Localized Fibrous Mesothelioma Research Articles

Doege-Potter Syndrome Secondary to a Solitary Fibrous Tumor of the Abdominopelvic Cavity: A Case Report

Solitary fibrous tumors (SFTs) are rare neoplasms initially identified as "localized fibrous mesothelioma" predominantly found in the pleural cavity. Common clinical manifestations include pain, the presence of a palpablemass, as well as neurological or vascular symptoms. Tumors located in the abdomen or pelvis can exert pressure on adjacent structures, leading to symptoms such as urinary obstruction or retention, bowel obstruction or constipation, and abdominal distention. Doege-Potter syndrome is characterized by hypoglycemia resulting from excessive production of insulin-like growth factors by the tumor. We report the case of a 54-year-old male patient, diagnosed with type II diabetes 8 years ago, currently not undergoing any treatment, Admitted for investigation of recurrent episodes of hypoglycemia.

Primary Cutaneous Solitary Fibrous Tumor on the Back

Solitary fibrous tumors (SFT) are uncommon mesenchymal tumors. SFT have several synonyms including localized fibrous tumor, benign mesothelioma, localized fibrous mesothelioma, and submesothelial fibroma. SFT usually occur in the pleura or other serosal surfaces, but SFT can also develop in extrapleural areas including the nasal cavity, orbit, retroperitoneum, and pelvis. Cutaneous SFT is extremely rare, and more likely to occur in the head and neck region. Histologically, this tumor can mimic a variety of benign and malignant tumors such as dermatofibroma, dermatofibrosarcoma protuberans, spindle cell lipoma or other mesenchymal tumors. Most cases of SFT show non-aggressive clinical courses, with low recurrence rates. Herein, we describe a case of primary cutaneous SFT which presented with huge mass on the back.

Solitary benign fibrous mesothelioma of the peritoneum: A rare entity in a 2-year-old child

Solitary benign fibrous mesothelioma (BFM) is uncommon and is termed as solitary fibrous mesothelioma or localized fibrous mesothelioma. Although the most common site for its development is the pleural region (65%), it has also been reported in the peritoneum. They are mostly seen in adults (average age: 54 years). Herein, we present a case of BFM in a 2-year-old male child, who presented to our hospital with abdominal pain and a lump in the abdomen. Differential diagnosis included solitary fibrous tumor, gastrointestinal stromal tumor, and benign fibrous lesions of mesentery. Establishing a preoperative diagnosis is difficult on the basis of clinical parameters or imaging studies and final diagnosis can only be assessed based on the results of histopathological and immunohistochemical examination.

Solitary fibrous tumor: A pathological enigma and clinical dilemma.

Solitary fibrous tumors are ubiquitous rare spindle cell neoplasms, most commonly arising from the pleura. Whilst now considered to be derived from mesenchymal cells, the histiogenesis has been the subject of debate. In 1931 Klemperer and Rabin first documented the occurrence of a distinctive localized pleural based tumour and proposed a submesothelial cell origin (1). Later, based on tissue culture experiments, Stout and Murray claimed derivation from mesothelial cells (2). This controversy is reflected in the variety of synonyms used for solitary fibrous tumors in the past including localized fibrous tumor, localized fibrous mesothelioma, solitary fibrous mesothelioma, fibrous mesothelioma, subserosal fibroma and submesothelial fibroma. With the advent of immunohistochemistry a fibroblastic origin, occasionally with myofibroblastic differentiation, is firmly established. This is further reinforced by the description of solitary fibrous tumors in extrathoracic sites devoid of mesothelial cells.

Solitary Fibrous Tumor as Misdiagnosed as Bladder Cancer

Seung Kyu Lee, Kyung Hyun Moon, Young Hwan JI, Hyun Ho Hwang, Hyun Soo Choo, Young Min Kim, Ro Jung Park From the Departments of Urology and Pathology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea Solitary fibrous tumor (SFT) was previously named localized fibrous mesothelioma, and this is a rare mesenchymal neoplasm that usually shows benign behavior. It is the most commonly recognized tumor of the pleura. These tumors have been recently reported to be found in unexpected locations. To the best of our knowledge, there have been only 2 reports of SFT arising from the urinary bladder in Koreans. We review this third case of SFT that was misdiagnosed as bladder cancer. This tumor was removed from a 40-year-old man who had a history of lower urinary tract symptoms. (Korean J Urol 2007;48:1319-1321) 󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏

Solitary fibrous tumour of the tongue: a case report with immunohistochemical studies

The solitary fibrous tumour (SFT), also known as a localized fibrous mesothelioma, is a neoplasm characterized by the proliferation of capillaries surrounded by masses of round or spindle-shaped cells. SFT has been discovered in many locations, however, it is extremely rare for SFT to be found in the intraoral region. We report here case of SFT arising from the tongue of a 75-year-old woman. To our knowledge, this is the second case reported of SFT originating from the tongue.

SOLITARY FIBROUS TUMOR OF THE PLEURA-A CASE REPORT-

A 50-year-old woman was admitted to the hospital because of an abnormal shadow detected incidentally by a routine chest X-ray, examination 4 years previously, when she was asymptomatic. The tumor gradually increased in size in those years. After admission, a partial resection of the lung including the tumor was performed. The tumor was attached to the visceral pleura of right lower lobe by a pedicle. Pathologically the tumor was solitary fibrous tumor of the pleura (localized fibrous mesothelioma). The histogenesis of solitary fibrous tumor is still controversial, but the mesencymal origin is preferred on the basis of immunohistochemical findings including CD34 positivity. In this case tumor cells also demonstrated positive for CD34.

Successful operation for solitary fibrous tumor of the epicardium

Successful operation for solitary fibrous tumor of the epicardium

Solitary fibrous tumour: Report of two new locations in the upper respiratory tract

Solitary fibrous tumours are uncommon spindle cell neoplasms generally associated with serosal surfaces, especially the pleura ('localized fibrous mesothelioma'). Recently, these tumours have been documented in extraserosal sites. We report two solitary fibrous tumours, including one occurring in the paediatric age group, arising in two previously unreported locations, parapharyngeal space and epiglottis. These cases expand the range of sites where this tumour may originate and confirm the tendency of extrapleural cases to involve the upper respiratory tract and adjacent structures.

A large well marginated round mass containing calcification.

A 31-year-old male has a sized relatively well marginated round mass containing peripheral calcification in left upper lung field on chest roentgenograms and computed tomogram. There are no presenting symptoms including weight loss, and occupational exposures. Definitive diagnosis must differentiate from the variety of diseases whether malignancy or benign, extrapulmonary or intrapulmonary. This report described one case of malignant localized fibrous mesothelioma histologically.

Localized fibrous pleural mesothelioma: CT findings

The CT findings in 16 patients (20 examinations) with proven localized fibrous mesothelioma are described. These lesions proved to be large, uninvasive, sometimes heterogeneous, and enhancing solitary masses. These morphologic findings in an asymptomatic patient should be suggestive of this lesion.

Unusual Primary Lung Neoplasms: Spindle Cell and Undifferentiated Lung Carcinomas Expressing only Vimentin

Two unusual primary carcinomas of the lung are described. One occurred in a 31-year-old man and was composed of large, undifferentiated, ovoid to polygonal cells. The other occurred in a 72-year-old man, was composed of spindle-shaped cells, and was initially diagnosed as a localized fibrous mesothelioma. The neoplastic cells of these tumors expressed only vimentin intermediate filaments and showed no other immunohistochemical features of epithelial neoplasms, although they exhibited a metastatic pattern characteristic of lung carcinomas. These two malignant neoplasms further expand the spectrum of unusual lung neoplasms, and suggest that there are pulmonary carcinomas that contain only vimentin intermediate filaments.

Localized Fibrous Tumor of the Serosal Cavities: Immunohistochemical, Electron-Microscopic, and Flow-Cytometric DNA Study

Localized fibrous tumor of the serosal cavities (localized fibrous mesothelioma) is a generally benign spindle cell neoplasm of uncertain histogenesis. Fourteen histologically similar primary tumors from different mesothelium-lined sites (11 pleural and 1 each in the pericardium, peritoneal cavity, and pouch of Douglas) and 2 recurrences of those tumors (pericardium and pouch of Douglas) were examined histopathologically and by flow cytometry to relate histologic features and DNA ploidy to biologic behavior (follow-up, 48-255 months among 13 patients). All 16 tumors (14 primaries and 2 recurrences) displayed diploid DNA pattern, and none of 13 patients died of disease (1 patient was lost to follow-up). To elucidate the histogenesis, seven primary tumors were examined for vimentin and keratin immunostaining and six primary tumors were assessed by electron microscopy. All cases exhibited spindle-fibroblastic cell proliferation with a prominent hemangiopericytic pattern. All cases so examined had positive results for vimentin and negative results for keratin. Ultrastructurally, the tumor cells showed mesenchymal-fibroblastic features. These results support a mesenchymal origin, most likely from submesothelial fibroblasts. Further, this neoplasm may recur but retain its basic histologic features, diploidy, and benign outcome.

Localized fibrous tumor (localized fibrous mesothelioma) of the liver

A case of localized fibrous tumor (LFT) (localized fibrous mesothelioma) of the liver in an 83-year-old woman is presented. The tumor was 15 x 9 x 8 cm and was confined to the left lateral segment of the liver. Occasional mitotic figures (MF) (2 to 3 per 50 high-power fields [HPF]) were present. Strong, diffuse vimentin positivity was demonstrated by immunohistochemistry. Immunoreactivity for cytokeratins (AE1-3), epithelial membrane antigen (EMA), desmin, and desmosomal proteins (desmoplakin I + II) was absent. Electron microscopic examination showed a mesenchymal appearance of the majority of neoplastic cells, with a few ultrastructural features suggestive of mesothelial differentiation. These findings supported a submesothelial origin of the tumor. After a partial hepatectomy with total gross and microscopic removal of the tumor, the patient was alive without recurrence at 2 years, 5 months later. A review of the English literature showed six additional cases that are probably similar. Currently, all tumors have been clinically benign, although follow-up information has been limited.

BENIGN LOCALIZED PLEURAL MESOTHELIOMA EXISTED IN INTER LOBAR SPACE WITH A DIFFICULTY IN DIAGNOSIS

A case of benign localized pleural mesothelioma which was found in the visceral pleura between left upper and lower lobe is reported. A 39-year-old man was pointed out an abnormal lung shadow in the chest X-ray film two years ago. He was referred to our ward for a recent enlargement of the shadow. A plain chest film revealed a homogenous shadow with positive extrapleural sign in the left superior mediastinum. The shadow had enlarged and moved downward by about 3cm during two years. Right anterior oblique projection showed a wrighting brush-like shadow toward the hilus which suggested an interlobar disease, but chest CT scan suggested a mediastinal tomor. Since it was difficult to make an established diagnosis preoperatively, thoracotomy was prformed. There was a pedunculated mass in the visceral pleura between left upper and lower lobe, and the mass was removed with normal lung tissue. Histological examination could confirm that it was a benign localized fibrous mesothelioma.

Localized Fibrous Mesothelioma of Pleura Following External Ionizing Radiation Therapy

Carcinogenesis is a well-known complication of radiation exposure. Ionizing radiation also leads to an increased incidence of benign tumors. A 36-year-old woman had a localized fibrous mesothelioma of the pleura and an ipsilateral breast carcinoma 23 years after receiving external radiation therapy for treatment of a chest wall keloid.

Intrapulmonary Localized Fibrous Tumor: Intraparenchymal So-Called Localized Fibrous Mesothelioma

This report describes three cases of intrapulmonary fibromas which are histologically identical to localized fibrous tumors of pleura (localized fibrous mesothelioma). Morphologically these tumors are characterized by a haphazard proliferation of cytologically bland spindle cells separated by variable amounts of wavy hyalinized collagen. Entrapped bronchiolar and alveolar epithelium is common. These spindle cells lack expression of cytoplasmic keratin, S-100 protein, desmin, and epithelial membrane antigen, but are strongly decorated for intracellular vimentin. The clinical behavior, differential diagnosis, and histogenesis of these lesions are discussed.

CT findings in localized fibrous mesothelioma of the pleural fissure.

Three patients with fibrous mesothelioma of a pleural fissure are presented. Although the appearance of lung surrounding a mass is typical of an intraparenchymal lesion, attention to the position of the mass in relationship to the fissure may suggest the possibility of a pleural mass. Localized fibrous mesothelioma should be included in the differential diagnosis of an apparent solitary lung mass located in the region of a fissure.

Malignant fibrosarcomatous mesothelioma and benign pleural fibroma (localized fibrous mesothelioma) in tissue culture:A comparison of the in Vitropattern of growth in relation to the cell of origin

Two cases of fibrous mesothelioma are presented. The first is a malignant tumor containing bundles of spindle-shaped cells with a dense reticulin network and nests of epithelial-like cells. The second is a benign tumor made up of spindle-shaped cells arranged in bundles with abundant reticulin and collagen fibers. Tissue culture in the first case revealed plagues similar to those formed by epithelial tumors. The second case had a fibroblastic pattern with single isolated spindle-shaped cells. These findings confirmed the mesothelial nature of fibrosarcomatous mesothelioma and supported the view that the so-called localized fibrous mesotheliomas could be fibroblastic neoplasms derived from the submesothelial connective tissue.