Maxillary canines are one of the most common impacted teeth. The objective in localization of an impacted canine is to be able to decide such a radiographic technique which has minimal radiation dose, cost and minimum superimpositions. Panoramic radiograph, being a screening radiograph, can satisfy the above needs. Taking this into consideration, the present study was done to evaluate the reliability of panoramic radiograph in localization of impacted permanent maxillary canines, when compared to cone-beam computed tomography.OPG and CBCT images of 100 maxillary impacted canines were included in the study irrespective of site. Each OPG was evaluated for vertical angulation and the data obtained was tabulated and subjected to statistical analysis.In the present study, the female to male ratio was 2.57:1, with a slightly higher prevalence of impacted maxillary canines on left side. The results of the present study show a 100% concordance between OPG and CBCT for palatal and buccal impactions, and 91% for mid-alveolus impactions.Based on the results of the present study, it may be concluded that panoramic radiographs are useful for predicting the location of impacted maxillary canines against the confirmatory radiographic modality like CBCT.