China has hundreds of thousands of oil and water wells, about 30% of which have been abandoned currently. If we can convert abandoned wells into geothermal wells, it will save lots of money and reduce drilling and completion time greatly. In this paper, six enhanced geothermal system (EGS) well layout schemes are proposed based on the utilization of abandoned oil–water wells and common oilfield well pattern. Here six common injection-production well patterns in oilfield are combined to hot dry rock (HDR) production and the heat extraction performance is simulated. The results show that the injection well number and the location of injection wells have critical influence on the heat extraction performance. Under the same total injection mass flow rate, the injection well number is the key factor and the fracture area is the secondary factor on heat extraction when the HDR energy is enough. For electricity generation, the life span is 20.2, 19.2, 19.0, 19.2, 18.2 and 13.9 years, and the heat extraction ratio is 65.83, 57.35, 65.96, 62.79, 59.30 and 43.09% from case 1 to case 6, respectively. For heating demand, the life span is 30.0, 30.0, 29.9, 30.0, 29.8, and 27.7 years, the heat extraction ratio is 78.91, 69.63, 77.02, 75.92, 72.27 and 58.94% from case 1 to case 6, respectively. The total injection mass flow rate and injection temperature also have a negative effect on the heat extraction performance. Case 1 (row parallel well layout), Case 3 (four-spot well layout) and Case 4 (five-spot well layout) are a good choice both for electricity generation and heating demand. This study provides good guidance for the selection and optimization of different EGS well layout.