Long-term Gain Research Articles

Global Trend of Glacier Melting or Growing and its Impact on Heavy Storms

Scientists calculate how much the ice sheet is growing or shrinking from the changes in surface height that are measured by the satellite altimeters. In locations where the amount of new snowfall accumulating on an ice sheet is not equal to the ice flow downward and outward to the ocean, the surface height changes and the ice-sheet mass grows or shrinks. But it might only take a few decades for Antarctica’s growth to reverse, according to Zwally. If the losses of the Antarctic Peninsula and parts of West Antarctica continue to increase at the same rate they’ve been increasing for the last two decades, the losses will catch up with the long-term gain in East Antarctica in 20 or 30 years and it is questionable whether there will be enough snowfall increase to offset these losses. The study analyzed changes in the surface height of the Antarctic ice sheet measured by radar altimeters on two European Space Agency European Remote Sensing (ERS) satellites, spanning from 1992 to 2001, and by the laser altimeter on NASA’s Ice, Cloud, and land Elevation Satellite (ICESat) from 2003 to 2008. The good news is that Antarctica is not currently contributing to sea level rise, but is taking 0.23 millimeters per year away. But, this is also bad news. If the 0.27 millimeters per year of sea level rise attributed to Antarctica in the IPCC report is not really coming from Antarctica, there must be some other contribution to sea level rise that is not accounted for. On other hand, globally every country is facing heavy storm, disastrous rain fall and variance in Climate Change, causing greater loss in production of food grain, disruption of smooth living and development and enhancement of hazardous deceases on account of Global Warming and Climatic Changes. This paper focuses on the current issues and its remedial efforts to be made essentially to curb these issues and save human life and beautiful creatures on the globe.

Hematopoietic stem cell transplantation for people with sickle cell disease.

Sickle cell disease is a genetic disorder involving a defect in the red blood cells due to its sickled hemoglobin. The main therapeutic interventions include preventive and supportive measures. Hematopoietic stem cell transplantations are carried out with the aim of replacing the defective cells and their progenitors (hematopoietic (i.e. blood forming) stem cells) in order to correct the disorder. This is an update of a previously published review. To determine whether stem cell transplantation can improve survival and prevent symptoms and complications associated with sickle cell disease. To examine the risks of stem cell transplantation against the potential long-term gain for people with sickle cell disease. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Group's Haemoglobinopathies Trials Register complied from electronic searches of the Cochrane Central Register of Controlled Trials (CENTRAL) (updated each new issue of The Cochrane Library) and quarterly searches of MEDLINE.Unpublished work was identified by searching the abstract books of major conference proceedings and we conducted a search of the website: www.ClinicalTrials.gov.Date of the most recent search of the Group's Haemoglobinopathies Trials Register: 06 October 2015. Randomized controlled and quasi-randomized studies that compared any method of stem cell transplantation with either each other or with any of the preventive or supportive interventions (e.g. periodic blood transfusion, use of hydroxyurea, antibiotics, pain relievers, supplemental oxygen) in people with sickle cell disease irrespective of the type of sickle cell disease, gender and setting. No relevant trials were identified. Ten trials were identified by the initial search and none for the update. None of these trials were suitable for inclusion in this review. Reports on the use of hematopoietic stem cell transplantation improving survival and preventing symptoms and complications associated with sickle cell disease are currently limited to observational and other less robust studies. No randomized controlled trial assessing the benefit or risk of hematopoietic stem cell transplantations was found. Thus, this systematic review identifies the need for a multicentre randomized controlled trial assessing the benefits and possible risks of hematopoietic stem cell transplantations comparing sickle status and severity of disease in people with sickle cell disease.

Association of mGFR of the Remaining Kidney Divided by Its Volume before Donation with Functional Gain in mGFR among Living Kidney Donors.

The predictors of long-term renal function in living kidney donors are currently discussed. Our objectives were to describe the predictors of functional gain of the remaining kidney after kidney donation. We hypothesized that GFR of the remaining kidney divided by volume of this kidney (rk-GFR/vol) would reflect the density of functional nephrons and be inversely associated with functional gain of the remaining kidney. We conducted a prospective monocentric study including 63 living donors (26 men; 50.3±11.8 years old) who had been evaluated for (51)Cr-EDTA and measured GFR, split renal function by scintigraphy before donation (between 2004 and 2009), and measured GFR at 5.7±0.5 years after donation. For 52 donors, volume of the remaining kidney (measured and estimated with the ellipsoid formula using renal computed tomography scannography) was determined before donation. We tested our hypothesis in an external validation cohort of 39 living donors (13 men; 51.0±9.4 years old) from another single center during the same time period. For the main cohort, the mean measured GFR was 97.6±13.0 ml/min per 1.73 m(2) before donation and 63.8±9.4 ml/min per 1.73 m(2) at 5 years. Functional gain averaged 16.2±7.2 ml/min per 1.73 m(2) (+35.3%±16.7%). Multivariate analysis showed that age, body mass index, and rk-GFR/vol at donation were negatively correlated with functional gain and had strong predictive power of the 5-year functional gain (adjusted 5-year functional gain for age: -0.4 [95% confidence interval (95% CI), -0.5 to -0.1]; body mass index: -0.3 [95% CI, -0.6 to -0.1]; rk-GFR/vol: -55.1 [95% CI, -92.3 to -17.9]). We tested this model in the external validation cohort (adjusted 5-year functional gain for age: -0.1 [95% CI, -0.5 to 0.3]; body mass index: -0.9 [95% CI, -1.8 to -0.1]; rk-GFR/vol: -97.6 [95% CI, -137.5 to -57.6]) and confirmed that rk-GFR/vol was inversely associated with 5-year functional gain. For given age and body mass index, the long-term functional gain of the remaining kidney is inversely associated with the new variable rk-GFR/vol at donation.

Assessing long-term QALYs gain from averting and reversing overweight and obesity in childhood.

Interventions to tackle childhood obesity have been devised in response to the rising prevalence of childhood obesity. However, efficiency of these interventions remains a concern. Cost-utility analysis, representing health benefits in terms of quality-adjusted life years (QALYs), is a type of economic evaluation that has widely been recommended in assessing efficiency of health interventions. However, certain limitations in using QALYs remain specifically difficult in QALYs estimation. This study estimates the long-term QALYs gain from reversing childhood obesity in Thailand. An economic model was developed to estimate long-term QALYs of the youth aged 3-18 for the BMI status in childhood, which were categorized into three groups: normal weight, overweight, and obese. Long-term QALYs were estimated between ages 35 and 100, according to children's age, sex, and BMI status. Differences in QALYs between BMI status groups were calculated to represent the QALYs gain for youth from reversing obesity and overweight. The future outcomes were discounted at 3% per annum in the base-case analysis; the discount rates of 0, 1.5, 3.5, and 5% were also applied in the sensitivity analyses. QALYs gained from reversing childhood obesity increase with age, starting from 0.040 and 0.083 QALYs at age 3 to 0.590 and 0.553 QALYs at age 18 in boys and girls, respectively. Reversing overweight and obesity in girls produces more QALYs than in boys between ages 3 and 17. Efficiency is an important issue in allocating public healthcare resources to maximize social benefits. The results of this study facilitate long-term QALYs estimation with respect to BMI status in childhood, which could encourage more routine economic evaluation of child obesity interventions and maximize their health benefits.

Real-World-Time Simulation of Memory Consolidation in a Large-Scale Cerebellar Model.

We report development of a large-scale spiking network model of the cerebellum composed of more than 1 million neurons. The model is implemented on graphics processing units (GPUs), which are dedicated hardware for parallel computing. Using 4 GPUs simultaneously, we achieve realtime simulation, in which computer simulation of cerebellar activity for 1 s completes within 1 s in the real-world time, with temporal resolution of 1 ms. This allows us to carry out a very long-term computer simulation of cerebellar activity in a practical time with millisecond temporal resolution. Using the model, we carry out computer simulation of long-term gain adaptation of optokinetic response (OKR) eye movements for 5 days aimed to study the neural mechanisms of posttraining memory consolidation. The simulation results are consistent with animal experiments and our theory of posttraining memory consolidation. These results suggest that realtime computing provides a useful means to study a very slow neural process such as memory consolidation in the brain.

Short-term pain for long-term gain: Market deregulation and monetary policy in small open economies

This paper explores the effects of labor and product market reforms in a New Keynesian, small open economy model with labor market frictions and endogenous producer entry. We show that it takes time for reforms to pay off, typically at least a couple of years. This is partly because the benefits materialize through firm entry and increased hiring, both of which are gradual processes, while any reform-driven layoffs are immediate. Some reforms – such as reductions in employment protection – increase unemployment temporarily. Implementing a broad package of labor and product market reforms minimizes transition costs. Importantly, reforms do not have noticeable deflationary effects, suggesting that the inability of monetary policy to deliver large interest rate cuts in their aftermath – either because of the zero bound on policy rates or because of the membership in a monetary union – may not be a relevant obstacle to reform. Alternative simple monetary policy rules do not have a large effect on transition costs.

Resolving China's Corporate Debt Problem

Corporate credit growth in China has been excessive in recent years. This credit boom is related to the large increase in investment after the Global Financial Crisis. Investment efficiency has fallen and the financial performance of corporates has deteriorated steadily, affecting asset quality in financial institutions. The corporate debt problem should be addressed urgently with a comprehensive strategy. Key elements should include identifying companies in financial difficulties, proactively recognizing losses in the financial system, burden sharing, corporate restructuring and governance reform, hardening budget constraints, and facilitating market entry. A proactive strategy would trade off short-term economic pain for larger longer-term gain.

Inclusive Economic Institutions in the Gulf Cooperation Council States: Current Status and Theoretical Implications

AbstractWhile the social conflict theory (SCT) suggests that absolute monarchies will not tolerate inclusive economic institutions, the Gulf Cooperation Council (GCC) countries have regularly achieved above global average ratings for property rights protection, entry barriers, disruptive wealth redistribution and corruption. This paper discusses the extent to which GCC states have potential to further improve their institutional quality. We explore whether inclusive economic institutions may emerge in GCC states, such as: (1) regional economic integration and competition which alleviate rulers’ capability to expropriate private property and ease entry barriers to the market, (2) rulers of resource rich economies sustain political power with control of natural resources as opposed to the extraction of private property; and (3) prospect of long-term gain for the ruler incentivizes the adoption of a market-based economy. Strong state involvement in manufacturing and the monopoly of some services, the effect of tribalism in economic affairs and the distribution of resources, as well as a sponsorship system for foreign workers in these states may all impede the development of a truly competitive and free economy.

Vertical Movements and Patterns in Diving Behavior of Whale Sharks as Revealed by Pop-Up Satellite Tags in the Eastern Gulf of Mexico.

The whale shark (Rhincodon typus) is a wide-ranging, filter-feeding species typically observed at or near the surface. This shark’s sub-surface habits and behaviors have only begun to be revealed in recent years through the use of archival and satellite tagging technology. We attached pop-up satellite archival transmitting tags to 35 whale sharks in the southeastern Gulf of Mexico off the Yucatan Peninsula from 2003–2012 and three tags to whale sharks in the northeastern Gulf off Florida in 2010, to examine these sharks’ long-term movement patterns and gain insight into the underlying factors influencing their vertical habitat selection. Archived data were received from 31 tags deployed on sharks of both sexes with total lengths of 5.5–9 m. Nine of these tags were physically recovered facilitating a detailed long-term view into the sharks’ vertical movements. Whale sharks feeding inshore on fish eggs off the northeast Yucatan Peninsula demonstrated reverse diel vertical migration, with extended periods of surface swimming beginning at sunrise followed by an abrupt change in the mid-afternoon to regular vertical oscillations, a pattern that continued overnight. When in oceanic waters, sharks spent about 95% of their time within epipelagic depths (<200 m) but regularly undertook very deep (“extreme”) dives (>500 m) that largely occurred during daytime or twilight hours (max. depth recorded 1,928 m), had V-shaped depth-time profiles, and comprised more rapid descents (0.68 m sec-1) than ascents (0.50 m sec-1). Nearly half of these extreme dives had descent profiles with brief but conspicuous changes in vertical direction at a mean depth of 475 m. We hypothesize these stutter steps represent foraging events within the deep scattering layer, however, the extreme dives may have additional functions. Overall, our results demonstrate complex and dynamic patterns of habitat utilization for R. typus that appear to be in response to changing biotic and abiotic conditions influencing the distribution and abundance of their prey.

Long-Term Gains from Electrification in Rural India

We know surprisingly little about the long-run impacts of household electrification. This paper studies the impacts on consumption in rural India over a 17-year period, allowing for both internal a...

Terra and Aqua MODIS Thermal Emissive Bands On-Orbit Calibration and Performance

Since launch, the Moderate Resolution Imaging Spectroradiometer (MODIS) instruments on the Terra and Aqua spacecraft have operated successfully for more than 14 and 12 years, respectively. A key instrument for National Aeronautics and Space Administration Earth Observing System missions, MODIS was designed to make continuous observations for studies of Earth's land, ocean, and atmospheric properties and to extend existing data records from heritage Earth observing sensors. The 16 thermal emissive bands (TEBs) (3.75–14.24 $\mu\mbox{m} $ ) are calibrated on orbit using a temperature controlled blackbody (BB) . Both Terra and Aqua MODIS BBs have displayed minimal drift over the mission lifetime, and the seasonal variations of the BB temperature are extremely small in Aqua MODIS. The long-term gain and noise equivalent difference in temperature performance of the 160 TEB detectors on both MODIS instruments have been well behaved and generally very stable. Small but noticeable variations of Aqua MODIS bands 33–36 (13.34–14.24 $\mu\mbox{m} $ ) response in recent years are primarily due to loss of temperature control margin of its passive cryoradiative cooler. As a result, fixed calibration coefficients, previously used by bands when the BB temperature is above their saturation temperatures, are replaced by the focal-plane-temperature-dependent calibration coefficients. This paper presents an overview of the MODIS TEB calibration, the on-orbit performance, and the challenging issues likely to impact the instruments as they continue operating well past their designed lifetime of six years.

Soil water capture trends over 50 years of single-cross maize (Zea mays L.) breeding in the US corn-belt.

Breeders have successfully improved maize (Zea mays L.) grain yield for the conditions of the US corn-belt over the past 80 years, with the past 50 years utilizing single-cross hybrids. Long-term improvement for grain yield under water-limited conditions has also been reported. Grain yield under water-limited conditions depends on water use, water use efficiency, and harvest index. It has been hypothesized that long-term genetic gain for yield could be due, in part, to increased water capture from the soil. This hypothesis was tested using a set of elite single-cross hybrids that were released by DuPont Pioneer between 1963 and 2009. Eighteen hybrids were grown in the field during 2010 and 2011 growing seasons at Woodland, CA, USA. Crops grew predominantly on stored soil water and drought stress increased as the season progressed. Soil water content was measured to 300cm depth throughout the growing season. Significant water extraction occurred to a depth of 240-300cm and seasonal water use was calculated from the change in soil water over this rooting zone. Grain yield increased significantly with year of commercialization, but no such trend was observed for total water extraction. Therefore, the measured genetic gain for yield for the period represented by this set of hybrids must be related to either increased efficiency of water use or increased carbon partitioning to the grain, rather than increased soil water uptake.

O21.3 Pre-therapy inflammation/coagulation activation and long-term cd4 response to antiretroviral therapy

Background Pre-antiretroviral therapy (ART) inflammation/coagulation activation biomarkers predict clinical outcomes, but whether they predict CD4 response to ART initiation is unknown. Methods Study cohort was a subset of 2 international trials, SMART (evaluating continuous versus interrupted ART) and FIRST (evaluating 3 first-line ART regimens with ≥2 classes). At the start of follow-up (baseline), participants had to be ART-naive/off ART, have C-reactive protein (CRP), interleukin-6 (IL-6) and D-dimer measured and be (re)initiating ART. Using random effects linear models, we assessed the association between quartiles of each of the baseline biomarker and change in CD4 to up to 24 months after ART-initiation. Analyses adjusted for baseline CD4, study arm, follow-up time and other known confounders. Sensitivity analyses included separate analyses by trials and excluding the interrupted ART arm in SMART. Results Overall, 1084 individuals (659 from SMART (26% ART naive) and 425 from FIRST) met the eligibility criteria, providing 8264 CD4 measurements. 75% were male with the mean age of 42 years, 37% and 47% were white and black respectively, and 10% and 33%, respectively, were hepatitis B and C positive. The median (inter-quartile range) baseline CD4 (cells/mm 3 ) were 360 (265–473) overall and 416 (350–530) and 100 (22–300) in SMART and FIRST, respectively. All of the biomarkers were inversely associated with baseline CD4 in FIRST but not in SMART. Curves of CD4 change over time by pre-ART biomarker quartiles significantly overlapped for all biomarkers. In adjusted models, there was no significant relationship between baseline biomarker levels and mean change in CD4 (P for trend: CRP: 0.97; IL-6: 0.25 and D-dimer: 0.29). Sensitivity analyses yielded similar results. Conclusion Pre-ART inflammation/coagulation activation markers do not predict CD4 response to ART. These biomarkers appear to influence the risk of clinical outcomes through mechanisms other than by blunting long-term CD4 gain. Disclosure The SMART and FIRST studies were funded by grants from US National Institutes of Health (NIH). Kirby Institute, UNSW Australia, is funded through the Australian Government Department of Health and Ageing. No other disclosures.

Studies of THGEM-based detector at low-pressure Hydrogen/Deuterium, for AT-TPC applications

We study the performance of single- and double- THick Gas Electron Multiplier (THGEM) detectors in pure Hydrogen (H2) and Deuterium (D2) at low pressures, in the range of 100–450 torr. The effect of the pressure on the maximum achievable gain, ion-back flow and long-term gain stability are investigated for single and double cascade detectors. In particular, it was found that maximum achievable gains above 104, from single-photoelectrons avalanche, can be achieved for pressures of 200 torr and above; for lower pressure the gains are limited by avalanche-induced secondary effects to a values of around 103. The results of this work are relevant in the field of avalanche mechanism in low-pressure, low-mass noble gases, in particular for applications of THGEM end-cap readout for active-target Time Projection Chambers (TPC) in the field of nuclear physics and nuclear astrophysics.

Fishery consequences of marine reserves: short-term pain for longer-term gain

Fishery consequences of marine reserves: short-term pain for longer-term gain

High-Resolution Three-Dimensional Structural Data Quantify the Impact of Photoinhibition on Long-Term Carbon Gain in Wheat Canopies in the Field.

Photoinhibition reduces photosynthetic productivity; however, it is difficult to quantify accurately in complex canopies partly because of a lack of high-resolution structural data on plant canopy architecture, which determines complex fluctuations of light in space and time. Here, we evaluate the effects of photoinhibition on long-term carbon gain (over 1 d) in three different wheat (Triticum aestivum) lines, which are architecturally diverse. We use a unique method for accurate digital three-dimensional reconstruction of canopies growing in the field. The reconstruction method captures unique architectural differences between lines, such as leaf angle, curvature, and leaf density, thus providing a sensitive method of evaluating the productivity of actual canopy structures that previously were difficult or impossible to obtain. We show that complex data on light distribution can be automatically obtained without conventional manual measurements. We use a mathematical model of photosynthesis parameterized by field data consisting of chlorophyll fluorescence, light response curves of carbon dioxide assimilation, and manual confirmation of canopy architecture and light attenuation. Model simulations show that photoinhibition alone can result in substantial reduction in carbon gain, but this is highly dependent on exact canopy architecture and the diurnal dynamics of photoinhibition. The use of such highly realistic canopy reconstructions also allows us to conclude that even a moderate change in leaf angle in upper layers of the wheat canopy led to a large increase in the number of leaves in a severely light-limited state.

Earnings Management of Firms Reporting Long Term Debt: An Alternative Method

This study aims to apply an alternative detection model to prove that the earnings management will be occured when a company has long-term debts as well as the pressure of operating income. Generally, the literature study of earnings management indicates that the detection of earnings management can be grouped into two objectives, 1] to find variables for detecting earnings management (accruals, real activity and classification shifting) and 2] to use some advanced statistical or mathematical models to detect earnings management. This study applies a quantitative approach using secondary data of financial statements. The study was conducted on 50 companies with the largest market capitalization, 50 of the most active companies based on trading volume, 50 of the most active companies based on the value of trade and 50 of the most active companies by frequency trading. All of them are 200 public company (listed in the Indonesia Stock Exchange-ID) based on IDX statistical report 2013. The results of this study are expected to provide a new method to detect earnings management and its application in the context of positive accounting theory (PAT). The results of the study proves that the model is able to detect earnings management by utilizing foreign exchange transaction losses and use these models to support PAT (particularly on debt covenant hypothesis). These results contribute that earnings management can be done by using the foreign exchange gain / loss. However, the limitation of this study is the model has not been able to capture the phenomenon of earnings management if a company does not report any long-term debt nor foreign exchange gain/ loss.

The impact of socio-economic deprivation on incidence, treatment and mortality from prostate cancer in England, 1990–2010

Objective: To explore any association between socio-economic deprivation and prostate cancer diagnosis and/or treatment. Patients and methods: Data was extracted as follows: We gained the incident cases and staging from the National Cancer Data Repository, survival from the Cancer Information System, mortality from the Office for National Statistics, treatment data from Hospital Episode Statistics and National Clinical Analysis and Specialised Applications Team. Our analysis regarding socio-economic deprivation was controlled for age distribution. Results: We recorded 518,453 diagnoses of prostate cancer; 174,579 prostate cancer deaths; 33,889 prostatectomies and 21,351 radiotherapy treatments. Incidence is increasing in all groups, but the highest is amongst the least deprived. Mortality is decreasing, with survival consistently better in the least deprived. Prostatectomies are more frequent in the least deprived; however, this gap is narrowing. Conclusions: Prostate cancer incidence, survival and treatment are associated with socio-economic deprivation. Prostatectomy rates show a decrease in the gap of inequality. Multiple potential confounding factors, such as rates of prostate specific antigen (PSA) testing and access to health care are associated with socio-economic deprivation. The unifying influences of Improving Outcomes Guidance and the National Treatment Guidelines are intended to counteract the above inequalities. Particularly in prostate cancer, where long-term gain depends on multiple factors, individualised treatment decisions are paramount.

Unpacking Vaccine Hesitancy Among Healthcare Providers

Unpacking Vaccine Hesitancy Among Healthcare Providers

Selection on Optimal Haploid Value Increases Genetic Gain and Preserves More Genetic Diversity Relative to Genomic Selection.

Doubled haploids are routinely created and phenotypically selected in plant breeding programs to accelerate the breeding cycle. Genomic selection, which makes use of both phenotypes and genotypes, has been shown to further improve genetic gain through prediction of performance before or without phenotypic characterization of novel germplasm. Additional opportunities exist to combine genomic prediction methods with the creation of doubled haploids. Here we propose an extension to genomic selection, optimal haploid value (OHV) selection, which predicts the best doubled haploid that can be produced from a segregating plant. This method focuses selection on the haplotype and optimizes the breeding program toward its end goal of generating an elite fixed line. We rigorously tested OHV selection breeding programs, using computer simulation, and show that it results in up to 0.6 standard deviations more genetic gain than genomic selection. At the same time, OHV selection preserved a substantially greater amount of genetic diversity in the population than genomic selection, which is important to achieve long-term genetic gain in breeding populations.