long-term instability in the production of collective good Social Welfare: A qualitative analysis of insurance evasion

Short-term profitability of stakeholders and long-term instability in the production of collective good Social Welfare: A qualitative analysis of insurance evasion

Bony Bankart Lesion: Diagnosis, Management, and Outcomes.

» Bony Bankart lesions are fractures of the anteroinferior glenoid rim, commonly associated with a traumatic anterior shoulder dislocation, and are diagnosed through radiological imaging and physical examination. Young male athletes playing contact sports are at highest risk of these injuries. Early diagnosis and treatment are crucial because, if left untreated, recurrent anterior shoulder instability and glenoid bone loss can occur. Both nonsurgical and surgical treatment options are available depending on the size of the lesion, with arthroscopic repair being the most common treatment method. After repair, patients typically have favorable outcomes with low rates of recurrent instability. This review aims to discuss the etiology, diagnosis, and treatment of bony Bankart lesions.» Bony Bankart lesions are fractures of the anteroinferior glenoid rim and occur in up to 22% of first-time anterior shoulder dislocations.» Young men involved in contact sports or combat training are at the highest risk of sustaining bony Bankart lesions.» Diagnosis and treatment of bony Bankart lesions are essential to prevent long-term shoulder instability.» Bony Bankart lesions can be treated either nonoperatively or operatively (arthroscopic vs open repair), with the size of the glenoid defect being the primary determinant of treatment.

Assessing the progress of internal instability of fill dam material in South Korea through long-term seepage tests

Several studies investigating the internal instability of well-graded soils have suggested that well-graded soils show characteristics and developments different from those of gap-graded soils. Moreover, the cause and progression of long-term internal instability in well-graded soils have not yet been established. This study aimed to address this knowledge gap by conducting long-term seepage tests to analyze the progress and cause of the internal instability of well-graded soils generally utilized in fill dams in South Korea. The test results revealed that well-graded soils in internally stable conditions exhibited clogging due to fine particles, reducing overall permeability. A similar phenomenon was identified under internally unstable conditions. The subsequent unclogging process resulted in a rapid increase in permeability and erosion rate with the collapse of the soil structure. Consequently, the internal instabilities of well-graded soils progress through suffosion. Based on the test results, the mechanism of internal instability and its progression in well-graded soils were proposed.

Construction of a stable expression HEK293T engineered cell line adapted to high-density suspension culture

The HEK293 cell line has received FDA approval and is increasingly used to produce therapeutic glycoproteins. However, the cell line faces the challenge of long-term expression instability. This problem could be solved by specifically integrating exogenous genes into stable sites and developing a HEK293 cell platform to efficiently and stably express recombinant proteins with large-scale suspension culture. The study uses CRISPR/Cas9 and recombinase-mediated cassette exchange (RMCE) technologies to integrate a variety of exogenous genes into specific chromosomal sites, such as the hROSA26 site, AAVS1 site, and CCR5 site. We evaluated the stability and expression intensity of exogenous proteins at different insertion sites under suspension culture conditions. A monoclonal cell line expressing enhanced green fluorescent protein (EGFP) is obtained using CRISPR/Cas9-mediated specific integration. The positive monoclonal cell lines express EGFP after 60 consecutive passages, and no significant differences in protein expression titer are observed. These results show that, under suspension culture conditions, the hROSA26 locus could stably express exogenous proteins after 60 generations. HEK293 cell lines integrating HSA (68 kDa) and IFNβ-HSA (89 kDa) genes at the above three sites were obtained respectively using Bxb1-mediated RMCE technology, and batch experiments demonstrated their expression capacity. In summary, a stable and efficient protein expression platform of HEK293 cells is successfully constructed and could be adapted to serum-free suspension culture.

An integrated evaluation strategy for anaerobic digestion monitoring based on acid-base balance and thermodynamics of volatile fatty acid degradation

Process monitoring is a top priority for anaerobic digestion (AD), yet it poses a significant challenge due to its inherent inaccuracies and case-specific nature in diagnosing reactor status. Herein, a long-term instability simulation experiment using lignocellulosic biomass was conducted with varying organic loading rate (OLR) and hydraulic retention time (HRT) levels. The increase in OLR (0.75 to 20 kg VS m−3·d−1) and decrease in HRT (20 to 4 d) led to substantial total volatile fatty acids (TVFA) accumulation (>14 g/L) with a concomitant decrease in methane yield and organics removal. Full processing capacity with considerable conversion efficiency at four steps (hydrolysis: 60.43 ± 2.82 %, acidogenesis: 56.13 ± 3.27 %, acetogenesis: 56.03 ± 3.31 %, methanogenesis: 55.93 ± 3.32 %) and optimal methane yield (3.13 ± 0.17 L/(L·d)) was achieved at an OLR of 18 Kg VS·m−3·d−1 and HRT of 4 days. An integrated evaluation strategy for AD process stability is proposed based on the acid-base balance and thermodynamics of VFA degradation. Propionate, iso-valerate, TVFA/bicarbonate alkalinity (BA), and BA/total alkalinity (TA) were identified as potential auxiliary indicators for diagnosing AD imbalances, while ΔG for propionate and valerate degradation served as the early warning signs. To enhance the efficacy and universality of early warnings, relative variations for acid-base indicators based on steady-state (∼15 %) and the absolute threshold value for ΔGPropionate (-40 KJ/mol) and ΔGValerate (-55 KJ/mol) were adopted. This approach integrates considerations for microbial adaption, thereby enhancing an assessment of whether a given signal reflects irreversible acidification or is merely a temporary fluctuation induced by reversible acidification. The proposed strategy enables a reliable and accurate early warning, holding great promise for practical applications.

Erasing narrow paravisceral true lumen with endoseptostomy to favor adequate expansion of branched endograft during postdissection thoracoabdomimal aortic aneurysm endovascular repair

Narrow paravisceral aortic true lumen in postdissection thoracoabdominal aneurysm, represents a challenging situation when branched endovascular aneurysm repair is required; it may be responsible for intraprocedural technical difficulties, such as inadequate main endograft deployment, difficult vessels catheterization, or long-term branch instability related to compression. We describe the case of a 56-year-old man with post-type B thoracoabdominal aortic aneurysm and a severely narrow true lumen (10 mm) at the paravisceral segment. Endovascular aortic septostomy was performed first, to erase the narrow paravisceral aortic true lumen, and subsequently allow branched endograft adequate expansion and regular vessels catheterization.

Assessing the Initial Responsibilities of the Afghan Government for Mitigating Climate Change, Effects and Harms

Long-term instability, lack of rule of law, rampant corruption, and weakness of governments and so on was something, that affected combating climate change, and because of this, droughts, water reservoirs, various diseases, reduced food security, floods, rising temperatures, and other incidents have caused problems the lives of people. In this study, the initial responsibilities of the Afghan government for mitigating climate change, effects, and harms have been investigated, to effectively combat climate change, attract international aid, and save the people from serious problems. The research is qualitative, utilizing structured interviews and employing the judgmental non-probability sampling method. And the data were analyzed Thematic. The findings show that the Afghan government has the responsibility to enact comprehensive laws and seriously implement them, to mitigate climate change, sign international agreements and join respective conventions. In addition, organize continuous public awareness programs, and pay attention to crucial means that affect climate change, such as protecting forests, preventing pollution from factories, and well management of water resources. Also, take steps to prevent displacement and serious measures for the basic rights of internally displaced people caused by climate effects.

Fabrication of a Nanoscale Magnesium/Copper Metal-Organic Framework on Zn-Based Guided Bone Generation Membranes for Enhancing Osteogenesis, Angiogenesis, and Bacteriostasis Properties.

Recently, zinc (Zn) and its alloys have demonstrated great potential as guided bone regeneration (GBR) membranes to treat the problems of insufficient alveolar bone volume and long-term osseointegration instability during dental implantology. However, bone regeneration is a complex process consisting of osteogenesis, angiogenesis, and antibacterial function. For now, the in vivo osteogenic performance and antibacterial activity of pure Zn are inadequate, and thus fabricating a platform to endow Zn membranes with multifunctions may be essential to address these issues. In this study, various bimetallic magnesium/copper metal-organic framework (Mg/Cu-MOF) coatings were fabricated and immobilized on pure Zn. The results indicated that the degradation rate and water stability of Mg/Cu-MOF coatings could be regulated by controlling the feeding ratio of Cu2+. As the coating and Zn substrate degraded, an alkaline microenvironment enriched with Zn2+, Mg2+, and Cu2+ was generated. It significantly improved calcium phosphate deposition, differentiation of osteoblasts, and vascularization of endothelial cells in the extracts. Among them, Mg/Cu1 showed the best comprehensive performance. The superior antibacterial activity of Mg/Cu1 was demonstrated in vitro and in vivo, which indicated significantly enhanced bacteriostatic activity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli as compared to that of the bare sample. Bimetallic Mg/Cu-MOF coating could properly coordinate the multifunction on a Zn membrane and could be a promising platform for promoting its bone regeneration, which could pave the way for Zn-based materials to be used as barrier membranes in oral clinical trials.

Biphenyl-rGO composite room temperature gas sensor for enhanced amine sensing

Amines, which are classified as volatile organic compounds (VOCs), serve a variety of purposes in the fields of environmental monitoring, food safety, and healthcare diagnosis. The present technique for detecting amine levels involves sophisticated setups and bulky equipment. Here. In this study, a chemoresistive gas sensor is developed that is cost-effective and easy to operate at room temperature (RT). The sensor is designed specifically for the detection of Ammonia, dimethylamine (DMA), trimethylamine (TMA), and total volatile basic nitrogen (TVB-N). Using biphenyl-reduced graphene oxide (B-rGO) composite gas sensors effectively addresses the issues of low sensitivity-selectivity and long-term instability commonly observed in conventional amine sensors. B-rGO sensor produced sensitivity of ∼3500 and selectivity above 30 for TVB-N sensing. The sensor is stable for temperature fluctuations below 50 °C and shows stable sensing response for period of over 3 months. A Chemoresistive B-rGO sensor was developed using an ultrasonic spray deposition system with optimized flow rate of 50 mL/h. Rapid evaporation of solvent using hot plate has resulted in unique morphology for B-rGO film sensors. The highest sensitivity, ∼836, is obtained for 100 ppm of ammonia with ammonia > DMA > TMA as a sensitivity order. B-rGO showed almost seven times higher amine sensitivity than rGO which highlights the importance of biphenyl in the B-rGO composite. Sensor calibration curve has been presented in the study to understand change in the sensitivity of sensor with increasing analyte gas concentration. The calibration curve has an average R-squared value of 0.98.